PRIMARY NONFAMILIAL HEMOLYTIC ANEMIA

Abstract In our experience, in half of the cases of primary hemolytic anemia in which there is no family history of anemia, jaundice or splenomegaly, examination of the blood disclosed microspherocytic erythrocytes and increased fragility of erythrocytes. The results of splenectomy in these cases are better than in those in which microspherocytosis is absent. True macrocytosis was observed in only one instance. Females predominated in both groups of cases. Agglutinins and hemolysins have not appeared to play any significant role in the production of the hemolytic syndrome in our cases. We do not feel justified in expressing an opinion as to whether the microspherocytosis indicates a familial or congenital blood disorder. From a practical standpoint, it makes no great difference since splenectomy should be considered seriously in any case of chronic primary hemolytic anemia. It may be of value in some cases of secondary or symptomatic hemolytic anemia.

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Screening for thalassaemia among group of students of a higher institution – our experience

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v10i1.692 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Norlelawati AT ◽

Siti Hadijah M ◽

Siti Nor Haiza H ◽

Rusmawati I ◽

Salman MS ◽

...

Keyword(s):

Family History ◽

Molecular Study ◽

Full Blood Count ◽

Blood Samples ◽

Blood Disorder ◽

Higher Institution ◽

Haemoglobin Disorders ◽

Thalassaemia Trait ◽

History Of ◽

Alpha Thalassaemia

Introduction: Thalassaemia is an inherited blood disorder and is a significant public health alarm in Malaysia with many not knowing they are carriers of this haemoglobin disorders. Materials and methods: This study conducted a one off collection of blood samples from 72 Malays students of International Islamic University Malaysia (IIUM) in Kuantan. Blood samples were subjected to conventional haemoglobin analyses that include full blood count and picture, HPLC, Haemoglobin electrophoresis and H-inclusion test. All samples were also genotyped for alpha thalassaemia–1 of Southeast Asia (a-Thal1SEA). Result: There were 17(23.6%) students who were diagnosed as thalassaemia carriers. Out of this, four (5.5 %) and six (8.3 %) students were presumptive β-thalassaemia trait and Haemoglobin-E trait as determined by the HPLC assay respectively. Nine (12.5%) students were genotyped a-Thal1SEA among whom two were also β-thalassaemia carriers. All thalassaemia cases had MCH of < 27pg. Nonetheless, two out of six Haemoglobin-E trait and three out of nine a-Thal1SEA carrier had MCV value of >80fL. Two out of four (50%) presumptive β -thalassaemia trait and one out of six (17%) students of presumptive Haemoglobin-E trait had family history of thalassaemia respectively. Conclusion: The high occurrence of the three common types of thalassaemia carrier (β, Hb-E and a-Thal1SEA thalassaemia) in our small group of subjects could be due to better participation of students who had family history of thalassaemia. The study reaffirmed the importance of molecular study for detection of alpha-thalassaemia and the use of MCH value of <27pg rather than MCV value of < 80fL for prediction of thalassaemia.

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Relation of the Leu40Arg variant of glycoprotein IIIA to personal and family history of myocardial infarction

Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences ◽

10.2478/v10046-009-0025-6 ◽

2009 ◽

Vol 63 (3) ◽

pp. 100-103

Author(s):

Normunds Līcis ◽

Gustavs Latkovskis ◽

Baiba Krivmane ◽

Milāna Zabunova ◽

Marina Berzina ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Heart Disease ◽

Heart Disease ◽

Family History ◽

Significant Role ◽

Fibrinogen Receptor ◽

Glycoprotein Iiia ◽

History Of

Relation of the Leu40Arg variant of glycoprotein IIIA to personal and family history of myocardial infarction GPIIb/IIIa fibrinogen receptor is a key element of the thrombotic pathway. In this study, we investigated the possible relation of PlA1/A2 polymorphism (1565T>C; Leu33Pro) and a rare 1586T>G (Leu40Arg) variation of GPIIIa gene to personal and family history of myocardial infarction (MI) among 601 patients with angiographically confirmed coronary heart disease. Four hundred and fifteen patients had MI and 94 of individuals reported family history of premature MI. The Arg40 (1586G) variant (n = 4) was present exclusively in MI-patients and significantly correlated with a family history of premature MI (P = 0.013), whereas the Pro33 (1565C; PlA2) allele (n = 204) was similarly prevalent among different groups of patients. These data indicate the importance of the Arg40 variant but do not support a significant role of Pro33 allele in susceptibility to MI.

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Studying Genealogy as a Factor of Cultural Self-Identification of the Person

Discourse ◽

10.32603/2412-8562-2020-6-1-62-71 ◽

2020 ◽

Vol 6 (1) ◽

pp. 62-71

Author(s):

M. E. Kudryavtseva

Keyword(s):

Family History ◽

Cultural Identity ◽

Significant Role ◽

Social Role ◽

Protective Mechanisms ◽

Self Identity ◽

History Of ◽

Internet Study ◽

Cultural Self ◽

The Stability

Introduction. The paper considers the problem of cultural identity influenced by the study of ancestry. The scientific novelty of this paper is due to the attention to the psychological aspects of self-identity under the influence of the study of person, her or his ancestry, and, above all, in a situation of detection of undesirable information about his or her family's past. It is hypothesized that motifs associated with the need to rethink its social role in terms of responsibility for the acts of their ancestors, do not play a significant role in the study of family history.Methodology and sources. The paper analyzes the results of the pilot Internet study conducted to determine the motives and methods of the study of person's ancestry, as well as the stability of interest in this activity. The target audience of this study were all who are interested in learning their ancestors, regardless of age or occupational category. The questionnaire used was semi-closed. A total of 154 people were interviewed.Results and discussion. The results showed that 46.8 % of respondents interest in their ancestry has a playful nature; 37.0 % desire through your family history to better understand the history of their country; 33.0 % of respondents are interested in their ancestry in order to better understand the reasons for their behavior (which is a necessary component of self identification); 32.0 % would like to find ancestors, who could be proud of. Nevertheless, in the case of unsolicited information about the life of their ancestors, are ready to make conclusions about his or her own life less than four percent of the respondents.Conclusion. The author believes that the paper put forward the hypothesis that motifs associated with the need to rethink its social role in terms of responsibility for the acts of their ancestors, do not play a significant role in the study of family history is confirmed by the results of the study. In case of detection of unwanted results, mainly protective mechanisms are becoming actual, ensuring the preservation of psychological comfort.

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Language Onset and Concomitant Speech and Language Problems in Subgroups of Stutterers and Their Siblings

Journal of Speech Language and Hearing Research ◽

10.1044/jshr.2504.482 ◽

1982 ◽

Vol 25 (4) ◽

pp. 482-486 ◽

Cited By ~ 12

Author(s):

Robin A. Seider ◽

Keith L. Gladstien ◽

Kenneth K. Kidd

Keyword(s):

Family History ◽

Same Sex ◽

Speech And Language ◽

Negative Family History ◽

Late Talkers ◽

Language Problems ◽

History Of ◽

Language Onset

Time of language onset and frequencies of speech and language problems were examined in stutterers and their nonstuttering siblings. These families were grouped according to six characteristics of the index stutterer: sex, recovery or persistence of stuttering, and positive or negative family history of stuttering. Stutterers and their nonstuttering same-sex siblings were found to be distributed identically in early, average, and late categories of language onset. Comparisons of six subgroups of stutterers and their respective nonstuttering siblings showed no significant differences in the number of their reported articulation problems. Stutterers who were reported to be late talkers did not differ from their nonstuttering siblings in the frequency of their articulation problems, but these two groups had significantly higher frequencies of articulation problems than did stutterers who were early or average talkers and their siblings.

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