scholarly journals Single-cell heterogeneity in Sézary syndrome

2018 ◽  
Vol 2 (16) ◽  
pp. 2115-2126 ◽  
Author(s):  
Terkild Brink Buus ◽  
Andreas Willerslev-Olsen ◽  
Simon Fredholm ◽  
Edda Blümel ◽  
Claudia Nastasi ◽  
...  
Keyword(s):  
Single Cell ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cell Heterogeneity ◽  
Key Points ◽  
Precision Therapy

Key Points Individual patients with Sézary syndrome contain several distinct malignant subpopulations and show marked single-cell heterogeneity. Malignant subpopulations exhibit differences in their sensitivity to treatment warranting precision therapy.

scholarly journals 070 Comprehensive single-cell analysis of Sézary syndrome reveals novel expression and therapeutic biomarkers

2021 ◽  
Vol 141 (5) ◽  
pp. S12
Author(s):  
N. Borcherding ◽  
N. Henderson ◽  
L. Ortolan ◽  
V. Liu ◽  
B. Link ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cell Analysis

scholarly journals Lack of durable disease control with chemotherapy for mycosis fungoides and Sézary syndrome: a comparative study of systemic therapy

Blood ◽  
2015 ◽  
Vol 125 (1) ◽  
pp. 71-81 ◽  
Author(s):  
Charlotte F. M. Hughes ◽  
Amit Khot ◽  
Christopher McCormack ◽  
Stephen Lade ◽  
David A. Westerman ◽  
...  
Keyword(s):  
Comparative Study ◽  
Disease Control ◽  
Median Time ◽  
Mycosis Fungoides ◽  
Systemic Therapy ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Key Points

Key Points Chemotherapy results in a short median time to next treatment in patients with mycosis fungoides/Sézary syndrome. α-interferon achieves a superior time to next treatment compared with chemotherapy, regardless of stage.

scholarly journals Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML

Blood ◽  
2017 ◽  
Vol 129 (17) ◽  
pp. 2384-2394 ◽  
Author(s):  
Rebecca Warfvinge ◽  
Linda Geironson ◽  
Mikael N. E. Sommarin ◽  
Stefan Lang ◽  
Christine Karlsson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cell ◽  
Single Cell ◽  
Gene Expression Analysis ◽  
Therapy Response ◽  
Cell Heterogeneity ◽  
Key Points ◽  
Cell Gene Expression ◽  
Cell Subpopulations ◽  
Cell Gene

Key Points Single-cell gene expression analysis reveals CML stem cell heterogeneity and changes imposed by TKI therapy. A subpopulation with primitive, quiescent signature and increased survival to therapy can be high-purity captured as CD45RA−cKIT−CD26+.

From single-cell signature to prognostic factors: the case of Sézary syndrome

2012 ◽  
Vol 8 (8) ◽  
pp. 699-701 ◽  
Author(s):  
Enrico Scala ◽  
Maria Grazia Narducci ◽  
Giandomenico Russo
Keyword(s):  
Prognostic Factors ◽  
Single Cell ◽  
Sézary Syndrome ◽  
Sezary Syndrome

scholarly journals Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome

Blood ◽  
2016 ◽  
Vol 127 (26) ◽  
pp. 3387-3397 ◽  
Author(s):  
Wesley J. Woollard ◽  
Venu Pullabhatla ◽  
Anna Lorenc ◽  
Varsha M. Patel ◽  
Rosie M. Butler ◽  
...  
Keyword(s):  
Dna Repair ◽  
High Frequency ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Dna Repair Genes ◽  
Genome Maintenance ◽  
Driver Genes ◽  
T Cell Lymphomas ◽  
Key Points ◽  
Repair Genes

Key Points Aberrations in genome maintenance and DNA repair genes including POT1 occur at a high frequency in Sézary syndrome. Candidate driver genes and affected pathways in Sézary syndrome show extensive heterogeneity but overlap with other mature T-cell lymphomas.

scholarly journals Single-cell trajectories in Sézary syndrome

Blood ◽  
2021 ◽  
Vol 138 (16) ◽  
pp. 1384-1386
Author(s):  
Audrey Gros ◽  
Jean-Philippe Merlio
Keyword(s):  
Single Cell ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cell Trajectories

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

Blood ◽  
2013 ◽  
Vol 122 (10) ◽  
pp. 1802-1812 ◽  
Author(s):  
Shen Dong ◽  
Sylvie Maiella ◽  
Aliénor Xhaard ◽  
Yuanyu Pang ◽  
Lynn Wenandy ◽  
...  
Keyword(s):  
Single Cell ◽  
Graft Versus Host Disease ◽  
Cell Populations ◽  
Cell Heterogeneity ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points ◽  
Lineage Reprogramming ◽  
Single Cell Profiling ◽  
Acute Graft

Key Points Single-cell heterogeneity, rather than lineage reprogramming, explains the remarkable complexity and functional diversity of human Tregs. Altered homeostasis of Treg subpopulations in patients developing acute graft-versus-host disease.

scholarly journals Comprehensive analysis of PTEN status in Sézary syndrome

Blood ◽  
2013 ◽  
Vol 122 (20) ◽  
pp. 3511-3520 ◽  
Author(s):  
Cristina Cristofoletti ◽  
Maria Cristina Picchio ◽  
Cristina Lazzeri ◽  
Valeria Tocco ◽  
Elena Pagani ◽  
...  
Keyword(s):  
Comprehensive Analysis ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Gene Deletions ◽  
Key Points ◽  
Sézary Cells

Key Points PTEN is downregulated in Sézary syndrome by different mechanisms, mostly by gene deletions and microRNAs. PTEN deficiency activates AKT in skin resident but not circulating Sezary cells.

scholarly journals Phase 1/2 study of mogamulizumab, a defucosylated anti-CCR4 antibody, in previously treated patients with cutaneous T-cell lymphoma

Blood ◽  
2015 ◽  
Vol 125 (12) ◽  
pp. 1883-1889 ◽  
Author(s):  
Madeleine Duvic ◽  
Lauren C. Pinter-Brown ◽  
Francine M. Foss ◽  
Lubomir Sokol ◽  
Jeffrey L. Jorgensen ◽  
...  
Keyword(s):  
Overall Response Rate ◽  
Response Rate ◽  
Cell Lymphoma ◽  
Phase 1 ◽  
Sézary Syndrome ◽  
Sezary Syndrome ◽  
Cutaneous T Cell Lymphoma ◽  
Key Points ◽  
Previously Treated Patients ◽  
Previously Treated

Key Points Mogamulizumab was well-tolerated in 41 patients with previously treated mycosis fungoides or Sézary syndrome. Durable responses observed with a global overall response rate of 36.8%; patients with Sézary syndrome had a response rate of 47.1%.

Mycosis fungoides? Sezary syndrome

1970 ◽  
Vol 101 (2) ◽  
pp. 244-246 ◽  
Author(s):  
H. H. Roenigk
Keyword(s):  
Mycosis Fungoides ◽  
Sézary Syndrome ◽  
Sezary Syndrome
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