Racial Differences in Thrombotic Risk Factors Associated with Adverse Pregnancy Outcome Among Women Obtaining Care in US Thrombosis and Hemostasis Centers.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 2982-2982
Author(s):  
Claire S. Philipp ◽  
Ambarina Faiz ◽  
Sheetal Shrimanker ◽  
Michele G Beckman ◽  
Paula L. Bockenstedt ◽  
...  
Keyword(s):  
Black Women ◽  
Pregnancy Outcome ◽  
Racial Differences ◽  
White Women ◽  
Adverse Pregnancy Outcome ◽  
Factor V Leiden ◽  
Factor V ◽  
Factor V Leiden Mutation ◽  
History Of ◽  
Adverse Pregnancy

Abstract Abstract 2982 Poster Board II-958 Pregnancy complications such as recurrent miscarriage, intrauterine growth restriction (IUGR), and preeclampsia are common and have been associated with thrombophilia. However racial differences are poorly described for this population. The objective of this study was to determine racial differences in unexplained adverse pregnancy outcome among women obtaining care in the CDC Thrombosis and Hemostasis Centers Research and Prevention Network. Uniform data were prospectively collected from August 2003 to March 2009 in consenting women with a history of adverse pregnancy outcome obtaining care at Network Centers for pre-pregnancy, pregnancy, or postpartum consultation and/or management. Data from 407 women (mean age 38.5 ±12 yrs), including 326 white women (mean age 39.4 ± 12 yrs), and 60 black women (mean age 33.9 ± 11 yrs) were analyzed. Black women had significantly more second trimester pregnancy losses compared to white women (35% vs 22%, p=0.03) but the proportions of 1st trimester losses, 3rd trimester losses, IUGR, prematurity, abruption, and preeclampsia were not significantly different. The risk of thrombophilia differed by race, with Factor V Leiden mutation more common in white women compared to black women (19% vs 3%, p=0.002). Protein S deficiency was more common in black women compared to white women overall (15% vs 5%, p=0.006) and in the subgroup of non-pregnant women (14% vs 5%, p=0.04). There was no significant difference in the proportion of white and black women with antiphospholipid antibodies. Among 285 women evaluated when non-pregnant, body mass index (BMI) ≥ 25 was more frequent in black women (83%) compared to white women (63%) (p=0.04). Overall, black women had a significantly higher proportion with hypertension (27% vs 11%, p=0.002) and sickle cell disease (7% vs 0,%, p< 0.001). There was no significant racial difference in history of pregnancy associated, provoked, or idiopathic venous thromboembolism (VTE). A family history of thrombophilia (6% vs 0%, p=0.05), VTE (22% vs 7%, p=0.005), myocardial infarction (MI) or stroke (12% vs 0%, p=0.0042) was significantly more common in white women compared to black women (overall 32% vs 8%, p<0.0002). This study demonstrates that comorbidities including hypertension, sickle cell disease and BMI≥25 are more prevalent in black women with adverse pregnancy outcomes whereas white women have a higher prevalence of Factor V Leiden mutation, and positive family history of thrombophilia, VTE, MI, and stroke. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Differences in Thrombotic Risk Factors in Black and White Women with Adverse Pregnancy Outcome

2014 ◽  
Vol 133 (1) ◽  
pp. 108-111 ◽  
Author(s):  
Claire S. Philipp ◽  
Ambarina S. Faiz ◽  
Michele G. Beckman ◽  
Althea Grant ◽  
Paula L. Bockenstedt ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pregnancy Outcome ◽  
White Women ◽  
Adverse Pregnancy Outcome ◽  
Thrombotic Risk ◽  
Black And White ◽  
Adverse Pregnancy

The Association Between Parameters of Erythrocytes Morphology and Thrombophilia-Related Mutations

2021 ◽  
Vol 16 ◽  
Author(s):  
Ozlem Oz ◽  
Ataman Gonel
Keyword(s):  
Factor V Leiden ◽  
Mthfr C677t ◽  
Prothrombin G20210a ◽  
Factor V ◽  
Cross Sectional ◽  
Factor V Leiden Mutation ◽  
Erythrocyte Morphology ◽  
Mthfr A1298c ◽  
G20210a Mutation ◽  
History Of

Background: Alterations in erythrocyte morphology parameters have been identified and associated with hematological disorders and other chronic and cardiovascular diseases. Erythrocytes are abundant in thrombus content. Their hemoglobin density and differences in the ratio of macrocytic and microcytic cells may be associated with hypercoagulopathy in those with a history of thrombosis. Objective: This cross-sectional study aimed to investigate the relationship between hemogram parameters and thrombophilia genetic parameters. Method: A total of 55 patients whose thrombophilia panel was reviewed due to the diagnosis of thrombosis were included in the study. %MIC, %MAC, %HPO, %HPR and all hemogram parameters were measured using Abbott Alinity HQ. Prothrombin G20210A, MTHFR C677T, MTHFR A1298C, Factor V Leiden G169A and PAI-1 4G/5G mutations were studied using Real Time-PCR. Results: The MTHFR C677T mutation was detected in 58.2% of the patients. The Factor V Leiden mutation was detected in 5.5% of the patients. The MTHFR A1298C mutation was detected in 58.2%, The PAI mutation was detected in 74.5%, and the Factor 13 mutation was detected in 29% of the patients. Prothrombin G20210A mutation was not detected in any of the patients. Red blood cell (RBC) and Hct values were higher in Factor 13 mutant group; the Hgb and Htc values were higher in the MTHFR C677T mutant group. Conclusion: The MTHFR C677T and Factor 13 mutations may be associated with high Hct and RBC, Hgb, and Htc values, respectively and coagulation tendency in patients with a history of thrombosis.

Homozygous factor V Leiden mutation in a woman with multiple adverse pregnancy outcomes

2000 ◽  
Vol 264 (3) ◽  
pp. 164-165 ◽  
Author(s):  
H.-U. Pauer ◽  
J. Neesen ◽  
M. Schloesser ◽  
B. Hinney ◽  
R. Rauskolb
Keyword(s):  
Pregnancy Outcomes ◽  
Factor V Leiden ◽  
Adverse Pregnancy Outcomes ◽  
Factor V ◽  
Factor V Leiden Mutation ◽  
Adverse Pregnancy

PROTHROMBIN 20210 G: A MUTATION AND FACTOR V LEIDEN MUTATION IN WOMEN WITH A HISTORY OF SEVERE PREECLAMPSIA AND (H)ELLP SYNDROME*

2001 ◽  
Vol 20 (3) ◽  
pp. 291-298 ◽  
Author(s):  
M. G. van Pampus ◽  
Hanas Wolf ◽  
Maria M. W. Koopman ◽  
Abraham van den Ende ◽  
Harry R. Buller ◽  
...  
Keyword(s):  
Factor V Leiden ◽  
Severe Preeclampsia ◽  
Factor V ◽  
Factor V Leiden Mutation ◽  
History Of

scholarly journals Reproductive Concerns Among Female Leukemia and Lymphoma Survivors with the History of Adverse Pregnancy Outcomes after Cancer Treatment

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 5893-5893
Author(s):  
Ksenya Shliakhtsitsava ◽  
Emily Myers ◽  
Irene Su
Keyword(s):  
Pregnancy Outcome ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcome ◽  
Adverse Pregnancy Outcomes ◽  
The Future ◽  
Reproductive Concerns ◽  
History Of ◽  
Adverse Pregnancy ◽  
After Cancer ◽  
Lymphoma Survivors

Abstract Introduction Due to advances in cancer treatment the majority of young adults diagnosed with leukemia or lymphoma become long-term survivors. These individuals have been shown to have higher pregnancy risks as a result of cancer and treatment exposure. Adverse pregnancy outcomes including miscarriage and premature delivery may impact survivor's reproductive concerns after cancer. We hypothesized that reproductive-aged female leukemia and lymphoma survivors who experienced miscarriage or premature birth after cancer would have higher reproductive concerns as compared to female leukemia and lymphoma survivors who did not have an adverse pregnancy outcome after cancer. Methods This is a retrospective cohort study of young adult female leukemia and lymphoma survivors with at least one pregnancy after cancer, who are participants of the Reproductive Window study. Study participants were recruited between March 2015 and December 2017 from population-based cancer registries (California and Texas), physician and advocacy group referrals. Eligible women were age 18 to 40 at enrollment, age 15-35 at cancer diagnosis, and had at least one ovary. Enrolled participants answered a questionnaire on pregnancy outcomes and reproductive concerns using the Reproductive Concerns After Cancer (RCAC) Scale. The exposure was adverse pregnancy outcome (miscarriage or premature birth). The outcomes were RCAC subscales measuring concerns regarding becoming pregnant in the future and personal and offspring health. Subscale scores were dichotomized at 3, with >3 indicating moderate to severe reproductive concerns. Logistic regression models were used to test the association between an adverse pregnancy outcome (miscarriage or preterm birth) and RCAC subscales of interest, while adjusting for confounding Results 76 participants, mean age 34.3±3.9 years and mean years since cancer diagnosis 12.0± 5.8 years were included. The majority of participants were white (80%), completed college (72%) and were partnered (87%). Thirty eight percent of participants reported an adverse pregnancy outcome after cancer (18% miscarriage, 21% premature delivery). Thirty-two percent reported moderate to severe concerns about becoming pregnant in the future, 60% regarding offspring health, and 46% over personal health. History of miscarriage after cancer, but not preterm birth, was associated with higher concerns about becoming pregnant. In a multivariable model that adjusted for Hispanic ethnicity, current age, and live birth after cancer, participants who experienced a miscarriage after cancer were more likely to have moderate to high concerns about becoming pregnant in the future (adjusted OR 4.1, 95% CI 1.05-15.5, p=0.042) compared to participants with no history of miscarriage. Neither adverse pregnancy outcomes was associated with concerns about offspring or personal health. Conclusions In the cohort of young adult female leukemia and lymphoma survivors, experiencing a miscarriage after cancer was associated with higher concerns regarding becoming pregnant in the future. Additional research is needed to determine whether interventions such as preconception counseling with consideration of prior cancer treatments may help manage these concerns and improve pregnancy outcomes. Disclosures No relevant conflicts of interest to declare.

scholarly journals ASSOCIATION OF SEROPOSITIVITY FOR CMV IGM AND IGG WITH ADVERSE PREGNANCY OUTCOME

2021 ◽  
Vol 71 (3) ◽  
pp. 831-35
Author(s):  
Ambreen Amna ◽  
Farkhunda Nadeem ◽  
Amin Fahim ◽  
Altaf Hussian Jatoi ◽  
Kanwal Abbas ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Adverse Pregnancy Outcome ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
University Hospital ◽  
Igg Antibodies ◽  
Cross Sectional ◽  
History Of ◽  
Adverse Pregnancy ◽  
Reproductive Age Group

Objective: To find out the prevalence of antibodies against cytomegalovirus and their association with adverse pregnancy outcome in women, at Isra University Hospital Hyderabad. Study Design: Cross-sectional study. Place and Duration of Study: Department of Gynaecology & Obstetrics, Isra University Hospital (IUH) Hyderabad, from Jan to Jun 2018. Methodology: Cytomegalovirus IgM and IgG antibodies in 305 women of reproductive age group were measured using the Enzyme Linked Fluorescent Assaysystem kit. Results: The combined positivity of anti cytomegalovirus IgG and IgM antibodies was 93 (30.40%). About 37 (37.37%) and 28 (34.14%) women were found to be seropositive for cytomegalovirus antibodies who had history of spontaneous miscarriage and recurrent miscarriages respectively. Conclusion: Higher association of seropositivity for cytomegalovirus IgM and IgG with bad obstetrical history and low economy was found.

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