scholarly journals Chinese Herbal Medicine Versus Other Interventions in the Treatment of Type 2 Diabetes

2018 ◽  
Vol 23 ◽  
pp. 2515690X1878151 ◽  
Author(s):  
Ao Yu ◽  
David Adelson ◽  
David Mills
Keyword(s):  
Type 2 Diabetes ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Clinical Symptoms ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
The World

Diabetes affects 422 million people and directly caused 4.9 million deaths according to the global report on diabetes in 2014. Type 2 diabetes accounts for 90% of people with diabetes around the world. Chinese herbal medicine treatment for diabetes has more than 2000-year history in China. An increasing number of people around the world are trying to manage type 2 diabetes with Chinese herbal medicine. However, there is a lack of evidence to decide if Chinese herbal medicine is effective and safe when compared with other interventions for the treatment of type 2 diabetes We identified 58 randomized controlled trials involving 6637 participants with type 2 diabetes with trial periods lasting from 8 weeks to 1 year (average 12 weeks). We extracted data following a predefined hierarchy. A total of 132 different Chinese herbal medicines were examined. We included studies comparing Chinese herbal medicine with other interventions and excluded trials that did not satisfy the inclusion criteria. We evaluated primary outcomes of trials in accordance with the Cochrane Handbook for Systematic Reviews of Intervention. Fifty-six out of 58 studies reported evidence that Chinese herbal medicines were effective at controlling blood sugar, insulin resistance, and traditional Chinese medicine clinical symptoms for patients with type 2 diabetes. And outcome variables are summarized. However, the evidence is limited because of the quality of the studies. Well-designed long-term studies with large samples and multiple centers as well as standardization and quality control will be required to determine if Chinese herbal medicine treatment is effective and safe for type 2 diabetes.

scholarly journals A proposed protocol based on integrative metabonomics analysis for the rapid detection and mechanistic understanding of sulfur fumigation of Chinese herbal medicines

RSC Advances ◽  
2019 ◽  
Vol 9 (53) ◽  
pp. 31150-31161 ◽  
Author(s):  
Dai Shengyun ◽  
Wang Yuqi ◽  
Wang Fei ◽  
Mei Xiaodan ◽  
Zhang Jiayu
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Rapid Detection ◽  
Herbal Medicines ◽  
Lonicera Japonica ◽  
Current Work ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Mechanistic Understanding

In the current work, Lonicera japonica Flos (FLJ) was selected as a model Chinese herbal medicine (CHM) and a protocol was proposed for the rapid detection of sulfur-fumigated (SF) CHMs.

scholarly journals Does Adjuvant Treatment with Chinese Herbal Medicine to Antidiabetic Agents Have Additional Benefits in Patients with Type 2 Diabetes? A System Review and Meta-Analysis of Randomized Controlled Trials

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
De Jin ◽  
Jiaxing Tian ◽  
Qi Bao ◽  
Haiyu Zhang ◽  
Qiyou Ding ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Herbal Medicines ◽  
Controlled Trials ◽  
Antidiabetic Agents ◽  
Chinese Herbal Medicines ◽  
Randomized Controlled ◽  
Chinese Herbal

Introduction. In the present meta-analysis, we aimed to determine the effects of adjuvant treatment with Chinese herbal medicine (CHM) on antidiabetic agents having additional benefits in patients with type 2 diabetes. Methods. Randomized controlled trials were identified by searching the Cochrane Library, PUBMED, EMBASE, MEDLINE, the China National Knowledge Internet, Web of Science, Global Health, International Pharmaceutical Abstracts and the China biology medicine, Wanfang, and VIP databases. The intervention group received CHM as add-on treatment to antidiabetic agents therapy, and the control group received placebos in addition to antidiabetic agents or antidiabetic agents alone. We assessed pooled data, including weighted mean differences and 95% confidence intervals (CIs) using a random-effects model. Results. A total of 125 randomized controlled trials were included. 10 articles were included based on literature screening. All trials contrasted Chinese herbal medicines or Chinese herbal medicines + antidiabetic agents with placebo or antidiabetic agents + placebo and included a total of 2004 individuals with T2DM. All selected trials displayed evidence of high methodological quality and possessed a low risk of bias. Meta-analysis of the trials demonstrated that Chinese herbal medicines resulted in a more favorable blood glucose profile in contrast to placebo (P<0.05). The total efficacy rate differed significantly between the two groups (P<0.001). All ten included studies reported the occurrence of tolerable adverse effects. Conclusions. The results showed that in the intervention group, greater reductions were achieved for glucose control and body weight. The combined use of drugs improves the curative effect and has fewer adverse events and has additional benefits in patients with type 2 diabetes. This trial is registered with PROSPERO (CRD42018093867).

scholarly journals Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity onPseudomonas aeruginosa

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Weihua Chu ◽  
Shuxin Zhou ◽  
Yan Jiang ◽  
Wei Zhu ◽  
Xiyi Zhuang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Cell Communication ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Traditional Chinese Herbal Medicines

Traditional Chinese herbal medicines (TCHMs) were tested for their ability of antiquorum sensing. Water extracts ofRhubarb, Fructus gardeniae, and Andrographis paniculatashow antiquorumsensing activity when usingChromobacterium violaceumCV12472 as reporter; the sub-MIC concentrations of these TCHMs were tested against AHL-dependent phenotypic expressions of PAO1. Results showed significant reduction in pyocyanin pigment, protease, elastase production, and biofilm formation in PAO1 without inhibiting the bacterial growth, revealing that the QSI by the extracts is not related to static or killing effects on the bacteria. The results indicate a potential modulation of bacterial cell-cell communication,P. aeruginosabiofilm, and virulence factors by traditional Chinese herbal medicine. This study introduces not only a new mode of action for traditional Chinese herbal medicines, but also a potential new therapeutic direction for the treatment of bacterial infections, which have QSI activity and might be important in reducing virulence and pathogenicity of pathogenic bacteria.

scholarly journals Prevention of Type 2 Diabetes with the Chinese Herbal Medicine Tianqi Capsule: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 8 (6) ◽  
pp. 1227-1242 ◽  
Author(s):  
Bing Pang ◽  
Ying Zhang ◽  
Jing Liu ◽  
Li-sha He ◽  
Yu-jiao Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
Chinese Herbal

scholarly journals Correction to: Prevention of Type 2 Diabetes with the Chinese Herbal Medicine Tianqi Capsule: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 8 (6) ◽  
pp. 1243-1244 ◽  
Author(s):  
Bing Pang ◽  
Ying Zhang ◽  
Jing Liu ◽  
Li-sha He ◽  
Yu-jiao Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
Chinese Herbal

scholarly journals Prediction Methods of Herbal Compounds in Chinese Medicinal Herbs

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2303 ◽  
Author(s):  
Ke Han ◽  
Lei Zhang ◽  
Miao Wang ◽  
Rui Zhang ◽  
Chunyu Wang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Virtual Screening ◽  
Chinese Herbal Medicine ◽  
Screening Method ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Prediction Methods ◽  
Chinese Herbal Medicines ◽  
Advantages And Disadvantages ◽  
Chinese Herbal

Chinese herbal medicine has recently gained worldwide attention. The curative mechanism of Chinese herbal medicine is compared with that of western medicine at the molecular level. The treatment mechanism of most Chinese herbal medicines is still not clear. How do we integrate Chinese herbal medicine compounds with modern medicine? Chinese herbal medicine drug-like prediction method is particularly important. A growing number of Chinese herbal source compounds are now widely used as drug-like compound candidates. An important way for pharmaceutical companies to develop drugs is to discover potentially active compounds from related herbs in Chinese herbs. The methods for predicting the drug-like properties of Chinese herbal compounds include the virtual screening method, pharmacophore model method and machine learning method. In this paper, we focus on the prediction methods for the medicinal properties of Chinese herbal medicines. We analyze the advantages and disadvantages of the above three methods, and then introduce the specific steps of the virtual screening method. Finally, we present the prospect of the joint application of various methods.

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