scholarly journals Biological Activity of the Methanol and Water Extracts of the Fruits of Anthocyanin-Rich Plants Grown in South-West Poland

2015 ◽  
Vol 10 (3) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Paulina Strugala ◽  
Anna Dudra ◽  
Alicja Z. Kucharska ◽  
Anna Sokół-Łętowska ◽  
Dorota Wojnicz ◽  
...  
Keyword(s):  
Free Radical ◽  
Biological Effects ◽  
Radical Scavenging ◽  
Antibacterial Properties ◽  
Bacterial Biofilm ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Water Extracts ◽  
South West ◽  
Anti Inflammatory

In this study we focused on the chemical composition, antioxidant, anti-inflammatory and antibacterial properties of methanol and water extracts of fruits of six species grown in south-west Poland: blackberry, blackcurrant, chokeberry, cherry, gooseberry and raspberry. No general correlation could be drawn between extract chemical properties (i.e. antioxidant and free radical scavenging) and observed biological effects. However, blackcurrant and blackberry extracts (both methanol and water) appeared to be good antioxidants and free radical scavengers, as well as effective inhibitors of E. coli adhesion to the uroepithelial cells. On the other hand, the poorest antioxidants and free radical scavengers, cherry and gooseberry extracts, also poorly affected bacterial growth, swimming ability and adhesion to epithelial cells. Surprisingly, gooseberry extracts, which showed generally weak effects, appeared to be the most effective inhibitor of bacterial biofilm formation. Additionally, most of the studied extracts showed reasonably strong anti-inflammatory properties.

Target Size Analysis by Radiation Inactivation: The Use of Free Radical Scavengers

2005 ◽  
Vol 230 (7) ◽  
pp. 455-463 ◽  
Author(s):  
Gene C. Ness ◽  
Laura C. Pendleton ◽  
Michael J. McCreery
Keyword(s):  
Enzyme Activity ◽  
Free Radical ◽  
Functional Unit ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Target Size ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Radiation Inactivation ◽  
Glucose 6 Phosphate Dehydrogenase

Several model systems were employed to assess indirect effects that occur in the process of using radiation inactivation analysis to determine protein target sizes. In the absence of free radical scavengers, such as mannitol and benzoic acid, protein functional unit sizes can be drastically overestimated. In the case of glutamate dehydrogenase, inclusion of free radical scavengers reduced the apparent target size from that of a hexamer to that of a trimer based on enzyme activity determinations. For glucose-6-phosphate dehydrogenase, the apparent target size was reduced from a dimer to a monomer. The target sizes for both glutamate dehydrogenase and glucose-6-phosphate dehydrogenase in the presence of free radical scavengers corresponded to subunit sizes when determinations of protein by sodium dodecyl sulfate–polyacrylamide gel electrophoresis or immunoblotting were done rather than enzyme activity. The free radical scavengers appear to compete with proteins for damage by secondary radiation products, since irradiation of these compounds can result in production of inhibitory species. Addition of benzoic acid/mannitol to samples undergoing irradiation was more effective in eliminating secondary damage than were 11 other potential free radical scavenging systems. Addition of a free radical scavenging system enables more accurate functional unit size determinations to be made using radiation inactivation analysis.

Discovery of New N-hydrazinecarbothioamide Indazole Hybrids: As Potential Radical (ABTS and DPPH) Scavengers

2020 ◽  
Vol 17 (9) ◽  
pp. 1177-1185
Author(s):  
Rafaila Rafique ◽  
Arshia ◽  
Kanwal ◽  
Khalid Mohammed Khan ◽  
Sridevi Chigurupati ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Free Radicals ◽  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Synthetic Compounds ◽  
Free Radical Generation ◽  
Radical Generation

Background: Free radicals are the main cause of numerous diseases. Their overproduction needs to be controlled in order to combat several ailments. The current study deals with the discovery of new free radical scavengers. Methods: Substituted N-hydrazinecarbothioamide indazoles 1-18 were evaluated for DPPH and ABTS radical scavenging activities. Results: All synthetic compounds possess good radical DPPH and ABTS scavenging potential in the ranges of IC50 = 2.11 ± 0.17 - 5.3 ± 0.11 μM and IC50 = 2.31 ± 0.06 - 5.5 ± 0.07 μM, respectively, as compared to standard ascorbic acid having IC50 = 2.02 ± 0.11 μM for DPPH and IC50 = 2.1 ± 0.07 μM for ABTS. Conclusion: These compounds could serve as leads for antioxidant activity that have the ability to control free radical generation and ward off free radical-induced disorders.

scholarly journals Studies on free radical scavenging substances from microorganisms. II. Neocarazostatins A, B and C, novel free radical scavengers.

1991 ◽  
Vol 44 (8) ◽  
pp. 903-907 ◽  
Author(s):  
SHINICHIRO KATO ◽  
KAZUTOSHI SHINDO ◽  
YOKO KATAOKA ◽  
YUJI YAMAGISHI ◽  
JUNICHIRO MOCHIZUKI
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavengers ◽  
Radical Scavengers

FREE RADICAL SCAVENGING ACTIVITY OF ACACIA NILOTICA PODS

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (07) ◽  
pp. 14-22
Author(s):  
T. A Khan ◽  
◽  
A. Gohel
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Radical Scavenging Activity ◽  
Folk Medicine ◽  
Radical Scavenging ◽  
Acacia Nilotica ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Radical Production ◽  
Medicinal Value

Biomolecules can be oxidized by free radicals. This oxidative damage has an important etiological role in aging and the development of diseases like cancer, atherosclerosis, and other inflammatory disorders. Synthetic antioxidants, such as butylated hydroxyl anisole, are good free radical scavengers; however, they can be carcinogenic. Therefore, there is an increasing interest in searching for antioxidants of natural origin. Acacia nilotica has a versatile medicinal value as folk medicine. The present study aims at screening the methanol and aqueous extracts of the pods of Acacia nilotica for antioxidant activity. The effect of these extracts on inhibition of 1, 1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide radicals and of lipid peroxidation was studied. The results indicated that both the extracts exhibited a significant reduction in the DPPH and NO radical production along with a significant reduction in lipid peroxidation. The results indicate the pods of Acacia nilotica to be a cheap and easily available source of antioxidants

scholarly journals Preliminary Phytochemical Screening and Biological Activities ofBulbine abyssinicaUsed in the Folk Medicine in the Eastern Cape Province, South Africa

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Cromwell Mwiti Kibiti ◽  
Anthony Jide Afolayan
Keyword(s):  
Free Radical ◽  
Antimicrobial Agents ◽  
Protein Denaturation ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Antibacterial Properties ◽  
Free Radical Scavenging ◽  
Phytochemical Screening ◽  
Opportunistic Bacteria ◽  
Anti Inflammatory

Bulbine abyssinicaA. Rich. is used in traditional medicine to treat rheumatism, dysentery, bilharzia, cracked lips, back pain, infertility, diabetes mellitus, and gastrointestinal, vaginal, and bladder infections. Therefore, preliminary phytochemical screening, antioxidant, anti-inflammatory, and antibacterial properties of the whole plant (acetone and aqueous extracts) were determined using standard procedures. Thein vitroantioxidant model assays revealed that the plant possesses free radical scavenging potential varying with free radical species. The species showed significant protein denaturation inhibitory activity with good protection against erythrocyte membrane lysis indicating anti-inflammatory potential. The results also showed that the species was active against the growth of all the selected eight diabetic status opportunistic bacteria except one. Moreover, the species is characterized by appreciable amounts of total phenols, flavonoids, flavanols, proanthocyanidins, and alkaloids. Traces amounts of saponins and tannins were also observed. Amongst the identified phytochemicals present, empirical searches identified them being antioxidant, anti-inflammatory, and antimicrobial agents. The identification of these phytochemical constituents with their known pharmacological properties indicates that this plant is a good source of the free radical scavenging, anti-inflammatory, and antimicrobial agents. These findings also account for the multipharmacological use ofB. abyssinicain fork medicine.

Free radical scavengers, anti-inflammatory and analgesic activity ofAcaena magellanica

2002 ◽  
Vol 54 (6) ◽  
pp. 835-844 ◽  
Author(s):  
Gabriela Egly Feresin ◽  
Alejandro Tapia ◽  
Gutierrez R. Angel ◽  
Carla Delporte ◽  
Nadine Backhouse Erazo ◽  
...  
Keyword(s):  
Free Radical ◽  
Analgesic Activity ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Anti Inflammatory

Eco-Friendly Approach for the Synthesis of Thiophene Linked Benzothiazepines as Biocompatible Free Radical Scavengers

2021 ◽  
Vol 6 (1) ◽  
pp. 1-6
Author(s):  
P. Sudeep ◽  
K.R. Raghavendra ◽  
R. Sowmya ◽  
K. Ajay Kumar
Keyword(s):  
Free Radical ◽  
Hydroxyl Radical ◽  
Phase Transfer ◽  
Tetrabutylammonium Bromide ◽  
Radical Scavenging ◽  
Phase Transfer Catalyst ◽  
Free Radical Scavengers ◽  
Radical Scavengers ◽  
Citrus Juice

A series of new thiophene tethered benzothiazepines (5a-h) were synthesized through citrus juice mediated (4+3) annulations of thienyl chalcones with 2-aminobenzenethiol in the presence of tetrabutylammonium bromide as phase transfer catalyst under reflux conditions. The synthesized compounds were characterized by spectroscopic and CHN analysis. To check the antioxidant potentials of the synthesized compounds, in vitro DPPH and hydroxyl radical scavenging assays were conducted. The results shows that amongst the series, compounds 5b with (21.44-49.72%) and (16.88-42.60%); 5c with (24.88-56.00%) and (22.33-53.12%); and 5h with (22.80-47.10%) and (15.33-44.12%) excellent DPPH and hydroxyl radical potencies comparable with the respective standards used in the experiments.

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