The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis

In bronchiectasis, exacerbations are believed to be triggered by infectious agents, but often no pathogen can be identified. We hypothesised that acute air pollution exposure may be associated with bronchiectasis exacerbations.We combined a case-crossover design with distributed lag models in an observational record linkage study. Patients were recruited from a specialist bronchiectasis clinic at Ninewells Hospital, Dundee, UK.We recruited 432 patients with clinically confirmed bronchiectasis, as diagnosed by high-resolution computed tomography. After excluding days with missing air pollution data, the final model for particles with a 50% cut-off aerodynamic diameter of 10 µm (PM10) was based on 6741 exacerbations from 430 patients and for nitrogen dioxide (NO2) it included 6248 exacerbations from 426 patients. For each 10 µg·m−³ increase in PM10 and NO2, the risk of having an exacerbation that same day increased significantly by 4.5% (95% CI 0.9–8.3) and 3.2% (95% CI 0.7–5.8) respectively. The overall (lag zero to four) increase in risk of exacerbation for a 10 μg·m−3 increase in air pollutant concentration was 11.2% (95% CI 6.0–16.8) for PM10 and 4.7% (95% CI 0.1–9.5) for NO2. Subanalysis showed higher relative risks during spring (PM10 1.198 (95% CI 1.102–1.303), NO2 1.146 (95% CI 1.035–1.268)) and summer (PM10 2.142 (95% CI 1.785–2.570), NO2 1.352 (95% CI 1.140–1.602)) when outdoor air pollution exposure would be expected to be highest.In conclusion, acute air pollution fluctuations are associated with increased exacerbation risk in bronchiectasis.

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Effects of Short-Term Air Pollution Exposure on Venous Thromboembolism: A Case-Crossover Study

Annals of the American Thoracic Society ◽

10.1513/annalsats.202010-1337oc ◽

2021 ◽

Author(s):

Stacy A Johnson ◽

Daniel Mendoza ◽

Yue Zhang ◽

Cheryl S Pirozzi

Keyword(s):

Air Pollution ◽

Venous Thromboembolism ◽

Crossover Study ◽

Short Term ◽

Case Crossover ◽

Air Pollution Exposure ◽

Pollution Exposure

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The impact of air exchange rate on ambient air pollution exposure and inequalities across all residential parcels in Massachusetts

Journal of Exposure Science & Environmental Epidemiology ◽

10.1038/s41370-018-0068-3 ◽

2018 ◽

Vol 29 (4) ◽

pp. 520-530 ◽

Cited By ~ 2

Author(s):

Anna Rosofsky ◽

Jonathan I. Levy ◽

Michael S. Breen ◽

Antonella Zanobetti ◽

M. Patricia Fabian

Keyword(s):

Air Pollution ◽

Exchange Rate ◽

Ambient Air ◽

Ambient Air Pollution ◽

Air Exchange Rate ◽

Air Pollution Exposure ◽

Pollution Exposure ◽

The Impact ◽

Air Exchange

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Air pollution and the development of asthma from birth until young adulthood

European Respiratory Journal ◽

10.1183/13993003.00147-2020 ◽

2020 ◽

Vol 56 (1) ◽

pp. 2000147 ◽

Cited By ~ 5

Author(s):

Ulrike Gehring ◽

Alet H. Wijga ◽

Gerard H. Koppelman ◽

Judith M. Vonk ◽

Henriette A. Smit ◽

...

Keyword(s):

Air Pollution ◽

Particulate Matter ◽

Early Adulthood ◽

Childhood And Adolescence ◽

Asthma Incidence ◽

Mite Allergy ◽

Increased Risk ◽

Air Pollution Exposure ◽

Pollution Exposure ◽

The Impact

BackgroundAir pollution is associated with asthma development in children and adults, but the impact on asthma development during the transition from adolescence to adulthood is unclear. Adult studies lack historical exposures and consequently cannot assess the relevance of exposure during different periods of life. We assessed the relevance of early-life and more recent air pollution exposure for asthma development from birth until early adulthood.MethodsWe used data of 3687 participants of the prospective Dutch PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort and linked asthma incidence until age 20 years to estimated concentrations of nitrogen dioxide (NO2), particulate matter with a diameter <2.5 μm (PM2.5), <10 μm (PM10), and 2.5–10 μm, and PM2.5 absorbance (“soot”) at the residential address. We assessed overall and age-specific associations with air pollution exposure with discrete time-hazard models, adjusting for potential confounders.ResultsOverall, we found higher incidence of asthma until the age of 20 years with higher exposure to all pollutants at the birth address (adjusted odds ratio (95% CI) ranging from 1.09 (1.01–1.18) for PM10 to 1.20 (1.10–1.32) for NO2) per interquartile range increase) that were rather persistent with age. Similar associations were observed with more recent exposure defined as exposure at the current home address. In two-pollutant models with particulate matter, associations with NO2 persisted.ConclusionsExposure to air pollution, especially from motorised traffic, early in life may have long-term consequences for asthma development, as it is associated with an increased risk of developing asthma through childhood and adolescence into early adulthood.

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The short term burden of ambient gaseous air pollution on chronic obstructive pulmonary disease in Pudong New Area, China: A time-stratified case-crossover study with a distributed lag nonlinear model

10.21203/rs.3.rs-109352/v1 ◽

2020 ◽

Author(s):

Yichen Chen ◽

Xiaopan Li ◽

Hanyi Chen ◽

Lianghong Sun ◽

Tao Lin ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Air Pollution ◽

Air Pollutants ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Distributed Lag ◽

Case Crossover ◽

Distributed Lag Nonlinear Model ◽

Pudong New Area ◽

The Impact

Abstract Background: Air pollution is a severe and dangerous public health problem. However, the effect of ambient gaseous air pollution exposure on years of life lost (YLL) attributable to chronic obstructive pulmonary disease (COPD) mortality has not been quantitatively verified.Methods: We collected the data of 12,781 COPD deaths and ambient gaseous air pollutants, including sulfur dioxide (SO2), nitrogen dioxide (NO2), Carbon monoxide (CO), and ozone (O3), during the years 2013-2019 in the Shanghai Pudong New Area (PNA). Then we performed a time-stratified case-crossover study combined with a distributed lag nonlinear model (DLNM) to estimate the impact of those air pollutants on daily COPD deaths counts and YLL. The confounders including long-term trend and meteorological factors have been controlled for, and effects of age and educational attainment as effect modifiers have also been evaluated.Results: During the 2013-2019 time frame, increases of 10μg/m3 in SO2 and NO2 were associated with a 4.93% (95% CI: 1.47%, 8.50%) and 1.47% (95% CI: 0.14%, 2.82%) in daily COPD death counts at lag0-1day, respectively, a 2.52 (95% CI: 0.31, 4.72) YLL increase and 0.85 (95% CI: 0.01, 1.68) YLL increase at lag0-1day, respectively. A 1mg/m3 increase in CO was associated with a 9.46% (95% CI: 0.40%, 19.35%) at lag0 increase in daily COPD death counts. No significant impact from O3 on both daily COPD deaths counts and YLL (P>0.05). The impact of gaseous air pollutants on the daily COPD death count and YLL were significant in populations of older adults and the lower educated population, while an insignificant effect was observed in the younger population and higher educated population. The YLL due to COPD related to SO2 and CO for the lower educated population was significantly higher than those for the higher educated population.Conclusion: Reducing specific gaseous air pollutants will help to control COPD deaths and improve the population’s life expectancy.

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Exposure to outdoor air pollution and its human-related health outcomes: an evidence gap map

BMJ Open ◽

10.1136/bmjopen-2019-031312 ◽

2019 ◽

Vol 9 (12) ◽

pp. e031312 ◽

Cited By ~ 1

Author(s):

Zhuanlan Sun ◽

Demi Zhu

Keyword(s):

Air Pollution ◽

Health Outcomes ◽

Future Research ◽

Outdoor Air ◽

Eligibility Criteria ◽

Study Region ◽

Outdoor Air Pollution ◽

Air Pollution Exposure ◽

Pollution Exposure ◽

The Impact

ObjectivesOutdoor air pollution is a serious environmental problem worldwide. Current systematic reviews (SRs) and meta-analyses (MAs) mostly focused on some specific health outcomes or some specific air pollution.DesignThis evidence gap map (EGM) is to identify existing gaps from SRs and MAs and report them in broad topic areas.Data sourcesPubMed, Cochrane, Scopus and Web of Science were searched from their inception until June 2018. Citations and reference lists were traced.Eligibility criteriaSRs and MAs that investigated the impact of outdoor air pollution on human health outcomes were collected. This study excluded original articles and qualitative review articles.Data extraction and synthesisCharacteristics of the included SRs and MAs were extracted and summarised. Extracted data included authors, publication year, location of the corresponding author(s), publication journal discipline, study design, study duration, sample size, study region, target population, types of air pollution and health outcomes.ResultsAsia and North America published 93% of SRs and MAs included in this EGM. 31% of the SRs and MAs (27/86) included primary studies conducted in 5–10 countries. Their publication trends have increased during the last 10 years. A total of 2864 primary studies was included. The median number of included primary studies was 20 (range, 7–167). Cohort studies, case cross-over studies and time-series studies were the top three most used study designs. The mostly researched population was the group of all ages (46/86, 53%). Cardiovascular diseases, respiratory diseases and health service records were mostly reported. A lack of definite diagnostic criteria, unclear reporting of air pollution exposure and time period of primary studies were the main research gaps.ConclusionsThis EGM provided a visual overview of health outcomes affected by outdoor air pollution exposure. Future research should focus on chronic diseases, cancer and mental disorders.

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Respiratory Effects of Particulate Matter Exposure During Short-Term Cycling Among Healthy Adults in Three Chinese Cities

10.21203/rs.3.rs-134774/v1 ◽

2020 ◽

Author(s):

Lejian He ◽

Laijun Zhao ◽

Yonghong Liu ◽

Zhaowen Qiu ◽

H. Oliver Gao

Keyword(s):

Air Pollution ◽

Particulate Matter ◽

Lung Function ◽

Fine Particles ◽

Aerodynamic Diameter ◽

Short Term ◽

Respiratory Effects ◽

Air Pollution Exposure ◽

Pollution Exposure ◽

The Impact

Abstract Background: Cycling to work has been promoted as a green commute in many countries because of its reduced congestion relative to that of cars and its reduced environmental impact on air pollution. However, cyclists might be exposed to higher air pollution, causing adverse health effects. Few studies have examined the respiratory effects of traffic-related air pollution exposure during short-term cycling, especially in developing countries with heavy air pollution. The aim of this study was to assess the impact of air pollution exposure on lung function while cycling in traffic. Methods: Twenty-five healthy adults in total cycled on a specified route in each of three Chinese cities during four periods of a day. Lung function measures were collected immediately before and after cycling. Real-time particulate matter (PM) and the particle number count (PNC) for particles with different sizes were measured along each cycling route, while ambient sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), and carbon monoxide (CO) levels were measured at the nearest stations. Mixed-effect models were used to estimate the impact of short-term air pollution exposure on participants’ lung function measures during cycling. Results: We found that an interquartile increase in particulate matter consisting of fine particles (PM1, aerodynamic diameter £ 1 mm; and PM2.5, aerodynamic diameter £ 2.5 mm) was associated with a significant decrease in forced vital capacity (FVC) (PM1, –5.61%, p = 0.021; PM2.5, –5.57%, p = 0.022). Interquartile increases in the 99th percentile of PNC for fine particles (aerodynamic diameter 0.3–0.4 mm) also had significant negative associations with FVC (0.3 mm, –5.13%, p = 0.041; 0.35 mm, –4.81%, p = 0.045; 0.4 mm, –4.59%, p = 0.035). We also observed significant inverse relationships between ambient CO levels and FVC (–5.78%, p = 0.015).Conclusions: Our results suggest that short-term exposure to fine particles and CO while cycling in traffic contributes to a reduction in FVC of cyclists.

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