scholarly journals Children with Febrile Seizures have Lower Zinc Levels

2020 ◽  
Vol 24 (3) ◽  
pp. 245-248
Author(s):  
Syeda Mamoona Qudrat ◽  
Najaf Masood ◽  
Ammara Khalid ◽  
Tanzeela Rani ◽  
Mobeen Tabussum ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Research Committee ◽  
Cross Sectional ◽  
Medical College ◽  
Patient Profile ◽  
Zinc Levels ◽  
Tertiary Care Hospitals ◽  
Serum Zinc Levels

Objective: To find the association between zinc deficiency and febrile seizures in children of 6 months and 5 years of age. Materials and Methods: Cross-Sectional Descriptive Study was carried out at the Department of Pediatrics, Benazir Bhutto Hospital, Rawalpindi for a duration of six months (From 11th March to 31st August 2017). After taking approval of the Ethical Research Committee of Rawalpindi Medical College and taking informed consent from the parents/ guardians, children selected according to the inclusion/exclusion criteria. Patient profile including name, age, sex, address, hospital number, serial number, date of inclusion in the study was noted. Data was collected from the Patient’s charts and/or by direct interview of the child’s guardian. Using aseptic measures, 2ml of blood from venipuncture utilizing a 22-gauge antiseptic needle, in no more than 24 hours of hospital visitation was reserved. Evaluation of serum zinc was completed in no more than 6 hours of collection. The copy was then given to the lab testing and thus this report was then approved by the physician. Results: In our study, out of 145 cases, 52.41%(n=76) were between 1-3 years of age whereas 47.59% (n=69) were between 4-6 years of age, the mean and standard deviation was calculated as 3.54 + 1.50 years, 50.34% (n=73) were male whereas 49.66% (n=72) were females. Mean serum zinc levels were calculated as 64.28 + 12.13 mcg/dl. The frequency of hypozincemia in febrile seizures among children presenting at tertiary care hospitals was 54.48% (n=79). Conclusion: These analysis outcomes depicted that children with febrile seizures had notably lesser serum zinc measures.

scholarly journals FEBRILE SEIZURES

2018 ◽  
Vol 25 (03) ◽  
pp. 461-465
Author(s):  
Nathumal Maheshwari ◽  
Om Perkash ◽  
Mehmood Shaikh ◽  
Bilawal Hingorjo ◽  
Yasmeen Kazi ◽  
...  
Keyword(s):  
Venous Blood ◽  
Tertiary Care ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objectives: To determine the serum zinc levels in children with simple febrileseizures reporting at a tertiary care hospital of Sindh. Study Design: Cross sectional study.Place and Duration: Department of Paediatrics, Layari General Hospital Shaheed MuhtramaBenazir Bhutto Medical College from January 2015 to February 2016. Methodology: A sampleof 120 children (60 cases and 60 controls) was selected through non- probability (purposivesampling) by pre defined inclusion and exclusion criteria. 3 ml venous blood was taken from aperipheral vein. Blood was process, centrifuged and sera were used for the analysis of serumzinc. Data of cases and controls was analyzed on Statistix 10.0 software (USA). P-value of≤0.05 was considered statistically significant. Results: Age of controls and cases was notedas 13.68±8.74 and 15.75±9.11 months respectively and most common age group was 12 - 24months in the cases. Male children predominated. Means± SD serum zinc was 79.03±24.17and 62.82±14.66 in controls and cases respectively (P=0.0001). Low serum zinc was noted in66.6% of cases compared to 40% in controls (P=0.0001). Conclusion: We noted low serumzinc levels in children with febrile seizures which may provoke febrile seizures. Children with lowserum zinc levels are prone to febrile seizures. 

scholarly journals Serum Zinc Status in Post Menopausal Women Attending in a Tertiary Care Hospital of Bangladesh

2019 ◽  
Vol 9 (2) ◽  
pp. 147-150
Author(s):  
Nadia Ferdous ◽  
Farzana Akonjee Mishu ◽  
Shamsunnahar ◽  
Fahmida Islam ◽  
Shabnam Sarwar Sejooti
Keyword(s):  
Clinical Symptoms ◽  
Tertiary Care ◽  
Serum Zinc ◽  
Premenopausal Women ◽  
Care Hospital ◽  
College Hospital ◽  
Medical College ◽  
Significant Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Nutritional needs change throughout the various stages of life. While overall caloric needs tend to decrease with age, the requirements for individual micronutrients do not decrease. In fact, the needs for some micronutrients actually increase with age. The risk of nutritional disturbances mainly trace elements deficiencies is high during postmenopause causing or intensifying serious clinical symptoms. Methods: This cross-sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with the Department of Obstetrics and Gynecology , Mymensingh Medical College Hospital during the period from July 2013 to June 2014. A total of 100 subjects were included in this study. Among them 50 apperantly healthy postmenopausal womenaged between 45-70 years were considered as case and another 50 regular menstruating premenopausal women aged between 30-40 years were selected as control. Results: The mean age of case and control groups was 50.5± 2.3 years and 36.5± 4.4 years respectively. In this study serum zinc levels in cases and controls were 71.54 ± 5.69 ìg /dl and 74.68 ± 5.453 ìg/dl respectively, and there was significant difference(p<0.01). Conclusion: Serum zinc level was significantly decreased in postmenopausal group in comparison to premenopausal women (p< 0.01). Estimation of serum zinc levels might be incorporated in every postmenopausal for possible prevention of complications. Birdem Med J 2019; 9(2): 147-150

scholarly journals Estimation of serum zinc levels in children with febrile convulsions

2018 ◽  
Vol 5 (4) ◽  
pp. 1518 ◽  
Author(s):  
Ubaidur Rehman H. ◽  
Shamshad Ahmed Khan ◽  
Prakash R. Saldanha
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Significant Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Different studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no significant difference in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a significant difference between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

scholarly journals A study of zinc level in cord blood of neonates and its relationship with antropometric measurements in the neonates: a descriptive cross-sectional study

2019 ◽  
Vol 6 (2) ◽  
pp. 722
Author(s):  
Syed Mohamed ◽  
Santosh Kumar ◽  
J. Kumutha
Keyword(s):  
Cord Blood ◽  
Growth Parameters ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Cross Sectional ◽  
Medical College ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: During pregnancy, fast growth and cell differentiation takes place in both mother and foetus. Maternal nutritional factors play an important role in the growth of the neonate. Among the micronutrient zinc is an important micronutrient whose deficiency is associated with poor pregnancy outcomes. The objective the current study was to evaluate the relationship of serum zinc concentration of the maternal blood and the neonatal cord blood with that of the infant’s anthropometric measurements.Methods: A descriptive cross-sectional study was performed under the Department of Neonatology, Saveetha medical college. Duration of the study was from April 2017 to June 2018. The study included 82 singleton mother baby dyads born in Saveetha medical college. Anthropometric measurements such as birth weight, head circumference, neonate length apart from other clinical features of both the mother and neonates were recorded for statistical analysis. Serum zinc levels were estimated using 2-(5-bromo-2-pyridylazo)-5-(N-Propyl-N-sulfopropylamino)-phenol (5-Br-PAPS) protocol.Results: The mean maternal age of the study population is 25.3±2.3 years. Majority of the mother had natural mode of delivery (57%). The mean cord serum zinc level was found to be 94.0±1.6microgram /dl and the mother’s serum zinc level was 93.8±30.7microgram /dl (range from 49 to 171microgram /dl) which was not found to be statistically significant. Serum zinc levels of the cord was compared with the child anthropometrics and mother’s serum zinc levels to assess for the significance, but there was no correlation observed between the umbilical cord, and the birth weight (r=0.03), length of the child (r=-0.02), head circumference (r=-0.07) and mothers serum zinc levels (r=-0.002).Conclusions: According to our results authors were unable to establish a relationship between Neonates growth parameters and zinc levels in neonates cord blood and zinc levels in the mother. Further studies with a larger sample size and prospective design would establish a causal relationship between zinc and growth parameters in the neonate.

scholarly journals The association between hypozincemia and aortic stenosis prevalence in hemodialysis patients: a single-center cross-sectional study

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Satoshi Matsui ◽  
Tomonaga Ameku ◽  
Daisuke Takada ◽  
Shinji Ono
Keyword(s):  
Aortic Stenosis ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Single Center ◽  
Cross Sectional ◽  
Dialysis Vintage ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background Hypozincemia contributes to phosphate-induced vascular calcification in model animals of renal failure, but the association between hypozincemia and aortic stenosis (AS) prevalence in patients with end-stage kidney disease remains unreported in clinical settings. Methods To investigate the association between hypozincemia and AS prevalence in patients undergoing hemodialysis, we designed a single-center cross-sectional study. Our outcome “AS” was defined as prevalence of moderate or severe AS or surgical history for AS. Depending on serum zinc levels, we divided patients undergoing hemodialysis into deciles. The association between hypozincemia and AS prevalence was analyzed via logistic regression adjusted for age, sex, dialysis vintage, diabetes history, serum albumin, and history of taking calcium-containing phosphate binder. Results Ninety-three patients undergoing hemodialysis were eligible. The mean serum zinc level was 61.3 ± 13.9 μg/dL. Twelve patients who belonged to 1st decile had serum zinc levels ≤ 48 μg/dL. Of these twelve patients, six patients (50 %) had AS. On the other hand, of eighty one patients who belonged to 2nd–10th deciles (serum zinc levels > 48 μg/dL), thirteen patients (16 %) had AS. Hypozincemia (serum zinc levels ≤ 48 μg/dL) was associated with AS prevalence (P = 0.038; odds ratio 4.43; 95% confidence interval 1.09–18.0). Conclusions AS was more prevalent in patients undergoing hemodialysis with severe hypozincemia in our cross-sectional study, although interventional studies are required to elucidate the benefit of zinc supplementation for AS progression.

scholarly journals A Survey of Factors Influencing Drug Choice and the Prescribing Attitudes Among Junior Doctors of Two Major Tertiary Care Hospitals in Chittagong City

2018 ◽  
Vol 17 (1) ◽  
pp. 17-22
Author(s):  
Jannatul Ferdoush ◽  
Abhijit Chowdhury ◽  
Kohinoor Parveen ◽  
Maliha Ata ◽  
Sefa Sarwath Alam ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Complete Response ◽  
Continuous Medical Education ◽  
Junior Doctors ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Factors Influencing ◽  
Drug Choice ◽  
Tertiary Care Hospitals

Background: The magnitude of rational prescribing is well known but the irrationalities and errors in prescriptions are seen worldwide as the training of future doctors is still not up to the mark. This study aimed to find out the factors influencing drug choice and the prescribing attitudes among junior doctors of two major tertiary care hospitals in Chittagong city. Methods: A cross-sectional questionnaire survey was conducted among the junior doctors of Chittagong Medical College Hospital (CMCH) and Chattagram Maa -O- Shishu Hospital Medical College (CMOSHMC) to assess the factors influencing drug choice and the prescribing attitudes among junior doctors during August 2016. Results: The questionnaires were provided to 220 participants of whom 162 (73.63%) participants provided a complete response to the survey. The response rate was 75.89% in CMOSHMCH and 71.29% in CMCH. The majority (87.03%) of junior doctors mentioned that they are highly influenced by their supervising senior doctors’ patterns of prescriptions. About 79.01% of them took the cost of drugs into consideration while prescribing. 58.64% of the prescribers reported their confidence while prescribing without supervision. On the otherhand, 33.33% doctors mentioned that side effects of the drug changed their patterns of prescriptions. Only one-third (33.95%) of the junior doctors opined that the pharmaceutical promotional offers never influence them. Conclusion: Junior doctors decide their drug of choice mainly by copying their supervising senior doctors’ prescriptions without knowing how to choose, and they feel less confident while prescribing. Issues of drug cost, adverse drug reactions concerned the majority of the participants, but they do not have the clear ideas on how to deal with these practice behaviours. Moreover, pharmaceutical promotional offers significantly persuaded the junior doctors’ prescription patterns. So, there is a need for the continuous medical education programs in hospital settings to train the junior doctors for building capacities and competencies while prescribing. Chatt Maa Shi Hosp Med Coll J; Vol.17 (1); Jan 2018; Page 17-22

scholarly journals Association between serum zinc level and simple febrile seizures in children: a hospital-based study

2018 ◽  
Vol 6 (9) ◽  
pp. 3116
Author(s):  
Najmus Saqib ◽  
Mahvish Qazi
Keyword(s):  
Hospital Admissions ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Chi Square ◽  
Febrile Convulsions ◽  
Female Ratio ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common cause of convulsions in children and a frequent cause of emergency hospital admissions. There are different hypothesis about neurotransmitters and trace element (such as zinc) changes in cerebrospinal fluid and serum, which can have a role in pathogenesis of febrile convulsions. Hence we want to study this association in our set up. Objectives was to study the association between serum zinc levels and febrile seizures in childern in our set up.Methods: This hospital based, prospective case control study was done in SKIMS Soura Srinagar, Kashmir (J and K), India for one-year period from August 2015 to July 2016. A total of 100 children aged 6 months to 6 years admitted in the hospital presenting with febrile seizures after fulfilling our inclusion and exclusion criteria were enrolled for the study. Informed consent was taken from their attendants and classified into 2 groups of 50 each. Patients with history of simple febrile seizures were taken as cases and those with fever without seizures as controls. A detailed history was taken, and complete physical examination was done on the patients and recorded on a precoded and pretested proforma. Blood was collected within 12 hours of admission and serum zinc levels were estimated. For statistical analysis, SPSS 17 program using t-test was employed. Chi-square test was performed to compare proportion between 2 or more discrete variables. P<0.05 was considered statistically significant.Results: Out of 100 children enrolled, male to female ratio was 1.63:1. Majority of the children were between 6 to 12 months (36%). The clinical presentation comprised of mainly non localized fevers majority of which had clinical evidence to suggest viral etiology (60%), followed by ARI (20%), ASOM (10%), UTI (6%) and bronchiolitis (4%). Mean serum zinc level in cases was 30.96±7.93ugm/dl and in controls it was 35.95±9.25ugm/dl. Serum zinc level was found significantly low in cases of simple febrile seizures as compared to controls (P<0.05).Conclusions: This study reveals that there is positive correlation between low serum zinc levels and febrile convulsions.

scholarly journals Decreasing Zinc Levels in Stunting Toddlers in Lampung Province, Indonesia

2019 ◽  
Vol 12 (1) ◽  
pp. 239-243
Author(s):  
Khairun Nisa Berawi ◽  
Maya Nurul Hidayati ◽  
Susianti Susianti ◽  
Roro Rukmi W. Perdami ◽  
Tiwuk Susantiningsih ◽  
...  
Keyword(s):  
Univariate Analysis ◽  
Serum Zinc ◽  
Zinc Content ◽  
Zinc Level ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Stunting is a condition of chronic malnutrition in children that causes the posture is not optimal and triggers other disorders such as deacreasing of immunity and intelligence. The level of adequacy of zinc is one of the factors that influence the incidence of stunting. Zinc is needed to activate and begin the synthesis of Growth Hormone (GH) so that children with zinc deficiency cause GH receptors to be disrupted and GH production to be resistant. This study aims to examine the decrease in zinc levels by looking at the difference in mean zinc levels in stunting and non-stunting toddlers. The research method was carried out observational analytic with a cross sectional approach used in this study. The study sample was 40 toddlers aged 24-60 months with 18 stunting toddlers and 22 non-stunting toddlers in Gunung Sugih District, Central Lampung Regency. The results of univariate analysis revealed that the average zinc level of toddlers serum was 52.60 ug / dl with the largest value of 76 ug / dl and the lowest value was 24 ug / dl. The results of bivariate analysis showed that there were significant differences in the mean zinc levels of stunting and non-stunting children (p = 0.01). The mean zinc content of stunting infants was 45.06 ± 12.21 lower than the mean zinc level of non-stunting infants 58.77 ± 12.98. There is a decrease in serum zinc levels in stunting toddlers compared to non stunting toddlers.

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