scholarly journals Vitamin C further improves the protective effect of GLP-1 on the ischemia-reperfusion-like effect induced by hyperglycemia post-hypoglycemia in type 1 diabetes

2013 ◽  
Vol 12 (1) ◽  
pp. 97 ◽  
Author(s):  
Antonio Ceriello ◽  
Anna Novials ◽  
Emilio Ortega ◽  
Silvia Canivell ◽  
Gemma Pujadas ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Vitamin C ◽  
Protective Effect ◽  
Ischemia Reperfusion

scholarly journals Spirulina Extract Enhanced a Protective Effect in Type 1 Diabetes by Anti-Apoptosis and Anti-ROS Production

Nutrients ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 1363 ◽  
Author(s):  
Jiyeong Lee ◽  
Arum Park ◽  
Mi Kim ◽  
Hee-Joung Lim ◽  
Young-Ah Rha ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Protective Effect ◽  
Ros Production

Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model

2019 ◽  
Vol 24 (10) ◽  
pp. 1272-1277 ◽  
Author(s):  
Armin Mooranian ◽  
Nassim Zamani ◽  
Giuseppe Luna ◽  
Hesham Al-Sallami ◽  
Momir Mikov ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Bile Acid ◽  
Protective Effect ◽  
Murine Model ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Diabetes Development

scholarly journals Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study

Diabetologia ◽  
2019 ◽  
Vol 63 (2) ◽  
pp. 278-286 ◽  
Author(s):  
Markus Mattila ◽  
◽  
Iris Erlund ◽  
Hye-Seung Lee ◽  
Sari Niinistö ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Type 1 Diabetes ◽  
Vitamin C ◽  
Data Availability ◽  
Islet Autoimmunity ◽  
Plasma Ascorbic Acid ◽  
Background Population ◽  
Increased Risk ◽  
Nested Case Control

Abstract Aims/hypothesis We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes. Methods We used a risk set sampled nested case–control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched for family history of type 1 diabetes, clinical centre and sex. Plasma ascorbic acid concentration was measured at ages 6 and 12 months and then annually up to age 6 years. SNPs in vitamin C transport genes were genotyped using the ImmunoChip custom microarray. Comparisons were adjusted for HLA genotypes and for background population stratification. Results Childhood plasma ascorbic acid (mean ± SD 10.76 ± 3.54 mg/l in controls) was inversely associated with islet autoimmunity risk (adjusted OR 0.96 [95% CI 0.92, 0.99] per +1 mg/l), particularly islet autoimmunity, starting with insulin autoantibodies (OR 0.94 [95% CI 0.88, 0.99]), but not with type 1 diabetes risk (OR 0.93 [95% Cl 0.86, 1.02]). The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]). Conclusions/interpretation Higher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings. Data availability The datasets generated and analysed during the current study will be made available in the NIDDK Central Repository at https://www.niddkrepository.org/studies/teddy.

Protective effect of β-casomorphin-7 on type 1 diabetes rats induced with streptozotocin

Peptides ◽  
2010 ◽  
Vol 31 (9) ◽  
pp. 1725-1729 ◽  
Author(s):  
Hong Yin ◽  
Jinfeng Miao ◽  
Yuanshu Zhang
Keyword(s):  
Type 1 Diabetes ◽  
Protective Effect

scholarly journals Two Insulin Gene Single Nucleotide Polymorphisms Associated with Type 1 Diabetes Risk in the Finnish and Swedish Populations

2007 ◽  
Vol 23 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Antti-Pekka Laine ◽  
Hanna Holmberg ◽  
Anita Nilsson ◽  
Eva Örtqvist ◽  
Minna Kiviniemi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Protective Effect ◽  
Risk Estimation ◽  
Diabetes Risk ◽  
Insulin Gene ◽  
Protective Effects ◽  
Nucleotide Polymorphisms ◽  
Class Iii ◽  
Significant Discrepancy

We have developed high-throughput tests for the detection of the insulin gene region SNPs −23HphI and −2221MspI. The potential of these markers to enhance the efficiency of type 1 diabetes risk screening was then evaluated by analyzing them in Finnish and Swedish populations. Blood spots on filter paper were analyzed using PCR followed by sequence-specific hybridization and time-resolved fluorometry reading. Distribution of the genotypes at both positions differed significantly among the affected children compared to the controls. The risk genotypes (CC, AA) were significantly more common in Finland than in Sweden, both among patients and controls. The VNTR genotype homozygous for the protective class III alleles showed a significantly stronger protective effect than the heterozygote (p= 0.02). Analyzing both SNPs enabled the detection of VNTR class III subclasses IIIA and IIIB. The observed significance between effects of the protective genotypes was due to the strong protective effect of the IIIA/IIIA genotype. IIIA/IIIA was the only genotype with significant discrepancy between protective effects compared to the other class III genotypes. These observations suggest that heterogeneity between the protective IDDM2 lineages could exist, and analyzing both −23HphI and −2221MspI would thus potentially enhance the sensitivity and specificity of type 1 diabetes risk estimation.

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