scholarly journals Is calcar referenced tip-apex distance a better predicting factor for cutting out in biaxial cephalomedullary nails than tip-apex distance?

2017 ◽  
Vol 25 (3) ◽  
pp. 230949901772792 ◽  
Author(s):  
Kishore Puthezhath ◽  
Chundarathil Jayaprakash
Keyword(s):  
Cutting Out ◽  
Tip Apex Distance ◽  
Predicting Factor ◽  
Cephalomedullary Nails

scholarly journals Impact of tip–apex distance and femoral head lag screw position on treatment outcomes of unstable intertrochanteric fractures using cephalomedullary nails

2018 ◽  
Vol 46 (6) ◽  
pp. 2128-2140 ◽  
Author(s):  
Cheng-Hung Lee ◽  
Kuo-Chih Su ◽  
Kun-Hui Chen ◽  
Chien-Chou Pan ◽  
Yun-Che Wu
Keyword(s):  
Femoral Head ◽  
Intertrochanteric Fractures ◽  
Cephalomedullary Nail ◽  
Level Of Evidence ◽  
Maximum Displacement ◽  
Lag Screw ◽  
Biomechanical Behavior ◽  
Inferior Aspect ◽  
Tip Apex Distance ◽  
Cephalomedullary Nails

Background Cephalomedullary nails are frequently used in unstable intertrochanteric fractures. The implant position is an important factor for surgical success. Thus, in the present study, finite element analysis methods were used to investigate the biomechanical behavior of five different cephalomedullary nail positions in unstable intertrochanteric fractures. Methods Five different cephalomedullary nail implant positions were investigated. The observed indicators were the maximum displacement of the lag screw, the stress on the intertrochanteric fracture with involvement of the posteromedial cortex, and the tip–apex distance. Results The smallest lag screw displacement was achieved when the implant was closer to the inferior femoral head. Lower stress was placed on the posteromedial cortex when the implant was positioned closer to the inferior femoral head. However, the tip–apex distance increased when the lag screw was positioned more inferiorly. Conclusions The results of this study suggest that positioning the lag screw closer to the inferior aspect of the femoral head can reduce stress on the posteromedial cortex and deformation of the implant in unstable intertrochanteric fractures. These findings provide a biomechanical basis for selection of the cephalomedullary nail implantation site. Level of evidence III.

Application Of Electron Microscopy To Automotive Finish Defect Analysis

1990 ◽  
Vol 48 (2) ◽  
pp. 258-259
Author(s):  
Martin J. Mahon ◽  
Patrick W. Keating ◽  
John T. McLaughlin
Keyword(s):  
Electron Microscopy ◽  
Zero Tolerance ◽  
Polymeric Materials ◽  
Plant Management ◽  
Defect Analysis ◽  
X Ray ◽  
Root Cause ◽  
Cutting Out ◽  
Foreign Materials ◽  
Automotive Finish

Coatings are applied to appliances, instruments and automobiles for a variety of reasons including corrosion protection and enhancement of market value. Automobile finishes are a highly complex blend of polymeric materials which have a definite impact on the eventual ability of a car to sell. Consumers report that the gloss of the finish is one of the major items they look for in an automobile.With the finish being such an important part of the automobile, there is a zero tolerance for paint defects by auto assembly plant management. Owing to the increased complexity of the paint matrix and its inability to be “forgiving” when foreign materials are introduced into a newly applied finish, the analysis of paint defects has taken on unparalleled importance. Scanning electron microscopy with its attendant x-ray analysis capability is the premier method of examining defects and attempting to identify their root cause.Defects are normally examined by cutting out a coupon sized portion of the autobody and viewing in an SEM at various angles.

Holmes tremor: a delayed complication after resection of brainstem cavernomas

2020 ◽  
pp. 1-11
Author(s):  
Marco Cenzato ◽  
Davide Colistra ◽  
Giorgia Iacopino ◽  
Christian Raftopoulos ◽  
Ulrich Sure ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Neurophysiological Monitoring ◽  
Strict Adherence ◽  
Surgical Access ◽  
Holmes Tremor ◽  
Neurophysiological Studies ◽  
Metropolitan Hospital ◽  
Delayed Complication ◽  
Brainstem Cavernoma ◽  
Predicting Factor

OBJECTIVEIn this paper, the authors aimed to illustrate how Holmes tremor (HT) can occur as a delayed complication after brainstem cavernoma resection despite strict adherence to the safe entry zones (SEZs).METHODSAfter operating on 2 patients with brainstem cavernoma at the Great Metropolitan Hospital Niguarda in Milan and noticing a similar pathological pattern postoperatively, the authors asked 10 different neurosurgery centers around the world to identify similar cases, and a total of 20 were gathered from among 1274 cases of brainstem cavernomas. They evaluated the tremor, cavernoma location, surgical approach, and SEZ for every case. For the 2 cases at their center, they also performed electromyographic and accelerometric recordings of the tremor and evaluated the postoperative tractographic representation of the neuronal pathways involved in the tremorigenesis. After gathering data on all 1274 brainstem cavernomas, they performed a statistical analysis to determine if the location of the cavernoma is a potential predicting factor for the onset of HT.RESULTSFrom the analysis of all 20 cases with HT, it emerged that this highly debilitating tremor can occur as a delayed complication in patients whose postoperative clinical course has been excellent and in whom surgical access has strictly adhered to the SEZs. Three of the patients were subsequently effectively treated with deep brain stimulation (DBS), which resulted in complete or almost complete tremor regression. From the statistical analysis of all 1274 brainstem cavernomas, it was determined that a cavernoma location in the midbrain was significantly associated with the onset of HT (p < 0.0005).CONCLUSIONSDespite strict adherence to SEZs, the use of intraoperative neurophysiological monitoring, and the immediate success of a resective surgery, HT, a severe neurological disorder, can occur as a delayed complication after resection of brainstem cavernomas. A cavernoma location in the midbrain is a significant predictive factor for the onset of HT. Further anatomical and neurophysiological studies will be necessary to find clues to prevent this complication.

Investigation of irradiated metal of WWER-type reactor internals after 45 years of operation. Part 1. Research program and cutting out of samples from pressure vessel internals

2020 ◽  
pp. 135-143
Author(s):  
B. Z. Margolin ◽  
A. Ya. Varovin ◽  
A. J. Minkin ◽  
D. A. Gurin ◽  
V. A. Glukhov
Keyword(s):  
Research Program ◽  
Pressure Vessel ◽  
The Core ◽  
Type Reactor ◽  
Cutting Out ◽  
Cylindrical Samples ◽  
Reactor Internals

The program is presented for investigations of the metal of the most irradiated elements of the WWER-440 reactor of the Novovoronezh NPP Unit 3 decommissioned after 45 years of operation. The fragments (cylindrical samples) were cut out from various zones of the core baffle and segment of forming ring of core barrel.

scholarly journals OP0326 ACPA-INDUCED PAIN-BEHAVIOR, BONE LOSS AND TENDON INFLAMMATION IN MICE: A NOVEL MODEL FOR THE PRE-DISEASE PHASES OF ACPA-POSITIVE RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 200.2-200
Author(s):  
A. Krishnamurthy ◽  
Y. Kisten ◽  
A. Circiumaru ◽  
K. Sakurabas ◽  
P. Jarvolli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Loss ◽  
Joint Inflammation ◽  
Tendon Sheath ◽  
Joint Involvement ◽  
Subclinical Inflammation ◽  
Core Motif ◽  
Dixon Method ◽  
Hind Limbs ◽  
Predicting Factor

Background:In rheumatoid arthritis (RA), anti-citrullinated protein antibodies (ACPAs) are associated with bone loss and pain. Recently, tenosynovitis has been suggested as a predicting factor for arthritis progression in individuals at-risk for RA.Objectives:We aimed to investigate if transfer of human ACPAs into mice could induce tenosynovitis and/or subclinical inflammation.Methods:Monoclonal ACPA (1325:04C03 and 1325:01B09) and control (1362:01E02) antibodies (mAbs) were generated from synovial plasma or memory B cells of RA patients. 2mg of combination of monoclonal ACPAs or control antibody were injected in BALB/c female mice (age 12-16 weeks) (n= 9). Pain-like behavior was monitored by measuring mechanical hypersensitivity using von Frey filaments every 3 days and estimation by up-down Dixon method. Bone morphometrics was analyzed by micro-CT. Using specially designed mobilization casts, dedicated mouse MRI coils, and gadolinium enhanced contrast medium, the hind limbs of these mice were scanned in a 9.4 T scanner and resulting T1-weighted images were evaluated for signs of soft tissue joint inflammation. The MRI images were scored for the presence of joint involvement and tendon inflammatory changes by 3 readers in a blinded manner.Figure 1.NAPA performed on healthy donor mo-DCs incubated with native, PAD2-citrullinated, and PAD4-citrullinated fibrinogen. Alpha, beta, and gamma chains of fibrinogen are shown separately. Each colored line represents a unique peptide. Nested peptides with a common core motif are shown in the same color. Grey bar denotes peptides with identical core motif between samples.Results:ACPAs (1325:04C03 and 1325:01B09) induced pain-like behavior (lasting for at least 4 weeks) and reduction of the trabecular and cortical bone thickness in the hind limbs as compared to control monoclonal antibodies (p<0.05). While no macroscopic or MRI signs of synovial inflammation were detected, MRI subclinical inflammation of the tendon sheaths was present in mice injected with ACPAs, but not in those injected with control mAb. Semi-quantitative scoring of the inflammatory tendon changes showed significant higher values in mice injected with ACPA (median of 1, range 0 to 2) than those injected with control mAb (median of 0, range 0 to 1).Conclusion:We show that ACPA induces pain-like behavior, bone loss and tendon sheath inflammation in mice, a model that mimics the preclinical state of ACPA positive RA.References:[1]Harre, U. et al. J Clin Invest (2012)[2]Krishnamurthy, A. et al. Ann Rheum Dis (2016, 2019), JI 2019[3]Wigerblad, G. et al. Ann Rheum Dis (2016, 2019)[4]KleyerA, Seminars in Arthritis and Rheumatism (2016)Disclosure of Interests:Akilan Krishnamurthy: None declared, Yogan Kisten: None declared, Alexandra Circiumaru: None declared, Koji Sakurabas: None declared, Patrik Jarvolli: None declared, Juan Jimenez Jimenez Andrade: None declared, Peter Damberg: None declared, Heidi Wähämaa: None declared, Vivianne Malmström Grant/research support from: VM has had research grants from Janssen Pharmaceutica, Lars Klareskog: None declared, Camilla Svensson: None declared, Bence Réthi: None declared, Anca Catrina: None declared

scholarly journals Higher CD4/CD8 ratio of pleural effusion predicts better survival for lung cancer patients receiving immune checkpoint inhibitors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Po-Hsin Lee ◽  
Tsung-Ying Yang ◽  
Kun-Chieh Chen ◽  
Yen-Hsiang Huang ◽  
Jeng-Sen Tseng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pleural Effusion ◽  
Cancer Patients ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Lung Cancer Patients ◽  
Predicting Factor ◽  
Type 3

AbstractPleural effusion is a rare immune-related adverse event for lung cancer patients receiving immune checkpoint inhibitors (ICIs). We enrolled 281 lung cancer patients treated with ICIs and 17 were analyzed. We categorized the formation of pleural effusion into 3 patterns: type 1, rapid and massive; type 2, slow and indolent; and type 3, with disease progression. CD4/CD8 ratio of 1.93 was selected as the cutoff threshold to predict survival. Most patients of types 1 and 2 effusions possessed pleural effusion with CD4/CD8 ratios ≥ 1.93. The median OS time in type 1, 2, and 3 patients were not reached, 24.8, and 2.6 months, respectively. The median PFS time in type 1, 2, and 3 patients were 35.5, 30.2, and 1.4 months, respectively. The median OS for the group with pleural effusion CD4/CD8 ≥ 1.93 and < 1.93 were not reached and 2.6 months. The median PFS of those with pleural effusion CD4/CD8 ≥ 1.93 and < 1.93 were 18.4 and 1.2 months. In conclusion, patients with type 1 and 2 effusion patterns had better survival than those with type 3. Type 1 might be interpreted as pseudoprogression of malignant pleural effusion. CD4/CD8 ratio ≥ 1.93 in pleural effusion is a good predicting factor for PFS.

scholarly journals Crystallization of Random Matrix Orbits

2018 ◽  
Vol 2020 (3) ◽  
pp. 883-913 ◽  
Author(s):  
Vadim Gorin ◽  
Adam W Marcus
Keyword(s):  
Random Matrix ◽  
Special Functions ◽  
Free Field ◽  
Gaussian Free Field ◽  
Complex Quaternion ◽  
Cutting Out ◽  
Multiplicative Convolution ◽  
Global Asymptotics ◽  
Associated Special Functions ◽  
Derivatives Of

Abstract Three operations on eigenvalues of real/complex/quaternion (corresponding to $\beta =1,2,4$) matrices, obtained from cutting out principal corners, adding, and multiplying matrices, can be extrapolated to general values of $\beta&gt;0$ through associated special functions. We show that the $\beta \to \infty $ limit for these operations leads to the finite free projection, additive convolution, and multiplicative convolution, respectively. The limit is the most transparent for cutting out the corners, where the joint distribution of the eigenvalues of principal corners of a uniformly-random general $\beta $ self-adjoint matrix with fixed eigenvalues is known as the $\beta $-corners process. We show that as $\beta \to \infty $ these eigenvalues crystallize on an irregular lattice consisting of the roots of derivatives of a single polynomial. In the second order, we observe a version of the discrete Gaussian Free Field put on top of this lattice, which provides a new explanation as to why the (continuous) Gaussian Free Field governs the global asymptotics of random matrix ensembles.

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