Special Segment: Soft Tissue Matrices—Apligraf Bilayered Skin Substitute to Augment Healing of Chronic Wounds in Diabetic Patients

2009 ◽  
Vol 2 (6) ◽  
pp. 299-302 ◽  
Author(s):  
William T. DeCarbo
Keyword(s):  
Soft Tissue ◽  
Chronic Wounds ◽  
Skin Substitute ◽  
Diabetic Patients

scholarly journals Made in Germany: A Quality Indicator Not Only in the Automobile Industry But Also When It Comes to Skin Replacement: How an Automobile Textile Research Institute Developed a New Skin Substitute

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 143
Author(s):  
Herbert Leopold Haller ◽  
Matthias Rapp ◽  
Daniel Popp ◽  
Sebastian Philipp Nischwitz ◽  
Lars Peter Kamolz
Keyword(s):  
Wound Healing ◽  
Automobile Industry ◽  
Chronic Wounds ◽  
Water Vapor Permeability ◽  
Healing Time ◽  
Development Cooperation ◽  
Skin Substitute ◽  
Vapor Permeability ◽  
Clinical Use ◽  
Research Institute

Successful research and development cooperation between a textile research institute, the German Federal Ministry of Education and Research via the Center for Biomaterials and Organ Substitutes, the University of Tübingen, and the Burn Center of Marienhospital, Stuttgart, Germany, led to the development of a fully synthetic resorbable temporary epidermal skin substitute for the treatment of burns, burn-like syndromes, donor areas, and chronic wounds. This article describes the demands of the product and the steps that were taken to meet these requirements. The material choice was based on the degradation and full resorption of polylactides to lactic acid and its salts. The structure and morphology of the physical, biological, and degradation properties were selected to increase the angiogenetic abilities, fibroblasts, and extracellular matrix generation. Water vapor permeability and plasticity were adapted for clinical use. The available scientific literature was screened for the use of this product. A clinical application demonstrated pain relief paired with a reduced workload, fast wound healing with a low infection rate, and good cosmetic results. A better understanding of the product’s degradation process explained the reduction in systemic oxidative stress shown in clinical investigations compared to other dressings, positively affecting wound healing time and reducing the total area requiring skin grafts. Today, the product is in clinical use in 37 countries. This article describes its development, the indications for product growth over time, and the scientific foundation of treatments.

scholarly journals Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

2021 ◽  
Vol 22 (4) ◽  
pp. 1538 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Wound Healing ◽  
Soft Tissue ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Skin Wounds ◽  
Soft Tissue Defects ◽  
Chronic Skin ◽  
Tissue Defects

The number of clinical trials evaluating adipose-derived mesenchymal stem cells (AD-MSCs), platelet-rich plasma (PRP), and biomaterials efficacy in regenerative plastic surgery has exponentially increased during the last ten years. AD-MSCs are easily accessible from various fat depots and show intrinsic plasticity in giving rise to cell types involved in wound healing and angiogenesis. AD-MSCs have been used in the treatment of soft tissue defects and chronic wounds, employed in conjunction with a fat grafting technique or with dermal substitute scaffolds and platelet-rich plasma. In this systematic review, an overview of the current knowledge on this topic has been provided, based on existing studies and the authors’ experience. A multistep search of the PubMed, MEDLINE, Embase, PreMEDLINE, Ebase, CINAHL, PsycINFO, Clinicaltrials.gov, Scopus database, and Cochrane databases has been performed to identify papers on AD-MSCs, PRP, and biomaterials used in soft tissue defects and chronic wounds. Of the 2136 articles initially identified, 422 articles focusing on regenerative strategies in wound healing were selected and, consequently, only 278 articles apparently related to AD-MSC, PRP, and biomaterials were initially assessed for eligibility. Of these, 85 articles were excluded as pre-clinical, experimental, and in vitro studies. For the above-mentioned reasons, 193 articles were selected; of this amount, 121 letters, expert opinions, commentary, and editorials were removed. The remaining 72 articles, strictly regarding the use of AD-MSCs, PRP, and biomaterials in chronic skin wounds and soft tissue defects, were analyzed. The studies included had to match predetermined criteria according to the patients, intervention, comparator, outcomes, and study design (PICOS) approach. The information analyzed highlights the safety and efficacy of AD-MSCs, PRP, and biomaterials on soft tissue defects and chronic wounds, without major side effects.

scholarly journals Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice

2017 ◽  
Vol 5 (7) ◽  
pp. 1293-1303 ◽  
Author(s):  
Berna Senturk ◽  
Burak M. Demircan ◽  
Alper D. Ozkan ◽  
Sehmus Tohumeken ◽  
Tuncay Delibasi ◽  
...  
Keyword(s):  
High Risk ◽  
Chronic Wounds ◽  
Diabetic Patients ◽  
Diabetic Wound ◽  
Peptide Amphiphile ◽  
Efficient Treatment ◽  
Mimetic Peptide ◽  
Leg Amputation

There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation.

scholarly journals Stimulation of Healing of Non-Infected Stagnated Diabetic Wounds by Copper Oxide-Impregnated Wound Dressings

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1129
Author(s):  
Eyal Melamed ◽  
Alexei Rovitsky ◽  
Tohar Roth ◽  
Lior Assa ◽  
Gadi Borkow
Keyword(s):  
Wound Healing ◽  
Copper Oxide ◽  
Chronic Wounds ◽  
Wide Spectrum ◽  
Weight Bearing ◽  
Standard Of Care ◽  
Wound Dressings ◽  
Diabetic Patients ◽  
Intelligence System ◽  
Diabetic Wounds

Background and Objective: Copper, a wide spectrum biocide, also plays a key role in angiogenesis and wound healing. Antibacterial wound dressings impregnated with copper oxide microparticles (COD) have been recently cleared by the U.S. FDA and other regulatory bodies for the treatment of acute and chronic wounds, including diabetic wounds. Our objective was to evaluate the capacity of COD in stimulating the healing of non-infected stagnated wounds in diabetic patients initially treated with standard of care (SOC) dressings. Materials and Methods: The trial was divided into the three following phases: 1–2 weeks of screening, during which the patients were treated with SOC dressings; 4 weeks of treatment, during which the COD was applied twice weekly; and 2 weeks of follow-up, during which the patients were again treated with SOC dressings. The wound conditions and sizes were assessed by clinical evaluation and a wound imaging artificial intelligence system. Results: Following 1 month of COD treatment, there was a clear reduction in the mean wound area (53.2%; p = 0.003), an increase in granulation tissue (43.37; p < 0.001), and a reduction in fibrins (47.8%; p = 0.002). In patients with non-weight-bearing wounds, the reduction in wound size was even more dramatic (66.9%; p < 0.001). Conclusions: The results of this study, showing a statistically significant influence of COD on wound healing of hard-to-heal wounds in diabetic patients, strongly supports the notion that copper oxide-impregnated dressings enhance wound healing directly. Further larger controlled studies should be conducted to substantiate our findings.

Necrotising soft tissue infection of fungal origin in two diabetic patients

Mycoses ◽  
2006 ◽  
Vol 49 (5) ◽  
pp. 434-435 ◽  
Author(s):  
Muthukumarassamy Rajakannu ◽  
Roy Sumit Kumar ◽  
Vikram Kate ◽  
N. Ananthakrishnan
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Infection ◽  
Tissue Infection ◽  
Diabetic Patients

scholarly journals Flap Decisions and Options in Soft Tissue Coverage of the Lower Limb

2014 ◽  
Vol 8 (1) ◽  
pp. 423-432 ◽  
Author(s):  
Daniel J Jordan ◽  
Marco Malahias ◽  
Sandip Hindocha ◽  
Ali Juma
Keyword(s):  
Soft Tissue ◽  
Upper Limb ◽  
Lower Limb ◽  
Chronic Wounds ◽  
Soft Tissue Coverage ◽  
Form And Function ◽  
Flap Coverage ◽  
Surrounding Environment ◽  
And Function ◽  
Review Current

The lower extremities of the human body are more commonly known as the human legs, incorporating: the foot, the lower or anatomical leg, the thigh and the hip or gluteal region.The human lower limb plays a simpler role than that of the upper limb. Whereas the arm allows interaction of the surrounding environment, the legs’ primary goals are support and to allow upright ambulation. Essentially, this means that reconstruction of the leg is less complex than that required in restoring functionality of the upper limb. In terms of reconstruction, the primary goals are based on the preservation of life and limb, and the restoration of form and function. This paper aims to review current and past thoughts on reconstruction of the lower limb, discussing in particular the options in terms of soft tissue coverage.This paper does not aim to review the emergency management of open fractures, or the therapy alternatives to chronic wounds or malignancies of the lower limb, but purely assess the requirements that should be reviewed on reconstructing a defect of the lower limb.A summary of flap options are considered, with literature support, in regard to donor and recipient region, particularly as flap coverage is regarded as the cornerstone of soft tissue coverage of the lower limb.

A Comparative Study of the Reverse Sural Fascio-Cutaneous Flap Outcomes in the Management of Foot and Ankle Soft Tissue Defects in Diabetic and Trauma Patients

2018 ◽  
Vol 12 (5) ◽  
pp. 432-438 ◽  
Author(s):  
Chahine Assi ◽  
Camille Samaha ◽  
Moussa Chamoun Moussa ◽  
Tony Hayek ◽  
Kaissar Yammine
Keyword(s):  
Soft Tissue ◽  
Donor Site ◽  
Low Frequency ◽  
Group Versus ◽  
Healing Time ◽  
Diabetic Patients ◽  
Trauma Patients ◽  
Soft Tissue Defects ◽  
Cutaneous Flap ◽  
Tissue Defects

Introduction. Soft tissue defects in the distal leg and foot are challenging conditions for reconstruction. The widely used reverse sural fascio-cutaneous flap (RSFCF) has been reported with large variation in complication frequency. Some authors reported higher complications in the diabetic population when compared with trauma patients. We compared the reliability of the RSFCF in treating such defects among both populations. Methods. This is a retrospective series with a prospective data collection of 24 patients (11 with type 2 diabetes and 13 in trauma settings) treated with an ipsilateral RSFCF for soft tissue defects of the distal leg and the rear foot. Healing events and complications were recorded and compared for both groups. The mean follow-up was 32 months. Results. Diabetic group versus trauma group showed the following results; mean flap healing time of 24 versus 22 days, donor site healing time of 14 versus 16 days, 1 total flap necrosis in both groups, 3 versus 2 cases of skin edge necrosis, 2 cases of temporary venous congestion in both groups, and 8 versus 10 cases of transient hypoesthesia of the lateral border of the foot. No infection was encountered in both groups and no recurrence of infection in the primary infected diabetic patients. Conclusions. We found the RSFCF to be useful, reproducible, and reliable in treating soft tissue defects with a very low frequency of serious complications. Diabetic patients were found to have similar outcomes when compared with trauma patients. Therefore, diabetes might not be a major factor of flap failure. Levels of Evidence: Level III: Therapeutic

The effects of the diabetes related soft tissue hand lesions and the reduced hand strength on functional disability of hand in type 2 diabetic patients

2007 ◽  
Vol 77 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Serpil Savaş ◽  
Banu Kale Köroğlu ◽  
Hasan Rifat Koyuncuoğlu ◽  
Ertuğrul Uzar ◽  
Hakan Çelik ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Functional Disability ◽  
Hand Strength ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Adhesive Capsulitis of Shoulder (Frozen Shoulder) among the Diabetic Patients with Rheumatic Complaints

2020 ◽  
Vol 32 (1) ◽  
pp. 67-69
Author(s):  
Kazi Abdulah Al Mamun ◽  
Md Nurullah ◽  
Md Anwar Husain ◽  
Farjana Mansur ◽  
Md Shah Alam
Keyword(s):  
Soft Tissue ◽  
Elderly People ◽  
Adhesive Capsulitis ◽  
Frozen Shoulder ◽  
Diabetic Patients ◽  
Age Group ◽  
Physical Medicine ◽  
Physical Medicine And Rehabilitation ◽  
Soft Tissue Rheumatism ◽  
Medicine Today

Introduction: Adhesive capsulitis of shoulder is the most common soft tissue rheumatism among the diabetes patients with rheumatic complaints but the etiology is still unknown. To detect the incidence of adhesive capsulitis (frozen shoulder) among diabetic patients with rheumatic complaints. Materials and Methods: All patients having diabetes with rheumatic complaints attended in the department of Physical Medicine and Rehabilitation, BIRDEM and BSMMU, Dhaka during the period June 2003 to November 2003 were included in this study. Results: After discarding unsatisfactory samples, 273 samples were assayed for study. Out of 1665 patients 273 (16.40%) had adhesive capsulitis. Out of 273 patients 145 (53.12%) were female and 141 (51.65%) were housewives and of 206 (75.45%) patients was in age group 41-60 years. Conclusion: The incidence of adhesive capsulits of shoulder among diabetic patients female is more than male. It is found that housewives and elderly people are mostly sufferer with this disease. Medicine Today 2020 Vol.32(1): 67-69

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