Structure-Activity Relationships of Sandalwood Odorants: Synthesis of a New Campholene Derivative
2010 ◽
Vol 5
(9)
◽
pp. 1934578X1000500
Keyword(s):
Structural modifications of natural (-)-( Z)-β-santalol have shown that the sandalwood odor impression is highly sensitive, even to small structural changes. Particularly, the substitution of the quaternary carbon is of great influence on the scent. Epi-compounds with side chains in the endo-position possess sandalwood odor in only a few derivatives, whereas modifications at this side chain, as well as modification at the bicyclic ring systems mostly lead to a complete loss of sandalwood fragrance.