Serum zinc levels are low in children with simple febrile seizures compared with those in children with epileptic seizures and controls

2011 ◽  
Vol 31 (4) ◽  
pp. 345-349 ◽  
Author(s):  
R Ganesh ◽  
L Janakiraman ◽  
B Meenakshi
Keyword(s):  
Serum Zinc ◽  
Epileptic Seizures ◽  
Febrile Seizures ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals FEBRILE SEIZURES

2018 ◽  
Vol 25 (03) ◽  
pp. 461-465
Author(s):  
Nathumal Maheshwari ◽  
Om Perkash ◽  
Mehmood Shaikh ◽  
Bilawal Hingorjo ◽  
Yasmeen Kazi ◽  
...  
Keyword(s):  
Venous Blood ◽  
Tertiary Care ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objectives: To determine the serum zinc levels in children with simple febrileseizures reporting at a tertiary care hospital of Sindh. Study Design: Cross sectional study.Place and Duration: Department of Paediatrics, Layari General Hospital Shaheed MuhtramaBenazir Bhutto Medical College from January 2015 to February 2016. Methodology: A sampleof 120 children (60 cases and 60 controls) was selected through non- probability (purposivesampling) by pre defined inclusion and exclusion criteria. 3 ml venous blood was taken from aperipheral vein. Blood was process, centrifuged and sera were used for the analysis of serumzinc. Data of cases and controls was analyzed on Statistix 10.0 software (USA). P-value of≤0.05 was considered statistically significant. Results: Age of controls and cases was notedas 13.68±8.74 and 15.75±9.11 months respectively and most common age group was 12 - 24months in the cases. Male children predominated. Means± SD serum zinc was 79.03±24.17and 62.82±14.66 in controls and cases respectively (P=0.0001). Low serum zinc was noted in66.6% of cases compared to 40% in controls (P=0.0001). Conclusion: We noted low serumzinc levels in children with febrile seizures which may provoke febrile seizures. Children with lowserum zinc levels are prone to febrile seizures. 

scholarly journals Estimation of serum zinc levels in children with febrile convulsions

2018 ◽  
Vol 5 (4) ◽  
pp. 1518 ◽  
Author(s):  
Ubaidur Rehman H. ◽  
Shamshad Ahmed Khan ◽  
Prakash R. Saldanha
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Significant Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Different studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no significant difference in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a significant difference between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

scholarly journals Association between serum zinc level and simple febrile seizures in children: a hospital-based study

2018 ◽  
Vol 6 (9) ◽  
pp. 3116
Author(s):  
Najmus Saqib ◽  
Mahvish Qazi
Keyword(s):  
Hospital Admissions ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Chi Square ◽  
Febrile Convulsions ◽  
Female Ratio ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common cause of convulsions in children and a frequent cause of emergency hospital admissions. There are different hypothesis about neurotransmitters and trace element (such as zinc) changes in cerebrospinal fluid and serum, which can have a role in pathogenesis of febrile convulsions. Hence we want to study this association in our set up. Objectives was to study the association between serum zinc levels and febrile seizures in childern in our set up.Methods: This hospital based, prospective case control study was done in SKIMS Soura Srinagar, Kashmir (J and K), India for one-year period from August 2015 to July 2016. A total of 100 children aged 6 months to 6 years admitted in the hospital presenting with febrile seizures after fulfilling our inclusion and exclusion criteria were enrolled for the study. Informed consent was taken from their attendants and classified into 2 groups of 50 each. Patients with history of simple febrile seizures were taken as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. Blood was collected within 12 hours of admission and serum zinc levels were estimated. For statistical analysis, SPSS 17 program using t-test was employed. Chi-square test was performed to compare proportion between 2 or more discrete variables. P<0.05 was considered statistically significant.Results: Out of 100 children enrolled, male to female ratio was 1.63:1. Majority of the children were between 6 to 12 months (36%). The clinical presentation comprised of mainly non localized fevers majority of which had clinical evidence to suggest viral etiology (60%), followed by ARI (20%), ASOM (10%), UTI (6%) and bronchiolitis (4%). Mean serum zinc level in cases was 30.96±7.93ugm/dl and in controls it was 35.95±9.25ugm/dl. Serum zinc level was found significantly low in cases of simple febrile seizures as compared to controls (P<0.05).Conclusions: This study reveals that there is positive correlation between low serum zinc levels and febrile convulsions.

scholarly journals A study of serum zinc levels among children with seizures in comparison with febrile children without seizures

2020 ◽  
Vol 7 (4) ◽  
pp. 876
Author(s):  
Pranam G. M. ◽  
Usha Hirevenkanagoudar ◽  
Sanjeev Chetty
Keyword(s):  
Neuronal Excitability ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Seizure Threshold ◽  
Febrile Convulsions ◽  
Pediatric Age Group ◽  
High Zinc ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Infants and children are more prone to have seizures than adults. This reflects the greater neuronal excitability at certain ages as the excitatory glutamate system and inhibitory GABA system do not always balance each other. Febrile seizures are the most common type of seizures observed in pediatric age group. Febrile seizures occur in young children at a time in their development when seizure threshold is low. Objective of the study was to determine the levels of zinc in children with febrile seizures when compared to children with fever without seizures.Methods: To determine the levels of zinc in children with febrile seizures when compared to children with fever without seizures. A total of 50 Study subjects were selected into each group. Group 1: Children with Febrile Seizures. Group 2: Children with Fever and Without Febrile Seizures.Results: Among the cases with fever and convulsion Zinc level was found to be low among 72% of the subjects, 22 % of them had normal zinc levels and only 6% had high zinc levels. Among the subjects with Fever and no convulsions nearly 80% of them had normal zinc levels, 16 % had low levels of zinc and 4% had high zinc levels. The association of levels of Zinc between both the groups was found to be statistically significant.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions when compared to children with fever alone without convulsions, thus indicating that zinc deprivation plays significant role in the pathogenesis of febrile convulsions.

scholarly journals Children with Febrile Seizures have Lower Zinc Levels

2020 ◽  
Vol 24 (3) ◽  
pp. 245-248
Author(s):  
Syeda Mamoona Qudrat ◽  
Najaf Masood ◽  
Ammara Khalid ◽  
Tanzeela Rani ◽  
Mobeen Tabussum ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Research Committee ◽  
Cross Sectional ◽  
Medical College ◽  
Patient Profile ◽  
Zinc Levels ◽  
Tertiary Care Hospitals ◽  
Serum Zinc Levels

Objective: To find the association between zinc deficiency and febrile seizures in children of 6 months and 5 years of age. Materials and Methods: Cross-Sectional Descriptive Study was carried out at the Department of Pediatrics, Benazir Bhutto Hospital, Rawalpindi for a duration of six months (From 11th March to 31st August 2017). After taking approval of the Ethical Research Committee of Rawalpindi Medical College and taking informed consent from the parents/ guardians, children selected according to the inclusion/exclusion criteria. Patient profile including name, age, sex, address, hospital number, serial number, date of inclusion in the study was noted. Data was collected from the Patient’s charts and/or by direct interview of the child’s guardian. Using aseptic measures, 2ml of blood from venipuncture utilizing a 22-gauge antiseptic needle, in no more than 24 hours of hospital visitation was reserved. Evaluation of serum zinc was completed in no more than 6 hours of collection. The copy was then given to the lab testing and thus this report was then approved by the physician. Results: In our study, out of 145 cases, 52.41%(n=76) were between 1-3 years of age whereas 47.59% (n=69) were between 4-6 years of age, the mean and standard deviation was calculated as 3.54 + 1.50 years, 50.34% (n=73) were male whereas 49.66% (n=72) were females. Mean serum zinc levels were calculated as 64.28 + 12.13 mcg/dl. The frequency of hypozincemia in febrile seizures among children presenting at tertiary care hospitals was 54.48% (n=79). Conclusion: These analysis outcomes depicted that children with febrile seizures had notably lesser serum zinc measures.

scholarly journals Relationship between serum zinc levels and simple febrile seizures: hospital based case control study

2017 ◽  
Vol 5 (1) ◽  
pp. 42 ◽  
Author(s):  
. Hubaira ◽  
Zubir A. Wani ◽  
Syed Muneeb R. Qadri
Keyword(s):  
Case Control Study ◽  
Adult Life ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Case Control ◽  
Research Centre ◽  
History Of ◽  
Zinc Levels ◽  
Control Study ◽  
Serum Zinc Levels

Background: Owing to the excessive susceptibility of  the  immature  brain  to temperature, febrile seizures remain one of the common neurological conditions of childhood. Although simple febrile seizures do not pose any increased neurological problems in adult life, but the anxiety, hospitalization and prophylaxis for the episode do call for a genuine concern. A correlation between zinc deficiency and febrile seizures has been proposed and a few studies undertaken have shown mixed conclusions. This case control study was undertaken to compare the serum Zinc levels in patients with simple febrile seizures against the controlled patients with short febrile illness without seizures and to find the correlation if any between simple febrile seizures and serum zinc levels.Methods: The hospital based, observational case control study was done in Batra Hospital and Medical research Centre, New Delhi. A total of 200 children aged 6 months to 6 years admitted in the hospital with history of short pyrexia (fever for 2 days or less) and fulfilling our inclusion criteria were enrolled for the study after taking an informed consent from their attendants and classified into 2 groups of 100 each as cases and controls. Patients with history of simple febrile seizures as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. The data was analysed on SPSS 17.Results: Our results showed a mean of serum zinc levels in cases as 61.53±15.87 mcg/dl which was found to be lower compared to controls as 71.90+18.50 mcg /dl. Further the difference was found to be statistically significant (P<0.05).Conclusions: Low serum zinc levels in the patients of simple febrile seizures in association with other risk factors may enhance the occurrence of seizures triggered by fever. Thus, a possible correlation exists between the mean serum zinc level and simple febrile seizures.

scholarly journals Serum zinc levels in children with simple febrile seizures

2015 ◽  
pp. 424-427 ◽  
Author(s):  
Karthikeyan Pannerselvam ◽  
Prasanna Raju ◽  
Sathyamoorthy Mani ◽  
Sowjan Reddy ◽  
P. Sekar
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Levels ◽  
Serum Zinc Levels
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