scholarly journals A European Respiratory Society technical standard: exhaled biomarkers in lung disease

2017 ◽  
Vol 49 (4) ◽  
pp. 1600965 ◽  
Author(s):  
Ildiko Horváth ◽  
Peter J. Barnes ◽  
Stelios Loukides ◽  
Peter J. Sterk ◽  
Marieann Högman ◽  
...  
Keyword(s):  
Task Force ◽  
Exhaled Breath Condensate ◽  
Research Priorities ◽  
Disease Diagnosis ◽  
Future Research ◽  
Exhaled Breath ◽  
Sample Collection ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Breath Tests

Breath tests cover the fraction of nitric oxide in expired gas (FENO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FENO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FENO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

scholarly journals Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020)

2020 ◽  
Vol 29 (157) ◽  
pp. 200287 ◽  
Author(s):  
Chunxue Bai ◽  
Sanjay H. Chotirmall ◽  
Jordi Rello ◽  
George A. Alba ◽  
Leo C. Ginns ◽  
...  
Keyword(s):  
Hospital Care ◽  
Task Force ◽  
Research Priorities ◽  
Venous Thromboembolic Event ◽  
Future Research ◽  
Post Traumatic Stress ◽  
European Respiratory Society ◽  
Management Options ◽  
Venous Thromboembolic ◽  
Post Traumatic

BackgroundCoronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome-coronavirus-2. Consensus suggestions can standardise care, thereby improving outcomes and facilitating future research.MethodsAn International Task Force was composed and agreement regarding courses of action was measured using the Convergence of Opinion on Recommendations and Evidence (CORE) process. 70% agreement was necessary to make a consensus suggestion.ResultsThe Task Force made consensus suggestions to treat patients with acute COVID-19 pneumonia with remdesivir and dexamethasone but suggested against hydroxychloroquine except in the context of a clinical trial; these are revisions of prior suggestions resulting from the interim publication of several randomised trials. It also suggested that COVID-19 patients with a venous thromboembolic event be treated with therapeutic anticoagulant therapy for 3 months. The Task Force was unable to reach sufficient agreement to yield consensus suggestions for the post-hospital care of COVID-19 survivors. The Task Force fell one vote shy of suggesting routine screening for depression, anxiety and post-traumatic stress disorder.ConclusionsThe Task Force addressed questions related to pharmacotherapy in patients with COVID-19 and the post-hospital care of survivors, yielding several consensus suggestions. Management options for which there is insufficient agreement to formulate a suggestion represent research priorities.

scholarly journals Exhaled Breath Condensate: A Promising Source for Biomarkers of Lung Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Yan Liang ◽  
Samantha M. Yeligar ◽  
Lou Ann S. Brown
Keyword(s):  
Lung Diseases ◽  
Exhaled Breath Condensate ◽  
Analytical Techniques ◽  
Exhaled Breath ◽  
Sample Collection ◽  
Low Concentrations ◽  
Reduced And Oxidized Glutathione ◽  
Promising Source ◽  
Breath Condensate ◽  
Arachidonic Acid Derivatives

Exhaled breath condensate (EBC) has been increasingly studied as a noninvasive research method for sampling the alveolar and airway space and is recognized as a promising source of biomarkers of lung diseases. Substances measured in EBC include oxidative stress and inflammatory mediators, such as arachidonic acid derivatives, reactive oxygen/nitrogen species, reduced and oxidized glutathione, and inflammatory cytokines. Although EBC has great potential as a source of biomarkers in many lung diseases, the low concentrations of compounds within the EBC present challenges in sample collection and analysis. Although EBC is viewed as a noninvasive method for sampling airway lining fluid (ALF), validation is necessary to confirm that EBC truly represents the ALF. Likewise, a dilution factor for the EBC is needed in order to compare across subjects and determine changes in the ALF. The aims of this paper are to address the characteristics of EBC; strategies to standardize EBC sample collection and review available analytical techniques for EBC analysis.

scholarly journals Technical standards for respiratory oscillometry

2019 ◽  
Vol 55 (2) ◽  
pp. 1900753 ◽  
Author(s):  
Gregory G. King ◽  
Jason Bates ◽  
Kenneth I. Berger ◽  
Peter Calverley ◽  
Pedro L. de Melo ◽  
...  
Keyword(s):  
Quality Control ◽  
Signal Processing ◽  
Task Force ◽  
Forced Oscillation Technique ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Support Threshold ◽  
Adults And Children ◽  
Control Procedures ◽  
Testing Protocols

Oscillometry (also known as the forced oscillation technique) measures the mechanical properties of the respiratory system (upper and intrathoracic airways, lung tissue and chest wall) during quiet tidal breathing, by the application of an oscillating pressure signal (input or forcing signal), most commonly at the mouth. With increased clinical and research use, it is critical that all technical details of the hardware design, signal processing and analyses, and testing protocols are transparent and clearly reported to allow standardisation, comparison and replication of clinical and research studies. Because of this need, an update of the 2003 European Respiratory Society (ERS) technical standards document was produced by an ERS task force of experts who are active in clinical oscillometry research.The aim of the task force was to provide technical recommendations regarding oscillometry measurement including hardware, software, testing protocols and quality control.The main changes in this update, compared with the 2003 ERS task force document are 1) new quality control procedures which reflect use of “within-breath” analysis, and methods of handling artefacts; 2) recommendation to disclose signal processing, quality control, artefact handling and breathing protocols (e.g. number and duration of acquisitions) in reports and publications to allow comparability and replication between devices and laboratories; 3) a summary review of new data to support threshold values for bronchodilator and bronchial challenge tests; and 4) updated list of predicted impedance values in adults and children.

scholarly journals An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features

2015 ◽  
Vol 46 (4) ◽  
pp. 976-987 ◽  
Author(s):  
Aryeh Fischer ◽  
Katerina M. Antoniou ◽  
Kevin K. Brown ◽  
Jacques Cadranel ◽  
Tamera J. Corte ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Interstitial Pneumonia ◽  
Connective Tissue Disease ◽  
Task Force ◽  
American Thoracic Society ◽  
Classification Criteria ◽  
Future Research ◽  
Autoimmune Process ◽  
European Respiratory Society ◽  
Society Research

Many patients with an idiopathic interstitial pneumonia (IIP) have clinical features that suggest an underlying autoimmune process but do not meet established criteria for a connective tissue disease (CTD). Researchers have proposed differing criteria and terms to describe these patients, and lack of consensus over nomenclature and classification limits the ability to conduct prospective studies of a uniform cohort.The “European Respiratory Society/American Thoracic Society Task Force on Undifferentiated Forms of Connective Tissue Disease-associated Interstitial Lung Disease” was formed to create consensus regarding the nomenclature and classification criteria for patients with IIP and features of autoimmunity.The task force proposes the term “interstitial pneumonia with autoimmune features” (IPAF) and offers classification criteria organised around the presence of a combination of features from three domains: a clinical domain consisting of specific extra-thoracic features, a serologic domain consisting of specific autoantibodies, and a morphologic domain consisting of specific chest imaging, histopathologic or pulmonary physiologic features.A designation of IPAF should be used to identify individuals with IIP and features suggestive of, but not definitive for, a CTD. With IPAF, a sound platform has been provided from which to launch the requisite future research investigations of a more uniform cohort.

Standardization of spirometry: what’s new in 2019 update (Part 2)

2020 ◽  
Vol 1 (14) ◽  
pp. 10-18
Author(s):  
L. D. Kiryukhina ◽  
P. V. Struchkov
Keyword(s):  
Task Force ◽  
Test Session ◽  
American Thoracic Society ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Joint Task ◽  
Joint Task Force ◽  
International Joint ◽  
New Research

Improvements in equipment, new research studies and enhanced quality assurance approaches have led to the need to update the 2005 technical standards for spirometry. The article presents the main updates, developed by an international joint task force by the American Thoracic Society and the European Respiratory Society in 2019. The characteristics of acceptability, usability, and repeatability, criteria grading the quality of the test session, the choice of main reported values are described.

COVID-19: Internationale Kooperation für standardisierte Therapieempfehlungen und Forschungsprioritäten

2020 ◽  
pp. 1-3
Author(s):  
Johannes Knoch
Keyword(s):  
Hospital Care ◽  
Task Force ◽  
Research Priorities ◽  
Venous Thromboembolic Event ◽  
Future Research ◽  
Post Traumatic Stress ◽  
Management Options ◽  
Internationale Kooperation ◽  
Venous Thromboembolic ◽  
Post Traumatic

<b>Background:</b> Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome-coronavirus-2. Consensus suggestions can standardise care, thereby improving outcomes and facilitating future research. <b>Methods:</b> An International Task Force was composed and agreement regarding courses of action was measured using the Convergence of Opinion on Recommendations and Evidence (CORE) process. 70% agreement was necessary to make a consensus suggestion. <b>Results:</b> The Task Force made consensus suggestions to treat patients with acute COVID-19 pneumonia with remdesivir and dexamethasone but suggested against hydroxychloroquine except in the context of a clinical trial; these are revisions of prior suggestions resulting from the interim publication of several randomised trials. It also suggested that COVID-19 patients with a venous thromboembolic event be treated with therapeutic anticoagulant therapy for 3 months. The Task Force was unable to reach sufficient agreement to yield consensus suggestions for the post-hospital care of COVID-19 survivors. The Task Force fell one vote shy of suggesting routine screening for depression, anxiety and post-traumatic stress disorder. <b>Conclusions:</b> The Task Force addressed questions related to pharmacotherapy in patients with COVID-19 and the post-hospital care of survivors, yielding several consensus suggestions. Management options for which there is insufficient agreement to formulate a suggestion represent research priorities.

scholarly journals A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

2018 ◽  
Author(s):  
Marcin Muża ◽  
Lucyna Konieczna ◽  
Tomasz Bączek
Keyword(s):  
Exhaled Breath Condensate ◽  
Meta Analysis ◽  
Exhaled Breath ◽  
Sample Collection ◽  
Non Invasive ◽  
Interest In Research ◽  
Biomarker Evaluation ◽  
Analytical Approaches ◽  
Breath Condensate ◽  
Widespread Interest

Exhaled breath condensate (EBC) sample analysis is an entirely non-invasive novel sample collection method that is fast, easy to perform, and effort-appeared independent. EBC samples can be very useful in identifying the biomarkers of many diseases. This review provides an updated overview of EBC pH disturbances in different disorders as well as physiological levels among healthy individuals since 2012. Our meta-analysis addresses some of the key questions related to sample processing before pH measurement and discusses various methods of condensate standardization that can be employed prior to conducting a pH assay. Given the recent widespread interest in research into the use of EBC to identify biomarkers, it is necessary to establish a pathway leading from analytical methods for biomarker evaluation using EBC pH to clinical applications of this technology. This review fills a gap in the literature and attempts to connect theory to practical analytical approaches to analyzing EBC samples and making critical treatment-related decisions next to the patient's bed.

scholarly journals The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Ishaq Lat ◽  
◽  
Craig M. Coopersmith ◽  
Daniel De Backer ◽  
Craig M. Coopersmith
Keyword(s):  
Fluid Resuscitation ◽  
Literature Search ◽  
Task Force ◽  
Data Extraction ◽  
Research Priorities ◽  
Future Research ◽  
Vasopressor Therapy ◽  
Surviving Sepsis Campaign ◽  
Data Synthesis ◽  
Study Selection

Abstract Objective To expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Data Sources Original paper and literature search. Study Selection Several members of the original task force with expertise specific to the area of fluid resuscitation and vasopressor therapy. Data Extraction None. Data Synthesis None. Conclusion In the second of a series of manuscripts subsequent to the original paper, members with expertise in the subjects expound upon the three identified priorities related to fluid resuscitation and vasopressor therapies. This analysis summarizes what is known and what were identified as ongoing and future research.

scholarly journals The OMERACT Ultrasound Task Force — Advances and Priorities

2009 ◽  
Vol 36 (8) ◽  
pp. 1829-1832 ◽  
Author(s):  
MARIA-ANTONIETTA D’AGOSTINO ◽  
PHILIP G. CONAGHAN ◽  
ESPERANZA NAREDO ◽  
PHILIPPE AEGERTER ◽  
ANNAMARIA IAGNOCCO ◽  
...  
Keyword(s):  
Scoring System ◽  
Research Agenda ◽  
Task Force ◽  
Interobserver Reliability ◽  
Research Priorities ◽  
Added Value ◽  
Future Research ◽  
Future Research Agenda ◽  
Further Development ◽  
Deep Target

This article reports the most recent work of the OMERACT Ultrasound Task Force (post OMERACT 8) and highlights of future research priorities discussed at the OMERACT 9 meeting, Kananaskis, Canada, May 2008. Results of 3 studies were presented: (1) assessing intermachine reliability; (2) applying the scoring system developed in the hand to other joints most commonly affected in rheumatoid arthritis (RA); and (3) assessing interobserver reliability on a deep target joint (shoulder). Results demonstrated good intermachine reliability between multiple examiners, and good applicability of the scoring system for the hand on other joints (including shoulder). Study conclusions were discussed and a future research agenda was generated, notably the further development of a Global OMERACT Sonography Scoring (GLOSS) system in RA, emphasizing the importance of testing feasibility and added value over standard clinical variables. Future disease areas of importance to develop include a scoring system for enthesitis and osteoarthritis.

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