scholarly journals N-(4-Methylphenyl) benzenepropanamide - the First Isolated Amide from the Genus Paederia

2007 ◽  
Vol 2 (7) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Debasish Bandyopadhyay ◽  
Anupam Nayak ◽  
Bidyut Basak ◽  
Avijit Banerji ◽  
Julie Banerji ◽  
...  
Keyword(s):  
Natural Product ◽  
First Report ◽  
Isolation And Characterization ◽  
Paederia Foetida

Investigation of the stem of Paederia foetida (Rubiaceae) resulted in the isolation and characterization of N-( 4-methylphenyl)-benzopropanamide, which was hitherto unknown as a natural product This is the first report of an amide for the genus Paederia.

scholarly journals A Novel Iridoid from Plumeria Obtusa

2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300
Author(s):  
Firdous Imran Ali ◽  
Imran Ali Hashmi ◽  
Bina Shaheen Siddiqui
Keyword(s):  
Natural Product ◽  
Stem Bark ◽  
Spectroscopic Studies ◽  
Chemical Transformations ◽  
Compound Identification ◽  
Synthetic Compound ◽  
First Report ◽  
Isolation And Characterization

Phytochemical investigations of fresh leaves and stem bark of Plumeria obtusa Linn. have led to the isolation and characterization of a new iridoid, p-methoxy- E-cinnamoyloxy plumieride (1), to which the trivial name champalinin has been assigned, and a triterpene lactone, 3β-hydroxy-urs-12-one-13β,28-olide (2). This is the first report of compound 2 as a natural product, although it has been reported earlier as a synthetic compound. Identification of these compounds was achieved through spectroscopic studies and chemical transformations.

scholarly journals Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus terreus Associated with Apostichopus japonicus Using Zebrafish Assay

2017 ◽  
Vol 12 (2) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Jun Qi ◽  
Bo Zhao ◽  
Peipei Zhao ◽  
Airong Jia ◽  
Yonggang Zhang ◽  
...  
Keyword(s):  
Spectral Methods ◽  
Yellow Sea ◽  
Aspergillus Terreus ◽  
Apostichopus Japonicus ◽  
The Yellow Sea ◽  
First Report ◽  
Isolation And Characterization

Three compouds, (+)-butyrolactone IV (1), butyrolactone I (2) and terrelactone A (3) were isolated from the fungus Aspergillus terreus associated with Apostichopus japonicus from the Yellow Sea in China; their structures were elucidated by spectral methods. Compounds 1 and 2 were shown to have moderate antiangiogenesis activity when tested using the zebrafish assay. This is the first report of butyrolactones with antiangiogenesis activity.

First report and spore ultrastructure of Vairimorpha plodiae (Opisthokonta: Microspora) from Plodia interpunctella (Lepidoptera: Pyralidae) in Turkey

2016 ◽  
Vol 61 (2) ◽  
Author(s):  
Mustafa Yaman ◽  
F. Pınar Güngör ◽  
Beyza Gonca Güner ◽  
Renate Radek ◽  
Andreas Linde
Keyword(s):  
Plodia Interpunctella ◽  
First Report ◽  
Isolation And Characterization ◽  
Lepidoptera Pyralidae ◽  
Spore Ultrastructure

AbstractThe present study describes the first isolation and characterization of

scholarly journals New Kendomycin Derivative Isolated from Streptomyces sp. Cl 58-27

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6834
Author(s):  
Constanze Paulus ◽  
Oleksandr Gromyko ◽  
Andriy Luzhetskyy
Keyword(s):  
Nmr Spectroscopy ◽  
Natural Product ◽  
Gene Clusters ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Streptomyces Sp ◽  
Bioinformatic Tools ◽  
Isolation And Characterization ◽  
Metabolism Gene

In the course of screening new streptomycete strains, the strain Streptomyces sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already known kendomycins. The structure of the new kendomycin E was elucidated using NMR spectroscopy, and the corresponding biosynthetic gene cluster was identified by sequencing the genome of Streptomyces sp. Cl 58-27 and conducting a detailed analysis of secondary metabolism gene clusters using bioinformatic tools.

scholarly journals Chemical constituents of leaves Dialium cochinchinense Pierre

2021 ◽  
Vol 4 (3) ◽  
pp. 1131-1136
Author(s):  
Vu Thi Huyen ◽  
Doan Thi Thuy Ai ◽  
Nguyen Thi Hien
Keyword(s):  
Secondary Metabolites ◽  
Nmr Spectra ◽  
Spectroscopic Analysis ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Tropical Regions ◽  
First Report ◽  
Isolation And Characterization

The genus Dialium belongs to the Caesalpinioideae family, consisting of approximately 30 species distributed in the tropical regions. Secondary metabolites from the  Dialium genus have been reported to exhibit various biological activities including antioxidant, cytotoxicity and antimicrobial activities. This work describes the isolation and characterization of five compounds from the leaves of Dialium cochinchinense Pierre. Their structures were established by spectroscopic analysis, including MS and NMR spectra. Accordingly, the isolated compounds were identified to be lupeone (1), b-sitostenone (2), β-sitosterol (3), daucosterol (4), and dihydrokaempferide (5). To the best of our knowledge, this is the first report of the isolation of compounds 1 and 5 from the genus Dialium.

scholarly journals Isolation, Genomic and Metabolomic Characterization of Streptomyces tendae VITAKN with Quorum Sensing Inhibitory Activity from Southern India

2020 ◽  
Vol 8 (1) ◽  
pp. 121 ◽  
Author(s):  
Nabila Mohammed Ishaque ◽  
Ilia Burgsdorf ◽  
Jessie James Limlingan Malit ◽  
Subhasish Saha ◽  
Roberta Teta ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Natural Product ◽  
Chemical Space ◽  
Sequence Similarity ◽  
Gc Content ◽  
Gene Clusters ◽  
Biosynthetic Gene ◽  
Isolation And Characterization ◽  
Streptomyces Tendae

Streptomyces are among the most promising genera in terms of production ability to biosynthesize a variety of bioactive secondary metabolites with pharmaceutical interest. Coinciding with the increase in genomic sequencing of these bacteria, mining of their genomes for biosynthetic gene clusters (BGCs) has become a routine component of natural product discovery. Herein, we describe the isolation and characterization of a Streptomyces tendae VITAKN with quorum sensing inhibitory (QSI) activity that was isolated from southern coastal part of India. The nearly complete genome consists of 8,621,231bp with a GC content of 72.2%. Sequence similarity networks of the BGCs detected from this strain against the Minimum Information about a Biosynthetic Gene Cluster (MIBiG) database and 3365 BGCs predicted by antiSMASH analysis of publicly available complete Streptomyces genomes were generated through the BiG-SCAPE-CORASON platform to evaluate its biosynthetic novelty. Crude extract analysis using high-performance liquid chromatography connected to high resolution tandem mass spectrometry (HPLC-HRMS/MS) and dereplication through the Global Natural Product Social Molecular Networking (GNPS) online workflow resulted in the identification of cyclic dipeptides (2, 5-diketopiperazines, DKPs) in the extract, which are known to possess QSI activity. Our results highlight the potential of genome mining coupled with LC-HRMS/MS and in silico tools (GNPS) as a valid approach for the discovery of novel QSI lead compounds. This study also provides the biosynthetic diversity of BGCs and an assessment of the predicted chemical space yet to be discovered.

scholarly journals Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues

2015 ◽  
Vol 51 (78) ◽  
pp. 14617-14619 ◽  
Author(s):  
Camilo F. Martinez-Farina ◽  
David L. Jakeman
Keyword(s):  
Natural Product ◽  
Membered Ring ◽  
Isolation And Characterization

We report the production, isolation, and characterization of jadomycins with seven-, nine-, and ten-membered E-rings, all of which are unique natural product ring scaffolds.

scholarly journals Isolation and Characterization of Bacteriophages from Fermenting Sauerkraut

2002 ◽  
Vol 68 (2) ◽  
pp. 973-976 ◽  
Author(s):  
S. S. Yoon ◽  
R. Barrangou-Poueys ◽  
F. Breidt ◽  
T. R. Klaenhammer ◽  
H. P. Fleming
Keyword(s):  
Lactobacillus Plantarum ◽  
Leuconostoc Mesenteroides ◽  
Starter Culture ◽  
First Report ◽  
Isolation And Characterization

ABSTRACT This paper presents the first report of bacteriophage isolated from commercial vegetable fermentations. Nine phages were isolated from two 90-ton commercial sauerkraut fermentations. These phages were active against fermentation isolates and selected Leuconostoc mesenteroides and Lactobacillus plantarum strains, including a starter culture. Phages were characterized as members of the Siphoviridae and Myoviridae families. All Leuconostoc phages reported previously, primarily of dairy origin, belonged to the Siphoviridae family.

First Report of Mycovirus Infected Sclerotinia sclerotiorum in Cauliflower from Sirmaur District of Himachal Pradesh

2020 ◽  
Vol 14 (4) ◽  
pp. 283-294
Author(s):  
Tanvi Gupta ◽  
Vanshika ◽  
Chandresh Kumari ◽  
Saurabh Kulshrestha
Keyword(s):  
Sclerotinia Sclerotiorum ◽  
Fungal Pathogen ◽  
Biocontrol Agent ◽  
Sclerotinia Stem Rot ◽  
Environment Friendly ◽  
First Report ◽  
Isolation And Characterization ◽  
Different Parts ◽  
Chemical Fungicides

Background : Sclerotinia sclerotiorum is a ubiquitous fungal pathogen infecting more than 400 plant species. Sclerotinia stem rot is known to cause as high as 100% crop loss in many cases. Currently, chemical fungicides are the only known solution to this problem. Thus, there is an urgent need for developing environment-friendly alternatives for controlling this pathogen. The review of published articles revealed that a number of mycoviruses with the potential of a biocontrol agent against Sclerotinia had been identified from different parts of the world. Objective: The present investigation describes the isolation and characterization of isolates of S. sclerotiorum infecting cauliflower, peas, and mustard for the presence of a potent mycovirus from lower Himachal region of India. Methods: Various infected fields were visited and samples in the form of sclerotia were collected. Various isolates of S. sclerotiorum were obtained, and putative hypovirulent isolates were screened. Thereafter, hypovirulent strains were chosen and mycovirus isolation was performed. Finally, isolates showing an extra nucleic acid band were used for mycovirus isolation and further characterization. Curing of mycovirus was used to confirm if altered phenotype was due to the presence of this virus. Results: A ssDNA mycovirus was identified and confirmed from the growth defective isolate. Conclusion: This mycovirus can in turn act as a biocontrol agent, thus reducing dependency on chemical fungicides and can also be developed in the form of a patent once completely characterized and formulated. To our knowledge, this is the first report on mycovirus isolation from any Sclerotinia sclerotiorumisolate from India.

scholarly journals Isolation and characterization of tambjamine MYP1, a macrocyclic tambjamine analogue from marine bacteriumPseudoalteromonas citrea

MedChemComm ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 478-483 ◽  
Author(s):  
Katherine J. Picott ◽  
Julie A. Deichert ◽  
Ella M. deKemp ◽  
Gabriele Schatte ◽  
Françoise Sauriol ◽  
...  
Keyword(s):  
Natural Product ◽  
Marine Bacterium ◽  
Bond Rotation ◽  
Isolation And Characterization

Identification of a macrocyclic tambjamine natural product, tambjamine MYP1, from a marine bacterium that may enhance bioactivity by restraining bond rotation.

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