scholarly journals Increases in ambient particulate matter air pollution, acute changes in platelet function, and effect modification by aspirin and omega-3 fatty acids: A panel study

2016 ◽  
Vol 79 (6) ◽  
pp. 287-298 ◽  
Author(s):  
Adan Z. Becerra ◽  
Steve Georas ◽  
J. Thomas Brenna ◽  
Philip K. Hopke ◽  
Cathleen Kane ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Air Pollution ◽  
Particulate Matter ◽  
Platelet Function ◽  
Panel Study ◽  
Effect Modification ◽  
Omega 3 Fatty Acids ◽  
Ambient Particulate Matter ◽  
Omega 3 ◽  
Acute Changes

Ambient Particulate Air Pollution and Adverse Changes in Fibrinogen: Effect Modification by Omega-3 (n-3) Fatty Acids and Vitamin-D

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
David Q. Rich* ◽  
Daniel Croft ◽  
Scott J Cameron ◽  
Craig Morrell ◽  
Charles J Lowenstein ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Vitamin D ◽  
Air Pollution ◽  
Effect Modification ◽  
Omega 3 ◽  
Particulate Air Pollution

scholarly journals The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study

Blood ◽  
1981 ◽  
Vol 58 (5) ◽  
pp. 880-885 ◽  
Author(s):  
SH Jr Goodnight ◽  
WS Harris ◽  
WE Connor
Keyword(s):  
Fatty Acids ◽  
Platelet Function ◽  
Plasma Cholesterol ◽  
Control Diet ◽  
Normal Subjects ◽  
Controlled Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Atherosclerotic Vascular Disease ◽  
And Function

The rarity of atherosclerotic vascular disease and a mild bruising tendency in Greenland Eskimos has been linked to their ingestion of omega 3 fatty acids contained in foods obtained from the sea. Previous studies have shown that feeding salmon oil to normal volunteers resulted in reductions of plasma cholesterol and triglycerides. We wished to learn whether salmon oil feeding would result in the incorporation of omega 3 fatty acids into platelets and whether platelet function or platelet-vessel interaction would be altered. Diets containing salmon oils led to the incorporation of eicosapentaenoic acid (C20:5 omega 3) into platelets (6.1%) with a reduction in arachidonic acid (C20:4 omega 6). The ratio of C20:5/C20:4 increased from 0.0045 on the control diet to 0.3 on the salmon diet. Bleeding times were prolonged (from 6.75 to 10 min, p less than 0.005), platelet retention on glass beads was mildly reduced (from 89% to 78%, p less than 0.0005), and platelet aggregation in response to dilute concentrations of ADP was inhibited in the subjects ingesting the salmon oil. We conclude that in normal subjects dietary omega 2 fatty acids derived from salmon oil are incorporated into platelet phospholipids and that these changes are accompanied by alterations in bleeding time and platelet function.

scholarly journals The effects of dietary omega 3 fatty acids on platelet composition and function in man: a prospective, controlled study

Blood ◽  
1981 ◽  
Vol 58 (5) ◽  
pp. 880-885 ◽  
Author(s):  
SH Jr Goodnight ◽  
WS Harris ◽  
WE Connor
Keyword(s):  
Fatty Acids ◽  
Platelet Function ◽  
Plasma Cholesterol ◽  
Control Diet ◽  
Normal Subjects ◽  
Controlled Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Atherosclerotic Vascular Disease ◽  
And Function

Abstract The rarity of atherosclerotic vascular disease and a mild bruising tendency in Greenland Eskimos has been linked to their ingestion of omega 3 fatty acids contained in foods obtained from the sea. Previous studies have shown that feeding salmon oil to normal volunteers resulted in reductions of plasma cholesterol and triglycerides. We wished to learn whether salmon oil feeding would result in the incorporation of omega 3 fatty acids into platelets and whether platelet function or platelet-vessel interaction would be altered. Diets containing salmon oils led to the incorporation of eicosapentaenoic acid (C20:5 omega 3) into platelets (6.1%) with a reduction in arachidonic acid (C20:4 omega 6). The ratio of C20:5/C20:4 increased from 0.0045 on the control diet to 0.3 on the salmon diet. Bleeding times were prolonged (from 6.75 to 10 min, p less than 0.005), platelet retention on glass beads was mildly reduced (from 89% to 78%, p less than 0.0005), and platelet aggregation in response to dilute concentrations of ADP was inhibited in the subjects ingesting the salmon oil. We conclude that in normal subjects dietary omega 2 fatty acids derived from salmon oil are incorporated into platelet phospholipids and that these changes are accompanied by alterations in bleeding time and platelet function.

scholarly journals Cord Blood Methylmercury and Fetal Growth Outcomes in Baltimore Newborns: Potential Confounding and Effect Modification by Omega-3 Fatty Acids, Selenium, and Sex

2016 ◽  
Vol 124 (3) ◽  
pp. 373-379 ◽  
Author(s):  
Ellen M. Wells ◽  
Julie B. Herbstman ◽  
Yu Hong Lin ◽  
Jeffery Jarrett ◽  
Carl P. Verdon ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cord Blood ◽  
Fetal Growth ◽  
Effect Modification ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Growth Outcomes

Omega-3-fatty acids improve in vivo and in vitro platelet function

1994 ◽  
Vol 109 (1-2) ◽  
pp. 322
Author(s):  
C. Pirich ◽  
A. Gaszo ◽  
D. Horrobin ◽  
S. Granegger ◽  
H. Sinzinger
Keyword(s):  
Fatty Acids ◽  
Platelet Function ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals The Effects of Ambient Air Pollution on Mitochondrial Respiration in Circulating Platelets: The Role of Omega-3 Fatty Acids

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 473-473
Author(s):  
Wan Shen ◽  
Hao Chen ◽  
James Samet ◽  
Haiyan Tong
Keyword(s):  
Fatty Acids ◽  
Air Pollution ◽  
Mitochondrial Respiration ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Respiratory Parameters ◽  
Mitochondrial Respiratory

Abstract Objectives Circulating platelets act as “fast responders” to endothelial damages. Dietary long-chain polyunsaturated omega-3 fatty acids have been shown to ameliorate cardiovascular function decrement after exposure to air pollution. This project aimed to explore the role of omega-3 fatty acids in mitochondrial respiratory function in circulating platelets exposed to ambient air pollution. Methods Platelets were isolated from healthy male adult volunteers (n = 20) from the Research Triangle Area (RTP), NC and measured for mitochondrial respiratory rates using an extracellular flux analyzer (Seahorse Mitochondrial Stress Test). Omega-3 indices were measured in total blood by OmegaQuant LLC. Local ambient air pollution data were obtained from the ambient air quality monitoring stations. Results Oxygen consumption rates corresponding to maximum mitochondrial respiration and spare respiration capacity were correlated with PM2.5 levels (r = 0.56 and r = 0.57 respectively, all P < 0.05). Additionally, moderation analysis revealed that the associations between these respiratory parameters and PM2.5 levels were contingent upon the levels of omega-3 indices (all P < 0.05). Specifically, the Johnson-Neyman method indicated that for omega-3 indices of 5.11 or higher, the two associations reached statistically significant: levels of PM2.5 were positively correlated with the two respiratory parameters. Conclusions Taken together, these preliminary findings suggest that exposure to PM2.5 increases platelet mitochondrial respiration and that this effect is potentiated by omega-3 fatty acids. Funding Sources This project was supported by the U.S. EPA Intramural Research Program.

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