Complexes of Lapachol and Lawsone with Lanthanides

Naturally occurring 2-hydroxy-1,4-naphthoquinones are well known to form readily stable complexes with transition metals. In this short communication we describe for the first time the synthesis and preliminary data about structural characterization of complexes between two naturally widespread 2-hydroxy-1,4-naphthoquinones, namely lapachol (1) and lawsone (2), with selected lanthanides like lanthanum, gadolinium, and ytterbium. When tested as cytotoxic compounds, such complexes exhibited an activity that was either higher or equal to that of the parent naphthoquinone.

Download Full-text

Unusual Reactivity of “Proton Sponge” as a Hydride Donor to Transition Metals: Synthesis and Structural Characterization of Fluoroalkyl(hydrido) Complexes of Iridium(III) and Rhodium(III)

Organometallics ◽

10.1021/om0102347 ◽

2001 ◽

Vol 20 (14) ◽

pp. 3190-3197 ◽

Cited By ~ 31

Author(s):

Russell P. Hughes ◽

Ivan Kovacik ◽

Danielle C. Lindner ◽

Jeremy M. Smith ◽

Stefan Willemsen ◽

...

Keyword(s):

Transition Metals ◽

Structural Characterization ◽

Proton Sponge

Download Full-text

Structural and In Silico Characterization of Small Molecules Isolated from Eichhornia crassipes

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/1375639 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Andrew Mtewa ◽

Duncan C. Sesaazi ◽

Fanuel Lampiao

Keyword(s):

In Silico ◽

Eichhornia Crassipes ◽

Cytochrome P450 Enzymes ◽

Anticancer Activities ◽

H Nmr ◽

Cytotoxic Compounds ◽

In Silico Characterization ◽

First Time ◽

Nonanedioic Acid

Eichhornia crassipes has been reported to have various medicinal properties including anticancer activities. The plant was collected from the Shire river in Malawi, and two cytotoxic compounds, benzene-1,4-diol and nonanedioic acid, were isolated and characterized for the first time in the leaves and roots of the plant. 1H NMR, COSY, HSQC, HMBC, 13-C, and LCMS spectroscopic experimental techniques were used to identify the compounds in their pure forms. In silico experiments showed that both compounds do not have AMES toxicity and do not inhibit cytochrome P450 enzymes, but nonanedioic acid acts as a CYP2D6 substrate. This work showed that Eichhornia crassipes can be considered to have a role as a source of potential hits and leads to drug development that can be rationally optimized for drugs.

Download Full-text

Structural characterization of four different naturally occurring porcine collagen membranes suitable for medical applications

PLoS ONE ◽

10.1371/journal.pone.0205027 ◽

2018 ◽

Vol 13 (10) ◽

pp. e0205027 ◽

Cited By ~ 8

Author(s):

Thimo Maurer ◽

Michael H. Stoffel ◽

Yury Belyaev ◽

Niklaus G. Stiefel ◽

Beatriz Vidondo ◽

...

Keyword(s):

Structural Characterization ◽

Medical Applications ◽

Naturally Occurring ◽

Collagen Membranes ◽

Porcine Collagen

Download Full-text

Structural characterization of heterometallic platinum complexes with non-transition metals. Part II: heterotrimeric complexes

Main Group Metal Chemistry ◽

10.1515/mgmc-2012-0062 ◽

2013 ◽

Vol 36 (1-2) ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Milan Melník ◽

Peter Mikuš

Keyword(s):

Transition Metals ◽

Structural Characterization ◽

Platinum Complexes

Download Full-text

Spectroscopic and structural characterization of three silaisocyanides: exploring an elusive class of reactive molecules at high resolution

Chemical Communications ◽

10.1039/c5cc02548f ◽

2015 ◽

Vol 51 (56) ◽

pp. 11305-11308 ◽

Cited By ~ 8

Author(s):

Sven Thorwirth ◽

Ralf I. Kaiser ◽

Kyle N. Crabtree ◽

Michael C. McCarthy

Keyword(s):

High Resolution ◽

Spectral Resolution ◽

Structural Characterization ◽

High Spectral Resolution ◽

First Time

The fundamental silaisocyanides HCCNSi, HC4NSi, and NCNSi have been characterized at high spectral resolution for the first time. All three chains are good candidates for radio astronomical detection.

Download Full-text