scholarly journals Pituitary adenomas. Clinico-morphologic correlations.

1979 ◽  
Vol 27 (10) ◽  
pp. 1395-1397 ◽  
Author(s):  
A M Landolt
Keyword(s):  
Electron Microscopy ◽  
Natural History ◽  
Functional Activity ◽  
Pituitary Adenomas ◽  
Hypothalamic Regulation ◽  
History Of ◽  
Group A ◽  
Inactive Group ◽  
Low Rate

Immunohistochemistry and electron microscopy allow new insights into the biology and natural history of the proliferative processes of the hypophysis. Hyperplasia can be diffuse or focal. Its function and/or growth are controlled by hypothalamic factors. Hyperplasia may precede the formation of an adenoma. Function and/or growth of adenomas is partially or completely independent of hypothalamic regulation. Adenomas are divided according to their functional activity into an endocrine active and inactive group. A further subdivision is made according to the secreted hormone. Inactive adenomas may have lost the ability to produce hormones, may secrete hormones at a very low rate, or may secrete abnormal substances.

Is cancer associated thrombosis (CAT) an underestimated issue in oncology clinical practice? Real-world data regarding long term management of CAT.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e23150-e23150
Author(s):  
Nikolaos Tsoukalas ◽  
Alexandros Bokas ◽  
Evangelos Bournakis ◽  
Athina Christopoulou ◽  
Christos Papandreou ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Natural History ◽  
Disease Stage ◽  
Lower Probability ◽  
Bleeding Events ◽  
History Of ◽  
Group A ◽  
Group B ◽  
History Of Cancer

e23150 Background: Cancer is associated with thrombosis due to different pathophysiological processes. CAT is the 2nd cause of death in oncology patients and can occur anytime during the natural history of cancer. CAT is not rare complication, can delay anti-cancer therapy and increase health systems costs. Methods: A prospective observational study (Greek Management of Thrombosis-GMaT) conducted by HeSMO in Greek Oncology units for two years aiming to record clinical practice of CAT management. Patients with active cancer who received CAT treatment or thromboprophylaxis were enrolled after signing informed consent. Results: 546 patients were enrolled from 18 oncology units. Primary cancers were: lung 23.9%, pancreas 13.3%, breast 7.6%, colorectal 8.9%, stomach 8.3%, ovarian 7.6% and other 30.5%. 120 patients received LMWH for Venus Thombo-Embolism (VTE) treatment (Group A) and 426 for thromboprophylaxis (Group B). Group A: 89/120 (74.17%) patients continued in 2nd year and 58.6% received CAT treatment (6.9±4.4 months). Only 2 had VTE recurrence in 2nd year (versus 3 in 1st year). 4/120 (3.33%) had bleeding events (grade 1) in 1st year while no bleeding events occurred in 2nd year. Group B: 345/426 (80.98%) patients continued in 2nd year. 126 (30%) had Khorana score ≥3 and 300 (70%) had Khorana score ≤2. In 2nd year, 123 (35.65%) received thromboprophylaxis (7.3±3.7 months) while 79.4% of them were initially treated with High Thrombotic Treatment Agents (HTTA: e.g. platinum, 5-FU) and 83.1% had metastatic disease. In 2nd year, 52.5% received LMWHs at prophylactic dose and 47.5% at therapeutic dose. Overall, 12 (2.82%) had thrombotic events whereas 4 were recorded in 2nd year. Notably, patients treated with therapeutic doses had lower probability to have a thrombotic event (OR: 5.8, 95% CI: 1.7 to 20.5, p < .05). Six (1.41%) bleeding events (grade 1) occurred in 1st year and one (0.81%) in 2nd year. Conclusions: LMWHs can be used for long term CAT management. Therapeutic LMWHs doses as thromboprophylaxis are safe and effective. Khorana score is a useful model for CAT risk assessment but some other factors such as disease stage and HTTA might be taken into account. CAT can occur anytime during the natural history of cancer. Oncologists should be aware about CAT and its negative influences in patients’ prognosis and quality of life.

Optimal follow-up strategy based on the natural history of nonfunctioning pituitary adenomas

2018 ◽  
Author(s):  
Kim Jung Hee ◽  
Yun-Sik Dho ◽  
Kim Yong Hwy ◽  
Lee Jung Hyun ◽  
Lee Ji Hyun ◽  
...  
Keyword(s):  
Natural History ◽  
Pituitary Adenomas ◽  
Nonfunctioning Pituitary Adenomas ◽  
History Of

What Is the Natural History of Nonoperated Nonfunctioning Pituitary Adenomas?

2008 ◽  
Vol 63 (4) ◽  
pp. 228-229
Author(s):  
N Karavitaki ◽  
K Collison ◽  
J Halliday ◽  
J V. Byrnet ◽  
P Price ◽  
...  
Keyword(s):  
Natural History ◽  
Pituitary Adenomas ◽  
Nonfunctioning Pituitary Adenomas ◽  
History Of

The natural history of surgically treated but radiotherapy-naïve nonfunctioning pituitary adenomas

2009 ◽  
Vol 71 (5) ◽  
pp. 709-714 ◽  
Author(s):  
Eoin P. O’Sullivan ◽  
Conor Woods ◽  
Nigel Glynn ◽  
Lucy Ann Behan ◽  
Rachel Crowley ◽  
...  
Keyword(s):  
Natural History ◽  
Pituitary Adenomas ◽  
Nonfunctioning Pituitary Adenomas ◽  
History Of

scholarly journals Natural History of Postoperative Nonfunctioning Pituitary Adenomas: A Systematic Review and Meta-Analysis

2012 ◽  
Vol 96 (4) ◽  
pp. 333-342 ◽  
Author(s):  
Yong Chen ◽  
Cheng De Wang ◽  
Zhi Peng Su ◽  
Yun Xiang Chen ◽  
Lin Cai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural History ◽  
Pituitary Adenomas ◽  
Meta Analysis ◽  
Nonfunctioning Pituitary Adenomas ◽  
History Of

Incidental pituitary adenomas

2011 ◽  
Vol 31 (6) ◽  
pp. E18 ◽  
Author(s):  
Walavan Sivakumar ◽  
Roukoz Chamoun ◽  
Vinh Nguyen ◽  
William T. Couldwell ◽  
Keyword(s):  
Visual Field ◽  
Natural History ◽  
Pituitary Adenomas ◽  
Field Testing ◽  
Progressive Increase ◽  
Common Finding ◽  
Current Evidence ◽  
Endocrine Dysfunction ◽  
Sellar Lesions ◽  
History Of

Object Pituitary incidentalomas are a common finding with a poorly understood natural history. Over the last few decades, numerous studies have sought to decipher the optimal evaluation and treatment of these lesions. This paper aims to elucidate the current evidence regarding their prevalence, natural history, evaluation, and management. Methods A search of articles on PubMed (National Library of Medicine) and reference lists of all relevant articles was conducted to identify all studies pertaining to the incidence, natural history, workup, treatment, and follow-up of incidental pituitary and sellar lesions, nonfunctioning pituitary adenomas, and incidentalomas. Results The reported prevalence of pituitary incidentalomas has increased significantly in recent years. A complete history, physical, and endocrinological workup with formal visual field testing in the event of optic apparatus involvement constitutes the basics of the initial evaluation. Although data regarding the natural history of pituitary incidentalomas remain sparse, they seem to suggest that progression to pituitary apoplexy (0.6/100 patient-years), visual field deficits (0.6/100 patient-years), and endocrine dysfunction (0.8/100 patient-years) remains low. In larger lesions, apoplexy risk may be higher. Conclusions While the majority of pituitary incidentalomas can be managed conservatively, involvement of the optic apparatus, endocrine dysfunction, ophthalmological symptoms, and progressive increase in size represent the main indications for surgery.

Prolactinoma of pituitary with associated amyloid-like substances

1983 ◽  
Vol 59 (6) ◽  
pp. 1067-1070 ◽  
Author(s):  
Jun-ichi Kuratsu ◽  
Yasuhiko Matsukado ◽  
Masaki Miura
Keyword(s):  
Electron Microscopy ◽  
Pituitary Adenoma ◽  
Tumor Cells ◽  
Pituitary Adenomas ◽  
Light And Electron Microscopy ◽  
Rare Entity ◽  
Short History ◽  
Content Type ◽  
History Of ◽  
Fine Print

✓ A prolactin-secreting pituitary adenoma containing amyloid substance was studied by light and electron microscopy. The tumor was found in a 32-year-old woman who presented with a short history of amenorrhea and galactorrhea. Pituitary adenoma containing amyloid substance is a very rare entity, and the implications of this association are discussed. Previous reports, suggesting that mesenchymal cells or hormone-secreting tumor cells in pituitary adenomas produce amyloid substances, are reviewed.

scholarly journals Natural history of the social millipede Brachycybe lecontii Wood, 1864

2020 ◽  
Vol 8 ◽  
Author(s):  
Victoria Wong ◽  
Derek Hennen ◽  
Angie Macias ◽  
Michael Brewer ◽  
Matt Kasson ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Natural History ◽  
Spectral Reflectance ◽  
Paternal Care ◽  
Chemical Defence ◽  
The Social ◽  
Cuticular Structure ◽  
History Of ◽  
Scanning Electron

The millipede Brachycybe lecontii Wood, 1864 is a fungivorous social millipede known for paternal care of eggs and forming multi-generational aggregations. We investigated the life history, paternal care, chemical defence, feeding and social behaviour of B. lecontii and provided morphological and anatomical descriptions, using light and scanning electron microscopy. Based on observations of B. lecontii from 13 locations throughout its distribution, we report the following natural history aspects. The oviposition period of B. lecontii lasted from mid-April to late June and the incubation period lasted 3–4 weeks. Only males cared for the eggs and subsequent care of juveniles was not observed. In one case, the clutches of two males became combined and they were later cared for by only one of the males. The defensive compound of B. lecontii is stored in large glands occupying a third of the paranotal volume and were observed only in stadia II millipedes and older. We observed B. lecontii feeding on fungi of the order Polyporales and describe a cuticular structure on the tip of the labrum that may relate to fungivory. We found that their stellate-shaped aggregations (pinwheels) do not form in the absence of fungus and suggest the aggregation is associated with feeding. We describe and illustrate a previously undescribed comb-like structure on the tibia and tarsi of the six anterior-most leg-pairs and measure the colour and spectral reflectance of the B. lecontii exoskeleton.

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