Circulating levels of IL-18 are significantly influenced by the IL-18 +183 A/G polymorphism in coronary artery disease patients with diabetes type 2 and the metabolic syndrome: an Observational Study

There has been a dramatic increase in the worldwide prevalence of obesity, which is associated with the development of several chronic diseases such as metabolic syndrome, type 2 diabetes and cardiovascular diseases. Osteoprotegerin is a glycoprotein mainly secreted by bone but produced also by heart muscle and blood vessels. It inhibits the recruitment, proliferation, and activation of osteoclasts. The role of osteoprotegerin in the pathogenesis of metabolic syndrome, type 2 diabetes and cardiovascular diseases is still discussed. The study was carried out on 62 patients with metabolic syndrome aged 35-83 (34F and 28M). Type 2 diabetes was diagnosed in 76% of subjects and 62% of them suffered from coronary artery disease as a macrovascular complication. Determinations of biochemical parameters and anthropometric measurements were performed in the studied group. The relationships between serum osteoprotegerin concentrations and components of metabolic syndrome and total cholesterol, LDL-cholesterol, HbA1C, BMI, levels of calcium and phosphate in the blood and 24-hour urinary calcium have been analysed. Diabetics had higher osteoprotegerin concentrations than patients without diabetes (5.570 pmol/l vs 4.690 pmol/l). Osteoprotegerin levels in patients with diabetes and coronary artery disease were significantly higher (6.640pmol/l) than in those without macrovascular complications (5.295 pmol/l) (Z=1.986; p=0.047). Furthermore, the associations between osteoprotegerin and calcium and phosphate levels in the blood and 24-hour urinary calcium have been shown. A lower calcium level in the blood was negative but a lower phosphate level was positive correlated with OPG serum concentration (respectively: 6.825 pmol/l vs 5.195 pmol/l, Z=2.656, p=0.008; 4.250pmol/l vs 5.640 pmol/l, Z=2.718, p=0.007). What’s more, the inverse correlations between OPG concentrations and 24-hour urinary calcium and diastolic blood pressure have been observed. No associations between osteoprotegerin and waist circumference, BMI, cholesterol levels and HbA1C, were found. In summary, osteoprotegerin is not a use ful marker of all components of metabolic syndrome. It is level depends on the presence of hypertension, type 2 diabetes and coronary artery disease. This glycoprotein may serve a a marker of calcium and phosphate homeostasis. We concluded that the relationship between osteoprotegerin concentrations and calcification of atherosclerotic plaques in patients with metabolic syndrome and type 2 diabetes should be analysed in further investigations.

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Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease

Diabetologia ◽

10.1007/s00125-007-0743-8 ◽

2007 ◽

Vol 50 (9) ◽

pp. 1930-1937 ◽

Cited By ~ 118

Author(s):

M. von Eynatten ◽

P. M. Lepper ◽

D. Liu ◽

K. Lang ◽

M. Baumann ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Coronary Artery ◽

Retinol Binding Protein ◽

Retinol Binding Protein 4 ◽

The Metabolic Syndrome ◽

Artery Disease

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MicroRNA profile analysis in pericoronary adipose tissue of diabetic patients with significant coronary artery disease

European Heart Journal ◽

10.1093/eurheartj/ehab724.2634 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

M Marketou ◽

A Plevritaki ◽

J Kontaraki ◽

P Kalogerakos ◽

G Kochiadakis ◽

...

Keyword(s):

Coronary Artery Disease ◽

Adipose Tissue ◽

Coronary Artery ◽

Expression Patterns ◽

Significant Coronary Artery Disease ◽

Diabetes Type 2 ◽

Diabetes Type ◽

Diabetic Patients ◽

Artery Disease

Abstract Background Pericoronary adipose tissue (PCAT) regulates arterial homeostasis, is considered to act in paracrine manner,and plays a role in the pathogenesis of atherosclerosis. PCAT may be a source of microRNAs (miRs) that target other tissues and act as messengers for intercellular communication. In this study, we investigated whether the PCAT surrounding coronary occlusive atherosclerotic lesions shows specific miRs expression patterns in patients with diabetes type 2 compared to non-diabetic patients. Methods We enrolled 43 patients (29 men, aged 63±12 years old) with 3-vessel coronary artery disease who underwent elective coronary bypass surgery with and without diabetes type 2. The PCAT samples were received from all participants. miR-133a, miR-21, miR-26b, miR-9 and miR-143 expression levels in PCAT cells were quantified by real-time reverse transcription polymerase chain reaction. Results Twenty-one patients with diabetic type 2 (14 men, 64±10 years old) and twenty=two non-diabetic patients (15 men, 62±15 years old) were included in the study. PCAT analysis showed a significant upregulation of miR-21 levels in diabetic compared to non-diabetic patients (181±76 versus 21±15, p=0.04). Diabetic patients also revealed a significant increase of miR-26b and miR-143 expression in PCAT samples compared to on-diabetics (33±22 versus 16±13, p=0.02, 93±42 versus 16±23, p=0.01). No significant differences between the two sites were observed in PCAT expression of miR-133a and miR-9 (73±12 versus 130±143, 56±44 versus 34±33, respectively, p =NS for both). Conclusions miRs expression in PCAT from diabetic patients with significant coronary disease show a distinct expression profile. Our study opens new perspectives in the pathophysiologic role of PCAT in atherosclerotic complications of diabetes and should be further investigated. FUNDunding Acknowledgement Type of funding sources: None.

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Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease

Cardiovascular Diabetology ◽

10.1186/1475-2840-10-80 ◽

2011 ◽

Vol 10 (1) ◽

pp. 80 ◽

Cited By ~ 28

Author(s):

Duncan J Campbell ◽

Jithendra B Somaratne ◽

Alicia J Jenkins ◽

David L Prior ◽

Michael Yii ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Coronary Artery ◽

The Metabolic Syndrome ◽

Myocardial Structure ◽

Artery Disease

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Gender does not significantly affect the association between inflammation and the metabolic syndrome among patients with stable coronary artery disease

Atherosclerosis ◽

10.1016/j.atherosclerosis.2014.05.612 ◽

2014 ◽

Vol 235 (2) ◽

pp. e207

Author(s):

C.H. Saely ◽

A. Vonbank ◽

P. Rein ◽

A. Leiherer ◽

D. Zanolin ◽

...

Keyword(s):

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Coronary Artery ◽

Stable Coronary Artery Disease ◽

The Metabolic Syndrome ◽

Artery Disease

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The influence of cardiac rehabilitation on heart rate variability indices in men with type 2 diabetes and coronary artery disease

Diabetes and Vascular Disease Research ◽

10.1177/14791641211020184 ◽

2021 ◽

Vol 18 (3) ◽

pp. 147916412110201

Author(s):

Katarzyna Szmigielska ◽

Anna Jegier

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Heart Rate ◽

Heart Rate Variability ◽

Coronary Artery ◽

Cardiac Rehabilitation ◽

Interval Training ◽

Patients With Diabetes ◽

Artery Disease

The study evaluated the influence of cardiac rehabilitation (CR) on heart rate variability (HRV) in men with coronary artery disease (CAD) with and without diabetes. Method: The study population included 141 male CAD patients prospectively and consecutively admitted to an outpatient comprehensive CR program. Twenty-seven patients with type-2 diabetes were compared with 114 males without diabetes. The participants performed a 45-min cycle ergometer interval training alternating 4-min workload and a 2-min active restitution three times a week for 8 weeks. The training intensity was adjusted so that the patient’s heart rate achieved the training heart rate calculated according to the Karvonen formula. At the baseline and after 8 weeks, all the patients underwent the HRV assessment. Results: HRV indices in the patients with diabetes were significantly lower as compared to the patients without diabetes in SDNN, TP, LF parameters, both at the baseline and after 8 weeks of CR. After 8 weeks of CR, a significant improvement of TP, SDNN, pNN50% and HF occurred in the patients without diabetes, whereas in the patients with diabetes only HF component improved significantly. Conclusions: As regards HRV indices, CR seems to be less effective in patients with CAD and type-2 diabetes.

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