A "prime-pull" immunotherapy approach using a lentiviral vector and intratumoral TLR4 agonist redirects cytotoxic T cells

Journal for ImmunoTherapy of Cancer ◽

10.1186/2051-1426-2-s3-p190 ◽

2014 ◽

Vol 2 (S3) ◽

Author(s):

Tina C Albershardt ◽

Andrea J Parsons ◽

Patrick Flynn ◽

Peter Berglund ◽

Jan ter Meulen

Keyword(s):

T Cells ◽

Lentiviral Vector ◽

Cytotoxic T Cells ◽

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Abstract 5673: Large established B16 tumors in mice are eradicated by ZVex® (dendritic cell-targeting lentiviral vector) and G100 (TLR4 agonist) combination immunotherapy through increasing tumor-infiltrating effector T cells and inducing antigen spreading

10.1158/1538-7445.am2017-5673 ◽

2017 ◽

Author(s):

Tina C. Albershardt ◽

Andrea J. Parsons ◽

Jardin Leleux ◽

Peter Berglund ◽

Jan ter Meulen

Keyword(s):

T Cells ◽

Dendritic Cell ◽

Lentiviral Vector ◽

Effector T Cells ◽

Combination Immunotherapy ◽

Cell Targeting ◽

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Use of a lentiviral vector encoding a HCMV-Chimeric IE1-pp65 protein for epitope identification in HLA-Transgenic mice and for ex vivo stimulation and expansion of CD8+ cytotoxic T cells from human peripheral blood cells

Human Immunology ◽

10.1016/j.humimm.2004.02.018 ◽

2004 ◽

Vol 65 (5) ◽

pp. 514-522 ◽

Author(s):

Pierre S Rohrlich ◽

Sylvain Cardinaud ◽

Jacqueline Lulè ◽

Felix A Montero-Julian ◽

Virginie Prodhomme ◽

...

Keyword(s):

T Cells ◽

Transgenic Mice ◽

Peripheral Blood ◽

Blood Cells ◽

Lentiviral Vector ◽

Ex Vivo ◽

Human Peripheral Blood ◽

Cytotoxic T Cells ◽

Peripheral Blood Cells ◽

Epitope Identification

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Intratumoral injections of G100 (synthetic TLR4 agonist) increase trafficking of lentiviral vector-induced antigen-specific CD8 T cells to the tumor microenvironment

Journal for ImmunoTherapy of Cancer ◽

10.1186/2051-1426-3-s2-p290 ◽

2015 ◽

Vol 3 (S2) ◽

Author(s):

Tina C Albershardt ◽

Andrea J Parsons ◽

Peter Berglund ◽

Jan ter Meulen

Keyword(s):

T Cells ◽

Tumor Microenvironment ◽

Cd8 T Cells ◽

Lentiviral Vector ◽

Tlr4 Agonist ◽

Intratumoral Injections

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Author response for "The efficacy and safety of Epstein‐Barr virus specific antigen peptide‐activated cytotoxic T cells treatment for refractory or recurrent angioimmunoblastic T cell lymphoma: A prospective clinical observational study"

10.1002/hon.2726/v2/response1 ◽

2020 ◽

Author(s):

Wang Bingjie ◽

Wang Lihong ◽

Shi Yongjin ◽

Liu Huihui ◽

Ou Jinping ◽

...

Keyword(s):

T Cells ◽

Epstein Barr Virus ◽

Cell Lymphoma ◽

Cytotoxic T Cells ◽

Specific Antigen ◽

Efficacy And Safety ◽

Angioimmunoblastic T Cell Lymphoma ◽

Antigen Peptide ◽

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Altered surface expression of inhibitory KIR2DL3 and activating CD160, NKG2D receptors on NK and cytotoxic T cells in chronic HCV hepatitis

Zeitschrift für Gastroenterologie ◽

10.1055/s-2008-1079685 ◽

2008 ◽

Vol 46 (05) ◽

Author(s):

G Pár ◽

L Szereday ◽

T Berki ◽

A Miseta ◽

G Hegedûs ◽

...

Keyword(s):

T Cells ◽

Cytotoxic T Cells ◽

Surface Expression ◽

Altered Surface ◽

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Safety and Effectiveness of EBV-specific Cytotoxic T Cells for the Treatment for EBV Lymphomas or Other EBV-associated Malignancies

Case Medical Research ◽

10.31525/ct1-nct03988582 ◽

2019 ◽

Author(s):

Keyword(s):

T Cells ◽

Cytotoxic T Cells

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Faculty Opinions recommendation of SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1026204.323170 ◽

2005 ◽

Author(s):

Lynn Enquist

Keyword(s):

Gene Expression ◽

T Cells ◽

Cytotoxic T Cells ◽

Viral Gene Expression ◽

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Faculty Opinions recommendation of iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1999956.1567054 ◽

2010 ◽

Author(s):

Mark Smyth

Keyword(s):

T Cells ◽

Control Mouse ◽

Cytotoxic T Cells ◽

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Faculty Opinions recommendation of Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenstrom macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3346961.3035059 ◽

2010 ◽

Author(s):

Xavier Leleu

Keyword(s):

T Cells ◽

Nucleoside Analogue ◽

Cytotoxic T Cells ◽

Waldenström Macroglobulinemia ◽

Waldenstrom Macroglobulinemia

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Faculty Opinions recommendation of Potential environmental and host participants in the early white matter lesion of adreno-leukodystrophy: morphologic evidence for CD8 cytotoxic T cells, cytolysis of oligodendrocytes, and CD1-mediated lipid antigen presentation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718010258.793476650 ◽

2013 ◽

Author(s):

Peter Stys

Keyword(s):

T Cells ◽

White Matter ◽

Antigen Presentation ◽

White Matter Lesion ◽

Cytotoxic T Cells ◽

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