Zuclopenthixol, melperone and haloperidol/levomepromazine in the elderly. Meta-analysis of two double-blind trials at 15 nursing homes in Norway

1992 ◽  
Vol 12 (10) ◽  
pp. 615-622 ◽  
Author(s):  
H. A. Nygaard ◽  
E. Fuglum ◽  
K. Elgen
Keyword(s):  
Nursing Homes ◽  
Meta Analysis ◽  
The Elderly ◽  
Double Blind ◽  
Blind Trials

QUESTION FOR META-ANALYSTS: CAN YOU MAKE A SILKEN PURSE OUT OF A SOW'S EAR?

PEDIATRICS ◽  
1989 ◽  
Vol 84 (4) ◽  
pp. A108-A108
Author(s):  
Student
Keyword(s):  
Rheumatoid Arthritis ◽  
Meta Analysis ◽  
Multiple Comparisons ◽  
Measurement Scales ◽  
Double Blind ◽  
New Drug ◽  
Baseline Difference ◽  
Blind Trials

Choice of dose [in 196 double-blind trials of treatments for rheumatoid arthritis], multiple comparisons, wrong calculation, sub-group and within-group analyses, wrong sampling units. . . , change in measurement scales before analyses, baseline difference, and selecting reporting of significant results were some of the verified or possible causes for the large proportion of results that favored the [newly proposed] drug. Doubtful or invalid statements were found in 76% of the conclusions or abstracts. Bias consistently favored the new drug in 81 trials, and the control in only one trial. It is not obvious how a reliable meta-analysis could be done [reliably] in these trials.

Antidepressants and the elderly: Double-blind trials 1987-1992

1995 ◽  
Vol 10 (4) ◽  
pp. 265-279 ◽  
Author(s):  
Kaarin Anstey ◽  
Henry Brodaty
Keyword(s):  
The Elderly ◽  
Double Blind ◽  
Blind Trials
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