Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study

RationaleWhile cross-sectional studies have shown associations between certain occupational exposures and lower levels of lung function, there was little evidence from population-based studies with repeated lung function measurements.ObjectivesWe aimed to investigate the associations between occupational exposures and longitudinal lung function decline in the population-based Tasmanian Longitudinal Health Study.MethodsLung function decline between ages 45 years and 50 years was assessed using data from 767 participants. Using lifetime work history calendars completed at age 45 years, exposures were assigned according to the ALOHA plus Job Exposure Matrix. Occupational exposures were defined as ever exposed and cumulative exposure -unit- years. We investigated effect modification by sex, smoking and asthma status.ResultsCompared with those without exposure, ever exposures to aromatic solvents and metals were associated with a greater decline in FEV1 (aromatic solvents 15.5 mL/year (95% CI −24.8 to 6.3); metals 11.3 mL/year (95% CI −21.9 to – 0.7)) and FVC (aromatic solvents 14.1 mL/year 95% CI −28.8 to – 0.7; metals 17.5 mL/year (95% CI –34.3 to – 0.8)). Cumulative exposure (unit years) to aromatic solvents was also associated with greater decline in FEV1 and FVC. Women had lower cumulative exposure years to aromatic solvents than men (mean (SD) 9.6 (15.5) vs 16.6 (14.6)), but greater lung function decline than men. We also found association between ever exposures to gases/fumes or mineral dust and greater decline in lung function.ConclusionsExposures to aromatic solvents and metals were associated with greater lung function decline. The effect of aromatic solvents was strongest in women. Preventive strategies should be implemented to reduce these exposures in the workplace.

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Stability, Growth, and Decline in Adult Life Span Development of Declarative Memory: Cross-Sectional and Longitudinal Data From a Population-Based Study.

Psychology and Aging ◽

10.1037/0882-7974.20.1.3 ◽

2005 ◽

Vol 20 (1) ◽

pp. 3-18 ◽

Cited By ~ 381

Author(s):

Michael Rönnlund ◽

Lars Nyberg ◽

Lars Bäckman ◽

Lars-Göran Nilsson

Keyword(s):

Longitudinal Data ◽

Life Span ◽

Declarative Memory ◽

Adult Life ◽

Population Based ◽

Adult Life Span ◽

Cross Sectional ◽

Population Based Study ◽

Life Span Development

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LuftiBus in the school (LUIS): a population-based study on respiratory health in schoolchildren

10.1101/2020.10.14.20212076 ◽

2020 ◽

Author(s):

Rebeca Mozun ◽

Claudia E. Kuehni ◽

Eva S. L. Pedersen ◽

Myrofora Goutaki ◽

Johanna M. Kurz ◽

...

Keyword(s):

Lung Function ◽

Respiratory Health ◽

Environmental Exposures ◽

Population Based ◽

Cross Sectional ◽

Population Based Study ◽

Related Data ◽

School Head ◽

Single Breath ◽

Set Up

SummaryRespiratory disease is common in children and strongly associated with lifestyle and environmental exposures. Thus, it is important to study the epidemiology locally. LuftiBus in the school (LUIS) was set up to assess the respiratory health of schoolchildren in the canton of Zurich, Switzerland.LUIS is a cross-sectional population-based study that was carried out 2013 to 2016. Children aged 6-17 years living in the canton of Zurich were eligible to participate. All schools in the canton were approached and the school head decided whether the school would participate and with which classes. Consenting parents answered a standardized questionnaire at home and assenting children completed a shorter questionnaire by interview at school. Trained technicians measured children’s lung function including spirometry, double tracer gas single-breath washout (DTG-SBW) and fractional exhaled nitric oxide (FeNO). Address histories of participants were geocoded to be linked with area-based socioeconomic measures and environmental exposures like spatiotemporal air pollution estimates for specific time periods and locations. A subgroup was seen again 12 months later using the same procedures to collect longitudinal data.The study included 3870 children at baseline and 655 at the one-year follow-up. Median age was 12.7 years; 281 (8%) had wheezed in the past year. At baseline we collected 3457 (89%) parental and 3546 (92%) children’s questionnaires, and 3393 (88%) FeNO, 3446 (89%) spirometry, and 1795 (46%) DTG-SBW measurements.LUIS is a rich resource of health-related data, with information on lung function, environmental exposures and respiratory health on Swiss schoolchildren.Take home messageLuftiBus in the school (LUIS) is a population-based study with detailed lung function data and rich information on respiratory health in Swiss schoolchildren.

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Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: A cross-sectional population-based study in Korea

Respiratory Medicine ◽

10.1016/j.rmed.2008.08.009 ◽

2009 ◽

Vol 103 (2) ◽

pp. 284-288 ◽

Cited By ~ 13

Author(s):

Heung-Woo Park ◽

Jong-Eun Lee ◽

Se-Hoon Kim ◽

Yoon-Keun Kim ◽

Kyung-Up Min ◽

...

Keyword(s):

Genetic Variation ◽

Risk Factor ◽

Lung Function ◽

Children And Adolescents ◽

Population Based ◽

Cross Sectional ◽

Population Based Study

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Smoking, telomere length and lung function decline: a longitudinal population-based study

Thorax ◽

10.1136/thoraxjnl-2017-210294 ◽

2017 ◽

Vol 73 (3) ◽

pp. 283-285 ◽

Cited By ~ 10

Author(s):

Pascal Andujar ◽

Dominique Courbon ◽

Emilie Bizard ◽

Elisabeth Marcos ◽

Serge Adnot ◽

...

Keyword(s):

Lung Function ◽

Telomere Length ◽

Respiratory Health ◽

Population Based ◽

Lung Function Decline ◽

Cross Sectional ◽

Population Based Study ◽

Heavy Smoking ◽

Impaired Lung Function

Telomere shortening is associated with COPD and impaired lung function in cross-sectional studies, but there is no longitudinal study. We used data from 448 participants recruited as part of the French follow-up of the European Community Respiratory Health Survey. We found no relationship between telomere length at baseline and FEV1 decline after 11 years of follow-up. However, heavy smoking was associated with an accelerated FEV1 decline in individuals with short telomeres, but not in subjects with longer telomeres (p for interaction p=0.08). Our findings suggest that short telomere length in peripheral leucocytes might be a marker for increased susceptibility to the effect of smoking.

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