Listening to the heart-brain talk: persistent depressive symptoms are associated with hsCRP in apparently healthy individuals at high risk for coronary artery disease

2011 ◽  
Vol 19 (4) ◽  
pp. 857-863 ◽  
Author(s):  
Rima Azar ◽  
Robert P Nolan ◽  
Donna E Stewart
Keyword(s):  
Coronary Artery Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
High Risk ◽  
High Sensitivity ◽  
Coronary Event ◽  
Healthy Individuals ◽  
Persistent Symptoms ◽  
Artery Disease ◽  
Apparently Healthy

Background: This study examined whether mild-to-moderate depressive symptoms are associated with increased high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) levels in apparently healthy individuals at high risk for coronary artery disease. We investigated in individuals whether: (1) current depressive symptoms were associated with increased hsCRP and IL-6 levels; (2) persistent depressive symptoms at two time points 6 months apart were associated with hsCRP and IL-6; and (3), sex-based differences in inflammation were a function of depressive symptoms. Methods: We measured depressive symptoms (twice), hsCRP, and IL-6 (follow-up time point) in 84 apparently healthy individuals (52% women) at high cardiac risk. Results: Patients with persistent depressive symptoms had higher hsCRP, compared to participants without persistent symptoms (5.55 vs. 1.70 mg/l, p < 0.05, 95% CI 0.11 to 1.09, d = 0.67). Participants with current depressive symptoms had higher hsCRP (3.99 vs. 1.70 mg/l, p = 0.059) than those without symptoms. Findings remained unchanged after controlling for covariates. Women had higher adjusted hsCRP than men (2.91 vs. 1.87 mg/l, p < 0.001). When we entered depressive symptoms, the model remained significant, with a significant interaction between sex and symptoms: women with depressive symptoms had higher hsCRP than men with depressive symptoms and than women without symptoms (6.75 vs. 1.11 mg/l). The hypothesized differences were not observed with respect to IL-6, after controlling for body mass index (95% CI−0.77 to 0.73). Conclusions: Before a first ischaemic coronary event, persistent mild-to-moderate depressive symptoms were associated with increased hsCRP. Women with depressive symptoms had higher hsCRP than men with symptoms.

scholarly journals Serum Myeloperoxidase Levels Are Associated With the Future Risk of Coronary Artery Disease in Apparently Healthy Individuals

2007 ◽  
Vol 50 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Marijn C. Meuwese ◽  
Erik S.G. Stroes ◽  
Stanley L. Hazen ◽  
Joram N. van Miert ◽  
Jan Albert Kuivenhoven ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Individuals ◽  
The Future ◽  
Future Risk ◽  
Artery Disease ◽  
Apparently Healthy

Mo-W7:5 Myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals

2006 ◽  
Vol 7 (3) ◽  
pp. 24
Author(s):  
M.C. Meuwese ◽  
S.M. Boekholdt ◽  
J.J.P. Kastelein ◽  
S.L. Hazen ◽  
J.A. Kuivenhoven ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Individuals ◽  
The Future ◽  
Future Risk ◽  
Artery Disease ◽  
Apparently Healthy

scholarly journals Evaluation of efficacy and safety of improved transurethral plasma kinetic enucleation of the prostate in high-risk patients with benign prostatic hyperplasia and coronary artery disease

2021 ◽  
Vol 49 (11) ◽  
pp. 030006052110608
Author(s):  
Qingchao Meng ◽  
Jingmei Li ◽  
Mingfeng Li ◽  
Rangxue Qiu
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Risk ◽  
Troponin I ◽  
Urine Volume ◽  
High Sensitivity ◽  
Urinary Flow ◽  
High Risk Patients ◽  
Risk Patients ◽  
Artery Disease

Objective This prospective study aimed to evaluate the safety of improved transurethral plasma kinetic enucleation of the prostate (iTUPKEP) in the perioperative period in high-risk patients with benign prostatic hyperplasia (BPH) and coronary artery disease. Methods Patients with BPH underwent surgical treatment with transurethral vapour resection of the prostate (TUVP) or iTUPKEP. Serum endothelin-1, cardiac troponin-I, and high-sensitivity C-reactive protein concentrations were evaluated in the short term after surgery. The postvoid residual urine volume, maximum urinary flow rate, international prostate symptom score, and quality of life indicators were evaluated in the long term after surgery. Results Endothelin-1 concentrations were lower in the iTUPKEP group than in the TUVP group at 1 and 2 days postoperatively. The iTUPKEP group had lower cardiac troponin-I and high-sensitivity C-reactive protein concentrations at all time points postoperatively. The postvoid residual urine volume, international prostate symptom score, and quality of life values were lower, but the maximum urinary flow rate was higher, in the iTUPKEP group than in the TUVP group. Conclusions The iTUPKEP procedure has a smaller effect on vascular endothelial function compared with TUVP. Therefore, iTUPKEP may reduce the incidence of postoperative cardiovascular adverse events in high-risk patients with BPH and coronary artery disease.

scholarly journals Mindfulness-Based Stress Reduction for Coronary Artery Disease Patients: Potential Improvements in Mastery and Depressive Symptoms

2021 ◽  
Author(s):  
Oskar Lundgren ◽  
Peter Garvin ◽  
Lennart Nilsson ◽  
Viktor Tornerefelt ◽  
Gerhard Andersson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
Stress Reduction ◽  
Psychological Functioning ◽  
Mindfulness Meditation ◽  
Reference Group ◽  
Coronary Event ◽  
Mindfulness Based Stress Reduction ◽  
Artery Disease

AbstractDepressive symptoms after coronary events are associated with a worse prognosis. When changing the focus from psychopathology towards a resilience framework, treatments such as mindfulness meditation could offer novel ways to address psychological distress among coronary artery disease (CAD) patients. We studied the feasibility of mindfulness-based stress reduction (MBSR) for CAD patients with depressive symptoms. Seventy-nine CAD patients with elevated depressive symptoms were invited to an 8-week MBSR course. Twenty-four patients (30%) accepted and 16 (20%) completed MBSR. Depressive symptoms decreased immediately after the course (p = .006). After 12 months, this improvement remained, and Mastery scores increased (p = .005). A reference group of 108 CAD patients did not show any significant changes in depressive symptoms or Mastery between 1 and 12 months after a coronary event. MBSR thus appears to be a feasible alternative for CAD patients with elevated depressive symptoms. Future studies are warranted to study if MBSR can improve psychological functioning in CAD patients.Clinicaltrials.gov (Registration Number: NCT03340948).

scholarly journals High-Sensitivity Troponin I Is Associated With High-Risk Plaque and MACE in Stable Coronary Artery Disease

2017 ◽  
Vol 10 (10) ◽  
pp. 1200-1203 ◽  
Author(s):  
Adam J. Brown ◽  
Anoop S.V. Shah ◽  
Nick E.J. West ◽  
Charis Costopoulos ◽  
Mateusz Orzalkiewicz ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Risk ◽  
Troponin I ◽  
Stable Coronary Artery Disease ◽  
High Sensitivity ◽  
High Sensitivity Troponin ◽  
Artery Disease

scholarly journals Impact of subclinical hypothyroidism on the coronary artery disease in apparently healthy subjects

2011 ◽  
Vol 165 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Young Joo Park ◽  
You Jin Lee ◽  
Sang-Il Choi ◽  
Eun-Ju Chun ◽  
Hak Chul Jang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
High Risk ◽  
Subclinical Hypothyroidism ◽  
Healthy Subjects ◽  
Overt Hypothyroidism ◽  
Artery Disease ◽  
Mild Thyroid Failure ◽  
Apparently Healthy

ObjectiveCardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CAD), as detected by cardiac computed tomography (CT), in apparently healthy subjects.Subjects and methodsWe retrospectively enrolled 2404 asymptomatic subjects who underwent cardiac CT with an intermediate to high risk (Framingham 10-year risk ≥10%) of developing CAD but with no known CAD or thyroid disease. Coronary artery calcium score (CACS) was assessed by calcium scan, and the presence of the plaques (CAD), with ≥50% stenosis being indicative of obstructive CAD, was assessed by coronary CT angiography.ResultsOf the 2404 subjects, 2355 subjects were euthyroid (Eu; 53±9 years, 83 females) and 49 had SCH (58±12 years, seven females). CAD and CACS >100 were more prevalent in SCH subjects than in Eu subjects (Eu vs SCH: CAD, 948 (40.6%) vs 31 (63.3%), P=0.002; CACS >100, 239 (10.3%) vs 10 (20.4%), P=0.031). SCH was also an independent risk factor for CAD after a multivariate analysis (odds ratio: 2.125, 95% confidence interval: 1.049–4.307, P=0.036).ConclusionsSCH subjects who were at an intermediate-to-high risk of developing CAD were significantly more likely to exhibit occult CAD than Eu subjects, especially in men with SCH. These findings suggest that mild thyroid failure also independently contributes to the development of CAD.

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