The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study

Abstract The rarity of atherosclerotic vascular disease and a mild bruising tendency in Greenland Eskimos has been linked to their ingestion of omega 3 fatty acids contained in foods obtained from the sea. Previous studies have shown that feeding salmon oil to normal volunteers resulted in reductions of plasma cholesterol and triglycerides. We wished to learn whether salmon oil feeding would result in the incorporation of omega 3 fatty acids into platelets and whether platelet function or platelet-vessel interaction would be altered. Diets containing salmon oils led to the incorporation of eicosapentaenoic acid (C20:5 omega 3) into platelets (6.1%) with a reduction in arachidonic acid (C20:4 omega 6). The ratio of C20:5/C20:4 increased from 0.0045 on the control diet to 0.3 on the salmon diet. Bleeding times were prolonged (from 6.75 to 10 min, p less than 0.005), platelet retention on glass beads was mildly reduced (from 89% to 78%, p less than 0.0005), and platelet aggregation in response to dilute concentrations of ADP was inhibited in the subjects ingesting the salmon oil. We conclude that in normal subjects dietary omega 2 fatty acids derived from salmon oil are incorporated into platelet phospholipids and that these changes are accompanied by alterations in bleeding time and platelet function.

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The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study

Blood ◽

10.1182/blood.v58.5.880.bloodjournal585880 ◽

1981 ◽

Vol 58 (5) ◽

pp. 880-885 ◽

Cited By ~ 7

Author(s):

SH Jr Goodnight ◽

WS Harris ◽

WE Connor

Keyword(s):

Fatty Acids ◽

Platelet Function ◽

Plasma Cholesterol ◽

Control Diet ◽

Normal Subjects ◽

Controlled Study ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Atherosclerotic Vascular Disease ◽

And Function

The rarity of atherosclerotic vascular disease and a mild bruising tendency in Greenland Eskimos has been linked to their ingestion of omega 3 fatty acids contained in foods obtained from the sea. Previous studies have shown that feeding salmon oil to normal volunteers resulted in reductions of plasma cholesterol and triglycerides. We wished to learn whether salmon oil feeding would result in the incorporation of omega 3 fatty acids into platelets and whether platelet function or platelet-vessel interaction would be altered. Diets containing salmon oils led to the incorporation of eicosapentaenoic acid (C20:5 omega 3) into platelets (6.1%) with a reduction in arachidonic acid (C20:4 omega 6). The ratio of C20:5/C20:4 increased from 0.0045 on the control diet to 0.3 on the salmon diet. Bleeding times were prolonged (from 6.75 to 10 min, p less than 0.005), platelet retention on glass beads was mildly reduced (from 89% to 78%, p less than 0.0005), and platelet aggregation in response to dilute concentrations of ADP was inhibited in the subjects ingesting the salmon oil. We conclude that in normal subjects dietary omega 2 fatty acids derived from salmon oil are incorporated into platelet phospholipids and that these changes are accompanied by alterations in bleeding time and platelet function.

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Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study

Journal of Toxicology and Environmental Health Part A ◽

10.1080/15287394.2016.1157539 ◽

2016 ◽

Vol 79 (6) ◽

pp. 287-298 ◽

Cited By ~ 5

Author(s):

Adan Z. Becerra ◽

Steve Georas ◽

J. Thomas Brenna ◽

Philip K. Hopke ◽

Cathleen Kane ◽

...

Keyword(s):

Fatty Acids ◽

Air Pollution ◽

Particulate Matter ◽

Platelet Function ◽

Panel Study ◽

Effect Modification ◽

Omega 3 Fatty Acids ◽

Ambient Particulate Matter ◽

Omega 3 ◽

Acute Changes

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Effects of a high-fat-diet supplemented with probiotics and ω3-fatty acids on appetite regulatory neuropeptides and neurotransmitters in a pig model

Beneficial Microbes ◽

10.3920/bm2019.0197 ◽

2020 ◽

Vol 11 (4) ◽

pp. 347-359

Author(s):

D. Valent ◽

L. Arroyo ◽

E. Fàbrega ◽

M. Font-i-Furnols ◽

M. Rodríguez-Palmero ◽

...

Keyword(s):

Fatty Acids ◽

Animal Model ◽

Weight Gain ◽

Food Intake ◽

High Fat Diet ◽

Control Diet ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

High Fat ◽

Brain Functions

The pig is a valuable animal model to study obesity in humans due to the physiological similarity between humans and pigs in terms of digestive and associated metabolic processes. The dietary use of vegetal protein, probiotics and omega-3 fatty acids is recommended to control weight gain and to fight obesity-associated metabolic disorders. Likewise, there are recent reports on their beneficial effects on brain functions. The hypothalamus is the central part of the brain that regulates food intake by means of the production of food intake-regulatory hypothalamic neuropeptides, as neuropeptide Y (NPY), orexin A and pro-opiomelanocortin (POMC), and neurotransmitters, such as dopamine and serotonin. Other mesolimbic areas, such as the hippocampus, are also involved in the control of food intake. In this study, the effect of a high fat diet (HFD) alone or supplemented with these additives on brain neuropeptides and neurotransmitters was assessed in forty-three young pigs fed for 10 weeks with a control diet (T1), a high fat diet (HFD, T2), and HFD with vegetal protein supplemented with Bifidobacterium breve CECT8242 alone (T3) or in combination with omega-3 fatty acids (T4). A HFD provoked changes in regulatory neuropeptides and 3,4-dihydroxyphenylacetic acid (DOPAC) in the hypothalamus and alterations mostly in the dopaminergic system in the ventral hippocampus. Supplementation of the HFD with B. breve CECT8242, especially in combination with omega-3 fatty acids, was able to partially reverse the effects of HFD. Correlations between productive and neurochemical parameters supported these findings. These results confirm that pigs are an appropriate animal model alternative to rodents for the study of the effects of HFD on weight gain and obesity. Furthermore, they indicate the potential benefits of probiotics and omega-3 fatty acids on brain function.

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Omega-3 fatty acids and quality of life in psoriasis: an open, randomised controlled study

Our Dermatology Online ◽

10.7241/ourd.20191.3 ◽

2019 ◽

Vol 10 (1) ◽

pp. 12-16

Author(s):

Mohammad Adil

Keyword(s):

Quality Of Life ◽

Fatty Acids ◽

Controlled Study ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Randomised Controlled Study ◽

Randomised Controlled

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The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial

Global Journal of Health Science ◽

10.5539/gjhs.v8n7p18 ◽

2015 ◽

Vol 8 (7) ◽

pp. 18 ◽

Cited By ~ 26

Author(s):

Elham Rajaei ◽

Karim Mowla ◽

Ali Ghorbani ◽

Sara Bahadoram ◽

Mohammad Bahadoram ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Fatty Acids ◽

Disease Activity ◽

Active Rheumatoid Arthritis ◽

Controlled Study ◽

Unknown Etiology ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Weight Changes ◽

Double Blind

BACKGROUND: Rheumatoid arthritis is a symmetric peripheral polyarthritis of unknown etiology that, untreated or if unresponsive the therapy, typically leads to deformity and destruction of joints due to erosion of cartilage and bone. Omega-3 fatty acids have been shown to reduce morning stiffness, the number of tender joints and swollen joints in patients with rheumatoid arthritis. This study is designed for evaluation of omega-3 effects on disease activity and remission of rheumatoid arthritis in DMARDs treated patients and on weight changes and reduction of analgesic drugs consumption versus placebo.METHODS: Sixty patients with active rheumatoid arthritis (49 female and 11 male) underwent rheumatologist examination and disease activity score were calculated. Then patients were enrolled in this 12 week, double blind, randomized, placebo- controlled study. The patients in both groups continued their pre study standard treatment. The patients were visited every 4 weeks, 4 times and data were recorded.RESULTS: Significant improvement in the patient's global evaluation and in the physician's assessment of disease was observed in those taking omega-3. The proportions of patients who improved and of those who were able to reduce their concomitant analgesic medication were significantly greater with omega-3 consumption. There were no weight changes.CONCLUSION: Daily supplementation with omega-3 results has significant clinical benefit and may reduce the need for concomitant analgesic consumption without weight changes.

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