scholarly journals Risk factors and their impact on carotid intima-media thickness in young and middle-aged ischemic stroke patients and controls: The Norwegian Stroke in the Young Study

2014 ◽  
Vol 7 (1) ◽  
Author(s):  
Annette Fromm ◽  
Øystein Ariansen Haaland ◽  
Halvor Naess ◽  
Lars Thomassen ◽  
Ulrike Waje-Andreassen
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Middle Aged ◽  
Stroke Patients ◽  
Media Thickness ◽  
Stroke In The Young

scholarly journals Pengaruh Simvastatin Terhadap Ketebalan Intima-Media Karotis Pada Pasien Stroke Iskemik Dengan Diabetes Mellitus Tipe 2

2019 ◽  
Vol 6 (1) ◽  
pp. 20-23
Author(s):  
Aditya Kurnianto ◽  
Dodik Tugaswowo Pramukarso
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ischemic Stroke ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
T Test ◽  
Stroke Patients ◽  
Media Thickness

BACKGROUND :Ischemic stroke is the most common stroke comprising 70-80% of all cases. Carotid intima-media thickness (CIMT) is associated with the occurrence of stroke in older age and adults. Patients with type 2 diabetes mellitus tend to develop a thickening of intima-media carotid artery. Simvastatins inhibit further atherothrombotic process. OBJECTIVE : To analyze the effect of simvastatin for CIMT in ischemic stroke patient with type 2 diabetes mellitus. METHOD : This study was a Randomized Pretest-Posttest Design and conducted at the Hospital Inpatient Ward Dr. Kariadi and Ketileng Semarang from January to December 2014 for all first ischemic stroke patients with Type 2 Diabetes Mellitus. Subjects were divided into groups of 26 controls and 28 patients treated groups. Treatment group were given simvastatin 20 mg each daily for 24 weeks in 28 subjects with a history of acute ischemic stroke and type 2 Diabetes mellitus. Examine the CIMT at the 1st week and 24th week. The normality of the data were tested using Shapiro Wilk and the differences analyzed by using Paired t-test and independent t test. RESULT : There was a significant differences between delta carotid intima-media thickness on administration of simvastatin for ischemic stroke patients with type 2 diabetes mellitus (p=0,008). CONCLUSION : Simvastatin significantly decreases CIMT on ischemic stroke patients with type 2 diabetes mellitus. Keyword : simvastatin, ischemic stroke, carotid intima-media thickness, type 2 diabetes mellitus   LATAR BELAKANG :Stroke iskemik memiliki angka insidensi terbanyak yaitu 70-80% kasus stroke. Ketebalan Intima-media karotis berhubungan dengan terjadinyastroke pada usia tua.Pasien dengan Diabetes mellitus tipe 2 memiliki kemungkinan yang lebih besar mengalami penebalan intima-media carotis. Simvatatin menghambat proses aterotrombosis. TUJUAN :Untuk menganalisis pengaruh simvastatin terhadap ketebalan intima-media karotis pada pasien stroke iskemik dengan diabetes mellitus tipe 2. METODE :Penelitian ini adalah dengan Randomized Pretest-Posttest Design dan telah dilakukan di Rawat Jalan RSUP dr. Kariadi dan poli saraf rawat jalan RSUD Kota Semarang mulai Januari sampai dengan Desember 2014 untuk semua pasien stroke iskemik pertama kali dengan diabetes mellitus tipe 2. Subjek dibagi menjadi kelompok kontrol 26 pasien dan kelompok perlakuan 28 pasien. Kelompok perlakuan diberi simvastatin 20 mg sehari selama 24 minggu pada 28 subjek stroke iskemik dengan  diabetes mellitus tipe 2. Pemeriksaan ketebalan intima-media karotis dilakukan pada minggu ke-1 dan minggu ke-24. Data kemudian di uji normalitasnya menggunakan Saphiro wilk, lalu di analisis menggunakan uji beda paired t testdan independent t test. HASIL :  Kelompok perlakuan didapatkan penurunan ketebalan tunika intima arteri karotis (0,395 + 0,46; p=0,514), KESIMPULAN : Pemberian simvastatin menurunkan ketebalan intima-media karotis secara bermakna pada pasien stroke iskemik dengan diabetes mellitus tipe 2. Kata Kunci     :simvastatin,stroke iskemik, ketebalan intima-media karotis, diabetes mellitus tipe 2      

scholarly journals Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Yuyun Yueniwati ◽  
Valentina Yurina ◽  
Mohammad Rasjad Indra
Keyword(s):  
Ischemic Stroke ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Promoter Polymorphism ◽  
Stroke Patients ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Media Thickness ◽  
Pcr Method

Carotid intima media thickness (CIMT) is clearly associated with atherosclerosis. Studies in ischemic stroke patients reveal that there is a significant association between CIMT with monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN) promoter polymorphism. This research aims to explain the effect of MCP-1 and OPN promoter polymorphism toward CIMT changes identified in Javanese Indonesian children. Subjects were 54 children: 27 were from parents with ischemic stroke (cases), and 27 were from healthy parents (controlled). The CIMT was examined by utilizing high resolution B-mode ultrasound. Physical examination and genotyping analysis of MCP-1 promoter were conducted by employing PCR method. Research results indicate that two polymorphisms were obtained, that is, A-2138T and G-2464A, respectively. A-2138T polymorphism was found in 5% of case children and in 14.3% of controlled children. G-2464A polymorphism was found in 5% of case children. CIMT of case children was significantly different from that of controlled children (0.61±0.012 mm versus,0.52±0.015 mm,P=0.021). Subjects with MCP-1 promoter polymorphism have 1.471 times higher tendency to have thicker CIMT than subjects with no polymorphism in MCP1 promoter. OPN promoter T-66G was also studied but it did not indicate occurrence of polymorphism in samples.

scholarly journals Carotid intima media thickness as a reflection of generalized atherosclerosis is related to body mass index in ischemic stroke patients

2013 ◽  
Vol 5 (3) ◽  
pp. 228
Author(s):  
AmitShankar Singh ◽  
Virendra Atam ◽  
MunnaLal Patel ◽  
ShyamChand Chaudhary ◽  
KamalKumar Sawlani ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Ischemic Stroke ◽  
Body Mass ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Stroke Patients ◽  
Media Thickness

scholarly journals Prevalence of Microalbuminuria and Its Association with Subclinical Carotid Atherosclerosis in Middle Aged, Nondiabetic, Low to Moderate Cardiovascular Risk Individuals with or without Hypertension

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1716
Author(s):  
Eva Szabóová ◽  
Alexandra Lisovszki ◽  
Eliška Fatľová ◽  
Peter Kolarčik ◽  
Peter Szabó ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Carotid Plaque ◽  
Subclinical Atherosclerosis ◽  
Multiple Logistic Regression Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Functional Markers ◽  
Middle Aged ◽  
Media Thickness

Microalbuminuria is closely associated with the risk of cardiovascular disease and all-cause mortality in the general population. Less is known about its relationship with subclinical atherosclerosis. We aimed to assess the prevalence of microalbuminuria and its relationship with subclinical atherosclerosis in middle-aged, nondiabetic, apparently healthy individuals (N = 187; 40.1% men, 59.9% women; aged 35–55 years) as well as to evaluate its potential associations with established risk modifiers, especially with the presence of carotid plaque. Clinical and laboratory parameters, the estimated 10-year fatal cardiovascular risk (SCORE), as well as circulating, functional (flow mediated vasodilation, ankle-brachial index, augmentation index, and pulse wave velocity), and morphological markers (mean carotid intima–media thickness, and carotid plaque) of subclinical atherosclerosis were analysed in group with vs. without microalbuminuria. Microalbuminuria was present in 3.8% of individuals with SCORE risk 0.43 ± 0.79%. Functional markers predominated in both groups. Carotid intima–media thickness (mean ± SD) in both groups was in range: 0.5–0.55 ± 0.09–0.14 mm. Carotid plaque was more frequent in group with (14.3%) vs. without (4.4%) microalbuminuria. Microalbuminuria had no statistically significant effect on most markers of subclinical atherosclerosis, but the increasing value of microalbuminuria was significantly associated with the occurrence of carotid plaque (p = 0.035; OR = 1.035; 95% CI = 1.002–1.07). Additional multiple logistic regression analysis, where variables belonged to microalbuminuria, number of risk factors, and family history, finally showed only two variables: microalbuminuria (p = 0.034; OR = 1.04; 95%CI = 1.003–1.09) and the number of risk factors (p = 0.006; OR = 2.15; 95% CI = 1.24–3.73) with independent and significant impact on the occurrence of carotid plaque. Our results may indicate an association of microalbuminuria with the presence of carotid atherosclerotic plaque; in addition, microalbuminuria and the number of risk factors appear to be possible predictors of the carotid plaque occurrence. Monitoring microalbuminuria may improve the personalized cardiovascular risk assessment in nondiabetic, low-to-moderate cardiovascular risk individuals with or without hypertension.

scholarly journals Triglycerides and carotid intima-media thickness in ischemic stroke patients

2015 ◽  
Vol 243 (1) ◽  
pp. 186-191 ◽  
Author(s):  
Jana Batluk ◽  
Christopher O. Leonards ◽  
Ulrike Grittner ◽  
Kristin Sophie Lange ◽  
Stephan J. Schreiber ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Stroke Patients ◽  
Media Thickness

scholarly journals An Observational Study Of Risk Factors And Their Association With Carotid Intima- Media Thickness In Cases Of Ischemic Stroke

2020 ◽  
Vol 7 (05) ◽  
pp. 4788-4794
Author(s):  
Dr. Arun Tyagi ◽  
Dr. A.K Shrivastava ◽  
Dr Marcia Waran
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Ischemic Stroke ◽  
Observational Study ◽  
Carotid Stenosis ◽  
Tobacco Use ◽  
Heart Diseases ◽  
Intima Media Thickness ◽  
Stroke Patients ◽  
Media Thickness

INTRODUCTION Currently, ischemic heart diseases and stroke are the leading causes of morbidity and mortality worldwide and more than 80% of deaths occurring in the low and the middle-income countries. There are a number of risk factors associated with ischemic stroke; the important ones being hypertension, diabetes mellitus, tobacco use and hyperlipidemia. All the risk factors also contribute towards atherogenesis. Change in the carotid artery intima–media thickness (CIMT) is an indicator of generalized atherosclerosis. This study was conducted to find out correlation between risk factors and CIMT in the stroke patients of western Maharashtra. AIMS AND OBJECTIVES This observational study was conducted in department of medicine from February 2013 to June 2014 to study the risk factors and their association with CIMT if any, in patients of stroke. Fifty stroke patients admitted in the medical ICU were studied. RESULTS Thirty-five patients out of 50 studied had ischemic stroke. Tobacco use (82%) and hypertension (80%) were the commonest risk factors for stroke followed by, dyslipidemia, obesity, metabolic syndrome and diabetes mellitus. Twenty-four (68.5%) out of 35 ischemic stroke patients had CIMT value more than 1.00 mm. Out of 35 ischemic stroke patients 15 had carotid stenosis; four severe (>70%), five moderate (50% - 70%) and six patients had mild (<50%) stenosis. Out of the patients with carotid stenosis, 13 patients had hypertension, 12 were tobacco user, 8 dyslipidemia and 6 had diabetes mellitus. CONCLUSION Increased CIMT is a marker of generalized atherosclerosis and it correlates directly with other risk factors like age, tobacco use, hypertension, diabetes and dyslipidemia.

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