Late Breaking Abstract - Induction of the transcriptional repressor B lymphocytes-induced maturation protein-1 (Blimp-1) in lung cancer

AbstractTumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.

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Transcriptional repressor Snail promotes tumor growth and angiogenesis in human non-small cell lung cancer

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2008.06.096 ◽

2008 ◽

Vol 207 (3) ◽

pp. S47

Author(s):

Jane Yanagawa ◽

Tonya C. Walser ◽

Jay M. Lee ◽

Mariam Dohadwala ◽

Li X. Zhu ◽

...

Keyword(s):

Lung Cancer ◽

Tumor Growth ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Transcriptional Repressor ◽

Small Cell ◽

Small Cell Lung

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Homeobox C8 is a transcriptional repressor of E-cadherin gene expression in non-small cell lung cancer

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2019.06.005 ◽

2019 ◽

Vol 114 ◽

pp. 105557 ◽

Cited By ~ 2

Author(s):

Jie Zhang ◽

Mengqi Yang ◽

Dongjia Li ◽

Siqi Zhu ◽

Jin Zou ◽

...

Keyword(s):

Gene Expression ◽

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Transcriptional Repressor ◽

Small Cell ◽

Small Cell Lung ◽

E Cadherin

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Drosophila Blimp-1 Is a Transient Transcriptional Repressor That Controls Timing of the Ecdysone-Induced Developmental Pathway

Molecular and Cellular Biology ◽

10.1128/mcb.01304-07 ◽

2007 ◽

Vol 27 (24) ◽

pp. 8739-8747 ◽

Cited By ~ 36

Author(s):

Yasuo Agawa ◽

Moustafa Sarhan ◽

Yuji Kageyama ◽

Kazutaka Akagi ◽

Masayoshi Takai ◽

...

Keyword(s):

Drosophila Melanogaster ◽

Rna Interference ◽

B Lymphocyte ◽

Transcriptional Repressor ◽

Regulatory Mechanisms ◽

Developmental Pathway ◽

Spectroscopy Analysis ◽

Maturation Protein ◽

Precise Expression ◽

Mass Spectroscopy Analysis

ABSTRACT Regulatory mechanisms controlling the timing of developmental events are crucial for proper development to occur. ftz-f1 is expressed in a temporally regulated manner following pulses of ecdysteroid and this precise expression is necessary for the development of Drosophila melanogaster. To understand how insect hormone ecdysteroids regulate the timing of FTZ-F1 expression, we purified a DNA binding regulator of ftz-f1. Mass spectroscopy analysis revealed this protein to be a fly homolog of mammalian B lymphocyte-induced maturation protein 1 (Blimp-1). Drosophila Blimp-1 (dBlimp-1) is induced directly by 20-hydroxyecdysone, and its product exists during high-ecdysteroid periods and turns over rapidly. Forced expression of dBlimp-1 and RNA interference analysis indicate that dBlimp-1 acts as a repressor and controls the timing of FTZ-F1 expression. Furthermore, its prolonged expression results in delay of pupation timing. These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.

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