Alagille syndrome and pregnancy

Multisystem Disorder ◽

Adverse Pregnancy ◽

Alagille syndrome is an autosomal dominant multisystem disorder with an estimated frequency of 1 in 30 000. Only a small number of pregnancy outcomes have been described in women with this condition. The report details the pregnancy outcomes of two women with Alagille syndrome. We also review the literature pertaining to this syndrome in pregnancy and demonstrate a significant risk of adverse pregnancy outcomes.

Comparison of pregnancy outcomes after second trimester amniocentesis between procedures performed by experts and non-experts

Journal of Perinatal Medicine ◽

10.1515/jpm-2020-0430 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Tanapak Wisetmongkolchai ◽

Fuanglada Tongprasert ◽

Kasemsri Srisupundit ◽

Suchaya Luewan ◽

Kuntharee Traisrisilp ◽

...

Keyword(s):

Pregnancy Outcomes ◽

Loss Rate ◽

Fetal Loss ◽

Expert Group ◽

Second Trimester ◽

Single Institution ◽

Adverse Pregnancy ◽

In Pregnancy ◽

Singleton Pregnancies

AbstractObjectivesTo compare the rate of fetal loss in pregnancy after second trimester amniocentesis between procedures performed by experts and non-experts and to assess other pregnancy complications as secondary outcomes.MethodsA retrospective cohort study was performed on singleton pregnancies that underwent mid-trimester amniocenteses in a single institution. The fetal loss rates of procedures performed by experts and non-experts were collected and analyzed. Other adverse pregnancy outcomes were also examined.ResultsIn total, 14,450 amniocenteses were performed during the study period. These included 11,357 (78.6%) procedures in the group expert operators and 3,093 (21.4%) procedures in the group non-expert operators. In the non-expert group, the fetal loss rate was slightly increased but not significantly (p=0.24).In addition, the higher number of spontaneous abortions was associated with blood-stained amniotic fluid sample (p<0.001; RR=9.28). Multiple needle insertions also increased in the non-expert group significantly. However, no difference in pregnancy outcomes was found between in single and multiple needle insertions.ConclusionsThe amniocentesis procedures performed by the non-experts was not increase the fetal loss rate. However, the other adverse pregnancy outcomes, including preterm birth, low birth weight and fetal growth restriction were significantly increased in the non-expert group.

Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/j.1471-0528.2010.02742.x ◽

2010 ◽

Vol 117 (13) ◽

pp. 1593-1598 ◽

Cited By ~ 98

Author(s):

AW Shand ◽

N Nassar ◽

P Von Dadelszen ◽

SM Innis ◽

TJ Green

Keyword(s):

Vitamin D ◽

High Risk ◽

Pregnancy Outcomes ◽

Vitamin D Status ◽

Maternal Vitamin ◽

Adverse Pregnancy ◽

Maternal Vitamin D Status ◽

Schistosomiasis among pregnant women in the Njombe-Penja health district, Littoral region of Cameroon: A cross sectional study

10.1101/661900 ◽

2019 ◽

Author(s):

Calvin Tonga ◽

Charlie Ngo Bayoi ◽

Flore Chanceline Tchanga ◽

Jacqueline Félicité Yengue ◽

Godlove Bunda Wepnje ◽

...

Keyword(s):

Pregnant Women ◽

Pregnancy Outcomes ◽

Haemoglobin Concentration ◽

Epidemiological Data ◽

Health District ◽

Blood Levels ◽

Childbearing Age ◽

Adverse Pregnancy ◽

AbstractBackgroundSchistosomiasis is a Neglected Tropical Disease with endemic foci in Cameroon. Epidemiological data on schistosomiasis in pregnancy are scarce in the country. This study is about schistosomiasis among pregnant women in the Njombe-Penja health district, where schistosomiasis was reported since 1969.MethodologyOverall, 282 pregnant women were enrolled upon informed consent at first antenatal consultation. A questionnaire was administered to document socio-economic and obstetric information. Stool and terminal urine samples were collected and analysed using the Kato-Katz/formol-ether concentration techniques and centrifugation method respectively. Haemoglobin concentration was measured with finger prick blood, using a URIT-12® electronic haemoglobinometer.Principal findingsThe overall prevalence of schistosomiasis was 31.91%. Schistosoma guineensis, S. haematobium and S. mansoni infections were found in 0.35%, 04.96% and 28.01% of participants respectively. Co-infection with 2 species of Schistosoma was found in 04.44% of these women. The prevalence of schistosomiasis was significantly higher in younger women (≤20) and among residents of Njombe. All S. haematobium infected women were anemic and infection was associated with significantly lower haemoglobin levels (p=0.02).ConclusionThe prevalence of schistosomiasis is high in pregnant women of the Njombe-Penja health district, with possible adverse pregnancy outcomes. Female of childbearing age should be considered for mass drug administration.Author summaryPregnant women are known to be more vulnerable to infectious diseases and in their case, at least two lives are at risk. Although schistosomiasis remains a major public health issue in Cameroon, epidemiological data on schistosomiasis in pregnancy are scarce. These data are of high interest for informed decision-making. We examined stools and urines from 282 women of the Njombe-Penja Health district and measured their blood levels. Overall, 31.91% of women were infected, mostly younger ones and those living in the town of Njombe. Three species of Schistosoma parasite were identified. Women having urinary schistosomiasis had lower blood levels. These results show that the prevalence of schistosomiasis is high in pregnant women of Njombe. Also, because of the anemia it induces, the disease can lead to adverse pregnancy outcomes on the woman and her foetus. Treating female of childbearing age would cure the disease and prevent adverse outcomes.

Association Between Adverse Pregnancy Outcomes and Preceding Risk Factors: an Analytical Cross-Sectional Study

10.21203/rs.3.rs-403228/v1 ◽

2021 ◽

Author(s):

Prakash Prabhakarrao Doke ◽

Sonali Hemant Palkar ◽

Jayashree Sachin Gothankar ◽

Archana Vasantrao Patil ◽

Amruta Paresh Chutke ◽

...

Keyword(s):

Risk Factors ◽

Pregnancy Outcomes ◽

Significant Risk ◽

Tobacco Consumption ◽

Adverse Outcomes ◽

Mountainous Area ◽

Cross Sectional ◽

Heavy Work ◽

Adverse Pregnancy

Abstract Background: The health of women during the preconception phase though critical, is a comparatively ignored part in her life cycle. The presence of health risks is judged as hazardous to the wellbeing of women and their forthcoming progeny. The study aimed to estimate the prevalence of various pregnancy outcomes and assess the association between various risk factors and adverse outcomes. Methods: It was a population-based cross-sectional analytical study. The study was carried out in Nashik District, having a large mountainous area. It included two randomly selected blocks, one tribal and one nontribal, in which interventions were planned in the later stage. For comparison, two adjacent blocks, one tribal and one nontribal, were also included. All women who had a pregnancy outcome in the preceding 12 months (01 April 2017 to 31 March 2018) were interviewed. Trained Accredited Social Health Activists under the direct supervision of Auxiliary Nurse Midwives and Medical Officers conducted the survey. Multivariate analysis was carried out to find the adjusted risk ratio of having a particular adverse outcome because of the specified potential risk factors.Results: A total of 9,307 women participated in the study. The prevalence of adverse pregnancy outcomes was abortion 4.1%; stillbirth 1.6%; preterm birth 4.1%; LBW 11.2%; congenital physical defect 2.6%. Prevalence of consanguineous marriage, heavy work during the last six months of pregnancy, pre-existing illness, tobacco consumption, direct exposure to pesticides and domestic violence during pregnancy was 17.6%; 16.9%; 2.2%; 5.6%; 2.3%; and 0.8%, respectively. Risk factors that were significantly associated with abortion include existing illness at the time of conception and performing heavy work in the last six months of pregnancy. Consanguinity, tobacco consumption during pregnancy and pre-existing illness were identified as risk factors for stillbirth. Significant risk factors of LBW were heavy work in the last six months of pregnancy, pre-existing illness and residence in a tribal area. Conclusion: The survey showed that risk factors differentially affect outcomes of pregnancy. Preconception and antenatal care should include counselling about consanguineous marriages, identifying and managing a pre-existing illness, avoiding tobacco consumption in the prenatal and natal period, and avoiding heavy work during pregnancy.

142: Migraines in pregnancy and select adverse pregnancy outcomes

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2019.11.158 ◽

2020 ◽

Vol 222 (1) ◽

pp. S106

Author(s):

Gretchen Bandoli ◽

Rebecca J. Baer ◽

Laura L. Jelliffe-Pawlowski ◽

Christina Chambers

Keyword(s):

Pregnancy Outcomes ◽

Adverse Pregnancy ◽

The CRADLE-4 Trial: Can planned early birth in pre-eclampsia (high BP in pregnancy) reduce adverse pregnancy outcomes?

http://isrctn.com/ ◽

10.1186/isrctn10672137 ◽

2019 ◽

Author(s):

Alice Beardmore-Gray ◽

Andrew Shennan

Keyword(s):

Pregnancy Outcomes ◽

Adverse Pregnancy ◽

MO220MID TERM E GFR AND ITS IMPACT ON ADVERSE PREGNANCY OUTCOMES- IMPORTANCE OF GESTATIONAL HYPERFILTERATION

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab092.0098 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Anupma Kaul ◽

Amita Pandey

Keyword(s):

Pregnancy Outcomes ◽

Adverse Pregnancy Outcome ◽

Tertiary Care ◽

Significant Risk ◽

Significant Risk Factor ◽

Reference Level ◽

Singleton Pregnancy ◽

Baseline Serum ◽

Adverse Pregnancy

Abstract Background and Aims The hemodynamic adaptation plays a crucial role in maintaining gestation, the clinical significance of midterm renal hyperfiltration on pregnancy outcomes is unknown. The present study was retrospective study among all pregnant ladies whose midterm eGFR wascompared with their baseline and its change from baseline was considered as a surrogatemarker for Mid term hyperfilteration among women without underlying evidence of CKD tofurther evaluate its value as a prognostic factor of the eGFR during gestation Method All pregnant females aged 18-50 years whose pre gestational baseline serum creatinine was available and had a singleton pregnancy were included in the study .The study was conducted from January 2015 till December 2018 in a tertiary care Institute in Northern India . MRH was represented by the highest eGFR, which was calculated using the Chronic Kidney Disease Epidemiology Collaboration method. An adverse pregnancy event was defined by the composition of preterm birth (gestational age <37 weeks), low birth weight (<2.5 kg), and preeclampsia. Results Total of 1045 pregnancies were evaluated to study. Among them, 15 , 305, 680, and 45 mothers had midterm eGFR levels of 60–90, 90–120, 120–150, and ≥150 ml/min per 1.73 m2, respectively. The adjusted odds ratio and associated 95% confidence interval (95% CI) of an adverse pregnancy outcome for eGFR levels below and above the reference level of 120–150 ml/min per 1.73 m2 were 1.97 (95% CI, 1.34 to 2.89; P<0.001) for ≥150 ml/min per 1.73 m2; 1.57 (95% CI, 1.23 to 2.00; P<0.001) for 90–120 ml/min per 1.73 m2; and 4.93 (95% CI, 1.97 to 12.31; P<0.001) for 60–90 ml/min per 1.73 m2. Moreover, among mothers without baseline CKD, women with adverse pregnancy outcomes had less prominent MRH than those without (P<0.001) Conclusion There was an unique relationship between the midterm eGFR and adverse pregnancy outcomes, and the optimal range of midterm eGFR levels was 120–150 ml/min per 1.73 m2. In those females without evident functional renal impairment, the absence of prominent MRH could be a significant risk factor for poor pregnancy outcomes

Is Periodontal Disease in Pregnancy Associated with Adverse Pregnancy Outcomes?

Journal of Gynecology and Womens Health ◽

10.19080/jgwh.2017.06.555699 ◽

2017 ◽

Vol 6 (5) ◽

Author(s):

Irosha Rukmali Perera

Keyword(s):

Periodontal Disease ◽

Pregnancy Outcomes ◽

Adverse Pregnancy ◽

Abstract MP096: Patterns of Physical Activity Across Pregnancy and Their Association With Adverse Pregnancy Outcomes

Circulation ◽

10.1161/circ.135.suppl_1.mp096 ◽

2017 ◽

Vol 135 (suppl_1) ◽

Author(s):

Janet M Catov ◽

Corette B Parker ◽

Bethany B Gibbs ◽

Carla Bann ◽

Benjamin Carper ◽

...

Keyword(s):

Physical Activity ◽

Pregnancy Outcomes ◽

Activity Patterns ◽

Growth Mixture Modeling ◽

Metabolic Equivalents ◽

Nulliparous Women ◽

Adverse Pregnancy ◽

Low Activity ◽

Background: Cardiovascular disease (CVD) is the leading cause of death among women, and pregnancy complications reveal risk decades before overt CVD. While physical activity is related to CVD, less is known about how the activity patterns during pregnancy may contribute to adverse pregnancy outcomes. Hypothesis: Increasing activity across pregnancy is related to reduced risk of adverse pregnancy outcomes. Methods: Nulliparous women were enrolled at 8 centers early in pregnancy (n=10,020). Frequency and duration of up to three leisure activities reported in the first, second and third trimester were analyzed as metabolic equivalents (METs). Growth mixture modeling was used to identify activity patterns in pregnancy. Adverse outcomes (preterm birth [PTB], hypertensive disease of pregnancy [HDP], and gestational diabetes [GDM]) were collected by chart abstraction. Results: Four patterns of activity across pregnancy were identified: sustained high (3%, n=297); increasing (12%, n=1231); sustained low (77%, n=7717); and decreasing (8%, n=775; Figure). Women with sustained low activity were younger and more likely to be black or Hispanic, obese, or to have smoked prior to pregnancy when compared to those with increasing activity. Women with sustained low vs. increasing activity had higher rates of PTB (9.2 vs. 6.2%), HDP (13.8 vs. 10.5%), and GDM (4.7 vs. 2.5%; all p <0.01). After adjusting for maternal factors (age, race/ethnicity, BMI and smoking), the risk of GDM remained higher in women with sustained low activity compared with those having increasing activity patterns (adjusted OR 1.79 [1.21, 2.66]). Sustained low activity was also associated with higher risk of PTB (adjusted OR 1.36 [1.05, 1.76]). Conclusion: The majority of women have sustained low activity across pregnancy, and this is independently associated with higher risks of GDM and PTB. These associations raise the possibility that increased activity during pregnancy may improve pregnancy outcomes, and perhaps long-term maternal cardiovascular health.