scholarly journals Effect of corticosteroid therapy on the phagocytosis of antibody-coated platelets by human leukocytes

Blood ◽  
1978 ◽  
Vol 51 (5) ◽  
pp. 771-779 ◽  
Author(s):  
RI Handin ◽  
TP Stossel
Keyword(s):  
Platelet Count ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Corticosteroid Therapy ◽  
Direct Evidence ◽  
Corticosteroid Treatment ◽  
Phagocytic Cells ◽  
Oil Droplets ◽  
Thrombocytopenic Purpura ◽  
Medical Disorders ◽  
Paraffin Oil

Abstract Patients with idiopathic thrombocytopenic purpura (ITP), a disorder in which antibody coated platelets are cleared from the circulation by phagocytic cells, are often treated with glucocorticoids. The effect of corticosteroids on the recognition and ingestion of sensitized platelets by phagocytes can be quantified in these patients and compared to changes in platelet levels. Six patients with ITP were treated with 96 mg daily of methylprednisolone for 5 days. This treatment raised their platelet count and simultaneously decreased the ability of their granulocytes to phagocytize antibody-coated platelets and C3-coated paraffin oil droplets. Corticosteroid treatment did not affect the binding of antibody to platelets or the quantity of antibody in the patients' serum. The ingestion defect was present in isolated, washed leukocytes and persisted for 3–5 days after the corticosteroids were discontinued. Granulocytes and purified monocytes obtained from patients with other medical disorders receiving corticosteroids also ingested paraffin oil droplets and opsonized platelets at a slower rate. These studies provide direct evidence that corticosteroids induce a generalized phagocytic defect and that this may be the mechanism by which corticosteroids raise the platelet count in patients with ITP.

scholarly journals Effect of corticosteroid therapy on the phagocytosis of antibody-coated platelets by human leukocytes

Blood ◽  
1978 ◽  
Vol 51 (5) ◽  
pp. 771-779
Author(s):  
RI Handin ◽  
TP Stossel
Keyword(s):  
Platelet Count ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Corticosteroid Therapy ◽  
Direct Evidence ◽  
Corticosteroid Treatment ◽  
Phagocytic Cells ◽  
Oil Droplets ◽  
Thrombocytopenic Purpura ◽  
Medical Disorders ◽  
Paraffin Oil

Patients with idiopathic thrombocytopenic purpura (ITP), a disorder in which antibody coated platelets are cleared from the circulation by phagocytic cells, are often treated with glucocorticoids. The effect of corticosteroids on the recognition and ingestion of sensitized platelets by phagocytes can be quantified in these patients and compared to changes in platelet levels. Six patients with ITP were treated with 96 mg daily of methylprednisolone for 5 days. This treatment raised their platelet count and simultaneously decreased the ability of their granulocytes to phagocytize antibody-coated platelets and C3-coated paraffin oil droplets. Corticosteroid treatment did not affect the binding of antibody to platelets or the quantity of antibody in the patients' serum. The ingestion defect was present in isolated, washed leukocytes and persisted for 3–5 days after the corticosteroids were discontinued. Granulocytes and purified monocytes obtained from patients with other medical disorders receiving corticosteroids also ingested paraffin oil droplets and opsonized platelets at a slower rate. These studies provide direct evidence that corticosteroids induce a generalized phagocytic defect and that this may be the mechanism by which corticosteroids raise the platelet count in patients with ITP.

scholarly journals Postinfluenza Vaccination Idiopathic Thrombocytopenic Purpura in Three Elderly Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Joji Nagasaki ◽  
Masahiro Manabe ◽  
Kentaro Ido ◽  
Hiroyoshi Ichihara ◽  
Yasutaka Aoyama ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Platelet Count ◽  
Autoimmune Disease ◽  
Elderly Patients ◽  
Laboratory Test ◽  
Influenza Vaccination ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Corticosteroid Treatment ◽  
Thrombocytopenic Purpura ◽  
Influenza Vaccinations

The etiologies of secondary idiopathic thrombocytopenic purpura (ITP) include infection, autoimmune disease, and immunodeficiency. We report the cases of three elderly patients who developed ITP after receiving influenza vaccinations. The platelet count of an 81-year-old woman fell to 27,000/μL after she received an influenza vaccination. A 75-year-old woman developed thrombocytopenia (5,000 platelets/μL) after receiving an influenza vaccination. An 87-year-old woman whose laboratory test values included a platelet count of 2,000/μL experienced genital bleeding after receiving an influenza vaccination. AfterHelicobacter pylori(HP) eradication or corticosteroid treatment, all of the patients’ platelet counts increased. Influenza vaccination is an underlying etiology of ITP in elderly patients. HP eradication or corticosteroid treatment is effective for these patients. Clinicians should be aware of the association between ITP and influenza vaccinations.

Platelet kinetic study in patients with idiopathic thrombocytopenic purpura (ITP) refractory or relapsing after corticosteroid treatment

2002 ◽  
Vol 3 (3) ◽  
pp. 148-152 ◽  
Author(s):  
Giuseppe Rossi ◽  
Chiara Cattaneo ◽  
Maddalena Motta ◽  
Claudio Pizzocaro ◽  
Sabina Lanzi ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Corticosteroid Treatment ◽  
Thrombocytopenic Purpura

Use of high-altitude climate in therapy of childrenwith idiopathic thrombocytopenic purpura in Kyrgyz Republic

2018 ◽  
Author(s):  
С.М. Маматов ◽  
А.К. Эсенгелди ◽  
А.А. Махмануров
Keyword(s):  
Platelet Count ◽  
High Altitude ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Disease Duration ◽  
Hematological Parameters ◽  
Kyrgyz Republic ◽  
Duration Of Treatment ◽  
Thrombocytopenic Purpura ◽  
Hypoxia Exposure ◽  
The Subject

Введение. Вопрос о дальнейшем совершенствовании базисной терапии идиопатической тромбоцитопенической пурпуры (ИТП) по-прежнему широко обсуждается специалистами и является предметом оживленных дискуссий. Цель исследования: изучить динамику геморрагического синдрома и количества тромбоцитов у детей с ИТП в процессе высокогорной климатотерапии и оценить эффективность воздействия высокогорной гипоксии на течение болезни. Материалы и методы. В исследование включено 24 ребенка с хронической ИТП в возрасте от 5 до 14 лет (средний возраст — 10,25 ± 1,43 года) с длительностью заболевания от 4 до 8 лет. Для лечения детей поднимали на высокогорную базу Туя-Ашу (перевал Туя-Ашу, 3200 м над уровнем моря). Продолжительность лечения в высокогорье составляла 40 дней. Результаты. К концу срока пребывания в горах значительно уменьшались проявления геморрагического синдрома, полностью купировался анемический синдром, количество тромбоцитов достоверно увеличивалось с минимума 22,1 × 109/л до максимума 108,4 × 109/л. Заключение. Из 22 детей, получивших высокогорную климатотерапию, у 2 детей достигнута полная и у 15 — частичная ремиссия. У 4 детей улучшение клинико-гематологических показателей носило временный характер, и отсутствие эффекта зарегистрировано у 1 ребенка. Ремиссия достигнута у 77% больных детей. Introduction. Further improvement of the basic therapy of idiopathic thrombocytopenic purpura (ITP) is still widely discussedby specialists and is the subject of lively discussions. Aim: to study the dynamics of hemorrhagic syndrome and platelet count in children with ITP in the process of high-altitude climatotherapy and assess the eff ectiveness of high-altitude hypoxia exposure on the course of the disease. Materials and methods. The study included 24 children with chronic ITP aged 5 to 14 years (mean age — 10.25 ± 1.43 years) with disease duration from 4 to 8 years. For treatment children were raised to Tuya-Ashu high-altitude base (mountain pass Tuya Ashu, 3200 m above sea level). The duration of treatment in highlands was 40 days. Results. By the end of the treatment, the manifestations of hemorrhagic syndrome decreased signifi cantly, the anemic syndrome completely stopped, the platelet count increased significantly from minimum of 22.1 × 109/L to maximum of 108.4 × 109/L. Conclusion. High-altitude climatotherapy received 22 children, 2 children had complete remission and 15 — part remission. In 4 children the improvement of clinical and hematological parameters was temporal, and the absence of eff ect was registered in 1 child. Remission was achieved in 77% of ill children.

Clinical Study of TJ-137 Tsumura Kami-kihi-to in Patients with Idiopathic Thrombocytopenic Purpura (ITP)

1996 ◽  
Vol 2 (3) ◽  
pp. 213-218
Author(s):  
Nobuo Sakuragawa ◽  
Kojiro Yasunaga ◽  
Takeo Nomura ◽  
Junichi Akatsuka ◽  
Atsushi Kuramoto ◽  
...  
Keyword(s):  
Platelet Count ◽  
Clinical Study ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Thrombocytopenic Purpura ◽  
New Drug ◽  
Chronic Itp ◽  
Low Incidence

TJ-137 administered to patients with chronic ITP increased the platelet count "slightly" or more in 31.7% of the patients and showed a clinical effect in 40.9% with a rating of "modestly effective" or better. With a low incidence of adverse reactions, TJ-137 is ex pected to be a new drug for the treatment of ITP.

scholarly journals Autoimmune Hepatitis with Concomitant Idiopathic Thrombocytopenic Purpura Diagnosed by Transjugular Liver Biopsy

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Hiromi Fukuda ◽  
Kazuhide Takata ◽  
Takanori Kitaguchi ◽  
Ryo Yamauchi ◽  
Hideo Kunimoto ◽  
...  
Keyword(s):  
Platelet Count ◽  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Histological Examination ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Liver Dysfunction ◽  
Severe Thrombocytopenia ◽  
Percutaneous Liver Biopsy ◽  
Thrombocytopenic Purpura ◽  
Transjugular Liver Biopsy

Patients with autoimmune hepatitis (AIH) may sometimes have concomitant idiopathic thrombocytopenic purpura (ITP). Severe thrombocytopenia in ITP interferes with percutaneous liver biopsy for pathological diagnosis of AIH. Here, we report a case of AIH with ITP in a 63-year-old woman. The patient presented to our hospital with liver dysfunction and thrombocytopenia. For histological examination, transjugular liver biopsy (TJLB) was performed, leading to a diagnosis of AIH. Corticosteroids treatment led to an improvement in her liver enzyme levels and platelet count. In conclusion, patients with AIH may sometimes have concomitant ITP. TJLB was effective for making the diagnosis of AIH with severe thrombocytopenia due to ITP.

Central Serous Chorioretinopathy Complicating Systemic Corticosteroid Therapy

1997 ◽  
Vol 7 (3) ◽  
pp. 297-300 ◽  
Author(s):  
A.M. Abu El-Asrar
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Corticosteroid Therapy ◽  
Central Serous Chorioretinopathy ◽  
Systemic Corticosteroid ◽  
Spontaneous Recovery ◽  
Systemic Treatment ◽  
Steroid Treatment ◽  
Thrombocytopenic Purpura ◽  
Present Evidence ◽  
Systemic Corticosteroid Therapy

Purpose. To present evidence that systemic corticosteroid therapy may cause central serous chorioretinopathy. Methods. A 20-year-old male with idiopathic thrombocytopenic purpura was examined during systemic treatment with corticosteroids (100 mg daily). Results. The patient had central serous chorioretinopathy. Spontaneous recovery accompanied discontinuation of the steroid treatment. Conclusions. This case provides further evidence that Cortisol may play a role in the development of central serous chorioretinopathy.

scholarly journals Immunocytochemical Studies on Platelets. The Demonstration of a Common Antigen in Human Platelets and Megakaryocytes

Blood ◽  
1960 ◽  
Vol 16 (1) ◽  
pp. 968-974 ◽  
Author(s):  
JACINTO J. VAZQUEZ ◽  
JESSICA H. LEWIS
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Direct Evidence ◽  
Fluorescent Antibody ◽  
Human Platelets ◽  
Antigenic Structure ◽  
Common Antigen ◽  
Thrombocytopenic Purpura ◽  
Morphologic Study ◽  
Idiopathic Thrombocytopenia ◽  
Immunocytochemical Studies

Abstract By means of the fluorescent antibody technic of Coons and Kaplan it was possible to demonstrate a common antigenic structure in human platelets and megakaryocytes, both in nonthrombocytopenic cases and in cases with idiopathic thrombocytopenic purpura. Direct evidence for a marked increase in the number of platelets in the spleens of two cases of idiopathic thrombocytopenia is given. The pathogenetic significance of this finding is discussed. It is concluded that the fluorescent antibody technic is a valuable tool for the chemical and morphologic study of platelets and megakaryocytes both in tissues and smears.

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