The influence by body mass index on annual lung function decline is not related to smoking status

AbstractBile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute to lung pathophysiology. We also test the therapeutic potential of nitro-oleic acid (NO2-OA), a regulator of metabolic and inflammatory signaling pathways, to mitigate allergen and obesity-induced lung function decline in a murine model of asthma. Bile acids were measured in the plasma of healthy subjects and individuals with asthma and serum and lung tissue of mice with and without allergic airway disease (AAD). Lung function, indices of inflammation and hepatic bile acid enzyme expression were measured in obese mice with house dust mite-induced AAD treated with vehicle or NO2-OA. Serum levels of glycocholic acid and glycoursodeoxycholic acid clinically correlate with body mass index and airway hyperreactivity whereas murine levels of β-muricholic acid and tauro-β-muricholic acid were significantly increased and positively correlated with impaired lung function in obese mice with AAD. NO2-OA reduced murine bile acid levels by modulating hepatic expression of bile acid synthesis enzymes, with a concomitant reduction in small airway resistance and tissue elastance. Bile acids correlate to body mass index and lung function decline and the signaling actions of nitroalkenes can limit AAD by modulating bile acid metabolism, revealing a potential pharmacologic approach to improving the current standard of care.

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Gender Modifies the Effect of Body Mass Index on Lung Function Decline in Mild-to-Moderate COPD Patients: A Pooled Analysis

10.21203/rs.3.rs-45333/v2 ◽

2021 ◽

Author(s):

Wenjia Chen ◽

Mohsen Sadatsafavi ◽

J Mark FitzGerald ◽

Larry Lynd ◽

Don Sin

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Smoking Status ◽

Pooled Analysis ◽

Forced Expiratory Volume ◽

Rapid Decline ◽

Chronic Obstructive ◽

Lung Function Decline ◽

Copd Patients ◽

Male Patients

Abstract Background: Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship. Methods: We pooled data of 8,686 COPD patients from 7 studies with a median length of 36-months of follow up. Using a longitudinal natural cubic spline regression model, we examined the dose-response relationship between body mass index (BMI) and the rate of decline in forced expiratory volume in one second (FEV1) in patients with GOLD 1 and 2 disease, stratified by gender and adjusted for age, smoking status, and cohort effects. Results: There was an inverse linear relationship between BMI and the rate of FEV1 decline in GOLD Grades 1 and 2, which was modified by gender (p<0.001). In male patients, an increase of BMI by 1 kg/m2 reduced FEV1 decline by 1.05mL/year (95% CI: 0.96, 1.14). However, in female patients, BMI status did not have a clinically meaningful impact on FEV1 decline: an increase of baseline BMI by 1 kg/m2 reduced FEV1 decline by 0.16 ml/year (95% CI: 0.11, 0.21). These gender-modified relationships were similar between GOLD 1 and 2 patients, and between current and former smokers. Conclusion: In mild to moderate COPD, higher BMI was associated with a less rapid decline of FEV1 in male patients whereas this association was minimal in females patients. This gender-specific BMI effect was independent of COPD severity and smoking status.

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Gender Modifies the Effect of Body Mass Index on Lung Function Decline in Mild-to-Moderate COPD Patients: A Pooled Analysis

10.21203/rs.3.rs-45333/v1 ◽

2020 ◽

Author(s):

Wenjia Chen ◽

Mohsen Sadatsafavi ◽

J Mark FitzGerald ◽

Larry Lynd ◽

Don Sin

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Smoking Status ◽

Pooled Analysis ◽

Forced Expiratory Volume ◽

Rapid Decline ◽

Chronic Obstructive ◽

Lung Function Decline ◽

Copd Patients ◽

Male Patients

Abstract Background: Body weight is a poor prognostic risk factor in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship.Methods: We pooled data of 8,686 COPD patients from 7 studies. Using a longitudinal natural cubic spline regression model, we examined the dose-response relationship between body mass index (BMI) and the rate of decline in forced expiratory volume in one second (FEV1) in patients with GOLD 1 and 2 disease, stratified by gender and adjusted for smoking status and cohort effects. Results: There was an inverse, nearly relationship between BMI and the rate of FEV1 decline in GOLD Grades 1 and 2, which was modified by gender (p<0.001). In male patients, an increase of BMI by 1 kg/m2 reduced FEV1 decline by 1.05mL/year (95% CI: 0.96, 1.14). However, in female patients, BMI status barely clinically affected FEV1 decline: an increase of baseline BMI by 1 kg/m2 reduced FEV1 decline by 0.16 ml/year (95% CI: 0.11, 0.21). These gender-modified relationships were generally similar between GOLD 1 and 2 patients, and between current smokers and former smokers.Conclusion: In mild to moderate COPD, higher BMI was associated with a less rapid decline of FEV1 in male patients whereas it hardly affected females patients. This gender-specific BMI effect was independent of COPD severity and smoking status.

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Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study

Thorax ◽

10.1136/thoraxjnl-2019-213880 ◽

2020 ◽

Vol 75 (4) ◽

pp. 313-320 ◽

Cited By ~ 3

Author(s):

Gabriela P Peralta ◽

Alessandro Marcon ◽

Anne-Elie Carsin ◽

Michael J Abramson ◽

Simone Accordini ◽

...

Keyword(s):

Body Mass Index ◽

Weight Gain ◽

Lung Function ◽

Body Mass ◽

Weight Change ◽

High Weight ◽

Overweight And Obesity ◽

Lung Function Decline ◽

High Weight Gain

BackgroundPrevious studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS).MethodsWe included 3673 participants recruited at age 20–44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991–93, 1999–2003, 2010–14) until they were 39–67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations.ResultsIn individuals with normal BMI, overweight and obesity at baseline, moderate (0.25–1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had −1011 mL (95% CI −1.259 to −763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<−0.25 kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline.ConclusionModerate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.

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Body mass index, weight gain, and other determinants of lung function decline in adult asthma

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2009.01.040 ◽

2009 ◽

Vol 123 (5) ◽

pp. 1069-1074.e4 ◽

Cited By ~ 27

Author(s):

Alessandro Marcon ◽

Angelo Corsico ◽

Lucia Cazzoletti ◽

Massimiliano Bugiani ◽

Simone Accordini ◽

...

Keyword(s):

Body Mass Index ◽

Weight Gain ◽

Lung Function ◽

Body Mass ◽

Lung Function Decline ◽

Adult Asthma ◽

Index Weight

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The Effect Of Body Mass Index On The Relationship Between Reduced Air Pollution And Lung Function Decline

10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5423 ◽

2011 ◽

Author(s):

Tamara Schikowski ◽

Emmanuel Schaffner ◽

Harish Phuleria ◽

Andrea Vierkoetter ◽

Christian Schindler ◽

...

Keyword(s):

Body Mass Index ◽

Air Pollution ◽

Lung Function ◽

Body Mass ◽

Lung Function Decline ◽

The Relationship

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Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis

Respiratory Research ◽

10.1186/s12931-021-01656-5 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Wenjia Chen ◽

Mohsen Sadatsafavi ◽

J. Mark FitzGerald ◽

Larry D. Lynd ◽

Don D. Sin

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Smoking Status ◽

Pooled Analysis ◽

Forced Expiratory Volume ◽

Rapid Decline ◽

Chronic Obstructive ◽

Lung Function Decline ◽

Copd Patients ◽

Male Patients

Abstract Background Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship. Methods We pooled data of 8686 COPD patients from 7 studies with a median length of 36-months of follow up. Using a longitudinal natural cubic spline regression model, we examined the dose–response relationship between body mass index (BMI) and the rate of decline in forced expiratory volume in one second (FEV1) in patients with GOLD 1 and 2 disease, stratified by gender and adjusted for age, smoking status, and cohort effects. Results There was an inverse linear relationship between BMI and the rate of FEV1 decline in GOLD Grades 1 and 2, which was modified by gender (p < 0.001). In male patients, an increase of BMI by 1 kg/m2 reduced FEV1 decline by 1.05 mL/year (95% CI 0.96, 1.14). However, in female patients, BMI status did not have a clinically meaningful impact on FEV1 decline: an increase of baseline BMI by 1 kg/m2 reduced FEV1 decline by 0.16 ml/year (95% CI 0.11, 0.21). These gender-modified relationships were similar between GOLD 1 and 2 patients, and between current and former smokers. Conclusion In mild to moderate COPD, higher BMI was associated with a less rapid decline of FEV1 in male patients whereas this association was minimal in females patients. This gender-specific BMI effect was independent of COPD severity and smoking status.

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Infant Body Mass Index Trajectories, and Asthma & Lung Function

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2021.02.020 ◽

2021 ◽

Author(s):

Gulshan Bano Ali ◽

Dinh Son Bui ◽

Caroline Jane Lodge ◽

Nilakshi T. Waidyatillake ◽

Jennifer L. Perret ◽

...

Keyword(s):

Body Mass Index ◽

Lung Function ◽

Body Mass ◽

Body Mass Index Trajectories

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The Association Between Obstructive Sleep Apnea and Cotton-Wool Spots in Nonproliferative Diabetic Retinopathy

Journal of VitreoRetinal Diseases ◽

10.1177/2474126421989576 ◽

2021 ◽

pp. 247412642198957

Author(s):

Halward M.J. Blegen ◽

Grant A. Justin ◽

Bradley A. Bishop ◽

Anthony R. Cox ◽

James K. Aden ◽

...

Keyword(s):

Body Mass Index ◽

Obstructive Sleep Apnea ◽

Diabetic Retinopathy ◽

Sleep Apnea ◽

Body Mass ◽

Smoking Status ◽

Cotton Wool ◽

Nonproliferative Diabetic Retinopathy ◽

Cotton Wool Spots ◽

Obstructive Sleep

Purpose: This work reports the association of obstructive sleep apnea (OSA) and cotton-wool spots (CWS) seen in patients with nonproliferative diabetic retinopathy (DR). Methods: A random sample of patients diagnosed with DR between January 1, 2015 and December 31, 2018, were selected from medical-billing codes. Dilated funduscopic examination findings and medical history were analyzed by reviewing medical records. Results: CWS were present in 12 of 118 patients without OSA, compared with 11 of 32 patients with OSA (10.2% vs 34.4%, respectively; P = .002). OSA was more common in men (68.8%, P = .03) and associated with a higher body mass index (30.0 ± 5.0 without OSA vs 33.6 ± 5.5 with OSA, P < .001). When comparing those with and without OSA, there was no association with age; glycated hemoglobin A1c; stage of DR; insulin dependence; presence of diabetic macular edema; smoking status; or a history of hypertension, hyperlipidemia, cardiovascular disease, or other breathing disorder. Conclusions: The presence of OSA is associated with CWS in patients with DR, as well as male sex and a higher body mass index. Further research is needed to determine the ophthalmologist’s role in the timely referral of patients with CWS for OSA evaluation.

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