scholarly journals Bright light in elderly subjects with nonseasonal major depressive disorder: a double blind randomised clinical trial using early morning bright blue light comparing dim red light treatment

Trials ◽  
2008 ◽  
Vol 9 (1) ◽  
Author(s):  
Ritsaert Lieverse ◽  
Marjan M A Nielen ◽  
Dick J Veltman ◽  
Bernard M J Uitdehaag ◽  
Eus J W van Someren ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Red Light ◽  
Bright Light ◽  
Randomised Clinical Trial ◽  
Early Morning ◽  
Light Treatment ◽  
Elderly Subjects ◽  
Major Depressive ◽  
Double Blind ◽  
Bright Blue

Double Blind Randomised Clinical Trial of Bright Light Therapy in Elderly Subjects with Nonseaonal Major Depressive Disorder

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
R. Lieverse ◽  
M. Nielen ◽  
B. Uitdehaag ◽  
E. van Someren ◽  
J. Smit ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Red Light ◽  
Light Condition ◽  
Bright Light ◽  
Light Therapy ◽  
Elderly Subjects ◽  
Bright Light Therapy ◽  
Major Depressive ◽  
Double Blind

Background:The cause of depression is largely unknown, but several studies point to disturbances of biological rhythmicity. The functioning of the suprachiasmatic nucleus (SCN) is impaired, as evidenced by an increased prevalence of day-night rhythm perturbations, such as sleeping disorders. Moreover, the inhibitory SCN neurons on the hypothalamus-pituitary adrenocortical axis (HPA-axis) have decreased activity and HPA-activity is enhanced, when compared to non-depressed elderly. Using bright light therapy (BLT) the SCN can be stimulated. In addition, the beneficial effects of BLT on seasonal depression are well accepted. BLT is a potentially safe, nonexpensive and well accepted treatment option. But the current literature on BLT for depression is inconclusive.Methods/design:RCT (ClinicalTrials.gov identifier: NCT00332670) in 89 subjects, of 60 years and older with a diagnosis of major depressive disorder. After inclusion subjects were randomly allocated to the active (BLT) vs. placebo (dim red light) condition. just before the start of light therapy, after completion of three weeks therapy period, and three weeks thereafter several endocrinological, psychophysiological, psychometrically, neuropsychological measures are performed:Results:Main effect analyses on HADRS-17 scores revealed significant antidepressant effects from BLT. Primary results will be presented.Discussion:BLT reduces nonseasonal depression in elderly patients. Additional lightning may easily be implemented in the homes of patients to serve as add-on treatment to antidepressants or as a stand-alone treatment in elderly depressed patients. Our data support the role of a dysfunctional biological clock in depressed elderly subjects, such a finding may guide further development of novel chronobiological oriented treatment strategies.

scholarly journals Bright light therapy in pregnant women with major depressive disorder: study protocol for a randomized, double-blind, controlled clinical trial

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Babette Bais ◽  
Astrid M. Kamperman ◽  
Marjolein D. van der Zwaag ◽  
Gwen C. Dieleman ◽  
Hanneke W. Harmsen van der Vliet-Torij ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Pregnant Women ◽  
Bright Light ◽  
Light Therapy ◽  
Controlled Clinical Trial ◽  
Bright Light Therapy ◽  
Major Depressive ◽  
Double Blind

737 Prediction of drop out in an adjunctive light treatment trial in patients with non-seasonal depression and evening chronotype

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A287-A288
Author(s):  
Joey W Chan ◽  
Y K Wing ◽  
S P Lam ◽  
Shirley Xin Li ◽  
J Zhang
Keyword(s):  
Clinical Characteristics ◽  
Red Light ◽  
Bright Light ◽  
Fold Increase ◽  
Light Therapy ◽  
Light Treatment ◽  
Drop Out ◽  
Sleep Diary ◽  
Significant Difference ◽  
Seasonal Depression

Abstract Introduction Drop out during treatment hampers therapeutic effect of interventions. The current study examines the possible predictors of drop out during the five-week light treatment in patients with unipolar non-seasonal depression and evening-chronotype. Methods Baseline characteristics including demographics, sleep diary parameters, light treatment prescribed, and early clinical outcomes changes were compared between the Drop out and Non drop out group. Logistic regression analysis was used to examine predictors for drop out. All data were analyzed in a modified intention to treat analysis with last observation carried forward approach. Results A total of 91 subjects (Female 79%, 46.3 ± 11.8 years old) were included in the analysis. There was no significant difference in the baseline demographic and clinical characteristics between the Drop out and Non drop out group. There was also no significant difference in the improvement of clinical parameters over the first week among the two groups. However, treatment non-adherence (in terms of compliance of less than 80% of prescribed duration) over the first treatment week predicts a five-fold increase in risk of drop out during light therapy. (OR: 5.85, CI: 1.414–24.205, p=0.015) after controlling for potential confounders including age, gender, treatment group, patient expectation, and treatment-emergent adverse events. Conclusion This study found that baseline clinical characteristics including depression severity and improvement of depressive symptoms in the initial week did not differ between the Drop out and Non drop out group. The drop out was also not affected by the type of light (dim red versus bright red light), indirectly supporting dim red light as a valid placebo in bright light therapy trial. Treatment adherence is the early phase of light treatment is an important predictor of drop out. Support (if any):

scholarly journals Preventive Effect of Liothyronine on Electroconvulsive Therapy-Induced Memory Deficit in Patients with Major Depressive Disorder: A Double-Blind Controlled Clinical Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Arash Mohagheghi ◽  
Asghar Arfaie ◽  
Shahrokh Amiri ◽  
Masoud Nouri ◽  
Salman Abdi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Visual Memory ◽  
Memory Deficit ◽  
Control Group ◽  
Major Depressive ◽  
Double Blind ◽  
The Impact

Introduction and Objective. Despite the effectiveness of electroconvulsive therapy (ECT) in treating major depressive disorder (MDD), its cognitive side effects make it less popular. This study investigated the impact of liothyronine on ECT-induced memory deficit in patients with MDD.Methodology. This is a double-blind clinical trial, in which 60 patients with MDD who were referred for ECT were selected. The diagnosis was based on the criteria of DSM-IV-TR. Patients were divided randomly into two groups to receive either liothyronine (50 mcg every morning) or placebo. After the assessment with Wechsler Memory Scale-Revised (WMS-R) before first session of ECT, posttests were repeated again, two months after the completion of ECT.Findings. By controlling the pretest scores, the mean scores of the experimental group were higher than the control group in delayed recall, verbal memory, visual memory, general memory, and attention/concentration scales (P<0.05).Conclusion. Liothyronine may prevent ECT-induced memory impairment in patients with MDD. This study has been registered in IRCT underIRCT201401122660N2.

scholarly journals A novel peptide-based pan-influenza A vaccine: A double blind, randomised clinical trial of immunogenicity and safety

Vaccine ◽  
2015 ◽  
Vol 33 (2) ◽  
pp. 396-402 ◽  
Author(s):  
James N. Francis ◽  
Campbell J. Bunce ◽  
Claire Horlock ◽  
Jeannette M. Watson ◽  
Steven J. Warrington ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Influenza A ◽  
Randomised Clinical Trial ◽  
Double Blind
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