scholarly journals Characteristic comparison of triglyceride-rich remnant lipoprotein measurement between a new homogenous assay (RemL-C) and a conventional immunoseparation method (RLP-C)

2008 ◽  
Vol 7 (1) ◽  
pp. 18 ◽  
Author(s):  
Hiroshi Yoshida ◽  
Hideo Kurosawa ◽  
Yuji Hirowatari ◽  
Yutaka Ogura ◽  
Katsunori Ikewaki ◽  
...  
Keyword(s):  
Remnant Lipoprotein ◽  
Lipoprotein Measurement

scholarly journals Comparative Study of Bezafibrate and Pravastatin in Patients With Coronary Artery Disease and High Levels of Remnant Lipoprotein

2010 ◽  
Vol 74 (8) ◽  
pp. 1644-1650 ◽  
Author(s):  
Keita Sano ◽  
Takamitsu Nakamura ◽  
Mitsumasa Hirano ◽  
Yoshinobu Kitta ◽  
Tsuyoshi Kobayashi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Comparative Study ◽  
Remnant Lipoprotein ◽  
Artery Disease

Remnant Lipoprotein Cholesterol as a Factor Related to Adult Fatty Liver Disease

2021 ◽  
Author(s):  
Shuang Zhang ◽  
Shitong Cheng ◽  
Xue He ◽  
Wei Wang ◽  
Ke Yun ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Characteristic Curve ◽  
Health Check ◽  
Lipoprotein Cholesterol ◽  
Strong Positive Correlation ◽  
Variable Model ◽  
Remnant Lipoprotein

Abstract Context Dyslipidemia is related to fatty liver disease (FLD), whose relationship with remnant lipoprotein cholesterol (RLP-C), a component of blood lipids, remains unclear. Objective To clarify the correlation between RLP-C and the occurrence and severity of FLD and establish an FLD discriminant model based on health check indicators. Methods Retrospective study of participants who underwent health check-up in the First Affiliated Hospital of China Medical University (Shenyang, China) between January and December 2019. We categorized participants according to liver ultrasound results and analyzed the correlation between RLP-C and occurrence of FLD (n = 38 885) through logistic regression, restricted cubic spline, and receiver operating characteristic curve. We categorized the severity of FLD according to the control attenuation parameter and analyzed the correlation between RLP-C and FLD severity through multiple logistic regression; only males were included (n = 564). Results The adjusted OR (aOR) per SD between RLP-C and FLD was 2.33 (95% CI 2.21-2.46, P < .001), indicating a dose–response relationship (P < .0001). The optimal cut-off value of RLP-C was 0.45 mmol/L and the area under the curve (AUC) was 0.79. The AUC of the 8-variable model was 0.89 in both the training and the validation sets. FLD severity was related to the level of RLP-C (aOR per SD = 1.29, 95% CI 1.07-1.55, P = .008). Conclusion RLP-C has a strong positive correlation with FLD occurrence and FLD severity. These results may help clinicians identify and implement interventions in individuals with high FLD risk and reduce FLD prevalence.

scholarly journals Metabolism of remnant lipoprotein after oral fat loading

1999 ◽  
Vol 26 (11-12) ◽  
pp. 301-305
Author(s):  
Jurji KOBAYASHI ◽  
Yasushi SAITO
Keyword(s):  
Remnant Lipoprotein

scholarly journals Fasting Remnant Lipoprotein Cholesterol and Triglyceride Concentrations Are Elevated in Nondiabetic, Insulin-Resistant, Female Volunteers1

1999 ◽  
Vol 84 (11) ◽  
pp. 3903-3906 ◽  
Author(s):  
Fahim Abbasi ◽  
Tracey McLaughlin ◽  
Cindy Lamendola ◽  
Helen Yeni-Komshian ◽  
Akira Tanaka ◽  
...  
Keyword(s):  
Steady State ◽  
Plasma Concentrations ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Insulin Resistant ◽  
Remnant Lipoprotein ◽  
Increased Risk ◽  
Resistant Group ◽  
State Plasma

This study was initiated to test the hypothesis that plasma concentrations of remnant lipoproteins would be higher after an overnight fast in insulin-resistant compared to insulin-sensitive volunteers. Forty-three healthy nonobese women were studied, divided into insulin-resistant (n = 21) and insulin-sensitive (n = 22) groups on the basis of their steady state plasma glucose (SSPG) concentration at the end of a 180-min infusion of octreotide acetate, insulin, and glucose. Under these conditions, steady state plasma insulin concentrations are similar in all subjects (∼60μ U/mL), and the higher the SSPG concentrations, the more insulin resistant the individual. By selection, mean (±sem) SSPG concentrations were significantly higher (P < 0.001) in the insulin-resistant group (210 ± 7 vs. 78 ± 3 mg/dL). In addition, the insulin-resistant group had higher triglycerides (198 ± 27 vs. 101 ± 12 mg/dL; P < 0.005) and lower high density lipoprotein cholesterol (48 ± 4 vs. 60 ± 4 mg/dL; P < 0.05) concentrations. Finally, insulin resistance was associated with higher remnant lipoprotein particle concentrations of cholesterol (7.2 ± 0.8 vs. 4.4 ± 0.3; P < 0.005) and triglycerides (22.2 ± 3.4 vs. 8.5 ± 1.0; P < 0.001). All of these differences were seen despite the fact that the two groups were similar in terms of age and body mass index. These results identify additional abnormalities in lipoprotein metabolism that may contribute to the increased risk of coronary heart disease seen in insulin-resistant, nondiabetic subjects (syndrome X).

Comparing remnant lipoprotein cholesterol measurement methods to evaluate efficacy of ezetimibe/statin vs statin therapy

2019 ◽  
Vol 13 (6) ◽  
pp. 997-1007.e8
Author(s):  
Peter P. Toth ◽  
Harold E. Bays ◽  
W. Virgil Brown ◽  
Alberico L. Catapano ◽  
Michael H. Davidson ◽  
...  
Keyword(s):  
Statin Therapy ◽  
Measurement Methods ◽  
Lipoprotein Cholesterol ◽  
Remnant Lipoprotein ◽  
Cholesterol Measurement

scholarly journals Highly Sensitive Cholesterol Assay with Enzymatic Cycling Applied to Measurement of Remnant Lipoprotein-Cholesterol in Serum

2002 ◽  
Vol 48 (5) ◽  
pp. 737-741 ◽  
Author(s):  
Koji Kishi ◽  
Koji Ochiai ◽  
Yohsuke Ohta ◽  
Yahiro Uemura ◽  
Kazushi Kanatani ◽  
...  
Keyword(s):  
Cholesterol Oxidase ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Concentration ◽  
Separation Procedure ◽  
Enzymatic Method ◽  
Healthy Individuals ◽  
Apo B ◽  
Remnant Lipoprotein ◽  
Enzymatic Cycling ◽  
Highly Sensitive

Abstract Background: Remnant lipoprotein-cholesterol (RLP-C) concentrations in sera of healthy individuals are very low (0.080–0.437 mmol/L), making conventional cholesterol methods poorly suited to this purpose. We have developed a highly sensitive cholesterol assay (CD method) and applied it to the RLP-C assay. Methods: The CD shuttled cholesterol reversibly between reduced and oxidized forms in the presence of thio-NAD and NADH. The production rate of thio-NADH correlated with the cholesterol concentration and was measured by the absorbance at 404/500 nm. This CD method was combined with an immunoaffinity separation procedure with specific monoclonal antibodies to apolipoprotein (apo) A1 and apo B-100 and used for RLP-C assay. Results were compared with a RLP-C method that uses cholesterol oxidase, peroxidase, and chromogenic substrate. Results: The CD method could detect 0.10 × 10−3 mmol/L cholesterol and was at least 5 times more sensitive than the conventional enzymatic method. Within- and between-day imprecision (as CVs) of the RLP-C assay with the CD method was <4%. Regression analysis of RLP-C assays with the new (y) and conventional (x) cholesterol methods yielded: y = 1.02x − 0.008 mmol/L (Sy|x = 0.0065 mmol/L; r = 0.997; n = 297). Conclusions: Serum RLP-C can be measured by the CD method. The CD method may be useful for other assays that require sensitive cholesterol measurements in biological materials.

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