The prevalence of vascular calcification in patients with end-stage renal disease on hemodialysis: a cross-sectional observational study

INTRODUCTION:Inadequate dialysis accounts for the high mortality in patients with end stage renal disease (ESRD). In Nepal, due to various factors including financial and logistic limitations, hemodialysis is mostly performed twice-a-week. This study was undertaken to look at adequacy of dialysis in patients undergoing maintenance hemodialysis in Nepal where the patients profile, in terms of diet, body muscle mass, nutritional status etc are different from western world.METHODS:In this cross sectional observational study, 40 patients on maintenance hemodialysis in the dialysis unit were evaluated and enrolled if patients were regularly undergoing twice-a-week hemodialysis in preceding 6 months with each session of dialysis prescription consisting of 4 hours (240 minutes). Patients were excluded if they were admitted in the hospital for some acute problems or had received acute hemodialysis in preceding 6 months. Only 14 patients fulfilled the inclusion criteria. Hemodialysis adequacy was measured using well established urea kinetic modeling.RESULTS:The mean age of the patients was 49 +/- 24 years. Mean predialysis urea and post dialysis urea were 163.7 +/- 60.05 mg/dL, and 73.7 mg/dL +/- 30.55 respectively. Mean URR was 65.3%. Mean Kt/v as assessed by Jindals equation was 0.99.CONCLUSIONS:Our study showed that twice-a-week of maintenance hemodialysis did not achieve recommended adequacy of hemodialysis in our patients.Key words: Adequacy of dialysis, end stage renal disease, hemodialysis.

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Frail phenotype is associated with distinct quantitative electroencephalographic findings among end-stage renal disease patients: an observational study

BMC Geriatrics ◽

10.1186/s12877-017-0673-3 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 5

Author(s):

Chia-Ter Chao ◽

◽

Hsin-Jung Lai ◽

Hung-Bin Tsai ◽

Shao-Yo Yang ◽

...

Keyword(s):

Observational Study ◽

Renal Disease ◽

End Stage Renal Disease ◽

Stage Renal Disease ◽

End Stage ◽

Frail Phenotype

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Electrocardiogram changes in patients with end stage renal disease on chronic haemodialysis

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20194624 ◽

2019 ◽

Vol 7 (11) ◽

pp. 4020

Author(s):

Kareem Mohsin Yousif ◽

Hamid Obaid Khadhim Al Jaaed

Keyword(s):

Renal Disease ◽

Social History ◽

End Stage Renal Disease ◽

Cross Sectional Study ◽

Premature Ventricular Complex ◽

Chronic Haemodialysis ◽

Ecg Changes ◽

Cross Sectional ◽

Stage Renal Disease ◽

End Stage

Background: End stage renal disease (ESRD) is irreversible loss of renal function which is physiologically defined by a GFR of less than 15 ml / minute. ESRD is associated with a higher incidence of coronary artery disease and serious arrhythmia especially ventricular arrhythmia. The goal of study is to determine whether ESRD and haemodialysis (HD)are associated with occurrence of significant electrocardiogram (ECG) changes or not.Methods: This is a cross-sectional study design which involved 22 patients with ESRD on regular HD in Al Sadre teaching hospital / Al Najaf. Both sexes was included in this study. All patients underwent full medical history and examination which included the following aspects: Age, Sex, Occupation, BP, HR, RBS, B.urea, S.creatinine , Serum electrolyte (Na+, K+, Cl-, Ca++), Lipid profile (Cholesterol , Triglyceride, HDL, LDL), Duration of CRF, Duration of dialysis, Social history including (smoking, alcohol) and Drug used by the patient. Resting EGC and Hotler ECG.Results: Eighteen patients exhibited emergence of simple ectopic activity premature atrial complex (PAC) and premature ventricular complex (PVC) events and four patients exhibited (ST,T changes). Potentially lethal arrhythmias and other serious ECG changes are not detected in our patient’s sample.Conclusion: In this study, neither ESRD nor haemodialysis were associated with development of serious ECG changes or emergence of significant arrhythmia.

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Analysis of Endocan Levels in Hypertensive Patients as Risk Factors of Chronic Kidney Disease

INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY ◽

10.24293/ijcpml.v27i1.1571 ◽

2020 ◽

Vol 27 (1) ◽

Author(s):

Suryani Jamal ◽

Uleng Bahrun ◽

Ibrahim Abdul Samad ◽

Fitriani Mangarengi ◽

Hasyim Kasim ◽

...

Keyword(s):

Renal Disease ◽

End Stage Renal Disease ◽

Stage Ii ◽

University Hospital ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Elisa Method ◽

Cross Sectional ◽

Stage Renal Disease ◽

End Stage

This study aimed to analyze endocan levels as a marker of endothelial dysfunction in the control group, patients withstage I hypertension, stage II hypertension, and patients with end-stage renal disease. Endocan levels were measured withESM-1 (endocan) kit by Enzyme-Linked Immunosorbent Assay (ELISA) method. This study used a cross-sectional methodand was conducted in Dr. Wahidin Sudirohusodo Hospital, Makassar and Hasanuddin University Hospital from Septemberto October 2017. There were 83 samples in this study, consisting of 12 samples in the control group, 22 samples of stage Ihypertension, 28 samples of stage II hypertension, and 21 samples of end-stage renal disease aged 20-90 years old. Thisstudy showed significantly higher endocan levels in patients with stage II hypertension and end-stage renal disease(p< 0.05). Endocan levels were significantly higher (p<0.05) in patients with end-stage renal disease compared with thecontrol group and patients with stage I hypertension; but not significantly higher (p > 0.05) compared to patients with stageII hypertension. Also, the median of endocan levels in patients with the end-stage renal disease was higher (309,850 ng/L)compared to patients with stage II hypertension (273,050 ng/L).

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Acute Intradialytic Complications in End Stage Renal Disease on Maintenance Hemodialysis

Journal of Nepal Medical Association ◽

10.31729/jnma.358 ◽

2012 ◽

Vol 52 (187) ◽

Author(s):

R K Agrawal ◽

S Khakurel ◽

R Hada ◽

D Shrestha ◽

A Baral

Keyword(s):

Renal Failure ◽

Renal Disease ◽

End Stage Renal Disease ◽

Tertiary Care ◽

Cross Sectional Study ◽

Maintenance Hemodialysis ◽

Care Hospital ◽

Cross Sectional ◽

Stage Renal Disease ◽

End Stage

Introduction: Hemodialysis is the preferred method of treatment for Nepalese patients with End Stage Renal Disease. Despite the technological advances and better understanding of physiology associated with hemodialysis, a number of complications are known to be associated with hemodialysis. This study was undertaken to study the frequency of acute intradialytic complications in patients undergoing hemodialysis. Methods: A cross-sectional study was conducted at Nephrology unit of a tertiary care hospital from 15 June, 2007 to 15 December, 2007. A total of 28 patients were included in the study. Patients with acute renal failure and acute on chronic renal failure were excluded from the study. Results: Total sessions of hemodialysis during the period were 1455. Hypotensive episode were 66 (4.5%) and was the commonest complication and followed by hypertensive episodes were 58 (3.8%). Other problems encountered were transfusion reactions were 23 episodes (1.5%), rigors not related to transfusions were 13 episodes (0.8%), nausea/vomiting were 20 episodes (1.4%), muscle cramps were 12 episodes (0.8%), hypoglycemia were 6 episodes 5(0.4%). Conclusions: The frequency of intradialytic complications is low and many of them are not life threatening. Keywords: complications; end stage renal disease; hemodialysis; hypertension; hypotension.

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Pathogenesis and Management of Vascular Calcification in Patients with End-Stage Renal Disease

Contributions to Nephrology - Recent Advances in Dialysis Therapy in Japan ◽

10.1159/000485702 ◽

2018 ◽

pp. 71-77 ◽

Cited By ~ 4

Author(s):

Tetsuya Ogawa ◽

Kosaku Nitta

Keyword(s):

Renal Disease ◽

Vascular Calcification ◽

End Stage Renal Disease ◽

Stage Renal Disease ◽

End Stage

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Cardiovascular Disease as a Late Complication of End-Stage Renal Disease in Children

Peritoneal Dialysis International ◽

10.1177/089686080502503s32 ◽

2005 ◽

Vol 25 (3_suppl) ◽

pp. 123-126 ◽

Cited By ~ 22

Author(s):

Jaap Groothoff ◽

Mariken Gruppen ◽

Eric De Groot ◽

Martin Offringa

Keyword(s):

Cardiovascular Disease ◽

Aortic Valve ◽

Renal Disease ◽

End Stage Renal Disease ◽

Arterial Wall ◽

Aortic Valve Calcification ◽

Cross Sectional ◽

Valve Calcification ◽

Stage Renal Disease ◽

End Stage

♦ Objective To analyze the late cardiovascular outcome of end-stage renal disease (ESRD) in children. ♦ Design A nation-wide long-term follow-up study. Determinants of outcomes and causes of death were retrospectively assessed. Patients underwent assessment of overall health state, B- and M-mode ultrasound of the carotid arteries, and echocardiography for cross-sectional analysis. ♦ Results We analyzed the medical course of all 249 adult Dutch patients with ESRD onset between 1972 and 1992 at age 0 – 14 years, and who were born before 1979. Of the 187 living patients, 140 participated in the cross-sectional part of the study. The standardized mortality rate was 31.0. Overall 5-, 10-, and 20-year survival after ESRD onset was 87%, 82%, and 78%, respectively. Cardiovascular disease accounted for most deaths (41%). In the whole group, left ventricular hypertrophy (LVH), aortic valve calcification, and arterial wall stiffening were highly prevalent. LVH was associated with hypertension at time of assessment. Aortic valve calcification was strongly associated with a long total duration of peritoneal dialysis (β = 0.33, p < 0.001). Arterial wall pathology was not associated with current treatment modality. ♦ Conclusions As in adults, cardiovascular disease is the most important cause of death in children with ESRD. Stricter reduction of volume overload, prevention of high serum calcium–phosphate product, and more vigorous treatment of hypertension are important targets to improve cardiovascular survival in children with ESRD.

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