Association Between Genetic Polymorphisms in Metaloproteinases of the Matrix and Delayed Tooth Emergence: A Cross-sectional Study

2019 ◽  
Vol 10 (2) ◽  
pp. 91-96
Author(s):  
Silvane Silva Evangelista ◽  
Juliana Arid ◽  
Katia Regina Felizardo Vasconcelos ◽  
Giuseppe Valduga Cruz ◽  
André Luiz Tannus Dutra ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Cross Sectional Study ◽  
Permanent Tooth ◽  
Tooth Eruption ◽  
Permanent Teeth ◽  
Fisher Exact Test ◽  
Genotype Distribution ◽  
Sectional Study ◽  
Cross Sectional ◽  
Allele Distribution

Background and Aims: Animal models have been demonstrating that MMPs have an important function in the tooth eruption process. The aim of this study was to evaluate the association between genetic polymorphisms in MMP8 and MMP13 and delayed tooth eruption of permanent teeth. Materials and Methods: This cross-sectional study selected 216 children, 9- to 12-year-old, from public schools at Manaus, Amazonas, Brazil. During oral clinical examination, each permanent tooth emerged in the oral cavity was evaluated. Children were considered with delayed tooth eruption when at least one permanent tooth was delayed and were classified in 2 groups: children “with delayed tooth emergency” and “without delayed tooth emergency.” Saliva samples were collected from DNA extraction. The genetic polymorphisms rs17099443 and rs3765620 in MMP8, and rs478927 and rs2252070 in MMP13 were genotyped. Statistical Analysis: PLINK V1.07 ( http://pngu.mgh.harvard.edu/purcell/plink/ ) and GraphPad Prism 5.0 (San Diego, CA, USA) were used. The c2 or Fisher exact test was used to calculate genotypes and alleles distributions. To compare the mean number of delayed teeth according to genotypes, the Kruskal-Wallis test with multiple comparison Dunn test was used. The established alpha for all comparisons was .05. Results: The polymorphism rs17099443 in MMP8 was associated with delayed tooth eruption in the genotype distribution ( P = .05). In the allele distribution, the C allele was underrepresented in children with delayed tooth eruption ( P = .01; OR = 0.61, 95% confidence interval, 0.41–0.9). Conclusion: The genetic polymorphism rs17099443 in MMP8 is associated with delayed tooth eruption.

Human permanent tooth sizes are associated with genes encoding oestrogen receptors

2020 ◽  
pp. 146531252095871
Author(s):  
Arthur S Cunha ◽  
Luiza Vertuan dos Santos ◽  
Samantha Schaffer Pugsley Baratto ◽  
Zerrin Abbasoglu ◽  
Jennifer Tsi Gerber ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Oestrogen Receptor ◽  
Cross Sectional Study ◽  
Permanent Tooth ◽  
Permanent Teeth ◽  
Tooth Size ◽  
Oestrogen Receptors ◽  
Cross Sectional ◽  
Significant Difference ◽  
School Of Dentistry

Objective: To evaluate if genetic polymorphisms in the oestrogen receptor 1 ( ESR1) and oestrogen receptor 2 ( ESR2) genes encoded for oestrogen receptors alpha (ERα) and beta (ERβ) are involved in permanent tooth size. Design: Cross-sectional study. Setting: Orthodontic Clinic at School of Dentistry of Ribeirão Preto, University of São Paulo. Participants: A total of 108 orthodontic patients. Materials and Methods: Pre-treatment orthodontic records were evaluated. Dental casts were used to determine the maximum crown measurements of fully erupted permanent teeth in the mesiodistal dimensions. Second and third molars were not included in the analysis. Genomic DNA samples were used for the genotyping of four genetic polymorphisms: ESR1 (rs9340799 and rs2234693) and ESR2 (rs1256049 and rs4986938). The associations between tooth size and sex were evaluated using t test. The associations between tooth size and genotype were analysed with linear regression and adjusted by sex at an alpha of P⩽0.05. Results: Female patients presented smaller tooth size than male patients. A statistically significant difference was observed in almost all teeth ( P<0.05). The genetic polymorphisms in rs9340799, rs2234693, rs1256049 and rs4986938 were associated with some tooth sizes in both the maxilla and mandible ( P<0.05). Conclusion: This study provides evidence that genetic polymorphisms in ESR1 and ESR2 could be associated with tooth size in permanent teeth.

scholarly journals Risk Factors Associated with Cusp Fractures in Posterior Permanent Teeth—A Cross-Sectional Study

2021 ◽  
Vol 11 (19) ◽  
pp. 9299
Author(s):  
Susana Morimoto ◽  
Wilma K. C. Lia ◽  
Flavia Gonçalves ◽  
Denis Yudi Nagase ◽  
Thais Gimenez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dental Treatment ◽  
Cross Sectional Study ◽  
Endodontic Treatment ◽  
Permanent Teeth ◽  
Fisher Exact Test ◽  
Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Factors Associated

Objectives: This cross-sectional study aimed to evaluate the frequency and risk factors associated with cusp fractures in posterior permanent teeth. Methods: Patients presented cusp fractures on posterior permanent teeth, clinically assessed in up to 7 days after the event, and requesting dental treatment at two public services were included in this cross-sectional study. Fractured teeth already treated, with antagonist absence, or with prosthesis (total or removable) were excluded. Demographic and clinical data were collected to draw the patient profiles and establish how teeth were affected individually. Statistical analysis was performed by the Fisher exact test, and uni- and multivariate logistic regression (α = 0.05). Results: One hundred and seventy-seven (177) patients from 16 to 66 years old (±41.56), from 1998 to 2016, were included in this study. Non-functional and lingual cusps presented a higher fracture than functional and buccal cusps, respectively. Fractures were more common in teeth with isthmus wider than 1/3 of the intercuspid distance and/or more than three restored surfaces. Teeth with endodontic treatment presented a higher subgingival fracture. On lingual cusps, fracture type and location were significantly associated, being that total fractures were 3.2 times more likely to occur than partial fractures, and subgingival were 3.62 times more likely to occur than supragingival fractures. Conclusion: Indications of classic protection on functional cusps (LUBL) was refuted since, generally, nonfunctional cusps fractured more than the functional cusps. However, upper pre-molars showed more fractures in functional cusps and lower molars presented more fractures on the nonfunctional cusps. In general, lingual cusps were the most fractured and were associated with a higher prevalence of severe fractures (total fractures at the subgingival level). Fractures were more common in teeth where the restoration had an isthmus wider than 1/3 of the intercuspid distance and/or involved more than three restored surfaces. Most of the patients did not show previous symptoms and signs. Overall, teeth with endodontic treatment presented a higher subgingival fracture.

scholarly journals Knowledge of tooth avulsion first aid management among parents residing in UAE

2020 ◽  
Vol 19 ◽  
pp. e206950
Author(s):  
Afraa Hussain ◽  
Raghad Hashim ◽  
Aisha Khamees
Keyword(s):  
First Aid ◽  
Cross Sectional Study ◽  
Permanent Tooth ◽  
Permanent Teeth ◽  
Previous Knowledge ◽  
Sectional Study ◽  
Demographic Information ◽  
Cross Sectional ◽  
Tooth Avulsion ◽  
And Storage

Aim: This study aimed to evaluate the knowledge of parents visiting a specialized dental center in Ajman on permanent tooth avulsion and the required first aid procedure to achieve better prognoses. Methods: A cross-sectional study was conducted in Ajman Emirate, UAE. Three hundred eighty-eight parents from three nationalities (Emirati, Egyptian and Indian) residing in UAE answered a constructed questionnaire that included demographic information related to the participants and questions related to permanent tooth avulsion and the required first steps for its management. Results: Study findings reflect deficiencies in the following areas. Of the 388 parents, (236, 60.8%) had poor knowledge about permanent tooth avulsion. Parents who had previous knowledge obtained information from unsupported sources, such as friends (145, 37.4%). Out of 388 parents, (324, and 83.5%) would not replant the tooth. Finally, the majority of the participants did not know the proper media to store the avulsed permanent tooth with one-third of parents choosing cotton or water (142, 36.6%). Conclusion: This study showed a lack of knowledge regarding permanent tooth avulsion among parents from the major nationalities residing in UAE. However, the respondents represent major differences regarding related to knowledge, replant, and storage of avulsed permanent teeth.

scholarly journals Time and Eruption Sequence of Permanent Teeth in Hyderabad Children: A Descriptive Cross-sectional Study

2018 ◽  
Vol 11 (4) ◽  
pp. 330-337 ◽  
Author(s):  
Penmatsa Chaitanya ◽  
Jampanapalli S Reddy ◽  
Konda Suhasini ◽  
Inguva H Chandrika ◽  
Dalavai Praveen
Keyword(s):  
Cross Sectional Study ◽  
Permanent Teeth ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Relationship Between Undernutrition and Periodontal Diseases Among Yemen Population: a Cross-sectional Study

2020 ◽  
Author(s):  
Milad Al-kalisi ◽  
Manal Al-Hajri ◽  
Sarah Al-Rai
Keyword(s):  
Periodontal Diseases ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
Fisher Exact Test ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Mean Values ◽  
Khat Chewing ◽  
Chi Square Test

Abstract Background: Undernutrition is an inadequate supply of energy and nutrients. Periodontal diseases (PDs) defined as a broad form of chronic inflammatory diseases of the gingiva, bone and ligaments supporting the teeth. This study aimed to reveal the effect of undernutrition, using body mass index (BMI) and serum albumin level (Alb) on PDs and other risk factors as age, smoking and khat chewing. Methods: This was a cross-sectional study conducted at the faculty of dentistry, Sana’a University. Of 1920 patients attended to clinics, only 229 matched the study criteria. Oral examination was performed to assess the periodontal clinical parameters measurements. BMI and Alb was measured. Statistical analysis was used to present the association between categorical variables was assessed using Chi square test and Fisher-Exact test. ANOVA was used to assess the differences in the mean values of the quantitative outcomes. Chi square test was used to evaluate the association between BMI and age, gender, occupation, education level, smoking, khat chewing as well as BMI with PDs. Results: Most of participants (58.5%) were males and most of the study sample (91.3%) was at the age group of (18-35). Among all subjects, (81.2%) of cases were diagnosed with gingivitis. (60.7%) of study participants were mildly undernourished according to BMI. (93%) of participants showed normal Alb level. Regarding to habits, only (18.2%) of patients were smokers and more than half of participants (59.4%) were khat chewers. Conclusion: There was a relationship between PDs and undernutrition which was obviously seen between gingivitis and mild undernutrition.

scholarly journals REASONS FOR AND PATTERNS RELATING TO THE EXTRACTION OF PERMANENT TEETH IN A SAMPLE OF THE EGYPTIANPOPULATION: A CROSS-SECTIONAL STUDY

2020 ◽  
Vol 8 (6) ◽  
pp. 165-173
Author(s):  
Ramy H. Seif El Nasr El Shater ◽  
◽  
Christine K. Ramzy ◽  
Khaled M. Keraa ◽  
Tamer A. Nasr ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Permanent Teeth ◽  
Sectional Study ◽  
Cross Sectional
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