scholarly journals Increased burn healing time is associated with higher Vancouver Scar Scale score

2017 ◽  
Vol 3 ◽  
pp. 205951311769632 ◽  
Author(s):  
Vidya Finlay ◽  
Sally Burrows ◽  
Maddison Burmaz ◽  
Hussna Yawary ◽  
Johanna Lee ◽  
...  
Keyword(s):  
Wound Healing ◽  
Total Body Surface Area ◽  
Likelihood Estimation ◽  
Healing Time ◽  
Burn Wound ◽  
Interaction Terms ◽  
Burn Wound Healing ◽  
Primary Model ◽  
Burn Surgery ◽  
The Relationship

[Formula: see text] Increased burn wound healing time has been shown to influence abnormal scarring. This study hypothesised that scar severity increases commensurate to the increase in time to healing (TTH) of the wound. Wound healing and scar data from burn patients treated by the Burn Service of Western Australia at Royal Perth Hospital were examined. The relationship between TTH and scar severity, as assessed by the modified Vancouver Scar Scale (mVSS), was modelled using regression analysis. Interaction terms evaluated the effect of surgery and total body surface area – burn (TBSA) on the main relationship. Maximum likelihood estimation was used to account for potential bias from missing independent variable data. The sample had a median age of 34 years, TTH of 24 days, TBSA of 3% and length of stay of five days, 70% were men and 71% had burn surgery. For each additional day of TTH, the mVSS score increased by 0.11 points ( P ≤ 0.001) per day in the first 21 days and 0.02 points per day thereafter ( P = 0.004). The relationship remained stable in spite of TBSA or surgical intervention. Investigation of the effect of missing data revealed the primary model underestimated the strength of the association. An increase in TTH within 21 days of injury is associated with an increase in mVSS or reduced scar quality. The results confirm that efforts should be directed toward healing burn wounds as early as possible.

scholarly journals The Use of Stem Cells in Burn Wound Healing: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Fadi Ghieh ◽  
Rosalyn Jurjus ◽  
Amir Ibrahim ◽  
Alice Gerges Geagea ◽  
Hisham Daouk ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Therapeutic Effect ◽  
Healing Time ◽  
Burn Injuries ◽  
Burn Wound ◽  
Burn Wounds ◽  
Complex Processes ◽  
Burn Wound Healing

Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem cells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated.

scholarly journals Healing the third degree thermal burn in mice by Dielectric Barrier Discharge Plasma (DBD plasma): Comparison and evaluation of area, burn wound healing time, burn skin temperature

10.29007/fmkc ◽  
2020 ◽  
Author(s):  
Thi Minh Hien Ngo ◽  
Tuyet Nhi Do ◽  
Quoc Duy Nam Nguyen ◽  
Duy Phuong Nguyen ◽  
Nguyen Ngan Ha Lam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Time ◽  
Diagnostic Methods ◽  
Invasive Treatment ◽  
Burn Wound ◽  
Dbd Plasma ◽  
Thermal Burn ◽  
Non Invasive ◽  
Burn Wound Healing ◽  
Wound Healing Time

Burns are one of the most devastating conditions encountered in medicine. This injury is in skin or other tissues, caused by heat-cold, electricity or chemicals [1,2]. There are lots of methods to treat burns and each method has its own advantages, such as medicine, dressing, low-level laser, plasma, skin graft surgery... [3].This study experimented with the 3rd degree burn model in mice by heat, treating by DBD plasma, is a non-invasive treatment and using clinical diagnostic methods by (1) normal image, (2) thermal image, (3) HE staining. Aim of this research is evaluation and comparison the area, temperature and wound healing time of non-invasive treatment with DBD plasma and nontreatment. After 3-week experiment, using diagnostic methods and analysis tools have demonstrated that the 3rd thermal burn wound healing of plasma treatment recovers faster than non-treatment about: (1) Burn wound surface shrinkage rate is higher: ~ 5%; (2) Healing time is faster: 2-3 days; (3) The average temperature of the burn wound is lower: 1-2oC. Therefore, DBD plasma is a potential treatment in burns wound and wound healing in the future. Keywords: DBD plasma, burn wound, healing wound

Burn wound healing time assessed by laser Doppler imaging. Part 2: Validation of a dedicated colour code for image interpretation

Burns ◽  
2011 ◽  
Vol 37 (2) ◽  
pp. 249-256 ◽  
Author(s):  
S.M. Monstrey ◽  
H. Hoeksema ◽  
R.D. Baker ◽  
J. Jeng ◽  
R.S. Spence ◽  
...  
Keyword(s):  
Wound Healing ◽  
Image Interpretation ◽  
Healing Time ◽  
Laser Doppler ◽  
Doppler Imaging ◽  
Laser Doppler Imaging ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Wound Healing Time

The Safety and Efficacy of Mupirocin Topical Spray for Burn Wound Healing in A Rat Model

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Sritharadol Rutthapol ◽  
Chunhachaichana Charisopon ◽  
Kumlungmak Sukanjana ◽  
Buatong Wilaiporn ◽  
Dechraksa Janwit ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Immunohistochemical Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Burn Wound ◽  
Safety And Efficacy ◽  
Burn Wound Healing ◽  
Tgf Β1

ABSTRACT This study evaluated the effect of mupirocin topical spray on burn wound healing in a rat model. Fifteen male Sprague Dawley rats were used to create full-thickness burns on the rat dorsum using a cylindrical stainless steel rod. The rats were topically treated with normal saline solution (NSS), mupirocin spray, ointment, and solution. The wound size and morphological evaluation were investigated by photographs and clinical criterions for wound healing. The histology was observed by hematoxylin and eosin (HandE) staining assay. The immunohistochemical study was evaluated by detection of transforming growth factor-beta 1 (TGF-β1), and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of matrix metalloproteinase-1 (MMP-9/TIMP-1) was quantified using the enzyme-linked immunosorbent assay (ELISA) assay. A complete healing was observed at 28 days in all treatments. Mupirocin formulations accelerated the wound healing faster than NSS in size. However, the clinical criteria indicated a desirable skin appearance in the mupirocin spray and ointment treated groups. The histological evaluations showed no differences between the treatments while the immunohistochemical study revealed that all treatments reduced the level of TGF-β1 over time, particularly on day 28 in the mupirocin spray and ointment treated groups. The MMP-9/TIMP-1 ratio was significantly lower in the mupirocin spray and ointment treated groups than in the NSS and mupirocin solution groups. This study shows the safety and efficacy in the use of mupirocin topical spray. The topical mupirocin spray is an alternative suitable for development as a human topical anti-infective and wound protection spray.

scholarly journals Validity of thermography for measuring burn wound healing potential

2019 ◽  
Vol 28 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Michelle E. Carrière ◽  
Louise E. M. Haas ◽  
Anouk Pijpe ◽  
Annebeth Meij‐de Vries ◽  
Kim L. M. Gardien ◽  
...  
Keyword(s):  
Wound Healing ◽  
Burn Wound ◽  
Burn Wound Healing

556 The Use of a Concentrated Surfactant Based Gel to Promote Burn Wound Healing

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S126-S127
Author(s):  
Rebecca Coffey ◽  
Rachel Penny
Keyword(s):  
Wound Healing ◽  
New Product ◽  
Ease Of Use ◽  
Burn Injuries ◽  
Full Thickness ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Care ◽  
Product Trial ◽  
Burn Wound Healing

Abstract Introduction Strategies to remove necrotic tissue from burn wounds include excisional and non-excisional debridement. Alternative treatments could promote burn wound healing while minimizing patient discomfort and the need for surgery. We evaluated the usage of a concentrated surfactant gel (CSG) to promote burn wound healing in those with indeterminate depth and full thickness burn injuries. Methods An IRB approved retrospective study was conducted during a 10-patient new product trial period with enrollment between September and October 2019. Patients included in this study had indeterminate or full thickness burn wounds and were treated with a concentrated surfactant-based gel. Patients with non-burn diagnoses were excluded. Data collected included demographic information, injury descriptors, and additional burn wound characteristics. Results A total of 10 patients were included in this study as part of a new product trial. The subjects were 80% male with an average TBSA of 7.5%. 40% had indeterminate and 60% had full thickness burn wounds. Prior to initiation of the CSG, the burn wounds had been open for an average of 41 days. There were no infections or complications with usage of the CSG. 90% of patients reported less pain than the standard of care topical agents for burns. Average duration of treatment with the CSG until healing was 28 days. After usage of the CSG, no patients required surgery. Conclusions Our findings support the usage of a concentrated surfactant-based gel in patients with burn wounds. Patients reported decreased pain during dressing changes and ease of use compared to the standard topical agent in burn care. It also prevented surgical debridement in those with indeterminate and full thickness burn injuries.

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