A Bioactive Diterpene from Smallanthus sonchifolius

The dichloromethane extract of the air-dried leaves and freeze-dried tubers of Smallanthus sonchifolius afforded ent-kaurenoic acid (1). The structure of 1 was elucidated by extensive 1D and 2D NMR spectroscopy and was found to exhibit significant analgesic and anti-inflammatory activities. Ent-kaurenoic acid (1), dissolved in dimethylsulfoxide, also displayed potential anti-diabetes and anti-toxicity activity. In addition, 1 showed low antimicrobial activities against E. coli, P. aeruginosa, S. aureus, C. albicans and T. mentagrophytes, but was found to be inactive against B. subtilis and A. niger.

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Comparative Study of Naphthoquinone Contents of Selected Greek Endemic Boraginaceae Plants - Antimicrobial Activities

Natural Product Communications ◽

10.1177/1934578x1701200209 ◽

2017 ◽

Vol 12 (2) ◽

pp. 1934578X1701200

Author(s):

Teisa Tufa ◽

Harilaos Damianakos ◽

Konstantia Graikou ◽

Ioanna Chinou

Keyword(s):

Antimicrobial Activity ◽

Nmr Spectroscopy ◽

Comparative Study ◽

Pathogenic Fungi ◽

2D Nmr ◽

Antimicrobial Activities ◽

2D Nmr Spectroscopy ◽

Chromatographic Separations ◽

Esi Ms ◽

Related Compounds

The cyclohexane (Ch) extracts of the roots of five Greek endemic Boraginaceae plants, Onosma kaheirei Teppner, O. graeca Boiss., O. erecta Sibth. & Sm., Alkanna sfikasiana Kit Tan, Vold and Strid and Cynoglossum columnae Ten, were investigated for the presence of alkannin/shikonin-related compounds. All species, s except C. columnae and O. erecta, were found to contain this type of compounds. Seven compounds were obtained after several chromatographic separations from the Ch extracts of the investigated plants: deoxyalkannin (1), 2″-( S)- α-methylbutyrylalkannin (2), isobutyrylalkannin (3), propionylalkannin (4), acetylalkannin (5), β-hydroxyisovalerylalkannin (6), and β,β-dimethylacrylalkannin (7). All structures were identified by 1D 1H-/13C- and 2D NMR spectroscopy, assisted also by ESI-MS. The extracts and the isolated compounds exhibiting an interesting antimicrobial profile when evaluated for their antimicrobial activity against six Gram-positive and -negative bacteria and three human pathogenic fungi.

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Monoterpene Indole Alkaloids from the Twigs of Kopsia arborea

Natural Product Communications ◽

10.1177/1934578x1400901010 ◽

2014 ◽

Vol 9 (10) ◽

pp. 1934578X1400901

Author(s):

Sarot Cheenpracha ◽

Achara Raksat ◽

Thunwadee Ritthiwigrom ◽

Surat Laphookhieo

Keyword(s):

Antibacterial Activity ◽

Nmr Spectroscopy ◽

Indole Alkaloids ◽

2D Nmr ◽

Positive Control ◽

Ache Inhibition ◽

2D Nmr Spectroscopy ◽

E Coli ◽

Inhibitory Activities ◽

Mic Value

The phytochemistry of Kopsia arborea Blume has received considerable attention, which has resulted in the isolation of a number of new unusual indole alkaloids with intriguing structures. In this study, a new eburnane-type alkaloid, phutdonginin (1), together with eight known alkaloids: 19-OH-(-)-eburnamonine (2), melodinine E (3), kopsinine (4), kopsilongine (5), kopsamine (6), (-)-methylenedioxy-11,12-kopsinaline (7), decarbomethoxykopsiline (8), and vincadifformine (9), were isolated from the twigs of K. arborea. Their structures were characterized extensively by 1D and 2D NMR spectroscopy and HR-ESI-MS. All compounds were submitted to TLC screening for acetylcholinesterase inhibitory activities. Only kopsamine and decarbomethoxykopsiline showed AChE inhibition with MIR values of 12.5 and 6.25 μg, respectively, compared with galanthamine (positive control, 0.004 μg). In addition, compounds 1 and 2 inhibited moderate antibacterial activity against E. coli TISTR 780 with the MIC value of 32 μg/mL.

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Demonstration of 2D NMR Spectroscopy in a Powered Magnet at 25 T Using Cascade Field Regulation

2019 American Control Conference (ACC) ◽

10.23919/acc.2019.8815326 ◽

2019 ◽

Author(s):

Benjamin D. McPheron ◽

Jeffrey L. Schiano ◽

Brian F. Thomson ◽

Kiran K. Shetty ◽

William W. Brey

Keyword(s):

Nmr Spectroscopy ◽

2D Nmr ◽

2D Nmr Spectroscopy

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Ambient-Temperature Synthesis of (E)-N-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanimine

Molbank ◽

10.3390/m1250 ◽

2021 ◽

Vol 2021 (3) ◽

pp. M1250

Author(s):

Diana Becerra ◽

Justo Cobo ◽

Juan-Carlos Castillo

Keyword(s):

Mass Spectrometry ◽

Nmr Spectroscopy ◽

Ambient Temperature ◽

Magnesium Sulfate ◽

Elemental Analysis ◽

Condensation Reaction ◽

2D Nmr ◽

2D Nmr Spectroscopy ◽

Temperature Synthesis ◽

Tert Butyl

We report the ambient-temperature synthesis of novel (E)-N-(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)-1-(pyridin-2-yl)methanamine 3 in 81% yield by a condensation reaction between 3-(tert-butyl)-1-methyl-1H-pyrazol-5-amine 1 and 2-pyridinecarboxaldehyde 2 in methanol using magnesium sulfate as a drying agent. The N-pyrazolyl imine 3 was full characterized by IR, 1D, and 2D NMR spectroscopy, mass spectrometry, and elemental analysis.

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Highly NIR-emitting ytterbium complexes containing 2-(tosylaminobenzylidene)-N-benzoylhydrazone anions: structure in solution and use for bioimaging

Dalton Transactions ◽

10.1039/d0dt03913f ◽

2021 ◽

Author(s):

Anton D Kovalenko ◽

Alexander A. Pavlov ◽

Ilya D. Ustinovich ◽

Alena S. Kalyakina ◽

Alexander S Goloveshkin ◽

...

Keyword(s):

Nmr Spectroscopy ◽

Lanthanide Complexes ◽

2D Nmr ◽

2D Nmr Spectroscopy ◽

Ytterbium Complexes ◽

Solution Behaviour ◽

Structure In Solution

Abstract: Solution behaviour in DMSO using 1D and 2D NMR spectroscopy was performed for lanthanide complexes Ln(L)(HL) and Ln(HL)2Cl, containing non-macrocyclic 2-(tosylamino)-benzylidene-N-benzoylhydrazone (H2L), and the structure of [Yb(L)]+ cation in...

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