Residual amounts of glycoprotein Ib concomitant with near-absence of glycoprotein IX in platelets of Bernard-Soulier patients
Keyword(s):
A study of the Bernard-Soulier syndrome in two unrelated families using different polyclonal antibodies in a sensitive immunoblot assay showed residual amounts of platelet membrane glycoprotein (GP) lb in the eight homozygotes, as well as the near-absence of GPlb beta and GPIX. The eight heterozygotes studied showed a double band pattern for GPlb and about half the normal level of GPlb beta and GPIX. Therefore, we conclude that the Bernard-Soulier syndrome is heterogeneous and is probably not due to gene deletions.
1999 ◽
Vol 81
(02)
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pp. 316-317
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1991 ◽
Vol 625
(1 Molecular and)
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pp. 835-836
2010 ◽
Vol 104
(11)
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pp. 894-902
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1985 ◽
Vol 82
(21)
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pp. 7424-7428
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1992 ◽
Vol 114
(6)
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pp. 1853-1857
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1992 ◽
Vol 18
(02)
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pp. 261-266
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