scholarly journals Molecular allergology approach to allergic diseases in the paediatric age

2009 ◽  
Vol 35 (1) ◽  
pp. 29 ◽  
Author(s):  
Claudia Alessandri ◽  
Danila Zennaro ◽  
Alessandra Zaffiro ◽  
Adriano Mari
Keyword(s):  
Allergic Diseases ◽  
Molecular Allergology ◽  
Paediatric Age

Human Microbiome and Allergic Diseases in Children: Pathogenetic Role and Therapeutic Options

2020 ◽  
Vol 16 (2) ◽  
pp. 89-94
Author(s):  
Paola Musso ◽  
Elena Chiappini ◽  
Roberto Bernardini
Keyword(s):  
Immune System ◽  
Immune Modulation ◽  
Neonatal Period ◽  
Human Microbiome ◽  
Allergic Diseases ◽  
Extensive Study ◽  
Special Focus ◽  
Rural Environments ◽  
Enormous Amount ◽  
Paediatric Age

The recent and extensive study of the microbiome has provided an enormous amount of data concerning the type and possible functions of microorganisms present in the gut, airways, genital tract, and skin. These data showed interpersonal differences in the composition of the microbiome and these differences suggest a link between the microbiome, the immune modulation, and the pathogenesis of allergic diseases. This research is particularly relevant in paediatrics, since allergic diseases are constantly increasing and there is evidence in the paediatric age that shows that the composition of the microbiome in the foetal and neonatal period plays a key role in the development of the immune system: vaginal delivery, breastfeeding, childhood spent in rural environments and/or in contact with animals result in a greater biodiversity of the microbiome with the presence of protective species that reduce the activation of Th2 lymphocytes, involved in allergic reactions. Further studies are necessary to better understand the microbiota role in the pathogenesis of atopy in order to understand if specific probiotics and prebiotics, administered orally or topically, can affect the microbiota composition and modulate immune system functions, producing a therapeutic effect in the treatment of allergic diseases. This narrative review analysed the available literature regarding the correlation between the microbiome and the development of allergic diseases and with special focus on paediatric studies. The skin, gut or lung dysbiosis can be a cofactor in the pathogenesis of allergies and the remodulation of the microbiome becomes an important therapeutic challenge.

Human Microbiome and Allergic Diseases in Children: Pathogenetic Role and Therapeutic Options

2020 ◽  
Vol 16 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Paola Musso ◽  
Elena Chiappini ◽  
Roberto Bernardini
Keyword(s):  
Immune System ◽  
Immune Modulation ◽  
Neonatal Period ◽  
Human Microbiome ◽  
Allergic Diseases ◽  
Extensive Study ◽  
Special Focus ◽  
Rural Environments ◽  
Enormous Amount ◽  
Paediatric Age

: The recent and extensive study of the microbiome has provided an enormous amount of data concerning the type and possible functions of microorganisms present in the gut, airways, genital tract, and skin. These data showed interpersonal differences in the composition of the microbiome and these differences suggest a link between the microbiome, the immune modulation, and the pathogenesis of allergic diseases. : This research is particularly relevant in paediatrics, since allergic diseases are constantly increasing and there is evidence in the paediatric age that shows that the composition of the microbiome in the foetal and neonatal period plays a key role in the development of the immune system: vaginal delivery, breastfeeding, childhood spent in rural environments and/or in contact with animals result in a greater biodiversity of the microbiome with the presence of protective species that reduce the activation of Th2 lymphocytes, involved in allergic reactions. : Further studies are necessary to better understand the microbiota role in the pathogenesis of atopy in order to understand if specific probiotics and prebiotics, administered orally or topically, can affect the microbiota composition and modulate immune system functions, producing a therapeutic effect in the treatment of allergic diseases. : This narrative review analysed the available literature regarding the correlation between the microbiome and the development of allergic diseases and with special focus on paediatric studies. The skin, gut or lung dysbiosis can be a cofactor in the pathogenesis of allergies and the remodulation of the microbiome becomes an important therapeutic challenge.

scholarly journals Alergeny ziół kulinarnych i warzyw ważne dla pielęgniarki lub dietetyczki

2020 ◽  
Vol 5 (3) ◽  
pp. 117-136
Author(s):  
Krzysztof Buczyłko ◽  
Keyword(s):  
At Risk ◽  
Allergic Diseases ◽  
Cross Reactivity ◽  
Oral Allergy Syndrome ◽  
Molecular Allergology ◽  
Culinary Herbs

Introduction. New allergenic sources causing the oral allergy syndrome and other allergic diseases have been reported. Overview. The spices, vegetables and some culinary herbs allergenic mole-cules have been identified and presented with their cross-reactivity possibili-ties. Some of the molecules generally considered not to be at risk for severe reactions have been demonstrated to pose a threat for inducing generalized reactions. Conclusions. Molecular allergology basic rules are useful for nurses and dieti-tians as well.

The prevalence of allergic diseases in primary school children in Edirne, Turkey

1997 ◽  
Vol 27 (3) ◽  
pp. 262-269 ◽  
Author(s):  
Z. TOROS SELCUK ◽  
T. CAG-LAR ◽  
T. ENUNLU ◽  
T. TOPAL
Keyword(s):  
Primary School ◽  
School Children ◽  
Allergic Diseases ◽  
Primary School Children

Predictors of Allergic Diseases Among Pregnant Women, Slovak Republic, 1997–1998

2003 ◽  
Vol 15 (01) ◽  
pp. 030-036
Author(s):  
Scott McNabb ◽  
Eva Reichrtova ◽  
Peter Ciznar ◽  
Lubica Palkovicova ◽  
Andrea Adamcakova ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Slovak Republic ◽  
Allergic Diseases

Iron Metabolism in the Human Body and Setting its Hygienic Limits for Drinking Water. Review. Part 2

2020 ◽  
Vol 99 (5) ◽  
pp. 504-508
Author(s):  
Natalija A. Egorova ◽  
N. V. Kanatnikova
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Iron Overload ◽  
Iron Metabolism ◽  
Subcutaneous Tissue ◽  
Allergic Diseases ◽  
The Body ◽  
Urogenital System ◽  
High Iron Content ◽  
Labile Iron Pool

Iron is an assential element for the growth, division, differentiation and functioning of any cell in the body. Iron is virtually important for human and danger at the same time, because with excessive accumulation it causes oxidative stress with formation of highly active oxygen radicals and reactive form of nitrogen that can destroy cell membranes, proteins, nucleic acids, reduce cell viability, with, according to modern concepts, can contribute to the development of many diseases (cardiovascular, rheumatic, gastrointestinal, neurodegenerative, oncological, metabolic and others), and also accelerate the aging process. Part 1 of this review discussed the issues of iron metabolism in human, including its regulation at the cellular and systemic levels, the intake, transport, use, accumulation and export of iron in cells, the role of the labile iron pool in the cytoplasm of cells and plasma non-transferrin bound iron. Data are provided on the causes, frequency and significance of iron overload in the formation of free radicals and the development of oxidative stress. Part 2 of the review provides information on diseases associated with iron overload as well as information on ferroptosis - a new type of iron-dependent regulated cell death. Attention is paid to the works of domestic authors, where it was found that prolonged use of drinking water with a high iron content is unfavorable for the population and leads to an increase in the overall incidence, the development of the diseases of the blood, skin and subcutaneous tissue, musculoskeletal system, digestive system, urogenital system, and allergic diseases. Separate publications are cited on the possibility of a negative effect of iron at concentrations in water of 0.3 mg/l and lower. The material of the review emphasizes the preventive significance of caution attitude to regulating iron in the water in the Russian Federation, where 1/3 of the population uses iron-containing water for drinking, and substantiate the feasibility of establishing a hygienic limit for iron in water not higher than 0.3 mg/l.

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