Comparison of urine dipstick, sulfosalicylic acid, urine protein-to-creatinine ratio and a feline-specific immunoassay for detection of albuminuria in cats with chronic kidney disease

Background: Cilnidipine is a dual blocker of L type and N type calcium channel and dilates both afferent and efferent arterioles. Hence it increases renal blood flow and reduces glomerular pressure ultimately reducing proteinuria. Thus, it may exert renoprotective effects. The present study was designed to compare the antiproteinuric effects of cilnidipine and amlodipine in hypertensive patients with chronic kidney disease as add on therapy to patients on losartan.Methods: This is a randomized, open label, prospective, parallel group study conducted in the out patient Department of Nephrology. The trial enrolled Diabetic CKD patients with hypertension and with spot urine protein creatinine ratio (PCR) ≥0.2 who were being treated with T. Losartan 50mg/day for >2 months. The subjects were then randomly assigned to 2 groups to receive either cilnidipine 10-20mg/day (Group A-46) or amlodipine 5-10mg/day (Group B- 50). The drugs were given for a duration of 6 months for each patient. The dose of losartan (50mg/day) was not adjusted throughout the study.Results: After 6 months, a significant reduction in systolic and diastolic blood pressure was seen in both the groups. The decrease in urinary protein creatinine ratio was significantly higher in cilnidipine group rather than amlodipine group. Thus, cilnidipine exerted greater antiproteinuric effect than amlodipine.Conclusions: Cilnidipine has antihypertensive effect equivalent to amlodipine but addition of cilnidipine rather than amlodipine to losartan decreased urine protein excretion in diabetic chronic kidney disease patients.

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Impact of salt restriction on renal function, urine protein–creatinine ratio and nutrition of patients with chronic kidney disease stages III–V

International Journal of Cardiology ◽

10.1016/j.ijcard.2011.08.809 ◽

2011 ◽

Vol 152 ◽

pp. S103-S104

Author(s):

Keng-Hee Koh ◽

Clare Tan ◽

Lawrence Hii

Keyword(s):

Chronic Kidney Disease ◽

Renal Function ◽

Kidney Disease ◽

Creatinine Ratio ◽

Urine Protein ◽

Salt Restriction ◽

Disease Stages

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Accuracy of spot urine protein creatinine ratio in measuring proteinuria in chronic kidney disease stage 3 and 4

Indian Journal of Nephrology ◽

10.4103/0971-4065.120340 ◽

2013 ◽

Vol 23 (6) ◽

pp. 428 ◽

Cited By ~ 3

Author(s):

RA Annigeri ◽

V Vadamalai ◽

R Seshadri ◽

S Balasubramanian ◽

BS Rao ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Chronic Kidney Disease Stage ◽

Disease Stage ◽

Creatinine Ratio ◽

Urine Protein ◽

Spot Urine

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Efficacy of a new dietary supplement in dogs with advanced chronic kidney disease

PeerJ ◽

10.7717/peerj.9663 ◽

2020 ◽

Vol 8 ◽

pp. e9663

Author(s):

Elisa Martello ◽

Francesca Perondi ◽

Maria Teresa Capucchio ◽

Ilaria Biasato ◽

Elena Biasibetti ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Dietary Supplement ◽

Control Group ◽

Common Disease ◽

Creatinine Ratio ◽

Serum Bicarbonate ◽

Phosphorus Level ◽

Urine Protein ◽

Advanced Chronic Kidney Disease

Chronic kidney disease (CKD) is a common disease in elderly dogs. The present study aims to evaluate the efficacy of a dietary supplement containing calcium carbonate, calcium-lactate gluconate, chitosan and sodium bicarbonate in dogs with IRIS stage 3 of CKD. Twenty dogs were enrolled in the study, ten were administered the new dietary supplementation for 180 days (T group) while the others were used as control group (C group). Haematologic, biochemical and urinalysis were performed every 30 days. A significant reduction in the T group compared to the C group in serum phosphorus level and increase in serum bicarbonate and ionized calcium values were recorded. The urine protein-to-creatinine ratio (UPC) was significantly lower in the T group at the end of the study compared to the C group. The tested supplement could be considered as a supportive treatment for dogs with advanced CKD.

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