Mo-W7:5 Myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals

2006 ◽  
Vol 7 (3) ◽  
pp. 24
Author(s):  
M.C. Meuwese ◽  
S.M. Boekholdt ◽  
J.J.P. Kastelein ◽  
S.L. Hazen ◽  
J.A. Kuivenhoven ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Individuals ◽  
The Future ◽  
Future Risk ◽  
Artery Disease ◽  
Apparently Healthy

scholarly journals Serum Myeloperoxidase Levels Are Associated With the Future Risk of Coronary Artery Disease in Apparently Healthy Individuals

2007 ◽  
Vol 50 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Marijn C. Meuwese ◽  
Erik S.G. Stroes ◽  
Stanley L. Hazen ◽  
Joram N. van Miert ◽  
Jan Albert Kuivenhoven ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Individuals ◽  
The Future ◽  
Future Risk ◽  
Artery Disease ◽  
Apparently Healthy

Listening to the heart-brain talk: persistent depressive symptoms are associated with hsCRP in apparently healthy individuals at high risk for coronary artery disease

2011 ◽  
Vol 19 (4) ◽  
pp. 857-863 ◽  
Author(s):  
Rima Azar ◽  
Robert P Nolan ◽  
Donna E Stewart
Keyword(s):  
Coronary Artery Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
High Risk ◽  
High Sensitivity ◽  
Coronary Event ◽  
Healthy Individuals ◽  
Persistent Symptoms ◽  
Artery Disease ◽  
Apparently Healthy

Background: This study examined whether mild-to-moderate depressive symptoms are associated with increased high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) levels in apparently healthy individuals at high risk for coronary artery disease. We investigated in individuals whether: (1) current depressive symptoms were associated with increased hsCRP and IL-6 levels; (2) persistent depressive symptoms at two time points 6 months apart were associated with hsCRP and IL-6; and (3), sex-based differences in inflammation were a function of depressive symptoms. Methods: We measured depressive symptoms (twice), hsCRP, and IL-6 (follow-up time point) in 84 apparently healthy individuals (52% women) at high cardiac risk. Results: Patients with persistent depressive symptoms had higher hsCRP, compared to participants without persistent symptoms (5.55 vs. 1.70 mg/l, p < 0.05, 95% CI 0.11 to 1.09, d = 0.67). Participants with current depressive symptoms had higher hsCRP (3.99 vs. 1.70 mg/l, p = 0.059) than those without symptoms. Findings remained unchanged after controlling for covariates. Women had higher adjusted hsCRP than men (2.91 vs. 1.87 mg/l, p < 0.001). When we entered depressive symptoms, the model remained significant, with a significant interaction between sex and symptoms: women with depressive symptoms had higher hsCRP than men with depressive symptoms and than women without symptoms (6.75 vs. 1.11 mg/l). The hypothesized differences were not observed with respect to IL-6, after controlling for body mass index (95% CI−0.77 to 0.73). Conclusions: Before a first ischaemic coronary event, persistent mild-to-moderate depressive symptoms were associated with increased hsCRP. Women with depressive symptoms had higher hsCRP than men with symptoms.

Adiponectin/C-reactive protein interplay in healthy individuals and in patients with coronary artery disease

2010 ◽  
Vol 144 (1) ◽  
pp. 82-84
Author(s):  
Mahmoud M. Ramadan ◽  
Makoto Kodama ◽  
Masahiro Ito ◽  
Nader El-Shahat ◽  
Mahmoud M. Yousif ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Individuals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Artery Disease

scholarly journals A Novel Polymorphism in the Promoter of theCYP4A11Gene Is Associated with Susceptibility to Coronary Artery Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Svetlana Sirotina ◽  
Irina Ponomarenko ◽  
Alexander Kharchenko ◽  
Marina Bykanova ◽  
Anna Bocharova ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Transcription Factors ◽  
Coronary Artery ◽  
In Silico Analysis ◽  
Healthy Individuals ◽  
Epistatic Interactions ◽  
Increased Risk ◽  
Artery Disease ◽  
Silico Analysis ◽  
Age And Sex

Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD). We investigated whether polymorphisms of theCYP4A11andCYP4F2genes are associated with the risk of CAD in Russian population. DNA samples from 1323 unrelated subjects (637 angiographically confirmed CAD patients and 686 age- and sex-matched healthy individuals) were genotyped for polymorphisms rs3890011, rs9332978, and rs9333029 ofCYP4A11and rs3093098 and rs1558139 ofCYP4F2by using the Mass-ARRAY 4 system. SNPs rs3890011 and rs9332978 ofCYP4A11were associated with increased risk of CAD in women: OR = 1.26, 95% CI: 1.02–1.57,P=0.004, andQ=0.01and OR = 1.45, 95% CI: 1.13–1.87,P=0.004, andQ=0.01, respectively. Haplotype G-C-A ofCYP4A11was associated with increased risk of CAD (adjusted OR = 1.41, 95% CI: 1.12–1.78, andP=0.0036). Epistatic interactions were found between rs9332978 ofCYP4A11and rs1558139 ofCYP4F2(Pinteraction=0.025). In silico analysis allowed identifying that SNP rs9332978 is located at a binding site for multiple transcription factors; many of them are known to regulate the pathways involved in the pathogenesis of CAD. This is the first study in Europeans that reported association between polymorphism rs9332978 ofCYP4A11and susceptibility to coronary artery disease.

Inflammation and future risk of symptomatic heart failure in patients with stable coronary artery disease

2014 ◽  
Vol 167 (5) ◽  
pp. 707-714 ◽  
Author(s):  
Alon Eisen ◽  
Michal Benderly ◽  
Solomon Behar ◽  
Uri Goldbourt ◽  
Moti Haim
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Stable Coronary Artery Disease ◽  
Symptomatic Heart Failure ◽  
Future Risk ◽  
Artery Disease
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