scholarly journals Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse

BMC Cancer ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Benjamin Lallemant ◽  
Alexandre Evrard ◽  
Christophe Combescure ◽  
Heliette Chapuis ◽  
Guillaume Chambon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Clinical Relevance ◽  
Neck Squamous Cell Carcinoma

Molecular Markers in Head and Neck Squamous Cell Carcinoma: Their Biological Function and Prognostic Significance

2001 ◽  
Vol 110 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Benjamin D. Smith ◽  
Bruce G. Haffty ◽  
Clarence T. Sasaki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Biological Function ◽  
Prognostic Significance ◽  
Growth Factor Receptor ◽  
Neck Squamous Cell Carcinoma ◽  
Increased Risk

Head and neck squamous cell carcinoma affects more than 500,000 people worldwide each year. Despite optimal treatment with surgery, irradiation, and chemotherapy, disease recurrence and progression remains a common and challenging oncological problem. Recently, interest has developed in identifying novel molecular markers that allow identification of those patients at increased risk for locoregional recurrence and death. This article reviews several such molecular markers studied in head and neck cancer, including p53, angiogenesis-related markers, cyclin D1, and epidermal growth factor receptor. The biological function of these markers and the potential clinical implications are discussed. The purpose of this review is to update the otolaryngologist on a rapidly emerging segment of applied translational research in our field.

Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma

2003 ◽  
Vol 103 (6) ◽  
pp. 768-774 ◽  
Author(s):  
Arnolda G. de Nooij-van Dalen ◽  
Guus A.M.S. van Dongen ◽  
Serge J. Smeets ◽  
Eline J.C. Nieuwenhuis ◽  
Marijke Stigter-van Walsum ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

Molecular markers of head and neck squamous cell carcinoma: Promising signs in need of prospective evaluation

Head & Neck ◽  
2006 ◽  
Vol 28 (3) ◽  
pp. 256-269 ◽  
Author(s):  
Phillipe Lothaire ◽  
Evandro de Azambuja ◽  
Didier Dequanter ◽  
Yassine Lalami ◽  
Christos Sotiriou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prospective Evaluation

scholarly journals Immune Escape Mechanisms and their Clinical Relevance in Head and Neck Squamous Cell Carcinoma

2020 ◽  
Author(s):  
Barbara Seliger ◽  
Chiara Massa ◽  
Bo Yang ◽  
Daniel Bethmann ◽  
Matthias Kappler ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Clinical Relevance ◽  
Immune Escape ◽  
Tumour Microenvironment ◽  
Neck Squamous Cell Carcinoma ◽  
Physical Factors ◽  
Immune Escape Mechanisms

Immunotherapy has been recently approved for the treatment of relapsed and metastatic head and neck squamous cell carcinoma (HNSCC). However, the response of patients is limited and the overall survival remains short with a low rate of long-term survivors. There exists growing evidence that immune escape mechanisms play an important role for the low efficacy of immunotherapies in this disease. These are caused by diverse complex processes characterized by (i) changes in the expression of immune modulatory factors in tumour cells, (ii) alterations in the frequency and composition of immune cell subpopulations in the tumour microenvironment and peripheral blood leading to reduced innate and adaptive immune responses, (iii) impaired homing of immune cells to the tumour site as well as (iv) the presence of immune suppressive soluble and physical factors in the tumour microenvironment. We here summarize the major immune escape strategies of HNSCC lesions, the role of the tumor microenvironment in this process, the clinical relevance of HNSCC-induced immune tolerance, currently employed immunotherapeutic approaches and possibilities to overcome resistance to immunotherapy thereby improving the HNSCC patients’ survival.

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