scholarly journals Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13

Blood ◽  
2014 ◽  
Vol 124 (24) ◽  
pp. 3608-3612 ◽  
Author(s):  
Suzan Imren ◽  
Michael Heuser ◽  
Maura Gasparetto ◽  
Philip A. Beer ◽  
Gudmundur L. Norddahl ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Cells ◽  
De Novo ◽  
Human Cord Blood ◽  
Self Renewal ◽  
Key Points ◽  
Cord Blood Cells

Key Points MN1 promotes self-renewal and inhibits differentiation of CD34+ cord blood cells in vitro. De novo leukemogenesis is engineered by MN1 and NUP98HOXD13 expression in cord blood cells.

scholarly journals Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

Blood ◽  
2013 ◽  
Vol 122 (18) ◽  
pp. 3129-3137 ◽  
Author(s):  
Alice M. S. Cheung ◽  
Long V. Nguyen ◽  
Annaick Carles ◽  
Philip Beer ◽  
Paul H. Miller ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Cells ◽  
Clonal Growth ◽  
Human Cord Blood ◽  
Self Renewal ◽  
Definitive Evidence ◽  
Nsg Mice ◽  
Human Cd34 ◽  
Key Points ◽  
Cord Blood Cells

Key Points The use of barcoding to track lineages in 196 human CD34+ CB clones in serially sampled primary and secondary transplanted NSG mice is described. Detection of early transient clones with later, more stable clones and definitive evidence of sustained self-renewal of multipotency is presented.

scholarly journals MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic stem cells using genome editing

2018 ◽  
Vol 2 (8) ◽  
pp. 832-845 ◽  
Author(s):  
Corina Schneidawind ◽  
Johan Jeong ◽  
Dominik Schneidawind ◽  
In-Suk Kim ◽  
Jesús Duque-Afonso ◽  
...  
Keyword(s):  
Stem Cells ◽  
Genome Editing ◽  
Blood Cells ◽  
Chromosomal Translocation ◽  
Chromosomal Translocations ◽  
Human Cord Blood ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Cord Blood Cells

Key Points Genome editing induces t(9;11) chromosomal translocations and transforms primary CD34+ human cord blood cells leading to acute leukemia. CD9 is upregulated in primary t(9;11) cells and is a useful marker for enrichment of genome-edited MLL-rearranged cells in vitro.

scholarly journals In Vitro Growth of Granulocytic Colonies From Circulating Cells in Human Cord Blood

Blood ◽  
1974 ◽  
Vol 43 (3) ◽  
pp. 357-361 ◽  
Author(s):  
Søren Knudtzon
Keyword(s):  
Cord Blood ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Newborn Infants ◽  
Peripheral Blood Cell ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord ◽  
Human Cord Blood ◽  
Cord Blood Cells

Abstract Human umbilical cord blood cells from 26 newborn infants and peripheral blood cells from 18 adults were cultured in vitro by using the agar-gel method of human hemopoietic cell culture. An increased concentration of colony-forming cells was seen in the cord blood cultures. Between 17 and 385 colonies, with a mean of 122, were formed in these cultures per 2 x 105 nucleated cells plated. The peripheral blood cell cultures from adults gave rise to 0-11 colonies, with a mean of 3, per 2 x 105 nucleated cells plated. The average number of cells per colony was 1000-1500 cells after 14 days of culture, predominantly granulocytic.

scholarly journals Clonal Heterogeneity in Growth Kinetics of CD34+CD38−Human Cord Blood Cells In Vitro Is Correlated with Gene Expression Pattern and Telomere Length

Stem Cells ◽  
2005 ◽  
Vol 23 (7) ◽  
pp. 946-957 ◽  
Author(s):  
Kerol Bartolović ◽  
Stefan Balabanov ◽  
Birgit Berner ◽  
Hans-Jörg Bühring ◽  
Martina Komor ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cord Blood ◽  
Growth Kinetics ◽  
Blood Cells ◽  
Gene Expression Pattern ◽  
Clonal Heterogeneity ◽  
Human Cord Blood ◽  
Cord Blood Cells ◽  
Kinetics Of

Sodium arsenite induces telomerase and telomeres modulation in human cord blood cells “in vitro”

2008 ◽  
Vol 180 ◽  
pp. S102-S103
Author(s):  
Daniele Ferrario ◽  
Daniele Ferrario ◽  
Maria Carfi’ ◽  
Marie Vahter ◽  
Laura Gribaldo
Keyword(s):  
Cord Blood ◽  
Blood Cells ◽  
Sodium Arsenite ◽  
Human Cord Blood ◽  
Cord Blood Cells

scholarly journals Is in vitro expansion of human cord blood cells clinically relevant?

1998 ◽  
Vol 21 (3) ◽  
pp. 225-232 ◽  
Author(s):  
PA Denning-Kendall ◽  
A Nicol ◽  
H Horsley ◽  
C Donaldson ◽  
B Bradley ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Cells ◽  
Human Cord Blood ◽  
In Vitro Expansion ◽  
Cord Blood Cells

Neural phenotype expression of cultured human cord blood cells in vitro

Neuroreport ◽  
2001 ◽  
Vol 12 (16) ◽  
pp. 3523-3527 ◽  
Author(s):  
Yoon Ha ◽  
Joong Uhn Choi ◽  
Do Heum Yoon ◽  
Dong Soo Yeon ◽  
Jean Ju Lee ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Cells ◽  
Human Cord Blood ◽  
Cord Blood Cells ◽  
Phenotype Expression

In Utero Transplantation of Human Cord Blood Cells into Rabbits

2005 ◽  
Vol 80 (2) ◽  
pp. 282-283 ◽  
Author(s):  
Georg S. Wengler ◽  
Guerino Lombardi ◽  
Tiziana Frusca ◽  
Daniele Alberti ◽  
Alberto Albertini ◽  
...  
Keyword(s):  
Cord Blood ◽  
Blood Cells ◽  
In Utero ◽  
Human Cord Blood ◽  
In Utero Transplantation ◽  
Cord Blood Cells
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