Simultaneous measurement of inhaled air and exhaled breath by “Double-MCC/IMS”. A new method for breath analysis. Results of a feasibility study

The high sensitivity of methods, which are applied in breath analysis, entails a high risk of detecting analytes which do not derive from endogenous production. Consequentially, it appears useful to have knowledge about the composition of inhaled air and to include alveolar gradients into interpretation.The current study aimed to standardise sampling procedures in breath analysis, especially with multicapillary column ion-mobility spectrometry (MCC-IMS), by applying a simultaneous registration of inhaled air and exhaled breath.A “Double MCC-IMS” device, which for the first time allows simultaneous analysis of inhaled air and exhaled breath, was developed and tested in 18 healthy individuals. For this two BreathDiscoverys® (BDs) were coupled with each other.Measurements of inhaled air and exhaled breath in 18 healthy individuals (mean age 46±10.9 years; 9 men, 9 women) identified 35 different volatile organic compounds (VOCs) for further analysis. Not all out of these had positive alveolar gradients and could be regarded as endogenous VOCs; 16 VOCs had a positive alveolar gradient in mean, 19 VOCs a negative one. 12 VOCs were positive in more than 12 of the healthy subjects.For the first time in our understanding a method is described, which enables simultaneous measurement of inhaled air and exhaled breath. This facilitates the calculation of alveolar gradients and selection of endogenous VOCs for exhaled breath analysis. Only a part of VOCs in exhaled breath are truly endogenous VOCs. The observation of different and varying polarities of the alveolar gradients needs further analysis.

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High-precision terahertz spectroscopy for noninvasive medicine diagnostics

Photonics and Lasers in Medicine ◽

10.1515/plm-2014-0026 ◽

2014 ◽

Vol 3 (4) ◽

Cited By ~ 4

Author(s):

Vladimir Vaks ◽

Elena Domracheva ◽

Ekaterina Sobakinskaya ◽

Mariya Chernyaeva

Keyword(s):

High Precision ◽

Terahertz Spectroscopy ◽

High Sensitivity ◽

Breath Analysis ◽

Exhaled Breath ◽

Frequency Range ◽

Phase Switching ◽

Exhaled Breath Analysis ◽

Wide Range ◽

The World

AbstractIn recent years methods for exhaled breath analysis have been developing all around the world. The exhaled breath analysis could result in a powerful tool for noninvasive medicine. The work presented in this paper is concerned with gas analyzers for exhaled breath diagnostics. The analyzers are based on high-precision spectrometers of the THz frequency range, which provide high resolution, high sensitivity and detect a wide range of detectable substances. The spectrometers work on non-stationary effects (phase-switching and fast sweep of frequency). The analyzers have been successfully applied for the detection of various biomarkers (nitric oxide, acetone, ammonia, methanol, ethanol) in the breath of conditionally healthy volunteers and patients with various cancerous and noncancerous diseases.

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Exhaled Breath Analysis to Predict Risk of Symptomatic Pneumonitis

Case Medical Research ◽

10.31525/ct1-nct04040244 ◽

2019 ◽

Author(s):

Keyword(s):

Breath Analysis ◽

Exhaled Breath ◽

Exhaled Breath Analysis

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A comparative study on the VOCs gas sensing properties of Zn2SnO4 nanoparticles, hollow cubes, and hollow octahedra towards exhaled breath analysis

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2021.130147 ◽

2021 ◽

pp. 130147

Author(s):

Nguyen Hong Hanh ◽

Trinh Minh Ngoc ◽

Lai Van Duy ◽

Chu Manh Hung ◽

Nguyen Van Duy ◽

...

Keyword(s):

Comparative Study ◽

Gas Sensing ◽

Breath Analysis ◽

Exhaled Breath ◽

Sensing Properties ◽

Exhaled Breath Analysis ◽

Gas Sensing Properties

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Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnostics and Utilization of Calibration Transfer Methods in Breath Analysis Studies

Molecules ◽

10.3390/molecules26123776 ◽

2021 ◽

Vol 26 (12) ◽

pp. 3776

Author(s):

Carsten Jaeschke ◽

Marta Padilla ◽

Johannes Glöckler ◽

Inese Polaka ◽

Martins Leja ◽

...

Keyword(s):

Real Life ◽

Sensor Arrays ◽

Breath Analysis ◽

Exhaled Breath ◽

Calibration Transfer ◽

Early Disease Detection ◽

Exhaled Breath Analysis ◽

Breath Analyzer ◽

Analysis Experiment ◽

Before And After

Exhaled breath analysis for early disease detection may provide a convenient method for painless and non-invasive diagnosis. In this work, a novel, compact and easy-to-use breath analyzer platform with a modular sensing chamber and direct breath sampling unit is presented. The developed analyzer system comprises a compact, low volume, temperature-controlled sensing chamber in three modules that can host any type of resistive gas sensor arrays. Furthermore, in this study three modular breath analyzers are explicitly tested for reproducibility in a real-life breath analysis experiment with several calibration transfer (CT) techniques using transfer samples from the experiment. The experiment consists of classifying breath samples from 15 subjects before and after eating a specific meal using three instruments. We investigate the possibility to transfer calibration models across instruments using transfer samples from the experiment under study, since representative samples of human breath at some conditions are difficult to simulate in a laboratory. For example, exhaled breath from subjects suffering from a disease for which the biomarkers are mostly unknown. Results show that many transfer samples of all the classes under study (in our case meal/no meal) are needed, although some CT methods present reasonably good results with only one class.

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