scholarly journals Mindfulness-Based Stress Reduction for Coronary Artery Disease Patients: Potential Improvements in Mastery and Depressive Symptoms

2021 ◽  
Author(s):  
Oskar Lundgren ◽  
Peter Garvin ◽  
Lennart Nilsson ◽  
Viktor Tornerefelt ◽  
Gerhard Andersson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
Stress Reduction ◽  
Psychological Functioning ◽  
Mindfulness Meditation ◽  
Reference Group ◽  
Coronary Event ◽  
Mindfulness Based Stress Reduction ◽  
Artery Disease

AbstractDepressive symptoms after coronary events are associated with a worse prognosis. When changing the focus from psychopathology towards a resilience framework, treatments such as mindfulness meditation could offer novel ways to address psychological distress among coronary artery disease (CAD) patients. We studied the feasibility of mindfulness-based stress reduction (MBSR) for CAD patients with depressive symptoms. Seventy-nine CAD patients with elevated depressive symptoms were invited to an 8-week MBSR course. Twenty-four patients (30%) accepted and 16 (20%) completed MBSR. Depressive symptoms decreased immediately after the course (p = .006). After 12 months, this improvement remained, and Mastery scores increased (p = .005). A reference group of 108 CAD patients did not show any significant changes in depressive symptoms or Mastery between 1 and 12 months after a coronary event. MBSR thus appears to be a feasible alternative for CAD patients with elevated depressive symptoms. Future studies are warranted to study if MBSR can improve psychological functioning in CAD patients.Clinicaltrials.gov (Registration Number: NCT03340948).

Listening to the heart-brain talk: persistent depressive symptoms are associated with hsCRP in apparently healthy individuals at high risk for coronary artery disease

2011 ◽  
Vol 19 (4) ◽  
pp. 857-863 ◽  
Author(s):  
Rima Azar ◽  
Robert P Nolan ◽  
Donna E Stewart
Keyword(s):  
Coronary Artery Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
High Risk ◽  
High Sensitivity ◽  
Coronary Event ◽  
Healthy Individuals ◽  
Persistent Symptoms ◽  
Artery Disease ◽  
Apparently Healthy

Background: This study examined whether mild-to-moderate depressive symptoms are associated with increased high-sensitivity C-reactive protein (hsCRP) and interleukin 6 (IL-6) levels in apparently healthy individuals at high risk for coronary artery disease. We investigated in individuals whether: (1) current depressive symptoms were associated with increased hsCRP and IL-6 levels; (2) persistent depressive symptoms at two time points 6 months apart were associated with hsCRP and IL-6; and (3), sex-based differences in inflammation were a function of depressive symptoms. Methods: We measured depressive symptoms (twice), hsCRP, and IL-6 (follow-up time point) in 84 apparently healthy individuals (52% women) at high cardiac risk. Results: Patients with persistent depressive symptoms had higher hsCRP, compared to participants without persistent symptoms (5.55 vs. 1.70 mg/l, p < 0.05, 95% CI 0.11 to 1.09, d = 0.67). Participants with current depressive symptoms had higher hsCRP (3.99 vs. 1.70 mg/l, p = 0.059) than those without symptoms. Findings remained unchanged after controlling for covariates. Women had higher adjusted hsCRP than men (2.91 vs. 1.87 mg/l, p < 0.001). When we entered depressive symptoms, the model remained significant, with a significant interaction between sex and symptoms: women with depressive symptoms had higher hsCRP than men with depressive symptoms and than women without symptoms (6.75 vs. 1.11 mg/l). The hypothesized differences were not observed with respect to IL-6, after controlling for body mass index (95% CI−0.77 to 0.73). Conclusions: Before a first ischaemic coronary event, persistent mild-to-moderate depressive symptoms were associated with increased hsCRP. Women with depressive symptoms had higher hsCRP than men with symptoms.

scholarly journals Medicine-based evidence: the case of antidepressants in patients with coronary artery disease

2018 ◽  
Vol 28 (1) ◽  
pp. 18-20
Author(s):  
C. Barbui ◽  
G. Ostuzzi
Keyword(s):  
Coronary Artery Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
Depressive Symptomatology ◽  
Rehabilitation Program ◽  
Everyday Clinical Practice ◽  
Production Of Knowledge ◽  
Antidepressant Use ◽  
Artery Disease ◽  
Harmful Effects

AbstractIn individuals with coronary artery disease and concurrent depressive symptomatology, the evidence on the beneficial and harmful effects of antidepressants is very limited. Recently, a study was carried out to describe depressive symptoms and the treatments provided under real-world circumstances to cardiac patients who entered the Mayo Clinic cardiac rehabilitation program. Antidepressant use was associated with reductions in depressive symptoms, but also with poorer cardiovascular outcomes. In this commentary, the results of this study are discussed in view of their clinical implications for everyday clinical practice and for the production of knowledge.

scholarly journals 1072-215 Depressive symptoms are associated with reduced heart rate variability in individuals without coronary artery disease

2004 ◽  
Vol 43 (5) ◽  
pp. A120-A121
Author(s):  
Viola Vaccarino ◽  
Rachel Lampert ◽  
Forrester Lee ◽  
J.Douglas Bremner ◽  
Jerome L Abramson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
Artery Disease

scholarly journals Serum Levels of FGF21, β-Klotho, and BDNF in Stable Coronary Artery Disease Patients With Depressive Symptoms: A Cross-Sectional Single-Center Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Yeshun Wu ◽  
Zijun Chen ◽  
Jiahao Duan ◽  
Kai Huang ◽  
Bin Zhu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
Stable Coronary Artery Disease ◽  
Depression Scale ◽  
Serum Levels ◽  
Fibroblast Growth Factor 21 ◽  
Healthy Population ◽  
Cross Sectional ◽  
Artery Disease

Background: The incidence of depressive symptoms (DS) in patients with stable coronary artery disease (SCAD) is significantly higher than those in healthy population, and that DS are independent risk factors for cardiovascular events. Previous studies have reported that fibroblast growth factor 21 (FGF21), β-klotho, mature brain-derived neurotrophic factor (mBDNF), and BDNF precursor (proBDNF) play important roles in the pathogenesis and treatment of coronary heart disease and depression. With this in mind, the present study aimed to clarify the relationship between FGF21, β-klotho, mBDNF, and proBDNF and SCAD with comorbid depression, in addition to also exploring the underlying mechanisms of these disease processes.Methods: A total of 116 patients with SCAD and 45 healthy controls were recruited. Patients with SCAD were further divided into two subgroups based on the Zung Self-Rating Depression Scale (SDS), which were characterized as those with no DS (NDS) and those with DS. Baseline data were collected, and serum levels of FGF21, β-klotho, mBDNF, and proBDNF were determined.Results: In SCAD patients, Gensini scores—denoting the degree of coronary arteriostenosis—were significantly greater in the DS group than in the NDS group. There was also a positive correlation between the Gensini scores and the SDS scores. Patients in the SCAD group demonstrated a lower serum FGF21. Serum β-klotho, mBDNF, and mBDNF/proBDNF were also significantly lower in the DS group than in the NDS group. Furthermore, β-klotho and mBDNF were negatively correlated with the SDS scores. Additionally, SCAD patients were divided into lower- and higher-level groups using hierarchical cluster analysis, with the results highlighting that patients in the lower mBDNF group had a higher incidence of DS.Conclusions: The depression score was positively correlated with the severity of coronary artery stenosis, and serum FGF21, β-klotho, mBDNF, and proBDNF were closely related to the development of DS in patients with SCAD. These observations suggest FGF21, β-klotho, mBDNF, and proBDNF as potential diagnostic and/or therapeutic targets for SCAD with co-morbid depression.

scholarly journals Depressive symptoms in patients with coronary artery disease

2016 ◽  
Vol 34 (2) ◽  
Author(s):  
Débora Maria Mendonça da Cunha ◽  
◽  
Thaynara Silva dos Anjos ◽  
Cristiane Franca Lisboa Gois ◽  
Maria Cláudia Tavares de Mattos ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Depressive Symptoms ◽  
Coronary Artery ◽  
Artery Disease
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