Two New Geranylated Biphenyl Esters From Artocarpus altilis

Two new geranylated biphenyl esters, 2,3′,4,4′-tetrahydroxy-3-geranyl-5-carboxyethyl-biphenyl methyl ester (1), 2,3′,4,4′-tetrahydroxy-3-geranyl-5-carboxymethyl-biphenyl methyl ester (2), together with 4 known compounds were isolated from the methanol extract of the leaves of Artocarpus altilis. Their structures were established by spectroscopic means and by comparison with literature data. Compound 1 possessed moderate cytotoxicity toward MDA-MB-231 (a breast carcinoma cell line) with a half-maximal inhibitory concentration value of 30 µM and inhibited the growth of 8 bacteria, including gram-negative and gram-positive organisms, but was inactive against fungi.

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Effects of curcumin on global gene expression profiles in the highly invasive human breast carcinoma cell line MDA‑MB 231: A gene network-based microarray analysis

Experimental and Therapeutic Medicine ◽

10.3892/etm.2012.754 ◽

2012 ◽

Cited By ~ 2

Author(s):

Pornngarm Limtrakul

Keyword(s):

Gene Expression ◽

Breast Carcinoma ◽

Cell Line ◽

Gene Network ◽

Carcinoma Cell ◽

Expression Profiles ◽

Gene Expression Profiles ◽

Global Gene Expression ◽

Breast Carcinoma Cell Line ◽

Human Breast

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CHEMICAL AND BIOLOGICAL ANALYSIS OF THE BIOCTIVE FRACTIONS OF THE LEAVES OF SCAEVOLA TACCADA (GAERTN.) ROXB

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2021v13i3.40257 ◽

2021 ◽

pp. 35-41

Author(s):

EMAN M. ABDEL GHANI ◽

ABEER M. EL SAYED ◽

SOAD H. TADROS ◽

FATHY M. SOLIMAN

Keyword(s):

Ethyl Acetate ◽

Petroleum Ether ◽

Cell Line ◽

Carcinoma Cell ◽

Antioxidant Effect ◽

Carcinoma Cell Line ◽

Biologically Active ◽

Breast Carcinoma Cell Line ◽

Gram Positive ◽

Butanol Fraction

Objective: Scaevola taccada. (Gaertn.) Roxb. is widely dispersed all along the coasts of Africa. It is used in folk medicine for diversity of ailments. This study aims to investigate the major phytoconstituents and biological activities of the leaves of S. taccada (Gaertn.) Roxb. Methods: In vitro biological examination viz. antimicrobial, cytotoxic and antioxidant activities of the ethanol extract of the leaves (EE) and its fractions; (petroleum ether (PE), methylene chloride (MC), ethyl acetate (EA) and n-butanol(BuOH)) were carried out. Estimation of the phytochemicals of biologically active fractions was done. Results: n-butanol fraction displayed remarkable antimycobacterium activity. Petroleum ether as well as n-butanol fractions evidenced a cytotoxic effect on breast carcinoma cell line (MCF7) and colon carcinoma cell line (HCT) with IC50 11.7 and 15.04 µg/ml respectively. Moreover, ethyl acetate fraction exhibits an antioxidant effect with EC50 476.7±0.57 µg/ml. n-tetradecane 1, α-amyrin palmitate 2, α-amyrin acetate 3, α-amyrin 4, stigmasterol 5, luteolin-7-O-β-glucoside 6, rutin 7 and alidyjosioside 8 were identified in S. taccada (Gaertn.) Roxb. leaves. Conclusion: Petroleum ether fraction is a cytotoxic candidate, especially against (MCF-7). It exhibited a moderate antifungal and antibacterial against certain Gram-positive bacteria. Ethyl acetate showed an antioxidant effect along with moderate antifungal activity. n-butanol fraction exerted potential antimycobacterial, significant cytotoxic activity against (HCT), good antifungal and antibacterial against Gram-positive and Gram-negative bacteria. Stigmasterol, luteolin-7-O-β-glucoside, rutin and alidyjosioside were isolated for the first time from S. taccada (Gaertn.) Roxb. Leaves.

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