scholarly journals Neurosarcoidosis resembling multiple meningiomas: A misleading presentation of the disease and diagnostic challenge

2021 ◽  
Vol 10 (7) ◽  
pp. 205846012110365
Author(s):  
Marta D Switlyk ◽  
Pitt Niehusmann ◽  
Mette Sprauten ◽  
Henriette Magelssen ◽  
Mads Aarhus ◽  
...  

Sarcoidosis is characterized by the presence of noncaseating granulomatous inflammation in the affected organs. Neurosarcoidosis denotes the involvement of the nervous system and can be either isolated or coexisting with extraneural systemic inflammation. The diagnosis of isolated neurosarcoidosis may be challenging due to unspecific symptoms and similar appearances with other disease processes. This report presents an uncommon case of intracranial sarcoidosis mimicking multiple meningiomas. Familiarity with the spectrum of magnetic resonance imaging findings in neurosarcoidosis is crucial to prevent interpretive errors which may in turn lead to an inappropriate diagnosis and treatment.

2015 ◽  
Author(s):  
Jeffrey M Gelfand ◽  
Barney Stern

Sarcoidosis is an inflammatory disorder of unclear cause characterized by nonnecrotizing (noncaseating) granulomatous inflammation. Neurosarcoidosis—involvement of the nervous system by the granulomatous inflammatory process of sarcoidosis—affects approximately 5 to 15% of people with sarcoidosis and is a major cause of morbidity from the disease. Neurosarcoidosis is often invoked in the differential diagnosis of suspected inflammatory neurologic syndromes. This chapter discusses the epidemiology, etiology, genetics, pathophysiology and pathogenesis, diagnosis and differential diagnosis, treatment, complications, and prognosis of neurosarcoidosis. Figures show magnetic resonance imaging features of neurosarcoidosis. Tables outline a clinical framework for categorizing neurosarcoidosis and neurologic organ system involvement by sarcoidosis.   This chapter contains 1 highly rendered figure, 2 tables, 124 references, 1 teaching slide set, and 5 MCQs.


2021 ◽  
Vol 104 (5) ◽  
pp. 872-885

Fungal infections of the central nervous system (CNS) are usually identified in immunocompromised patients but rare in immunocompetent hosts. The clinical and imaging manifestations are mainly influenced by types of fungal pathogen and immune status of the patients. The CNS fungal infections can develop through hematogenous dissemination from primary site of infection, cerebrospinal fluid seeding, or direct extension from adjacent sources of infection. Fungal infections can result in meningitis, meningoencephalitis, cerebritis, granuloma, or abscess formation, which imaging findings are often non-specific and difficult to distinguish from bacterial or tuberculous infection, non-infectious inflammatory disease, or even intracranial neoplasm. Vascular complications including vasculitis, cerebral infarction, or mycotic aneurysm are commonly present due to angioinvasion of fungal hyphae. In addition, some characteristic imaging features of fungal infections can be identified by computed tomography (CT) or magnetic resonance imaging (MRI), such as intracavitary projections in fungal abscesses and gelatinous pseudocysts in cryptococcosis that could help suggest the diagnosis. Recognizing the imaging findings of common intracranial fungal infections combined with appropriate clinical setting is crucial for allowing early diagnosis and leading to early specific treatment. The present article reviewed common imaging findings of CNS fungal infections and distinct imaging features of specific pathogens. Keywords: Fungal infection, Brain abscess, Cryptococcosis, Central nervous system (CNS), Computed tomography (CT), Diffusion weighted imaging (DWI), Magnetic resonance imaging (MRI)


2013 ◽  
Vol 24 (5) ◽  
pp. 929-931 ◽  
Author(s):  
Zehra Akkaya ◽  
Aysegul Gursoy ◽  
Ayse Erden

AbstractDistinguishing the benign and malignant cardiac masses is usually a diagnostic challenge, and safe, non-invasive, and reliable techniques are necessary to avoid any delay in treatment. The previously described “sun ray” appearance is an important sign in the diagnosis of cardiac angiosarcoma, and in this report we present 3-T magnetic resonance imaging findings to distinguish the rare but fatal cardiac angiosarcoma.


1988 ◽  
Vol 45 (1) ◽  
pp. 36-37 ◽  
Author(s):  
R. H. Glantz ◽  
R. B. Wright ◽  
M. S. Huckman ◽  
D. C. Garron ◽  
I. M. Siegel

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