Human permanent tooth sizes are associated with genes encoding oestrogen receptors

2020 ◽  
pp. 146531252095871
Author(s):  
Arthur S Cunha ◽  
Luiza Vertuan dos Santos ◽  
Samantha Schaffer Pugsley Baratto ◽  
Zerrin Abbasoglu ◽  
Jennifer Tsi Gerber ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Oestrogen Receptor ◽  
Cross Sectional Study ◽  
Permanent Tooth ◽  
Permanent Teeth ◽  
Tooth Size ◽  
Oestrogen Receptors ◽  
Cross Sectional ◽  
Significant Difference ◽  
School Of Dentistry

Objective: To evaluate if genetic polymorphisms in the oestrogen receptor 1 ( ESR1) and oestrogen receptor 2 ( ESR2) genes encoded for oestrogen receptors alpha (ERα) and beta (ERβ) are involved in permanent tooth size. Design: Cross-sectional study. Setting: Orthodontic Clinic at School of Dentistry of Ribeirão Preto, University of São Paulo. Participants: A total of 108 orthodontic patients. Materials and Methods: Pre-treatment orthodontic records were evaluated. Dental casts were used to determine the maximum crown measurements of fully erupted permanent teeth in the mesiodistal dimensions. Second and third molars were not included in the analysis. Genomic DNA samples were used for the genotyping of four genetic polymorphisms: ESR1 (rs9340799 and rs2234693) and ESR2 (rs1256049 and rs4986938). The associations between tooth size and sex were evaluated using t test. The associations between tooth size and genotype were analysed with linear regression and adjusted by sex at an alpha of P⩽0.05. Results: Female patients presented smaller tooth size than male patients. A statistically significant difference was observed in almost all teeth ( P<0.05). The genetic polymorphisms in rs9340799, rs2234693, rs1256049 and rs4986938 were associated with some tooth sizes in both the maxilla and mandible ( P<0.05). Conclusion: This study provides evidence that genetic polymorphisms in ESR1 and ESR2 could be associated with tooth size in permanent teeth.

Association Between Genetic Polymorphisms in Metaloproteinases of the Matrix and Delayed Tooth Emergence: A Cross-sectional Study

2019 ◽  
Vol 10 (2) ◽  
pp. 91-96
Author(s):  
Silvane Silva Evangelista ◽  
Juliana Arid ◽  
Katia Regina Felizardo Vasconcelos ◽  
Giuseppe Valduga Cruz ◽  
André Luiz Tannus Dutra ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Cross Sectional Study ◽  
Permanent Tooth ◽  
Tooth Eruption ◽  
Permanent Teeth ◽  
Fisher Exact Test ◽  
Genotype Distribution ◽  
Sectional Study ◽  
Cross Sectional ◽  
Allele Distribution

Background and Aims: Animal models have been demonstrating that MMPs have an important function in the tooth eruption process. The aim of this study was to evaluate the association between genetic polymorphisms in MMP8 and MMP13 and delayed tooth eruption of permanent teeth. Materials and Methods: This cross-sectional study selected 216 children, 9- to 12-year-old, from public schools at Manaus, Amazonas, Brazil. During oral clinical examination, each permanent tooth emerged in the oral cavity was evaluated. Children were considered with delayed tooth eruption when at least one permanent tooth was delayed and were classified in 2 groups: children “with delayed tooth emergency” and “without delayed tooth emergency.” Saliva samples were collected from DNA extraction. The genetic polymorphisms rs17099443 and rs3765620 in MMP8, and rs478927 and rs2252070 in MMP13 were genotyped. Statistical Analysis: PLINK V1.07 ( http://pngu.mgh.harvard.edu/purcell/plink/ ) and GraphPad Prism 5.0 (San Diego, CA, USA) were used. The c2 or Fisher exact test was used to calculate genotypes and alleles distributions. To compare the mean number of delayed teeth according to genotypes, the Kruskal-Wallis test with multiple comparison Dunn test was used. The established alpha for all comparisons was .05. Results: The polymorphism rs17099443 in MMP8 was associated with delayed tooth eruption in the genotype distribution ( P = .05). In the allele distribution, the C allele was underrepresented in children with delayed tooth eruption ( P = .01; OR = 0.61, 95% confidence interval, 0.41–0.9). Conclusion: The genetic polymorphism rs17099443 in MMP8 is associated with delayed tooth eruption.

A Study on Bolton Anterior Tooth Size Discrepancies among Different Malocclusion Groups

2013 ◽  
Vol 1 (2) ◽  
pp. 1-4
Author(s):  
AW Ali ◽  
MZ Hossain
Keyword(s):  
Cross Sectional Study ◽  
Normal Group ◽  
Anterior Tooth ◽  
Tooth Size ◽  
Class Iii ◽  
Cross Sectional ◽  
Normal Occlusion ◽  
Significant Difference ◽  
The Mean ◽  
Bangladeshi Population

Aim: To investigate the correlation between anterior tooth size discrepancies among Angle's Class l, ll, lll malocclusions and corresponding normal occlusion, as well as their prevalence in Bangladeshi population. This study would act as a reference for diagnosis, treatment planning and assessment of prognosis in some orthodontic cases. Methods: This cross sectional study was conducted in the Department of Orthodontics & Dentofacial Orthopedics, Dhaka Dental College & Hospital. A total number of 200 subjects were selected in Angle's Class l, ll, lll and corresponding normal group. Each group had 50 subjects with males and females. A chi-square test was performed to statistically compare the prevalence of anterior tooth size discrepancies among Angle's Class l, ll, lll malocclusions and corresponding normal occlusion and two genders. Analysis of variance was used to compare the mean Bolton anterior tooth size ratios as a function of angle classification and gender. Statistical differences were determined at the 95% confidence level (p< 0.05). Results: No significant difference was observed in the mean Bolton anterior ratio between normal group and class-I malocclusion group (p = 0.343). Significant differences were observed between Class-II malocclusion and normal group (p=0.001), and also between Class-III malocclusion and normal group (p = 0.001). Individuals with Angle Class lll and Class ll malocclusions showed significantly greater prevalence of tooth size discrepancy than Class l malocclusion and corresponding normal group. Conclusion: The great diversity and ethnic mix of Bangladeshi population should alert our orthodontist to use Bolton analysis as an important diagnostic tool and become aware of the moderate variations that may be present and treated. It may somehow guide planning of this type of study in future. DOI: http://dx.doi.org/10.3329/bjodfo.v1i2.15982 Ban J Orthod & Dentofac Orthop, April 2011; Vol-1, No.2, 1-4

Comparison of Maxillary Central Inclination, Crown Angulation and Tooth Size Variation in Aesthetic and Non-aesthetic Smiles, A Cross Sectional Study

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Tarulatha Revanappa Shyagali ◽  
Rachita Singh ◽  
Anil Tiwari ◽  
Abhishek Gupta
Keyword(s):  
Size Variation ◽  
Cross Sectional Study ◽  
Tooth Size ◽  
Central Incisor ◽  
Cross Sectional ◽  
Maxillary Central Incisor ◽  
Normal Occlusion ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
The Aesthetic

Background: An attractive smile is often attributed to incisor alignment and proclined or retroclined incisors could contribute to a less aesthetic smile. Objectives: This study was aimed to evaluate the maxillary central incisor crown inclination, crown angulation and tooth size variation in aesthetic and unattractive smiles. Methods: This study was conducted among 100 females (equally divided into aesthetic and unaesthetic smile groups), aged between15 - 25 years, with Angle’s Class I normal occlusion and balanced profiles. Variations in maxillary central incisor crown inclination and angulation were measured on lateral cephalograms, photographs and the study models of the subjects. Variations in tooth morphology were also evaluated by measuring crown height and width in both groups. Mann-Whitney U test was performed to evaluate the difference between the aesthetic and unaesthetic smiles. P < 0.05 was considered as significant. Results: This study showed that incisor angulation was significantly higher in the unaesthetic group compared to the aesthetic group (P < 0.001). However, there was no statistically significant difference for the incisor inclination relative to the Palatal Plane between the aesthetic and unaesthetic smile groups (P = 0.086). In addition, there were significant differences between the aesthetic and the non-aesthetic groups regarding the central incisor height (P < 0.05). Conclusions: The findings of this study indicate that the possible variations in aesthetics are related to the ethnic elements that are associated with differences in crown angulations, as well as tooth size.

scholarly journals A Cross-Sectional Study on the Preference of Root Canal Sealers Among Pediatric Dentists For Obturating Permanent Teeth

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 226-232
Author(s):  
Lakshmi Lakshmanan ◽  
Subramanian EMG ◽  
Ganesh Jeevanandan ◽  
Mebin George Mathew
Keyword(s):  
Zinc Oxide ◽  
Calcium Hydroxide ◽  
Root Canal ◽  
Cross Sectional Study ◽  
Permanent Teeth ◽  
Cross Sectional ◽  
Zinc Oxide Eugenol ◽  
Significant Difference ◽  
Pediatric Dentists ◽  
Root Canal Sealers

Utilisation of root canal sealers to perform obturation procedures is an endorsed method in endodontics and has an indispensable role in the success of treatment. The objective of this study was to explore the pediatric dentists’ preference for root canal sealers for obturating permanent teeth. 360 permanent teeth with gutta-percha obturation done by pediatric dentists were analyzed for the study. The variety of root canal sealers that are utilised for obturating the permanent teeth by pediatric dentists were assessed. The data were obtained from a patient management software. Chi-square test was performed. Out of the 360 permanent teeth, 186 teeth were obturated using resin-based sealers, 101 teeth using zinc oxide eugenol-based sealers and 73 teeth were obturated using calcium hydroxide-based sealers, with statistically significant difference between the three materials (P<0.05). Based on the findings of the present study, resin sealers followed by zinc oxide eugenol sealers and calcium hydroxide sealers were more preferred by pediatric dentists for root canal therapy in permanent teeth. 

scholarly journals Genetic polymorphisms of the CYP1A1, GSTM1, and GSTT1 enzymes and their influence on cardiovascular risk and lipid profile in people who live near a natural gas plant

2017 ◽  
Vol 68 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Daria Pašalić ◽  
Natalija Marinković
Keyword(s):  
Cardiovascular Risk ◽  
Natural Gas ◽  
Lipid Profile ◽  
Genetic Polymorphisms ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Framingham Risk ◽  
Genotype Frequencies ◽  
Significant Difference

Abstract The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Fasting serum concentrations of biochemical parameters were determined with standard methods. Genetic polymorphisms of CYP 1A1 rs4646903, rs1048943, rs4986883, and rs1799814 were genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFPL), while GSTM1 and GSTT1 deletions were detected with multiplex PCR. Cardiovascular risk was assessed with Framingham risk score, and the subjects divided in two groups: >10% risk and ≤10% risk. The two groups did not differ in the genotype frequencies. MANCOVA analysis, which included lipid parameters, glucose, and BMI with sex, age, hypertension and smoking status as covariates, showed a significant difference between the GSTT1*0 and GSTT1*1 allele carriers (p=0.001). UNIANCOVA with same covariates showed that total cholesterol and triglyceride levels were significantly higher in GSTT1*1 allele carriers than in GSTT1*0 carriers (p<0.001 and p=0.006, respectively). Our findings suggest that CYP1A1, GSTM1, and GSTT1 polymorphisms are not associated with the higher risk of CAD, but that GSTT1 affects lipid profile.

scholarly journals Timings of Permanent Tooth Emergence in Children of Rural Vanuatu, Melanesia

2021 ◽  
Vol 21 (8) ◽  
pp. 510-518
Author(s):  
Elizabeth Webb ◽  
Lisa Woods ◽  
Carol Stewart ◽  
Peggy Fairbairn Dunlop ◽  
Jenny Tangis ◽  
...  
Keyword(s):  
Oral Health ◽  
Cross Sectional Study ◽  
Permanent Tooth ◽  
Permanent Teeth ◽  
Cross Sectional ◽  
Oral Health Education ◽  
Permanent Molars ◽  
Tooth Emergence ◽  
First Permanent Molars ◽  
Logistic Modelling

Introduction Global patterning and timing of permanent tooth emergence is influenced by ethnicity, with no known timings reported for ethnic Melanesian children living in the tropical archipelago of Vanuatu. Aim To determine timings of permanent tooth emergence and sequencing for children who reside in rural Vanuatu. Methods Children aged 4-17 years (n=1026), part of a larger oral health cross-sectional study, were examined recording all permanent teeth present, across four spatially separated islands. Binary logistic modelling established children’s median age of emergence of each permanent tooth for each study area. Results The median emergence of first permanent molars for girls is 4.9-years and 5.3 -years for boys. In all locations, children had all permanent teeth emerge by age 11 years (excluding 3rd molars). Clinically important differences exist for permanent tooth emergence by study area. Discussion Permanent teeth emerge earlier for Ni-Vanuatu children compared to both Melanesian children of Papua New Guinea as well as other ethnicities across Oceanic countries. These results can be used as a set standard for Vanuatu. Early tooth emergence suggests oral health education programmes should target pregnant women with clinical preventive strategies commencing for their children before 5-years of age.

scholarly journals Knowledge of tooth avulsion first aid management among parents residing in UAE

2020 ◽  
Vol 19 ◽  
pp. e206950
Author(s):  
Afraa Hussain ◽  
Raghad Hashim ◽  
Aisha Khamees
Keyword(s):  
First Aid ◽  
Cross Sectional Study ◽  
Permanent Tooth ◽  
Permanent Teeth ◽  
Previous Knowledge ◽  
Sectional Study ◽  
Demographic Information ◽  
Cross Sectional ◽  
Tooth Avulsion ◽  
And Storage

Aim: This study aimed to evaluate the knowledge of parents visiting a specialized dental center in Ajman on permanent tooth avulsion and the required first aid procedure to achieve better prognoses. Methods: A cross-sectional study was conducted in Ajman Emirate, UAE. Three hundred eighty-eight parents from three nationalities (Emirati, Egyptian and Indian) residing in UAE answered a constructed questionnaire that included demographic information related to the participants and questions related to permanent tooth avulsion and the required first steps for its management. Results: Study findings reflect deficiencies in the following areas. Of the 388 parents, (236, 60.8%) had poor knowledge about permanent tooth avulsion. Parents who had previous knowledge obtained information from unsupported sources, such as friends (145, 37.4%). Out of 388 parents, (324, and 83.5%) would not replant the tooth. Finally, the majority of the participants did not know the proper media to store the avulsed permanent tooth with one-third of parents choosing cotton or water (142, 36.6%). Conclusion: This study showed a lack of knowledge regarding permanent tooth avulsion among parents from the major nationalities residing in UAE. However, the respondents represent major differences regarding related to knowledge, replant, and storage of avulsed permanent teeth.

scholarly journals Interproximal contact areas of primary molars based on OXIS classification – a two centre cross sectional study

2021 ◽  
Vol 5 ◽  
pp. 285
Author(s):  
Tarun Walia ◽  
M Kirthiga ◽  
Carel Brigi ◽  
M S Muthu ◽  
Ruba Odeh ◽  
...  
Keyword(s):  
Research Question ◽  
Cross Sectional Study ◽  
Permanent Teeth ◽  
Primary Molars ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Contact Areas ◽  
Significant Difference ◽  
Chi Square Test

Background: Contact areas in primary teeth are known to be broader, flatter and situated farther gingivally than permanent teeth. The purpose of this study was to assess the prevalence of OXIS contact areas between primary molars using die models of children from two different ethnic populations. The research question of the present study is “What is the prevalence OXIS contact areas of primary molars in the populations studied?”. Methods: A cross-sectional study was planned in a representative sample of 200 caries-free contact areas among children aged 3-6 years in two centers, Ajman and Puducherry. Data collection was performed from sectional or full-arch die stone models. The contacts were assessed according to OXIS classification by a single calibrated examiner at Center 2. Prevalence was expressed as numbers and percentages. The Chi-square test was applied to determine the association of OXIS contacts across genders and arches. Results: The prevalence of O, X, I, and S contacts were 19%, 22.5%, 53%, and 5.5% in Center 1 and 6%, 1.5%, 75.5%, and 17% in Center 2, respectively. Significant results (p=0.005) were obtained in Center 1 when inter-arch comparison was performed and between the centers with respect to type of contact. No significant difference was obtained with respect to gender and OXIS contact areas. Conclusions: The present study confirmed OXIS contacts in both the centers. The ‘O’ and ‘X’ types of contacts were observed more in Center 1, whereas ‘I’ and ‘S’ contacts were observed more in Center 2.

scholarly journals OXIS contact areas of primary molars – a two center cross-sectional study

2020 ◽  
Vol 5 ◽  
pp. 285
Author(s):  
Tarun Walia ◽  
M Kirthiga ◽  
Carel Brigi ◽  
M S Muthu ◽  
Ruba Odeh ◽  
...  
Keyword(s):  
Research Question ◽  
Cross Sectional Study ◽  
Permanent Teeth ◽  
Primary Molars ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Contact Areas ◽  
Significant Difference ◽  
Chi Square Test

Background: Contact areas in primary teeth are known to be broader, flatter and situated farther gingivally than permanent teeth. The purpose of this study was to assess the prevalence of OXIS contact areas between primary molars using die models of children from two different ethnic populations. The research question of the present study is “What is the prevalence OXIS contact areas of primary molars in the populations studied?”. Methods: A cross-sectional study was planned in a representative sample of 200 caries-free contact areas among children aged 3-6 years in two centers, Ajman and Puducherry. Data collection was performed from sectional or full-arch die stone models. The contacts were assessed according to OXIS classification by a single calibrated examiner at Center 2. Prevalence was expressed as numbers and percentages. The Chi-square test was applied to determine the association of OXIS contacts across genders and arches. Results: The prevalence of O, X, I, and S contacts were 19%, 22.5%, 53%, and 5.5% in Center 1 and 6%, 1.5%, 75.5%, and 17% in Center 2, respectively. Significant results (p=0.005) were obtained in Center 1 when inter-arch comparison was performed and between the centers with respect to type of contact. No significant difference was obtained with respect to gender and OXIS contact areas. Conclusions: The present study confirmed OXIS contacts in both the centers. The ‘O’ and ‘X’ types of contacts were observed more in Center 1, whereas ‘I’ and ‘S’ contacts were observed more in Center 2.

scholarly journals Evaluation of the Effect of Removable Maxillary Expanders on Facial Vertical Dimension

2021 ◽  
Vol 13 (2) ◽  
pp. 42-46
Author(s):  
Sepideh Soheilifar ◽  
Yousef AhmadPour ◽  
Sanaz Soheilifar ◽  
Ashkan Neshati ◽  
Pouria Teymouri
Keyword(s):  
Transverse Dimension ◽  
Cross Sectional Study ◽  
T Test ◽  
Vertical Dimension ◽  
Cross Sectional ◽  
Palatal Expansion ◽  
Mandibular Plane ◽  
Significant Difference ◽  
The Face ◽  
School Of Dentistry

Background: Palatal expansion is one of the most common types of orthodontic treatment, which is administered employing different appliances, and is used for the correction of posterior cross bite. This treatment can elevate the palatal cusp on the maxillary first molar, lead to the rotation of mandible, and increase the height of the lower third of the face. In some cases, the use of bite plane is suggested to avoid vertical dimension changes of the face. This study aimed to assess the effect of removable maxillary expanders on facial vertical dimensions. Methods: In this cross-sectional study, 68 patients referring to Hamedan School of Dentistry and being treated using removable maxillary expander with or without bite plane were examined. Pretreatment and post treatment cephalograms of the patients were analyzed by Dolphin Imaging Software 11.9 version, and the results from 5 cephalometric variables, namely the mandibular plane related to SN line, the angle of mandibular plane related to FH, Y axis, the maxillary plane angulation, as well as the lower facial height were calculated. Patient’s transverse dimension was measured by a caliper on the dental casts along the mesiobuccal cusp of maxillary first molars. Paired t test and independent t-test were adopted for carrying out data analysis. Results: There was no significant difference between the two groups in terms of age and sex at the beginning of treatment. However, maxillary plane angulation and Y axis changed significantly in group with bite plane. (P=0.034, P=0.007). The changes were less than 1.5 degrees. No significant difference was observed between the groups with or without bite plane regarding the changes of cephalometric variables during the treatment. The transverse dimension of the arch was increased significantly in both groups. The changes were similar in two groups. Conclusions: According to the results from this study, the presence of bite plane had no advantage over its absence. However, it seemed necessary to design a randomized clinical trial in this regard.

Sign in / Sign up

Export Citation Format

Share Document