scholarly journals Role of immune responses for extracellular matrix remodeling in the ischemic brain

2018 ◽  
Vol 11 ◽  
pp. 175628641881809 ◽  
Author(s):  
Egor Dzyubenko ◽  
Daniel Manrique-Castano ◽  
Christoph Kleinschnitz ◽  
Andreas Faissner ◽  
Dirk M. Hermann
Keyword(s):  
Extracellular Matrix ◽  
Immune Responses ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Ischemic Brain

scholarly journals The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor Progression

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1046
Author(s):  
Jorge Martinez ◽  
Patricio C. Smith
Keyword(s):  
Extracellular Matrix ◽  
Type I Collagen ◽  
Cell Metabolism ◽  
Breast Tumors ◽  
Extracellular Matrix Remodeling ◽  
Type I ◽  
Matrix Remodeling ◽  
Desmoplastic Reaction ◽  
The Impact

Desmoplastic tumors correspond to a unique tissue structure characterized by the abnormal deposition of extracellular matrix. Breast tumors are a typical example of this type of lesion, a property that allows its palpation and early detection. Fibrillar type I collagen is a major component of tumor desmoplasia and its accumulation is causally linked to tumor cell survival and metastasis. For many years, the desmoplastic phenomenon was considered to be a reaction and response of the host tissue against tumor cells and, accordingly, designated as “desmoplastic reaction”. This notion has been challenged in the last decades when desmoplastic tissue was detected in breast tissue in the absence of tumor. This finding suggests that desmoplasia is a preexisting condition that stimulates the development of a malignant phenotype. With this perspective, in the present review, we analyze the role of extracellular matrix remodeling in the development of the desmoplastic response. Importantly, during the discussion, we also analyze the impact of obesity and cell metabolism as critical drivers of tissue remodeling during the development of desmoplasia. New knowledge derived from the dynamic remodeling of the extracellular matrix may lead to novel targets of interest for early diagnosis or therapy in the context of breast tumors.

Abstract 311: The Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling

2018 ◽  
Vol 38 (Suppl_1) ◽  
Author(s):  
Marika Fava ◽  
Javier Barallobre-Barreiro ◽  
Ursula Mayr ◽  
Ruifang Lu ◽  
Athanasios Didangelos ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Remodeling ◽  
Aortic Dilatation ◽  
Matrix Remodeling

scholarly journals Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling

2018 ◽  
Vol 38 (7) ◽  
pp. 1537-1548 ◽  
Author(s):  
Marika Fava ◽  
Javier Barallobre-Barreiro ◽  
Ursula Mayr ◽  
Ruifang Lu ◽  
Athanasios Didangelos ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Extracellular Matrix Remodeling ◽  
Aortic Dilatation ◽  
Matrix Remodeling

scholarly journals The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression

2018 ◽  
Vol 45 (1) ◽  
pp. 356-365 ◽  
Author(s):  
Xiaoming Zhong ◽  
Bin Chen ◽  
Zhiwen Yang
Keyword(s):  
Extracellular Matrix ◽  
Tumor Microenvironment ◽  
Colorectal Carcinoma ◽  
Tumor Growth ◽  
Immune Cells ◽  
Strong Evidence ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Tumor Associated Macrophages

Tumor-associated macrophages (TAMs) are one of the most abundant immune cells in the tumor microenvironment, and they play a pivotal role in prompting the various tumor growth. However, the role of TAMs in colorectal carcinoma (CRC) is controversial, because a few papers report that TAMs is beneficial to CRC patients. In this review, we discuss the good or bad roles of TAMs in CRC progression. Interestingly, recent studies provide strong evidence that TAMs facilitate CRC growth, but do not exert tumor suppressive activities. TAMs can stimulate CRC growth by altering extracellular matrix remodeling, tumor metabolism, angiogenesis, as well as the tumor microenvironment. Therefore, TAMs could serve as a target for CRC therapeutic treatment.

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