scholarly journals A review on the production, structure, bioactivities and applications of Tremella polysaccharides

2021 ◽  
Vol 35 ◽  
pp. 205873842110005
Author(s):  
Xia Ma ◽  
Meng Yang ◽  
Yan He ◽  
Chuntao Zhai ◽  
Chengliang Li
Keyword(s):  
Biologically Active ◽  
Research Progress ◽  
Research Trend ◽  
Production Structure ◽  
Health States ◽  
Preparation Methods ◽  
The Past ◽  
Structure Activity ◽  
Relationship Of ◽  
Active Natural

Tremella polysaccharide is known to be structurally unique and biologically active natural products, abundant and versatile in activities and applications in food industry, daily chemical industry and medicine industry. In order to improve the industrialisation of Tremella polysaccharide, the limitations of preparation and structure-activity relationship of Tremella polysaccharide were reviewed in this paper. The research progress of Tremella polysaccharide in the past 20 years was summarized from the sources, preparation methods, molecular structure, activity and application, and the research trend in the future was also prospected. The application prospect of Tremella polysaccharide in against multiple sub-health states was worth expecting.

scholarly journals Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities

2015 ◽  
Vol 81 (16) ◽  
pp. 5326-5334 ◽  
Author(s):  
Jun Huang ◽  
An-Liang Chen ◽  
Hui Zhang ◽  
Zhen Yu ◽  
Mei-Hong Li ◽  
...  
Keyword(s):  
Polyketide Synthase ◽  
Gene Replacement ◽  
Bursaphelenchus Xylophilus ◽  
Genetically Engineered ◽  
Streptomyces Avermitilis ◽  
Content Type ◽  
The Past ◽  
Structure Activity ◽  
New Generation ◽  
Relationship Of

ABSTRACTAvermectin (AVM) and ivermectin (IVM) are potent pesticides and acaricides which have been widely used during the past 30 years. As insect resistance to AVM and IVM is greatly increasing, alternatives are urgently needed. Here, we report two novel AVM derivatives, tenvermectin A (TVM A) and TVM B, which are considered a potential new generation of agricultural and veterinary drugs. The molecules of the TVMs were designed based on structure and pharmacological property comparisons among AVM, IVM, and milbemycin (MBM). To produce TVMs, a genetically engineered strain, MHJ1011, was constructed fromStreptomyces avermitilisG8-17, an AVM industrial strain. In MHJ1011, the nativeaveA1gene was seamlessly replaced withmilA1fromStreptomyces hygroscopicus. The total titer of the two TVMs produced by MHJ1011 reached 3,400 mg/liter. Insecticidal tests proved that TVM had enhanced activities againstTetranychus cinnabarinusandBursaphelenchus xylophilus, as desired. This study provides a typical example of exploration for novel active compounds through a new method of polyketide synthase (PKS) reassembly for gene replacement. The results of the insecticidal tests may be of use in elucidating the structure-activity relationship of AVMs and MBMs.

scholarly journals Botanical, Pharmacological, Phytochemical, and Toxicological Aspects of the Antidiabetic PlantBidens pilosaL.

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Wen-Chin Yang
Keyword(s):  
Present Review ◽  
Bidens Pilosa ◽  
Traditional Use ◽  
The Past ◽  
Preliminary Information ◽  
Structure Activity ◽  
Biological Studies ◽  
Relationship Of

Bidens pilosaL. is an easy-to-grow, widespread, and palatable perennial on earth. Hence, it has traditionally been used as foods and medicines without noticeable adverse effects. Despite significant advancement in chemical and biological studies ofB. pilosaover the past few years, comprehensive and critical reviews on its anti-diabetic properties are missing. The present review is to summarize up-to-date information on the pharmacology, phytochemistry, and toxicology ofB. pilosa, in regard to type 1 diabetes and type 2 diabetes from the literature. In addition to botanical studies and records of the traditional use ofB. pilosain diabetes, scientific studies investigating antidiabetic action of this species and its active phytochemicals are presented and discussed. The structure and biosynthesis ofB. pilosaand its polyynes in relation to their anti-diabetic action and mechanism are emphasized. Although some progress has been made, rigorous efforts are further required to unlock the molecular basis and structure-activity relationship of the polyynes isolated fromB. pilosabefore their clinical applications. The present review provides preliminary information and gives guidance for further anti-diabetic research and development of this plant.

Research Progress on the Natural Product Aloperine and Its Derivatives

2021 ◽  
Vol 21 ◽  
Author(s):  
Yu Cheng ◽  
Abdur Rauf ◽  
Xiandao Pan
Keyword(s):  
Natural Product ◽  
Recent Progress ◽  
Molecular Mechanisms ◽  
Structure Activity Relationship ◽  
Research Progress ◽  
Activity Relationship ◽  
Pharmacological Effects ◽  
Structure Activity ◽  
Relationship Of

: In this review, an effort towards the presentation of an all-around account of the recent progress on the natural product, aloperine is made, and the antivirus structure-activity relationship of its derivatives is also summarized comprehensively. In addition, the principal pharmacological effects and corresponding molecular mechanisms of aloperine are discussed. Some new modification directions of aloperine are given in the end, which might be brief guidance for further investigations on the natural product aloperine.

scholarly journals Furochinoline alkaloids in plants from Rutaceae family – a review

2016 ◽  
Vol 29 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Aldona Adamska-Szewczyk ◽  
Kazimierz Glowniak ◽  
Tomasz Baj
Keyword(s):  
Natural Products ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
The Past ◽  
Pharmacological Studies ◽  
Other Substances ◽  
Hiv And Cancer ◽  
Active Natural ◽  
Methods Of Isolation

Abstract Over the past five years, phytochemical and pharmacological studies have been conducted on material extracted from members of the Rutaceae family. In such work, new furochinoline-structured alkaloids were isolated from Ruta sp. and Dictamnus sp. Beyond the aforementioned, other substances with promising activity were isolated from the less-known species of Zanthoxylum, Evodia, Lonchocarpus, Myrthopsis and Teclea. Currently used forms of extraction, as well as methods of isolation and detection, allow the obtaining of pure, biologically active compounds. Many of these have antifungal, anti-bacterial and anti-plasmodial properties. Others are still being researched as potential drugs, which, in future, may be used in treating those afflicted with HIV and cancer. This article is designed to give the readers a thorough review of the active natural products from the Rutaceae family.

scholarly journals Relación entre la diversificación de productos y la rentabilidad empresarial / Relationship between product diversification and corporate profitability

Ciencia Unemi ◽  
2016 ◽  
Vol 9 (18) ◽  
pp. 73 ◽  
Author(s):  
Mariana Puente Riofrio ◽  
Francisco Andrade Dominguez
Keyword(s):  
Transformation Process ◽  
Product Diversification ◽  
Portfolio Diversification ◽  
Research Progress ◽  
The Past ◽  
Business Results ◽  
Business Dynamics ◽  
Relationship Of ◽  
The Relationship ◽  
A Company

El objetivo del presente artículo es evidenciar avances investigativos respecto a propuestas teóricas, a partir de pruebas empíricas, sobre la relación de la diversificación de la cartera de productos en los resultados empresariales, subrayando en teorías de diversificación y rentabilidad; se busca analizar la dinámica de las empresas dentro de un proceso de transformación basada en alcanzar resultados rentables. Al momento de utilizar las proyecciones financieras en la investigación se determinó una relación entre el pasado y el futuro de la empresa, factor que permitió concluir que la rentabilidad empresarial es directamente proporcional a la diversificación de la cartera de productos de una empresa. AbstractThe aim of this paper is to show research progress about theoretical proposals from empirical evidence, on the relationship of diversifying products portfolio on business results, emphasizing diversification theories and profitability; it is sought to analyze the business dynamics within a transformation process based on achieving profitable results. At the time of using the financial projections in the research, a link between the past and the future of the company was determined; a factor which led us to conclude that corporate profitability is directly proportional to the portfolio diversification of goods in a company.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Biologically active natural products from Cassine viburnifolia

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
T Grkovic ◽  
R Akee ◽  
J Evans ◽  
JM Collins ◽  
B O'Keefe
Keyword(s):  
Natural Products ◽  
Biologically Active ◽  
Active Natural
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