scholarly journals Prediction Methods of Herbal Compounds in Chinese Medicinal Herbs

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2303 ◽  
Author(s):  
Ke Han ◽  
Lei Zhang ◽  
Miao Wang ◽  
Rui Zhang ◽  
Chunyu Wang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Virtual Screening ◽  
Chinese Herbal Medicine ◽  
Screening Method ◽  
Herbal Medicines ◽  
Chinese Herbs ◽  
Prediction Methods ◽  
Chinese Herbal Medicines ◽  
Advantages And Disadvantages ◽  
Chinese Herbal

Chinese herbal medicine has recently gained worldwide attention. The curative mechanism of Chinese herbal medicine is compared with that of western medicine at the molecular level. The treatment mechanism of most Chinese herbal medicines is still not clear. How do we integrate Chinese herbal medicine compounds with modern medicine? Chinese herbal medicine drug-like prediction method is particularly important. A growing number of Chinese herbal source compounds are now widely used as drug-like compound candidates. An important way for pharmaceutical companies to develop drugs is to discover potentially active compounds from related herbs in Chinese herbs. The methods for predicting the drug-like properties of Chinese herbal compounds include the virtual screening method, pharmacophore model method and machine learning method. In this paper, we focus on the prediction methods for the medicinal properties of Chinese herbal medicines. We analyze the advantages and disadvantages of the above three methods, and then introduce the specific steps of the virtual screening method. Finally, we present the prospect of the joint application of various methods.

scholarly journals Effect of Active Ingredients of Chinese Herbal Medicine on the Rejuvenation of Healthy Aging: Focus on Stem Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Chen Wang ◽  
Shuang Ling ◽  
Jin-Wen Xu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Herbal Medicines ◽  
Stem Cell Differentiation ◽  
Chinese Herbs ◽  
Active Ingredients ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal

Stem cells (SCs) are special types of cells with the ability of self-renewal and multidirectional differentiation. As the organism ages, the ability to maintain homeostasis and regeneration deteriorates and the number and activity of stem cells decline. Theoretically, the restoration of stem cells might reverse aging. However, due to their own aging, donor-derived immune rejection, and difficulties in stem cell differentiation control, a series of problems need to be solved to realize the potential for clinical application of stem cells. Chinese herbal medicine is a nature drug library which is suitable for the long-term treatment of aging-related diseases. Modern pharmacological studies have revealed that many active ingredients of Chinese herbal medicines with the effect of promoting stem cells growth and differentiation mainly belong to “reinforcing herbs.” In recent years, exploration of natural active ingredients from Chinese herbal medicines for delaying aging, improving the stem cell microenvironment, and promoting the proliferation and differentiation of endogenous stem cells has attracted substantial attention. This article will focus on active ingredients from Chinese herbs-mediated differentiation of stem cells into particular cell type, like neural cells, endothelial cells, cardiomyocytes, and osteoblasts. We will also discuss the effects of these small molecules on Wnt, Sonic Hedgehog, Notch, eNOS-cGMP, and MAP kinase signal transduction pathways, as well as reveal the role of estrogen receptor α and PPAR γ on selectively promoting or inhibiting stem cells differentiation. This review will provide new insights into the health aging strategies of active ingredients in Chinese herbal medicine in regenerative medicine.

scholarly journals A proposed protocol based on integrative metabonomics analysis for the rapid detection and mechanistic understanding of sulfur fumigation of Chinese herbal medicines

RSC Advances ◽  
2019 ◽  
Vol 9 (53) ◽  
pp. 31150-31161 ◽  
Author(s):  
Dai Shengyun ◽  
Wang Yuqi ◽  
Wang Fei ◽  
Mei Xiaodan ◽  
Zhang Jiayu
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Rapid Detection ◽  
Herbal Medicines ◽  
Lonicera Japonica ◽  
Current Work ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Mechanistic Understanding

In the current work, Lonicera japonica Flos (FLJ) was selected as a model Chinese herbal medicine (CHM) and a protocol was proposed for the rapid detection of sulfur-fumigated (SF) CHMs.

scholarly journals Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity onPseudomonas aeruginosa

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Weihua Chu ◽  
Shuxin Zhou ◽  
Yan Jiang ◽  
Wei Zhu ◽  
Xiyi Zhuang ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Cell Communication ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Traditional Chinese Herbal Medicines

Traditional Chinese herbal medicines (TCHMs) were tested for their ability of antiquorum sensing. Water extracts ofRhubarb, Fructus gardeniae, and Andrographis paniculatashow antiquorumsensing activity when usingChromobacterium violaceumCV12472 as reporter; the sub-MIC concentrations of these TCHMs were tested against AHL-dependent phenotypic expressions of PAO1. Results showed significant reduction in pyocyanin pigment, protease, elastase production, and biofilm formation in PAO1 without inhibiting the bacterial growth, revealing that the QSI by the extracts is not related to static or killing effects on the bacteria. The results indicate a potential modulation of bacterial cell-cell communication,P. aeruginosabiofilm, and virulence factors by traditional Chinese herbal medicine. This study introduces not only a new mode of action for traditional Chinese herbal medicines, but also a potential new therapeutic direction for the treatment of bacterial infections, which have QSI activity and might be important in reducing virulence and pathogenicity of pathogenic bacteria.

scholarly journals Application of Molecular Methods in the Identification of Ingredients in Chinese Herbal Medicines

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2728 ◽  
Author(s):  
Ke Han ◽  
Miao Wang ◽  
Lei Zhang ◽  
Chunyu Wang
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Future Development ◽  
Rapid Development ◽  
Herbal Medicines ◽  
Taxonomic Identification ◽  
Traditional Methods ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Speed And Accuracy

There are several kinds of Chinese herbal medicines originating from diverse sources. However, the rapid taxonomic identification of large quantities of Chinese herbal medicines is difficult using traditional methods, and the process of identification itself is prone to error. Therefore, the traditional methods of Chinese herbal medicine identification must meet higher standards of accuracy. With the rapid development of bioinformatics, methods relying on bioinformatics strategies offer advantages with respect to the speed and accuracy of the identification of Chinese herbal medicine ingredients. This article reviews the applicability and limitations of biochip and DNA barcoding technology in the identification of Chinese herbal medicines. Furthermore, the future development of the two technologies of interest is discussed.

Application of Wireless Sensor Network in the Monitoring System for Valuable Chinese Herbal Medicine Growth

2013 ◽  
Vol 475-476 ◽  
pp. 442-445
Author(s):  
Ying Li Zhu ◽  
Ling Qin Xie
Keyword(s):  
Wireless Sensor Network ◽  
Herbal Medicine ◽  
Sensor Network ◽  
Monitoring System ◽  
Chinese Herbal Medicine ◽  
Herbal Medicines ◽  
Wireless Sensor ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Artificial Cultivation

Chinese herbal medicine with no side effects can help people resist disease and keep healthy, due to predatory excavation, and heavy deforestation, the destruction ecological environment, lots of the precious Chinese herbal medicines are on the edge of exhaustion. In order to protect Chinese herbal medicines and do artificial cultivation, the paper presents a real-time monitoring system based wireless sensor network. The system gives the hardware design of wireless sensor node and software implementations. The nodes are mainly responsible for collecting and transporting the environment parameters of the Chinese herbal medicine including temperature, humidity and light intensity and so on, and send the data through the GPRS module to the remote monitoring center. The system can make the artificial cultivation of the medicines more modern, scientific and objective.

scholarly journals Chinese Herbal Medicine Versus Other Interventions in the Treatment of Type 2 Diabetes

2018 ◽  
Vol 23 ◽  
pp. 2515690X1878151 ◽  
Author(s):  
Ao Yu ◽  
David Adelson ◽  
David Mills
Keyword(s):  
Type 2 Diabetes ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Clinical Symptoms ◽  
Herbal Medicines ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
The World

Diabetes affects 422 million people and directly caused 4.9 million deaths according to the global report on diabetes in 2014. Type 2 diabetes accounts for 90% of people with diabetes around the world. Chinese herbal medicine treatment for diabetes has more than 2000-year history in China. An increasing number of people around the world are trying to manage type 2 diabetes with Chinese herbal medicine. However, there is a lack of evidence to decide if Chinese herbal medicine is effective and safe when compared with other interventions for the treatment of type 2 diabetes We identified 58 randomized controlled trials involving 6637 participants with type 2 diabetes with trial periods lasting from 8 weeks to 1 year (average 12 weeks). We extracted data following a predefined hierarchy. A total of 132 different Chinese herbal medicines were examined. We included studies comparing Chinese herbal medicine with other interventions and excluded trials that did not satisfy the inclusion criteria. We evaluated primary outcomes of trials in accordance with the Cochrane Handbook for Systematic Reviews of Intervention. Fifty-six out of 58 studies reported evidence that Chinese herbal medicines were effective at controlling blood sugar, insulin resistance, and traditional Chinese medicine clinical symptoms for patients with type 2 diabetes. And outcome variables are summarized. However, the evidence is limited because of the quality of the studies. Well-designed long-term studies with large samples and multiple centers as well as standardization and quality control will be required to determine if Chinese herbal medicine treatment is effective and safe for type 2 diabetes.

scholarly journals Chinese Herbal Medicine Hepatotoxicity: The Evaluation and Recognization Based on Large-scale Evidence Database

2019 ◽  
Vol 20 (2) ◽  
pp. 138-146 ◽  
Author(s):  
Zhi Liu ◽  
Xin He ◽  
Lili Wang ◽  
Yunhua Zhang ◽  
Yue Hai ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Liver Injury ◽  
Chinese Herbal Medicine ◽  
Large Scale ◽  
Evaluation Method ◽  
Liver Toxicity ◽  
Assessment Method ◽  
Chinese Herbs ◽  
Data Resource ◽  
Chinese Herbal

Background:Due to the special nature of Chinese Herbal medicine and the complexity of its clinical use, it is difficult to identify and evaluate its toxicity and resulting herb induced liver injury (HILI).Methods:First, the database would provide full profile of HILI from the basic ingredients to clinical outcomes by the most advanced algorithms of artificial intelligence, and it is also possible that we can predict possibilities of HILI after patients taking Chinese herbs by individual patient evaluation and prediction. Second, the database would solve the chaos and lack of the relevant data faced by the current basic research and clinical practice of Chinese Herbal Medicine. Third, we can also screen the susceptible patients from the database and thus prevent the accidents of HILI from the very beginning.Results:The Roussel Uclaf Causality Assessment Method (RUCAM) is the most accepted method to evaluate DILI, but at present before using the RUCAM evaluation method, data resource collection and analysis are yet to be perfected. Based on existing research on drug-metabolizing enzymes mediating reactive metabolites (RMs), the aim of this study is to explore the possibilities and methods of building multidimensional hierarchical database composing of RMs evidence library, Chinese herbal evidence library, and individualized reports evidence library of herb induced liver injury HILI.Conclusion:The potential benefits lie in its ability to organize, use vast amounts of evidence and use big data mining techniques at the center for Chinese herbal medicine liver toxicity research, which is the most difficult key point of scientific research to be investigated in the next few years.

scholarly journals Current Status and Major Challenges to the Safety and Efficacy Presented by Chinese Herbal Medicine

Medicines ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 14 ◽  
Author(s):  
Xian Zhou ◽  
Chun-Guang Li ◽  
Dennis Chang ◽  
Alan Bensoussan
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Chinese Herbs ◽  
Current Status ◽  
Evidence Based Practices ◽  
Safety And Efficacy ◽  
Chinese Herbal ◽  
The Status ◽  
Chemical Profiles ◽  
Standards And Regulations

Traditional Chinese medicine (TCM) is not only used prevalently in Asian countries but has also gained a stable market globally. As a principal form of TCM, Chinese herbal medicine (CHM) is comprised of treatments using multiple Chinese herbs which have complex chemical profiles. Due to a lack of understanding of its modality and a lack of standardization, there are significant challenges associated with regulating CHM’s safety for practice and understanding its mechanisms of efficacy. Currently, there are many issues that need to be overcome in regard to the safety and efficacy of CHM for the further development of evidence-based practices. There is a need to better understand the mechanisms behind the efficacy of CHM, and develop proper quality standards and regulations to ensure a similar safety standard as Western drugs. This paper outlines the status of CHM in terms of its safety and efficacy and attempts to provide approaches to address these issues.

scholarly journals Chinese Herbal Medicine Qi Ju Di Huang Wan for the Treatment of Essential Hypertension: A Systematic Review of Randomized Controlled Trials

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Jie Wang ◽  
Xingjiang Xiong ◽  
Guoyan Yang ◽  
Yuqing Zhang ◽  
Yongmei Liu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Herbal Medicine ◽  
Randomized Controlled Trials ◽  
Chinese Herbal Medicine ◽  
Antihypertensive Drugs ◽  
Chinese Herbs ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Chinese Herbal

Background. Chinese herbs are potentially effective for hypertension. Qi Ju Di Huang Wan (QJDHW) is a commonly used Chinese herbal medicine as a monotherapy or in combination with other antihypertensive agents for the treatment of essential hypertension (EH). However, there is no critically appraised evidence such as systematic reviews or meta-analyses on the effectiveness and safety of QJDHW for EH.Methods and Findings. CENTRAL, PubMed, CBM, CNKI, VIP, and online clinical trial registry websites were searched for published and unpublished randomized controlled trials (RCTs) of QJDHW for essential hypertension up to January 2013 with no language restrictions. A total of 10 randomized trials involving 1024 patients were included. Meta-analysis showed that QJDHW combined with antihypertensive drugs was more effective in lowering blood pressure and improving TCM syndrome for the treatment of essential hypertension than antihypertensive drugs used alone. No trials reported severe adverse events related to QJDHW.Conclusions. Our review suggests that QJDHW combined with antihypertensive drugs might be an effective treatment for lowering blood pressure and improving symptoms in patients with essential hypertension. However, the finding should be interpreted with caution because of the poor methodological quality of included trials. There is an urgent need for well-designed, long-term studies to assess the effectiveness of QJDHW in the treatment of essential hypertension.

scholarly journals Effect of a Traditional Chinese Herbal Medicine Formulation on Cell Survival and Apoptosis of MPP+-Treated MES 23.5 Dopaminergic Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Shuifen Ye ◽  
Ho Kee Koon ◽  
Wen Fan ◽  
Yihui Xu ◽  
Wei Wei ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Neurodegenerative Diseases ◽  
Cell Survival ◽  
Chinese Herbal Medicine ◽  
Chinese Herbs ◽  
Expression Ratio ◽  
Traditional Chinese Herbal Medicine ◽  
Dopaminergic Cells ◽  
Chinese Herbal ◽  
Bax Protein

Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is implicated in Parkinson’s disease (PD). The efficacy of these currently used drugs is limited while traditional Chinese medicine (TCM) has been used in the management of neurodegenerative diseases for many years. This study was designed to evaluate the effect of a modified traditional Chinese herbal medicine decoction, Cong Rong Jing (CRJ), on cell survival and apoptosis of 1-methyl-4-phenylpyridinium- (MPP+-) treated MES23.5 dopaminergic cells. CRJ was prepared as a decoction from three Chinese herbs, namely,Herba Cistanches,Herba Epimedii, andRhizoma Polygonati. We reported here that CRJ significantly enhanced the cell survival of MES23.5 cells after the exposure of MPP+and inhibited the production of intracellular reactive oxygen species (ROS) induced by MPP+. CRJ also prevented the MPP+-treated MES23.5 cells from apoptosis by reducing the externalization of phosphatidylserine and enhancing the Bcl-2/Bax protein expression ratio. Signaling proteins such as JAK2, STAT3, and ERK1/2 were also involved in the action of CRJ. Taken together, these results provide a preliminary mechanism to support clinical application of the TCM formulation in PD and possibly other neurodegenerative diseases associated with ROS injury and apoptosis.

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