Functional Analysis of Distraction Arthroplasty in the Treatment of Ankle Osteoarthritis

Category: Ankle Arthritis Introduction/Purpose: Ankle joint distraction arthroplasty (AJDA) is an alternative surgical procedure for the management of moderate to severe ankle osteoarthritis. However, the benefit of this procedure and failure relative factors are still in debate. The purpose of current study was to evaluate the functional outcomes of AJDA in treatment of moderate to severe ankle OA; and to evaluate the relative factors correlated with treatment failure. Methods: Forty-six van Dijk stage II and III ankle osteoarthritis patients were included. Fifteen males and 31 females with a mean age of 54.8 (range, 42-71) years were followed with a mean of 42.8 (range, 24-68) months. The Ankle Osteoarthritis Scale (AOS) and American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot score were used for functional outcomes evaluation. The talar tilt (TT) angle and ankle joint space distance (AJSD) were evaluated. The risk ratio (RR) was calculated for each potential failure relative factor. Results: The AOS and AOFAS scores were significantly improved at the last followup time (P＜0.01). The AJSD was improved in 61% of patients, and with a significant improvement compared with the preoperative conditions (P＜0.01). The TT angle and range of motion reached no significant difference. The failure rate was 21.7%. Patients with large TT (>=5°) angle (RR=3.81, 95%CI: 1.28-11.33, P=0.02) and obesity (RR=3.58, 95%CI: 1.30-9.89, P=0.01) were found have positive correlation with failure. No correlation was found between failure and gender, or overweight, or side, or age, or type and stage of OA, or pin infection. Conclusion: Current study confirmed the early functional outcomes of ankle distraction arthroplasty. However, this procedure still has a relatively high failure rate, especially for those obesity patients and the patients with large TT angles.

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Effect of Microfracture on Functional Outcomes and Subchondral Sclerosis Following Distraction Arthroplasty of the Ankle Joint

Foot & Ankle International ◽

10.1177/1071100720917144 ◽

2020 ◽

Vol 41 (6) ◽

pp. 631-638

Author(s):

Arianna L. Gianakos ◽

R. Sterling Haring ◽

Yoshiharu Shimozono ◽

Austin Fragomen ◽

John G. Kennedy

Keyword(s):

Ankle Joint ◽

Demographic Data ◽

Joint Space ◽

Ankle Arthrodesis ◽

Activity Levels ◽

Level Of Evidence ◽

Distraction Arthroplasty ◽

Concentrated Bone Marrow ◽

Post Traumatic ◽

End Stage

Background: Treatment for post-traumatic osteoarthritis (PTOA) of the ankle remains challenging. Distraction arthroplasty (DA) is an alternative for patients who are averse to or poor candidates for arthrodesis or joint replacement. The purpose of this study was to examine the role of microfracture (MFX) and concentrated bone marrow aspirate (CBMA) on the outcome of patients undergoing DA for end-stage PTOA of the ankle joint. Methods: Ninety-five patients who underwent DA for the treatment of end stage PTOA from 2009 to 2014 were selected from the hospital ankle registry. Demographic data, functional activity levels, complications, and radiographs taken at 6, 12, 24, and 36 months postoperatively were reviewed. Foot and Ankle Outcome Scores (FAOS) were obtained at the same time intervals. A total of 78 patients were included in this study. Interventions were divided into 4 groups for comparison: DA+MFX (n = 8), DA+MFX+CBMA (n = 35), DA+CBMA (n = 22), and DA alone (n = 13). Results: Patients undergoing DA+MFX or DA+MFX+CBMA had significantly worse motion ( P = .003) when compared with DA alone. Patients undergoing MFX had significantly reduced postoperative joint space and a greater length of time to return to activity when compared to subgroups not using MFX ( P = .01). The use of MFX was associated with significantly lower FAOS scores. Conclusion: The current study showed no benefit from MFX when combined with DA in the treatment of PTOA. CBMA may have helped mitigate the adverse effect of MFX but conferred no benefit when used with DA alone. DA remains a useful alternative to ankle arthrodesis and arthroplasty in patients with PTOA. However, MFX and biologic augmentation using CBMA appeared to have no additional benefit. Level of Evidence: Level III, comparative study.

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Effectiveness of distal tibial osteotomy with distraction arthroplasty in varus ankle osteoarthritis

10.21203/rs.2.17170/v2 ◽

2019 ◽

Author(s):

Koji Nozaka ◽

Naohisa Miyakoshi ◽

Takeshi Kashiwagura ◽

Yuji Kasukawa ◽

Hidetomo Saito ◽

...

Keyword(s):

Ankle Joint ◽

External Fixator ◽

Weight Bearing ◽

Tibial Osteotomy ◽

Ankle Arthritis ◽

Ankle Osteoarthritis ◽

Distraction Arthroplasty ◽

Circular External Fixator ◽

Joint Distraction ◽

Tibiotalar Arthrodesis

Abstract Background: Advanced to end-stage ankle osteoarthritis in highly active older individuals has traditionally been treated using tibiotalar arthrodesis. With tibiotalar arthrodesis, high levels of pain-free function are possible; however, there is a loss of ankle joint movement and a risk of future arthrosis in the adjacent joints. Distraction arthroplasty is a simple method that allows joint cartilage repair; however, the results are currently mixed, with some reports showing improved pain scores and others showing no improvement. Distal tibial osteotomy (DTO) without fibular osteotomy, a type of joint preservation surgery, has garnered attention in recent years. However, to our knowledge, there are no reports on DTO with joint distraction using a circular external fixator. Therefore, the purpose of this study was to examine the effect of DTO with joint distraction using a circular external fixator on ankle osteoarthritis. Methods: A total of 21 patients with medial ankle arthritis were examined. Arthroscopic synovectomy and a microfracture procedure were performed. Subsequently, angled osteotomy and correction of the distal tibia were performed. After ankle conditions improved, stabilization of the ankle joint was performed. An external fixator was used in all patients. In addition, joint distraction of about 5.8 mm was performed. All patients were allowed full weight-bearing walking immediately after surgery. Results: The anteroposterior mortise angle during weight-bearing, lateral mortise angle during weight-bearing, and talar tilt angle and anterior translation of the talus on ankle stress radiography significantly improved (P < 0.05). In addition, signal changes on magnetic resonance imaging improved in all patients. Visual analogue scale and American Orthopedic Foot & Ankle Society scores also improved significantly (P < 0.05). No severe complications were observed. Conclusion: DTO with joint distraction may be useful for older patients with a high physical activity level as a joint-preserving surgery for medial ankle osteoarthritis. Level of evidence: Level IV, retrospective case series Key words : distal tibial osteotomy, medial ankle arthritis, joint distraction, circular external fixator

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Effectiveness of distal tibial osteotomy with distraction arthroplasty in varus ankle osteoarthritis

10.21203/rs.2.17170/v3 ◽

2020 ◽

Author(s):

Koji Nozaka ◽

Naohisa Miyakoshi ◽

Takeshi Kashiwagura ◽

Yuji Kasukawa ◽

Hidetomo Saito ◽

...

Keyword(s):

Ankle Joint ◽

External Fixator ◽

Weight Bearing ◽

Tibial Osteotomy ◽

Ankle Arthritis ◽

Ankle Osteoarthritis ◽

Distraction Arthroplasty ◽

Circular External Fixator ◽

Joint Distraction ◽

Tibiotalar Arthrodesis

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Mobile- vs. Fixed-Bearing Total Ankle Prostheses

Foot & Ankle Orthopaedics ◽

10.1177/2473011417s000108 ◽

2017 ◽

Vol 2 (3) ◽

pp. 2473011417S0001 ◽

Cited By ~ 1

Author(s):

Alexej Barg ◽

Phinit Phisitkul ◽

Charles Saltzman

Keyword(s):

Failure Rate ◽

Fixed Effects ◽

Meta Analysis ◽

Mobile Bearing ◽

Fixed Bearing ◽

Ankle Osteoarthritis ◽

Total Exposure ◽

Ankle Replacement ◽

Number Of Patients ◽

Significant Difference

Category: Ankle, Ankle Arthritis Introduction/Purpose: Total ankle replacement (TAR) is a well-accepted treatment option in patients with end-stage ankle osteoarthritis. In general, TAR designs can be classified based on their number of components: 2-components (fixed-bearing) vs. 3- components (mobile-bearing). In the U.S. the STAR prosthesis is the only one mobile-bearing TAR with FDA approval. It remains unclear whether 3-component TAR designs have superior clinical outcomes including prosthesis survivorship. Therefore we performed a systematic review and meta-analysis of the available TAR designs to determine prosthesis survivorship and whether there is a statistically significant difference between mobile- and fixed-bearing TAR designs. Methods: We reviewed literature using common data bases. All searches were unlimited. For the search we used the subject heading terms: “ankle”, “replacement”, “arthroplasty”, and “prosthesis”. For meta-analysis a checklist was used as described by Meta-analysis Of Observational Studies in Epidemiology (MOOSE) Group. The quality of included studies was assessed using Coleman’s Methodology Score. The following parameters were reviewed: type of study, inventor bias, number of patients/ankles, mean age with range, gender, etiology of underlying ankle osteoarthritis, average and maximum follow-up, number of TAR failures, and total exposure time. For each study, failure rate was estimated as the number of failures/total exposure years. N-year (here, 5 or 10 years) failure rate was calculated as 1-exp(-N*failure rate). The pooled estimate of failure rate was a weighted average across studies using the inverse variance weighting method. The test for heterogeneity was not significant so fixed effects models were used. Results: In total, 32 studies with 3968 ankles were included into the analysis. Nine studies included 844 fixed-bearing TARs and 23 studies included 3124 mobile-bearing TARs. Patient characteristics were comparable in both study groups. For fixed-bearing TAR, the 5-year and 10-year failure rate was 0.077 and 0.149 with an average annual failure rate of 0.016 (95%CI 0.008-0.025). For mobile-bearing TAR, the 5-year and 10-year failure rate was 0.074 and 0.142with an annual failure rate of 0.015 (95%CI 0.011- 0.020). Two studies with fixed-bearing TAR and six studies with mobile-bearing TAR had inventor bias. The average annual failure rate was comparable in both groups (P = 0.88), with and without inventor bias, 0.013 vs. 0.018 (P = 0.87). Conclusion: We have shown that TAR has an overall failure rate of 0.149 and 0.142 at 10 years in patients with fixed-bearing and mobile-bearing TAR design, respectively. No superiority of one implant design over another can be supported by the available data.

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Minimum Distraction Gap: How Much Ankle Joint Space Is Enough in Ankle Distraction Arthroplasty?

HSS Journal ® ◽

10.1007/s11420-013-9359-3 ◽

2013 ◽

Vol 10 (1) ◽

pp. 6-12 ◽

Cited By ~ 12

Author(s):

Austin T. Fragomen ◽

Thomas H. McCoy ◽

Kathleen N. Meyers ◽

S. Robert Rozbruch

Keyword(s):

Ankle Joint ◽

Joint Space ◽

Distraction Arthroplasty

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Effectiveness of distal tibial osteotomy with distraction arthroplasty in varus ankle osteoarthritis

10.21203/rs.2.17170/v1 ◽

2019 ◽

Author(s):

Koji Nozaka ◽

Naohisa Miyakoshi ◽

Takeshi Kashiwagura ◽

Yuji Kasukawa ◽

Hidetomo Saito ◽

...

Keyword(s):

Ankle Joint ◽

External Fixator ◽

Weight Bearing ◽

Activity Level ◽

Tibial Osteotomy ◽

Ankle Osteoarthritis ◽

Distraction Arthroplasty ◽

Circular External Fixator ◽

Joint Distraction ◽

Tibiotalar Arthrodesis

Abstract Background Advanced to end-stage ankle osteoarthritis in highly active older individuals has traditionally been treated using tibiotalar arthrodesis. Tibiotalar arthrodesis is possible to have high levels of pain-free function, however there is loss of ankle joint movement and a risk of arthrosis of adjacent joints in the future. Distraction arthroplasty is a simple method with a possibility of the joint cartilage repair but current results are mixed with reports of patients with better pain scores and some without any improvement. Distal tibial osteotomy (DTO) without fibular osteotomy, a type of joint preservation surgery, has garnered attention in recent years, However, as far as we know, there are no reports on DTO with joint distraction using a circular external fixator. The purpose of this study was to examine the effect of DTO with joint distraction using a circular external fixator on ankle osteoarthritis.Materials and Methods A total of 21 patients with medial ankle arthritis were examined. Arthroscopic synovectomy and a microfracture procedure were performed. Then angled osteotomy and correction of the distal tibia were performed. After ankle conditions improved, the stabilization of the ankle joint was performed. An external fixator was used in all patients. In addition, joint distraction of about 5.8 mm was performed. All patients were allowed full weight-bearing walking immediately after surgery.Results Antero-posterior mortise angle during weight-bearing, lateral mortise angle during weight-bearing, and talar tilt angle and anterior translation of the talus in ankle stress radiography significantly improved (P < 0.05). In addition, signal changes in magnetic resonance imaging (MRI) improved in all patients. Visual Analogue Scale (VAS ) and The American Orthopaedic Foot & Ankle Society (AOFAS) scores also improved significantly (P < 0.05). No severe complications were observed.Conclusion DTO with joint distraction may be useful for older patients with a high physical activity level as joint preserving surgery for medial ankle osteoarthritis.

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Ankle Distraction Arthroplasty combined with PRP injection for Post-traumatic Ankle Arthritis

Foot & Ankle Orthopaedics ◽

10.1177/2473011419s00384 ◽

2019 ◽

Vol 4 (4) ◽

pp. 2473011419S0038

Author(s):

Zhongmin Shi ◽

Wenqi Gu

Keyword(s):

Ankle Joint ◽

Plantar Flexion ◽

Functional Limitation ◽

Ankle Arthrodesis ◽

Ankle Arthritis ◽

Distraction Arthroplasty ◽

Post Traumatic ◽

Pin Tract Infection ◽

American Orthopaedic ◽

Dorsal Extension

Category: Ankle Arthritis Introduction/Purpose: To summarize and evaluate the surgical technique and clinical outcome of ankle distraction arthroplasty with PRP injection for post-traumatic ankle arthritis. Methods: Totally 21 patients of post-traumatic ankle arthritis were treated at the department of orthopaedic surgery, Shanghai Sixth People’s Hospital. They were 13 males and 8 females with an average age of 32.5±6.2 years. The average course of disease were 14.0±2.8 months. After the failure of conservative management for at least 6 months, ankle distraction arthroplasty with PRP injection was performed in all patients. American Orthopaedic Foot & Ankle Society (AOFAS) ankle and hindfoot score system and Visual Analogue Scale (VAS) system were used to evaluate the final overall outcome. The range of motion (ROM) of ankle joint and complications were also recorded. Results: Pin tract infection was occurred in two patients, who were cured by alcohol care. 18 patients were followed for an average 36 months. The post-operative AOFAS ankle and hindfoot score was improved from 46.2±7.7 to 79.2±11.6 (t=-14.58, P ＜0.05), while the VAS score was decreased from 6.6±1.1 to 1.8±2.0 (t=16.424, P＜0.0001). The dorsal extension of ankle joint was increased from 1.3±9.3° to 8.1±5.5° (t=-4.675, P＜0.0001) and the plantar flexion was improved from 14.4±6.8° to 26.9±7.3°(t=-7.919, P＜0.05). The radiograph manifested the progressive course of ankle arthritis in four patients, two of which were cured by a salvage ankle arthrodesis by consequence of a failure of conservative treatment for persistent pain and functional limitation. Conclusion: The ankle distraction arthroplasty is an effective ankle preserving surgery, which could relieve symptoms, improve functions and delay the course of post-traumatic ankle arthritis

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Microfracture of subchondral bone leads to persistent subchondral sclerosis and poorer functional outcomes following distraction arthroplasty of the ankle joint while biologic augment may improve recovery times

Foot & Ankle Orthopaedics ◽

10.1177/2473011418s00056 ◽

2018 ◽

Vol 3 (3) ◽

pp. 2473011418S0005 ◽

Cited By ~ 2

Author(s):

Arianna Gianakos ◽

John Kennedy

Keyword(s):

Subchondral Bone ◽

Functional Outcomes ◽

Demographic Data ◽

Treatment Strategies ◽

Joint Space ◽

Additional Treatment ◽

Biologic Agent ◽

Distraction Arthroplasty ◽

Return To Activity

Category: Ankle Arthritis Introduction/Purpose: Treatment of ankle osteoarthritis (OA) continues to remain a challenge. Previous reports have demonstrated the short-term benefits of using joint distraction for the treatment of ankle (OA), however, its efficacy in long term clinical outcomes and its role in preserving the joint space remains controversial. The purpose of this study is to establish whether microfracture or biologics improve the outcomes of ankle distraction. Methods: Records of patients that underwent an ankle distraction procedure between January 2009-December 2013 were retrospectively reviewed. Four groups were identified: Group 1: distraction with no additional treatment, Group 2: distraction with microfracture, Group 3: distraction with microfracture and BMAC/PRP, Group 4: distraction with BMAC/PRP. Demographic data was recorded. Pre-and-postoperative range of motion, Foot and Ankle Outcome Scores (FAOS), complication rate, and return to activity were evaluated. Radiographic images were used to assess the joint space changes pre-operatively and post-operatively. Global comparisons were performed using chi square testing, while individual between-group comparisons were made using robust, resistant regression and Wald tests. Results: Eighty-one patients with a mean age of 47 (range, 37-69) underwent ankle distraction with a mean follow up of 5 years (range, 3-6). All treatment strategies resulted in statistically significant improvements in FAOS (<0.001). Groups that underwent microfracture had a statistically significant decrease in post-operative plantarflexion, dorsiflexion, subtalar inversion and subtalar eversion (p=0.003) as well as an overall decrease in joint space (0.002) with persistence of subchondral bone sclerosis. Patients who underwent distraction with no microfracture treatment resulted in a significant increase in post-operative joint space (p=0.001) and decreased sclerosis in the subchondral bone. Average return to activity was 6 months in patients who received BMAC/PRP with ankle distraction compared to 12 months in patients who were treated with ankle distraction and microfracture (p<0.01). Conclusion: Distraction arthroplasty results in good functional outcomes at medium term follow up. The addition of microfracture seems to create functional outcome deterioration, whereas the addition of a biologic agent either BMAC or PRP appears to benefit earlier return to function. Longer-term studies will be required to see if these effects are sustained.

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Detection of Circulating Tissue Factor and Factor VII in a Normal Population

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650365 ◽

1996 ◽

Vol 75 (05) ◽

pp. 772-777 ◽

Cited By ~ 30

Author(s):

Sybille Albrecht ◽

Matthias Kotzsch ◽

Gabriele Siegert ◽

Thomas Luther ◽

Heinz Großmann ◽

...

Keyword(s):

Tissue Factor ◽

Normal Population ◽

Mean Value ◽

Factor Vii ◽

Significant Difference ◽

Age Dependent ◽

The Mean ◽

Highly Correlated ◽

And Gender

SummaryThe plasma tissue factor (TF) concentration was correlated to factor VII concentration (FVIIag) and factor VII activity (FVIIc) in 498 healthy volunteers ranging in age from 17 to 64 years. Immunoassays using monoclonal antibodies (mAbs) were developed for the determination of TF and FVIIag in plasma. The mAbs and the test systems were characterized. The mean value of the TF concentration was 172 ± 135 pg/ml. TF showed no age- and gender-related differences. For the total population, FVIIc, determined by a clotting test, was 110 ± 15% and the factor VIlag was 0.77 ± 0.19 μg/ml. FVII activity was significantly increased with age, whereas the concentration demonstrated no correlation to age in this population. FVII concentration is highly correlated with the activity as measured by clotting assay using rabbit thromboplastin. The ratio between FVIIc and FVIIag was not age-dependent, but demonstrated a significant difference between men and women. Between TF and FVII we could not detect a correlation.

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The Influence of Age and Gender on Mandibular Indices among the Libyan Population

Journal of Oral & Dental Health ◽

10.33140/jodh.03.02.2 ◽

2019 ◽

Vol 3 (2) ◽

Keyword(s):

Negative Correlation ◽

Bone Mineralization ◽

Age Groups ◽

T Test ◽

Chi Square ◽

Age And Gender ◽

Significant Difference ◽

Chi Square Test ◽

And Gender ◽

Libyan Population

Radiographic Mandibular Indices serve as easy and relatively cheap tools for evaluating bone mineralization. Objectives: To examine the effect of age and gender on three mandibular indices: the panoramic mandibular index (PMI), the mandibular ratio (MR) and the mandibular cortical index (MCI), among Libyan population. Methods: The three indices were measured on 317 digital (OPGs) of adult humans (155 males, 162 females). The sample was divided into six age groups (from 18-25 years through 56-65 years). The measurements were analyzed for interactions with age and sex, using SPSS (Statistical Package for Social Studies) software version no. 22. The tests employed were two way ANOVA, the unpaired T-test and chi-square test. Results: The mean PMI fluctuated between 0.37 s.d. 0.012 and 0.38 s.d. 0.012. among the sixth age groups. One-way ANOVA statistical test revealed no significant of age on PMI. On the other hand gender variation has effect on PMI, since independent sample t-test disclosed that the difference between the male and female PMI means statistically significant. ANOVA test showed that the means of MR among age groups showed a negative correlation i.e. MR mean declined from 3.01 in 18-25 age groups to 2.7 in 55-65 age groups. In contrary, the gender showed no effect on MR according two sample t-test at p> 0.05. In regards with MCI, statistical analysis showed that it affected by age that is C1 was decreasing by age while C2 and C3 were increased by age. Using chi square test the result indicated that there is a significant difference among the different age group and the two genders in MCI readings. Conclusion: PMI was influenced significantly by age but minimally by the gender. MR is not affected by gender but has a negative correlation with age. MCI is affected by both age and gender

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