scholarly journals Bioactive calcium phosphate–based glasses and ceramics and their biomedical applications: A review

2017 ◽  
Vol 8 ◽  
pp. 204173141771917 ◽  
Author(s):  
Md Towhidul Islam ◽  
Reda M Felfel ◽  
Ensanya A Abou Neel ◽  
David M Grant ◽  
Ifty Ahmed ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biomedical Applications ◽  
Culture Medium ◽  
Glass Ceramics ◽  
Phosphate Glasses ◽  
Bioactive Materials ◽  
Test Parameters ◽  
Phosphate Buffered Saline ◽  
Hydroxyapatite Formation

An overview of the formation of calcium phosphate under in vitro environment on the surface of a range of bioactive materials (e.g. from silicate, borate, and phosphate glasses, glass-ceramics, bioceramics to metals) based on recent literature is presented in this review. The mechanism of bone-like calcium phosphate (i.e. hydroxyapatite) formation and the test protocols that are either already in use or currently being investigated for the evaluation of the bioactivity of biomaterials are discussed. This review also highlights the effect of chemical composition and surface charge of materials, types of medium (e.g. simulated body fluid, phosphate-buffered saline and cell culture medium) and test parameters on their bioactivity performance. Finally, a brief summary of the biomedical applications of these newly formed calcium phosphate (either in the form of amorphous or apatite) is presented.

In Vitro Assessment of New Niobium Phosphate Glasses and Glass Ceramics

2007 ◽  
Vol 361-363 ◽  
pp. 229-232 ◽  
Author(s):  
Marcelo Henrique Prado da Silva ◽  
C. Moura Ramirez ◽  
José Mauro Granjeiro ◽  
Antonella M. Rossi
Keyword(s):  
Calcium Phosphate ◽  
Glass Composition ◽  
Glass Ceramics ◽  
Phosphate Glasses ◽  
Biological Behavior ◽  
Bioactive Glasses ◽  
In Vitro Assessment ◽  
Niobium Phosphate

Niobo-phosphate glasses were produced in order to assess the citotoxicity of samples with different compositions. Different P2O5/Ca ratios were studied in an attempt to correlate the biological behavior of new niobo-phosphate bioactive glasses with conventional bioactive calcium phosphate glasses. The most biocompatible glass composition was chosen to produce glassreinforced hydroxyapatite composites.

scholarly journals Organic/Inorganic bioactive materials Part III: in vitro bioactivity of gelatin/silicocarnotite hybrids

2009 ◽  
Vol 7 (4) ◽  
pp. 721-730 ◽  
Author(s):  
Lachezar Radev ◽  
Maria Fernandes ◽  
Isabel Salvado ◽  
Daniela Kovacheva
Keyword(s):  
Calcium Phosphate ◽  
Hybrid Materials ◽  
Calcium Phosphates ◽  
Ceramic Powder ◽  
Structure Evolution ◽  
In Vitro Test ◽  
In Vitro Bioactivity ◽  
Bioactive Materials ◽  
Vitro Test

AbstractIn this work we present our experimental results on synthesis, structure evolution and in vitro bioactivity assessment of new gelatin/silicocarnotite hybrid materials. The hybrids were obtained by diluting gelatin (G) and silicocarnotite (S) ceramic powder with G:S ratios of 75:25 and 25:75 wt.% in hot (40°C) water. The hybrids were characterized using XRD, FTIR, SEM/EDS and XPS. FTIR depicts that the “red shift” of amide I and COO− could be attributed to the fact that the gelatin prefers to chelate Ca2+ from S. The growth of calcium phosphates on the surface of the hybrids synthesized and then immersed in 1.5 SBF for 3 days was studied by using of FTIR, XRD and SEM/EDS. According to FTIR results, after an immersion of 3 days, A and B-type CO3HA can be observed on the surface. XRD results indicate the presence of hydroxyapatite with well defined crystallinity. SEM/EDS of the precipitated layers show the presence of CO3HA and amorphous calcium phosphate on the surface of samples with different G/S content when immersed in 1.5 SBF. XPS of the G/S hybrid with 25:75 wt.% proved the presence of Ca-deficient hydroxyapatite after an in vitro test for 3 days.

scholarly journals An Anti-Inflammatory Poly(PhosphorHydrazone) Dendrimer Capped with AzaBisPhosphonate Groups to Treat Psoriasis

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 949 ◽  
Author(s):  
Ranime Jebbawi ◽  
Abdelouahd Oukhrib ◽  
Emily Clement ◽  
Muriel Blanzat ◽  
Cédric-Olivier Turrin ◽  
...  
Keyword(s):  
Topical Application ◽  
Therapeutic Efficacy ◽  
Biomedical Applications ◽  
Saline Solution ◽  
Active Pharmaceutical Ingredient ◽  
Systemic Injection ◽  
Human Immune ◽  
Anti Inflammatory ◽  
Phosphate Buffered Saline

Dendrimers are nanosized, arborescent macromolecules synthesized in a stepwise fashion with attractive degrees of functionality and structure definition. This is one of the reasons why they are widely used for biomedical applications. Previously, we have shown that a poly(phosphorhydrazone) (PPH) dendrimer capped with anionic azabisphosphonate groups (so-called ABP dendrimer) has immuno-modulatory and anti-inflammatory properties towards human immune cells in vitro. Thereafter, we have shown that the ABP dendrimer has a promising therapeutic efficacy to treat models of acute and chronic inflammatory disorders in animal models. In these models, the active pharmaceutical ingredient was administered systematically (intravenous and oral administrations), but also loco-regionally in the vitreous tissue. Herein, we assessed the therapeutic efficacy of the ABP dendrimer in the preclinical mouse model of psoriasis induced by imiquimod. The ABP dendrimer was administered in phosphate-buffered saline solution via either systemic injection or topical application. We show that the topical application enabled the control of both the clinical and histopathological scores, and the control of the infiltration of macrophages in the skin of treated mice.

scholarly journals PHOSPHATE GLASSES AND GLASS-CERAMICS FOR BIOMEDICAL APPLICATIONS

2012 ◽  
Vol 26 (0) ◽  
pp. 8-15 ◽  
Author(s):  
Toshihiro Kasuga ◽  
Tomokazu Hattori ◽  
Mitsuo Niinomi
Keyword(s):  
Biomedical Applications ◽  
Glass Ceramics ◽  
Phosphate Glasses

scholarly journals Ultrastructural study of degradation of calcium phosphate ceramic by human monocytes and modulation of this activity by HILDA/LIF cytokine.

1996 ◽  
Vol 44 (10) ◽  
pp. 1131-1140 ◽  
Author(s):  
M D Benahmed ◽  
D Heymann ◽  
M Berreur ◽  
M Cottrel ◽  
A Godard ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Culture Medium ◽  
Marked Decrease ◽  
Calcium Phosphate Ceramic ◽  
Multinuclear Cells ◽  
Residual Bodies ◽  
First Time

Biodegradation of ceramics in vivo is achieved essentially by monocytes and multinuclear cells (osteoclasts). Monocytes are the key element in this process because they intervene first at the biomaterial implantation site during inflammatory reaction. In this work, in vitro studies were conducted on an ultrastructural scale to determine the specific behavior of these cells with regard to a calcium phosphate (CaP) ceramic. Two types of phagocytosis were observed when cells came into contact with the biomaterial: either CaP crystals were taken up alone and then dissolved in the cytoplasm after disappearance of the phagosome membrane or they were incorporated together with large quantities of culture medium, in which case dissolution occurred after the formation of heterophagosomes. Phagocytosis of CaP coincided with autophagy and the accumulation of residual bodies in the cells. Addition of HILDA/LIF factor to these cultures induced a very marked decrease in phagocytotic activity directed at the capture of CaP crystals and culture medium. Autophagy was reduced, and residual bodies were rare or absent. This study specifies the role of monocytes in CaP biodegradation and demonstrates for the first time that HILDA/LIF has a biological effect on this cell line.

scholarly journals PENGGUNAAN CAIRAN FOLIKEL DALAM MEDIA MATURASI IN VITRO OOSIT KAMBING BLIGON

2014 ◽  
Vol 8 (1) ◽  
Author(s):  
Diah Tri Widayati ◽  
Devita Hery Fatmawati ◽  
Nony Ariesta ◽  
Kustono K
Keyword(s):  
Tissue Culture ◽  
Culture Medium ◽  
Tissue Culture Medium ◽  
Phosphate Buffered Saline

Penelitian ini bertujuan mengetahui pengaruh medium maturasi terhadap kompetensi perkembangan in vitro oosit kambing bligon. Ovarium kambing diperoleh dari Rumah Potong Hewan, dibawa ke laboratorium dalam 0,9% NaCl pada suhu 31-34 C. Oosit diaspirasi dari folikel berdiameter 2-6 mm dengan menggunakan syringe 3 ml dan jarum 23 G. Oosit dengan minimal 2 lapisan sel-sel kumulus diproses untuk maturasi in vitro. Oosit dicuci 3 kali dengan dulbecco’s phosphate buffered saline (DPBS) dan tissue culture medium 199 (TCM) 199, kemudian didistribusikan ke dalam 50 μl medium maturasi yang berbeda, yaitu TCM 199 (tanpa suplementasi),

In Vitro Evaluation of RF Magnetron-Sputtered Calcium Phosphate Films on Titanium

2007 ◽  
Vol 352 ◽  
pp. 305-309
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Tomoyuki Katsube ◽  
Hiroshi Kawamura ◽  
Takashi Goto
Keyword(s):  
Calcium Phosphate ◽  
Calcium Ions ◽  
Rf Magnetron Sputtering ◽  
Calcium Phosphate Coating ◽  
Apatite Formation ◽  
Coating Films ◽  
Before And After ◽  
Phosphate Buffered Saline ◽  
Titanium Substrates

Calcium phosphate coating films were fabricated on mirror-polished or blast-treated titanium substrates using radio-frequency (RF) magnetron sputtering and they were evaluated in vitro. Immersion tests for the films were conducted using phosphate-buffered saline (PBS(-)), and apatite formation and the elution of calcium ions from the films were investigated. The bonding strengths between the calcium phosphate films and titanium substrates before and after the immersion tests were evaluated. After the immersion tests, a decrease in the bonding strength was observed for the coating films on the mirror-polished titanium substrates, while that for the blast-treated titanium substrates was almost the same as that before the immersion tests.

Novel calcium phosphate ceramics prepared by powder sintering and crystallization of glasses in the pyrophosphate region

1998 ◽  
Vol 13 (12) ◽  
pp. 3357-3360 ◽  
Author(s):  
Toshihiro Kasuga ◽  
Yoshihiro Abe
Keyword(s):  
Calcium Phosphate ◽  
Glass Ceramics ◽  
Atomic Ratio ◽  
Phosphate Glasses ◽  
High Fracture Toughness ◽  
High Fracture ◽  
Powder Sintering ◽  
Phosphate Phase ◽  
Powder Compacts ◽  
Calcium Phosphate Phase

Silica-free phosphate glasses containing small amounts of Na2O and TiO2 with the composition of Ca/P = 1 in atomic ratio were obtained. When powder compacts of the glasses were heated at 850 °C, they crystallized and subsequently sintered, resulting in glass-ceramics containing β–Ca3(PO4)2 and β–Ca2P2O7 crystalline phases. The glass-ceramics show a relatively high fracture toughness of KIC ≈ 2 MPa m0.5. By soaking in simulated body fluid at 37 °C, a calcium phosphate phase was formed newly on the surface of the glass-ceramics.

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